CN108078804A - A kind of composite humectant and preparation method thereof - Google Patents
A kind of composite humectant and preparation method thereof Download PDFInfo
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- CN108078804A CN108078804A CN201711385421.0A CN201711385421A CN108078804A CN 108078804 A CN108078804 A CN 108078804A CN 201711385421 A CN201711385421 A CN 201711385421A CN 108078804 A CN108078804 A CN 108078804A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of composite humectants, are made of the raw material of following weight ratio example：10 13 parts of acetyl chitosamine, 15 18 parts of tremella polysaccharides, 18 20 parts of glycine betaine, 25 28 parts of erythrite, 28 30 parts of trehalose.The invention also discloses a kind of production methods of composite humectant.The present invention is natural and safe hygroscopic agent and moisturizer, it can be applied in all personal care products, such as facial cleanser, the bottom such as toner, smoothing toner product and lotion etc., moistening effect are good, salubriouser dermal sensation, mild non-greasy is applied in product of releiving after sunscreen product and solarization, provides mild, nice and cool moistening effect.
Description
Technical field
The invention belongs to cosmetic fields, and in particular to a kind of composite humectant and preparation method thereof.
Background technology
Moisturizer to simulate the natural moisture preserving system being made of in human skin oil, water, natural moisturizing factor (NMF),
Effect is moisture content is delayed to lose, increases the infiltration of dermal-epidermal moisture content.Protection for skin is temporarily provided, damage is reduced, promotes to repair
Multiple process.
From the perspective of moisturizing balance skin should be allowed to keep water tariff collection grease, and have NMF to keep the suction of skin
Aqueous and moisture retention.Promote skin moisturizing from the point of view of cosmetics angle, protect oil, manually add moisturizer, skin is made to have preferably
Moisturizing, the function of protecting oil.This is only cosmetics to the most important task of skin nursing.Natural moisture preserving system master in human skin
It to be made of water, lipid, NMF.Lipid is filled in stratiform between corneocyte, and main function is to form water barrier, is prevented
Loss of moist.
Skin moisturizer is made of main component and other auxiliary elements.Main component includes sealer, hygroscopic agent, parent
Water-based, preventing light agent and some special adding ingredients, and auxiliary element has emulsifier, preservative, fragrance, liposome etc..Component
Mostly chemical synthesis, can be irritant to skin, easily causes the symptoms such as allergy, and moistening effect is undesirable.
The content of the invention
It is an object of the invention to provide a kind of composite humectant and preparation method thereof, to solve institute in above-mentioned background technology
The problem of proposition.
To achieve the above object, the present invention provides following technical scheme：A kind of composite humectant, it is characterised in that：It is compound
Moisturizer is made of the raw material of following weight ratio example：10-13 parts of acetyl chitosamine, 15-18 parts of tremella polysaccharides, glycine betaine 18-20
Part, 25-28 parts of erythrite, 28-30 parts of trehalose.
A kind of production method of composite humectant, includes the following steps：
Step S1：Acetyl chitosamine and tremella polysaccharides are added in mixer, stirring at normal temperature 5 minutes, stirred to completely mixed
It closes uniform；
Step S2：Glycine betaine is slowly added in the mixer in step S1, stirring at normal temperature 10 minutes, stirred to completely mixed
It closes uniform；
Step S3：Erythrite is slowly added in the mixer in step S2, stirring at normal temperature 15 minutes, stirred to completely mixed
It closes uniform；
Step S4：Trehalose is slowly added in the mixer in step S3, stirring at normal temperature 15 minutes, stirred to completely mixed
It closes uniform.
Compared with prior art, the present invention is natural and safe hygroscopic agent and moisturizer, can be applied to all
In people's care product, such as the water-bed product and lotion etc. such as facial cleanser, toner, smoothing toner, moistening effect is good, salubriouser skin
Feel, mild non-greasy is applied in product of releiving after sunscreen product and solarization, provides mild, nice and cool moistening effect.
Specific embodiment
With reference to embodiment the present invention will be further explained explanation, but do not limit the scope of the invention.
