CN108066426A - A kind of antiphlogistic bezoar capsule and preparation method thereof - Google Patents
A kind of antiphlogistic bezoar capsule and preparation method thereof Download PDFInfo
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- CN108066426A CN108066426A CN201810088296.5A CN201810088296A CN108066426A CN 108066426 A CN108066426 A CN 108066426A CN 201810088296 A CN201810088296 A CN 201810088296A CN 108066426 A CN108066426 A CN 108066426A
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- 206010004542 Bezoar Diseases 0.000 title claims abstract description 19
- 239000002260 anti-inflammatory agent Substances 0.000 title claims abstract description 15
- 230000001741 anti-phlogistic effect Effects 0.000 title claims abstract description 15
- 239000002775 capsule Substances 0.000 title claims abstract description 15
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000003814 drug Substances 0.000 claims abstract description 22
- 239000000463 material Substances 0.000 claims abstract description 20
- 229940079593 drug Drugs 0.000 claims abstract description 14
- 229910052957 realgar Inorganic materials 0.000 claims abstract description 12
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 11
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 11
- 241000208671 Campanulaceae Species 0.000 claims abstract description 11
- 229940116229 borneol Drugs 0.000 claims abstract description 11
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 11
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229910052602 gypsum Inorganic materials 0.000 claims abstract description 11
- 239000010440 gypsum Substances 0.000 claims abstract description 11
- 240000004980 Rheum officinale Species 0.000 claims abstract description 10
- 235000008081 Rheum officinale Nutrition 0.000 claims abstract description 10
- 238000011221 initial treatment Methods 0.000 claims abstract description 4
- 238000000605 extraction Methods 0.000 claims description 18
- 239000007788 liquid Substances 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 15
- 239000012141 concentrate Substances 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 238000001556 precipitation Methods 0.000 claims description 6
- 238000000926 separation method Methods 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 238000012545 processing Methods 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical group [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 238000009835 boiling Methods 0.000 claims description 3
- 238000005520 cutting process Methods 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 239000012467 final product Substances 0.000 claims description 3
- 238000000227 grinding Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 238000007654 immersion Methods 0.000 claims description 3
- 238000002203 pretreatment Methods 0.000 claims description 3
- 238000007873 sieving Methods 0.000 claims description 3
- 239000007901 soft capsule Substances 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 239000006228 supernatant Substances 0.000 claims description 3
- 230000008719 thickening Effects 0.000 claims description 3
- 235000009508 confectionery Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 4
- 238000000746 purification Methods 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 2
- 206010000269 abscess Diseases 0.000 description 2
- 229910052785 arsenic Inorganic materials 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 240000005373 Panax quinquefolius Species 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 241000593989 Scardinius erythrophthalmus Species 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000007803 cold maceration Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 210000005096 hematological system Anatomy 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 229910052958 orpiment Inorganic materials 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 210000004994 reproductive system Anatomy 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/36—Arsenic; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/413—Gall bladder; Bile
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses a kind of antiphlogistic bezoar capsules and preparation method thereof；It is made of the material of following parts by weight：38 parts of calculus bovis factitius, 40 60 parts of realgar, 180 200 parts of gypsum, 180 200 parts of rheum officinale, 150 180 parts of radix scutellariae, 80 100 parts of campanulaceae, 20 30 parts of borneol, 40 60 parts of Radix Glycyrrhizae；Mainly include the primary treatment of medicinal material, the purification of drug, pharmacy；The present invention has the characteristics that preparation process is simple, easy to use, curative effect is high, at low cost.
Description
Technical field
The present invention relates to field of pharmaceutical preparations, are specially a kind of antiphlogistic bezoar capsule and preparation method thereof.