The present invention provides a kind of technical solution, and a kind of composite humectant is made of the raw material of following weight ratio example：Acetyl shell
10-13 parts of osamine, 15-18 parts of tremella polysaccharides, 18-20 parts of glycine betaine, 25-28 parts of erythrite, 28-30 parts of trehalose.
A kind of production method of composite humectant, includes the following steps：
Step S1：Acetyl chitosamine and tremella polysaccharides are added in mixer, stirring at normal temperature 5 minutes, stirred to completely mixed
It closes uniform；
Step S2：Glycine betaine is slowly added in the mixer in step S1, stirring at normal temperature 10 minutes, stirred to completely mixed
It closes uniform；
Step S3：Erythrite is slowly added in the mixer in step S2, stirring at normal temperature 15 minutes, stirred to completely mixed
It closes uniform；
Step S4：Trehalose is slowly added in the mixer in step S3, stirring at normal temperature 15 minutes, stirred to completely mixed
It closes uniform.
Acetyl chitosamine plays an important role of that improving pachylosis keratinization has the sodium hyaluronate generation of promotion skin moisturizing ingredients, because
It is the raw material of sodium hyaluronate in itself for acetyl chitosamine.Sodium hyaluronate has moisture retention, concentrates the tender degree of water tariff collection skin water.Increase
Into skin immunocompetence.It is degraded using natural manufacturing method ferment, oligosaccharides NAG is directly decomposed by chitin, be that human body is saturating
Bright matter acid and the precursor of chondroitin different phase, can promote human body synthesis hyaluronic acid and strengthen cartilaginous tissue.
Tremella polysaccharides is Basidiomycetes polysaccharide para-immunity reinforcing agent, there is the work for improving body's immunity and promoting leucocyte
With.Experimental study shows that tremella polysaccharides can significantly improve the phagocytic function of mouse reticuloendothelial cell, to caused by cyclophosphamide
Rat leukocyte reduction has preventive and therapeutic action.
Immune function:The immune function of tremella polysaccharides is concentrated mainly on two aspects, first, for non-immunological systems, promotes
Stomach and intestine are grown by beneficial microbe, adjust the formation of enteron aisle ideal microorganism species, and enhancing animal exogenous pathogen is supported
Anti- ability；Second is that for immune defense system, humoral immunity ability is improved, enhances phagocyte phagocytic activity；It is thin to improve lymph
Cytoactive and function, promote cytokine growth, and protection erythrocyte membrane is not easily susceptible to oxidative damage.So as to improve animal body certainly
Body immunocompetence makes animal body enhance disease resistance.In addition to having castering action to immunity of organisms, tremella polysaccharides may be used also
Protein and nucleic acid to be promoted to synthesize, increase the repair ability of itself, safeguard the function of each organ-tissue particularly liver.
Physiological function：1st, immunoregulation capability is improved, the phagocytic activity and specificity of Turnover of Mouse Peritoneal Macrophages can be activated
The formation of antibody can increase in peripheral blood, the quantity of T lymphocytes and bone-marrow-derived lymphocyte, can promote the potency of inducement interferon
Than being higher by 10-20 times (P ﹤ 0.01) than conventional group, delaying the atrophy of thymus gland, can resist and be drawn by Immunosuppressant Cyclophosphamide
It rises, cellular immunity and the low effect of humoral immunity.2nd, function of tumor inhibition is aided in, the phosphatide gland in tumour cell can be improved
The content of glycosides so as to influence the metabolism of its nucleic acid and protein, changes the splitting characteristic of tumour cell, is allowed to turn to normal direction
Change.3rd, delaying senility function can be substantially reduced the lipofuscin content of murine myocardium.Lipofuscin content can reduce in drosophila
24%, average life span extends 28%, can increase the SOD vigor 4 in mouse brain and hepatic tissue, adjust blood glucose, to by alloxan
The hyperglycaemia mouse of induction, be injected intraperitoneally 300mg/kg, 72 it is small when after blood glucose be decreased obviously, have protection to mouse islets β cells
Effect.5th, blood fat, pre- preventing thrombosis are adjusted, the cholesterol in serum that can be substantially reduced Hypertensive Rats is horizontal.It is real through rabbit simultaneously
It tests, the formation time of specific thrombus and fibrinous thrombus can be obviously prolonged, shorten thrombus length, decline thrombus weight, drop
Low platelet adhesion rate and blood viscosity reduce plasma fibrin member content, the vigor of reinforcing fiber lyase.6th, anti-spoke
It penetrates, radiotherapy person is carried out with Co60 rays, number of nucleated cells in marrow, than not authorizing 186% more than the control group of tremella polysaccharides.7th, protect
Gastric mucosa is protected, to emergency type gastric ulcer, there is obvious inhibiting effect, it is oral to reduce ulcer area, promote acetic acid type gastric ulcer
Healing.