Background technology
Detoxicating tablet of cow-bezoar is heat-clearing and detoxifying drug standing in family and traditional Chinese patent drug, by cow-bezoar, realgar, gypsum, big
Huang, radix scutellariae, campanulaceae, borneol and Radix Glycyrrhizae composition, play the role of it is clearing heat and detoxicating, for burning hot interior Sheng, abscess of throat, swelling and aching of gum,
The diseases such as aphthae, red eye, swell pain.Recently the study found that long-term use of detoxicating tablet of cow-bezoar, to nervous system, digestive system, secretes
The toxic side effects such as urinary system, blood, breathing, skin.Main noxious material is realgar in detoxicating tablet of cow-bezoar, and content is endured
Greatly, main component is orpiment, that is, the arsenic being commonly called as；Arsenic is except to liver, kidney, hematological system, nerveous system
System and the toxic effect of reproductive system, can also act on protein and cause anaphylaxis lesion；Except more than symptom, antiphlogistic bezoar
Piece can also cause some additive, and clinical manifestation is taken medicine again for serious withrawal symptom, abscess of throat exacerbation etc. occur after drug withdrawal
Above-mentioned symptom is alleviated rapidly afterwards.
The content of the invention
The purpose of the present invention is in place of overcome the deficiencies in the prior art, provide a kind of antiphlogistic bezoar capsule and its preparation side
Method, have it is clearing heat and detoxicating, relieve heat analgesic, cause for lung stomach intrinsic heat：Vertigo, mouth and nose life sore, acute toothache break out fire
Eye, has sore throat, syrigmus swelling and pain, constipation, skin urtication.
To achieve the above object, the present invention provides following technical solution：A kind of antiphlogistic bezoar capsule and preparation method thereof, by
The material composition of following parts by weight：3-8 parts of calculus bovis factitius, 40-60 parts of realgar, 180-200 parts of gypsum, 180-200 parts of rheum officinale,
150-180 parts of radix scutellariae, 80-100 parts of campanulaceae, 20-30 parts of borneol, 40-60 parts of Radix Glycyrrhizae；
A kind of method for preparing yellow detoxicating capsule, comprises the following steps：
Step 1：The primary treatment of medicinal material；
Medicinal material pre-treatment：By 5 parts of medicinal material calculus bovis factitius, 50 parts of realgar, 200 parts of gypsum, 200 parts of rheum officinale, 150 parts of radix scutellariae,
100 parts of campanulaceae, 25 parts of borneol, 50 parts of Radix Glycyrrhizae carry out net system, cutting, processing, drying, crushing；
Step 2；The extraction of drug ingedient；
(1) extract
Take a certain amount of natural drug coarse powder i.e.：Calculus bovis factitius, realgar, gypsum, rheum officinale, radix scutellariae, campanulaceae, borneol, Radix Glycyrrhizae
It is powdered after crushing, it is most of can be advisable by No. two sieves；Natural drug medicine materical crude slice or coarse powder are placed in appropriate decocting device
After appropriate water immersion medicinal material, heating is added to boil, slightly boiling is kept, is decocted after a certain period of time, filters out fried liquid, the dregs of a decoction continue to decoct 2-
3 times, merge each secondary decoction liquor, concentrate to obtain the final product；A small amount of extractions, boil 20-30 minutes, mass production for the first time, decoct about 1 for the first time
Hour, the 2nd, 3 time decocting time can cut down according to the circumstance；
(2) refine
It is refined also to cry separation, common separation method be generally divided into it is following several, i.e.,：Extraction, the precipitation method, water alcohol precipitation
Method；Extraction is used herein；It is initially charged with solution and adds extractant, vibrate, separatory funnel is placed on iron ring and is stood, makes its point
Layer opens separatory funnel stopcock, then opens cock, and lower floor's liquid is made to be released from separatory funnel lower end, treats oil-water interfaces and cock
It is suitable for reading it is tangent can cut-out tap；Supernatant liquid is poured out from separatory funnel is suitable for reading；
(3) concentrate
It will be concentrated after liquid filtering after extraction, thickening temperature is 65-70 DEG C, steam pressure 0.06-
0.08Mpa, vacuum degree 0.06-0.10Mpa, control relative density of medicine liquid is in 1.00-1.15, formation concentrate；
(4) dry, grinding, pharmacy
It is dry in low-temperature vacuum environment to take out solid for 24 hours by concentrate, it regrinds, sieving；And can should all it lead to
Cross No. two sieves；Qualified medicinal powder is packed among soft capsule, antiphlogistic bezoar capsule is made.
Preferably, in leaching process, temperature height is conducive to extract, but is divided into standard not to be broken to.
Preferably, extraction should follow a small amount of multiple principle, general to extract 3-4 times.