Tremella polysaccharides) preparation method：Tremella polysaccharides is a kind of acid heteroglycan, is obtained from Tremella fructification, master
Chain structure is by the mannosan of α-(1 → 3) glucosides key connection, and branch is made of glucuronic acid and xylose.It is present in white fungus
Acid heteroglycan in submerged fermentation sporinite, backbone structure is similar to above, otherwise varied only on branch.
Glycine betaine is a kind of alkaloid, has strong moisture pick-up properties, and glycine betaine is found first in Europe, 19 generation
Since discipline, with sugarcane, the same extraction sucrose that is originally used to uses beet, it is primarily present in the molasses of beet sugar, so
It gains the name, but its effect is just gradually realized until nineteen seventies.Glycine betaine is prevalent in animal and plant body, is
The intermediate product of object metabolism, plays a very important role in the metabolism of nutriment.It is very for the secondary metabolite of metabolism
Important osmotic adjustment enhances resistance, such as salt resistance alkali for plant, drought-enduring particularly significant.
Erythrite white crystals, slightly sweet, relative sweetness 0.65 has refrigerant sense, and caloric value is low, Chinese nickname：1,2,3,4-
Erythrol is one by natural presence, it has excellent compatibility and the sweetener to tooth friendly as zero calorie
It is widely used in food and beverage, index is generated as sugar.It is because having following that erythrite, which can regard natural as,
The reason for several aspects：Erythrite is present in natural food such as grape in itself, and lemon, honey and some fermented foods are such as
In cheese product, erythrite can be applied to be used as hygroscopic agent and moisturizer in cosmetics.
Trehalose plays an important role of to stablize biomembrane (cell membrane) and protein structure and resist drying, be illustrated for its application
Wide prospect.Trehalose is protected applied to biological products.In addition, trehalose plays an important role of that inhibiting ossein decomposes, thus
Available for improving osteoporosis.Trehalose may further be used to preserve research biological products, such as the enzyme of genetic engineering and other
Enzyme, cell membrane, antibody, antigen, organelle etc., food processing, fine chemistry industry etc..
Trehalose is also known as Radix Rhapontici seu Radix Echinopsis sugar, gill fungus sugar etc..It is a kind of safe and reliable natural carbohydrate.Trehalose is by two grapes
The nonreducing sugar that glycan molecule is formed with 1,1- glycosidic bonds has 3 kinds of isomers i.e. trehalose (α, α), isotrehalose (β, β) and new
Trehalose (α, β), and there is non-specific protective effect to various bioactivators.Trehalose has organism magical
Protective effect, be because trehalose under the severe environmental conditions such as high temperature, high and cold, hyperosmosis and dry dehydration in cell surface
Unique protective film can be formed, effectively protected protein matter molecule consistency inactivates, so as to the body that sustains life life process and
Biological characteristic.Many species that extraneous adverse circumstances are shown with outstanding degeneration-resistant tolerance all exist substantial amounts of in vivo with them
Trehalose has direct relation.And such as other carbohydrates of sucrose, glucose in nature, do not possess this function.This is solely
Special functional characteristic so that trehalose is except that can be used as pharmaceutical grade protein, enzyme, vaccine and the excellent activity of other biological product
Beyond protective agent, cytoactive, the important component of moisturizing class cosmetics are also to maintain.Two water crystallization trehaloses are in relative humidity
Less than 92% no hygroscopicity, and anhydrous trehalose has hygroscopicity in relative humidity more than 30%.It is low that this property makes it both have
Hygroscopicity.There is humectant again.Application of the trehalose on cosmetics is to be lived based on it with excellent holding cell
The characteristic of power and large biological molecule activity.Skin Cell, especially epidermal cell are in high temperature, high and cold, dry, intensive ultraviolet radiation
It waits under environment, easily dries out and keratinization or even death occurs come off to make skin damage.Trehalose in this case can
One layer of special protective film is formed in cell surface, the mucus being precipitated from film not only moistens Skin Cell, and also having will be outer
The function that the heat come is radiate.So as to protect skin that will not be damaged.With people to trehalose function and effect understanding,
The hot spot that trehalose will be consumed as the super moisturizing factor of a new generation as Cosmetic Market.Trehalose is a kind of natural
Carbohydrate, be present in many desert plants, when plant dries up formed one layer of vitreous matrix, protect its internal structure,
Until rainwater comes, plant can miraculously play " dead " and demutation.Substantial amounts of research with practice have shown that, trehalose can be protected effectively
Epidermal cell membrane structure is protected, activating cell nurses one's health skin, makes skin health natural, flexible.Epidermal cell high temperature, it is high and cold,
It under the environment such as drying, intensive ultraviolet radiation, easily dries out and makes skin damage, trehalose in this case can be thin
Born of the same parents surface layer forms one layer of special protective film, keeps the original nutrition of skin and moisture, avoids skin sunburn and melanin deposition, have
Effect resists skin ageing phenomenon；The mucus being precipitated from film can mild moisturizing, make bright skin jade-like stone, gloss, tender.
Glycerine will be added in lotion containing the present invention, and the moistening effect of the lotion to containing different glycerine dosage carries out
Comparison.Research includes the women of 100 healthy all ages and classes and the colour of skin, before test carries out, tests the initial moisture of skin,
In order to ensure test result is from the influence of capillary, the depth of measurement is 10-20 μm, and measurement is based on the aqueous of electric double layer
Amount.5 different lotions, wherein glycerine：The ratio of erythrite is respectively 3:0、2:1、1:1、1:2 and 0:3, and every time with 10
People tests.
Testing time is 2 weeks, and test lotion is applied to right hand forearm by subject daily.Retest is same after 2 weeks
The moisture of the skin in region, because counting reason, each tester takes 4 points to be tested, a point without handling, 3
The point handled with lotion.
The moisture in the region not handled with lotion does not change significantly, and 100 testers, using the region of lotion
Moisture all improve.Wherein, glycerine：The ratio of erythrite is 0:Lotion when 3 makes the moisture of skin improve 29%, glycerine：
The ratio of erythrite is 3:Lotion when 0 makes the moisture of skin improve 21%, glycerine：The ratio of erythrite is 2:1、1:1、1:2
The average moisture value added of lotion be 27%, and glycerine：The ratio of erythrite is 2:1 and 1:When 1, the moisture of skin, which improves, to be divided
Other 26% and 24%.The mixing trade-off effect of the two will be more than individual glycerine (21%).It is replaced simultaneously by using erythrite
Partial glycerol, the skin sense of skin are also significantly improved, and are described as with the lotion of glycerine sticky and uncomfortable, and have used red moss
The lotion that alcohol either individually or with glycerine compounds is all without negative impression and sensation.Erythrite is proven to have good
Skin-friendliness for those sensitive and allergic skins, when being contacted with those skin care item containing chemical composition, may cause
Skin irritatin, fash and allergic reaction, but 80 testers are with the skin care item containing erythrite, without the report of side reaction, even if
Those dry skins, sensitive are all accused during the test without the guarantor of skin irritatin.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Profit requirement rather than above description limit, it is intended that all by what is fallen within the meaning and scope of the equivalent requirements of the claims
Variation is included within the present invention, and any mark in claim should not be considered as to the involved claim of limitation.
Moreover, it will be appreciated that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
Using specification as an entirety, the technical solutions in each embodiment can also be properly combined, forms those skilled in the art
It is appreciated that other embodiment.
Claims (2)
1. a kind of composite humectant, it is characterised in that：The composite humectant is made of the raw material of following weight ratio example：Acetyl
10-13 parts of chitosamine, 15-18 parts of tremella polysaccharides, 18-20 parts of glycine betaine, 25-28 parts of erythrite, 28-30 parts of trehalose.