Compared with prior art, beneficial effects of the present invention are as follows：A kind of antiphlogistic bezoar capsule and preparation method thereof, this hair
Bright manufacturing technique requirent is higher, and technique is fine, during extraction, is extracted using decocting method, this method is easy to operate, and extraction efficiency is higher than
Cold-maceration；
Specific embodiment
Embodiment：To achieve the above object, the present invention provides following technical solution：A kind of antiphlogistic bezoar capsule and its preparation
Method is made of the material of following parts by weight：3-8 parts of calculus bovis factitius, 40-60 parts of realgar, 180-200 parts of gypsum, rheum officinale 180-
200 parts, 150-180 parts of radix scutellariae, 80-100 parts of campanulaceae, 20-30 parts of borneol, 40-60 parts of Radix Glycyrrhizae；
It is a kind of to prepare the method for subtracting taste antiphlogistic bezoar capsule, comprise the following steps：
Step 1：The primary treatment of medicinal material；
Medicinal material pre-treatment：By 5 parts of medicinal material calculus bovis factitius, 50 parts of realgar, 200 parts of gypsum, 200 parts of rheum officinale, 150 parts of radix scutellariae,
100 parts of campanulaceae, 25 parts of borneol, 50 parts of Radix Glycyrrhizae carry out net system, cutting, processing, drying, crushing；
The true and false should be carried out before medicinal material net system and differentiates that herbal species are various, source is complicated；Homonym, homonym are more
See；
Since Chinese medicine is mostly crude drug, mostly with soil and other foreign matters or have peculiar smell it is toxic or it is moist not
It is suitable for preservation etc., is handled by certain processing, can reach makes pure medicinal material, flavoring, reduces toxicity and drying and never degenerate
Purpose；In addition, process also have enhancing curative effect of medication, change pharmaceutical properties, convenient for adjust preparation the effects that；
Step 2；The extraction of drug ingedient；
(3) extract
Take a certain amount of natural drug coarse powder i.e.：Calculus bovis factitius, realgar, gypsum, rheum officinale, radix scutellariae, campanulaceae, borneol, Radix Glycyrrhizae
It is powdered after crushing, it is most of can be advisable by No. two sieves；Natural drug medicine materical crude slice or coarse powder are placed in appropriate decocting device
After appropriate water immersion medicinal material, heating is added to boil, slightly boiling is kept, is decocted after a certain period of time, filters out fried liquid, the dregs of a decoction continue to decoct 2-
3 times, merge each secondary decoction liquor, concentrate to obtain the final product；A small amount of extractions, boil 20-30 minutes, mass production for the first time, decoct about 1 for the first time
Hour, the 2nd, 3 time decocting time can cut down according to the circumstance；
(4) refine
It is refined also to cry separation, common separation method be generally divided into it is following several, i.e.,：Extraction, the precipitation method, water alcohol precipitation
Method；Extraction is used herein；It is initially charged with solution and adds extractant, vibrate, separatory funnel is placed on iron ring and is stood, makes its point
Layer opens separatory funnel stopcock, then opens cock, and lower floor's liquid is made to be released from separatory funnel lower end, treats oil-water interfaces and cock
It is suitable for reading it is tangent can cut-out tap；Supernatant liquid is poured out from separatory funnel is suitable for reading；
(3) concentrate
It will be concentrated after liquid filtering after extraction, thickening temperature is 65-70 DEG C, steam pressure 0.06-
0.08Mpa, vacuum degree 0.06-0.10Mpa, control relative density of medicine liquid is in 1.00-1.15, formation concentrate；
(4) dry, grinding, pharmacy
It is dry in low-temperature vacuum environment to take out solid for 24 hours by concentrate, it regrinds, sieving；And can should all it lead to
Cross No. two sieves；Qualified medicinal powder is packed among soft capsule, antiphlogistic bezoar capsule is made.
The basic principles, main features and the advantages of the invention have been shown and described above, for this field skill
For art personnel, it is clear that the invention is not restricted to the details of above-mentioned exemplary embodiment, and without departing substantially from the present invention spirit or
In the case of essential characteristic, the present invention can be realized in other specific forms；Therefore, in all respects, should all incite somebody to action
Embodiment regards exemplary as, and is non-limiting, the scope of the present invention by appended claims rather than on state
Bright restriction, it is intended that including all changes falling within the meaning and scope of the equivalent requirements of the claims in the present invention
It is interior, any mark in claim should not be considered as to the involved claim of limitation.
Moreover, it will be appreciated that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
Using specification as an entirety, the technical solutions in each embodiment can also be properly combined, forms those skilled in the art
It is appreciated that other embodiment.
Claims (2)
1. a kind of antiphlogistic bezoar capsule, it is characterised in that：It is made of the material of following parts by weight：3-8 parts of calculus bovis factitius, realgar
40-60 parts, it is 180-200 parts of gypsum, 180-200 parts of rheum officinale, 150-180 parts of radix scutellariae, 80-100 parts of campanulaceae, 20-30 parts of borneol, sweet
It is 40-60 parts careless.
2. a kind of preparation method of antiphlogistic bezoar capsule, which is characterized in that preparation method comprises the following steps：
Step 1：The primary treatment of medicinal material；
Medicinal material pre-treatment：By 5 parts of medicinal material calculus bovis factitius, 50 parts of realgar, 200 parts of gypsum, 200 parts of rheum officinale, 150 parts of radix scutellariae, campanulaceae
100 parts, 25 parts of borneol, 50 parts of Radix Glycyrrhizae carry out net system, cutting, processing, drying, crushing；
Step 2；The extraction of drug ingedient；
(1) extract
Take a certain amount of natural drug coarse powder i.e.：Calculus bovis factitius, realgar, gypsum, rheum officinale, radix scutellariae, campanulaceae, borneol, Radix Glycyrrhizae crush
Afterwards powdered, it is most of can be advisable by No. two sieves；By natural drug medicine materical crude slice or coarse powder, it is placed in appropriate decocting device plus suitable
Water immersion medicinal material to be measured, after heating is boiled, slightly boiling is kept, decocts after a certain period of time, filters out fried liquid, the dregs of a decoction continue to decoct 2-3 times,
Merge each secondary decoction liquor, concentrate to obtain the final product；A small amount of extractions, boil 20-30 minutes, mass production for the first time, and it is small to decoct about 1 for the first time
When, the 2nd, 3 time decocting time can cut down according to the circumstance；
(2) refine
It is refined also to cry separation, common separation method be generally divided into it is following several, i.e.,：Extraction, the precipitation method, the water alcohol precipitation method；
Extraction is used herein；It is initially charged with solution and adds extractant, vibrate, separatory funnel is placed on iron ring and is stood, makes its layering,
Separatory funnel stopcock is opened, then opens cock, lower floor's liquid is made to be released from separatory funnel lower end, treats that oil-water interfaces are suitable for reading with cock
It is tangent can cut-out tap；Supernatant liquid is poured out from separatory funnel is suitable for reading；
(3) concentrate
It will be concentrated after liquid filtering after extraction, thickening temperature is 65-70 DEG C, steam pressure 0.06-0.08Mpa, very
Reciprocal of duty cycle is 0.06-0.10Mpa, and control relative density of medicine liquid is in 1.00-1.15, formation concentrate；
(4) dry, grinding, pharmacy
It is dry in low-temperature vacuum environment to take out solid for 24 hours by concentrate, it regrinds, sieving；And it should can all pass through two
Number sieve；Qualified medicinal powder is packed among soft capsule, antiphlogistic bezoar capsule is made.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102091135A (en) * | 2009-12-14 | 2011-06-15 | 汤明昌 | Bezoar antidotal pills (tables and capsules) containing bezoar cultured in vitro and preparation method thereof |
| CN105497161A (en) * | 2016-01-22 | 2016-04-20 | 北京康而福药业有限责任公司 | Bezoar detoxicating soft capsule |
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2018
- 2018-01-30 CN CN201810088296.5A patent/CN108066426A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102091135A (en) * | 2009-12-14 | 2011-06-15 | 汤明昌 | Bezoar antidotal pills (tables and capsules) containing bezoar cultured in vitro and preparation method thereof |
| CN105497161A (en) * | 2016-01-22 | 2016-04-20 | 北京康而福药业有限责任公司 | Bezoar detoxicating soft capsule |
Non-Patent Citations (1)
| Title |
|---|
| 国家药典委员会: "《中国人民共和国药典 2010年版 第二增补本》", 30 September 2013, 中国医药科技出版社 * |
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