2. a kind of production method of composite humectant, it is characterised in that：The production method includes the following steps：
Step S1：Acetyl chitosamine and tremella polysaccharides are added in mixer, stirring at normal temperature 5 minutes, stirring is equal to being thoroughly mixed
It is even；
Step S2：Glycine betaine is slowly added in the mixer in step S1, stirring at normal temperature 10 minutes, stirring is equal to being thoroughly mixed
It is even；
Step S3：Erythrite is slowly added in the mixer in step S2, stirring at normal temperature 15 minutes, stirring is equal to being thoroughly mixed
It is even；
Step S4：Trehalose is slowly added in the mixer in step S3, stirring at normal temperature 15 minutes, stirring is equal to being thoroughly mixed
It is even.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711385421.0A CN108078804A (en) | 2017-12-20 | 2017-12-20 | A kind of composite humectant and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109276471A (en) * | 2018-11-07 | 2019-01-29 | 上海上水和肌化妆品有限公司 | Polypeptide anti-apolexis composition of fluid inclusion techniques and preparation method thereof |
| CN109662938A (en) * | 2019-02-14 | 2019-04-23 | 重庆市洲仨科技发展有限公司 | A kind of plant polyose moisturizing factor and the preparation method and application thereof |
| CN109953903A (en) * | 2018-10-24 | 2019-07-02 | 华南农业大学 | A kind of skin-moisturizing, skin cream containing Yeast-like conidium exocellular polysaccharide |
| CN111631981A (en) * | 2020-06-19 | 2020-09-08 | 广州科缇生物科技有限公司 | Composition with anti-wrinkle effect, cosmetic and application of composition |
| WO2021220124A1 (en) * | 2020-04-26 | 2021-11-04 | Shyam Sunder Singh | A pharmaceutical composition and method of treatment using l-carnosine and glutathione, its precursors or derivatives thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080069784A1 (en) * | 2006-06-30 | 2008-03-20 | Millikin Cheri L | Regulation of mammalian keratinous tissue using skin and/or hair care actives |
| CN107184486A (en) * | 2017-07-06 | 2017-09-22 | 曾万祥 | A kind of facial mask liquid and the facial mask containing the facial mask liquid |
-
2017
- 2017-12-20 CN CN201711385421.0A patent/CN108078804A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080069784A1 (en) * | 2006-06-30 | 2008-03-20 | Millikin Cheri L | Regulation of mammalian keratinous tissue using skin and/or hair care actives |
| CN107184486A (en) * | 2017-07-06 | 2017-09-22 | 曾万祥 | A kind of facial mask liquid and the facial mask containing the facial mask liquid |
Non-Patent Citations (2)
| Title |
|---|
| 佚名: ""天然保湿剂赤藓醇"", 《新浪博客》 * |
| 佚名: ""波普乐园•舒缓盈润胶囊面膜（维生素B5）"，获取网址：http://125.35.6.80:8181/ftban/itownet/hzp_ba/fw/pz.jsp?processid=20161126115135u0we8&nid=20161126115135u0we8", 《国产非特殊用途化妆品备案服务平台》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109953903A (en) * | 2018-10-24 | 2019-07-02 | 华南农业大学 | A kind of skin-moisturizing, skin cream containing Yeast-like conidium exocellular polysaccharide |
| CN109276471A (en) * | 2018-11-07 | 2019-01-29 | 上海上水和肌化妆品有限公司 | Polypeptide anti-apolexis composition of fluid inclusion techniques and preparation method thereof |
| CN109662938A (en) * | 2019-02-14 | 2019-04-23 | 重庆市洲仨科技发展有限公司 | A kind of plant polyose moisturizing factor and the preparation method and application thereof |
| WO2021220124A1 (en) * | 2020-04-26 | 2021-11-04 | Shyam Sunder Singh | A pharmaceutical composition and method of treatment using l-carnosine and glutathione, its precursors or derivatives thereof |
| CN111631981A (en) * | 2020-06-19 | 2020-09-08 | 广州科缇生物科技有限公司 | Composition with anti-wrinkle effect, cosmetic and application of composition |
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