CN108059593A - 一种芳香仲醇氧化裂解制备有机酸的方法 - Google Patents
一种芳香仲醇氧化裂解制备有机酸的方法 Download PDFInfo
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Abstract
本发明涉及到一种芳香仲醇氧化制备有机酸的方法。以空气或氧气为氧源,以铜盐和有机配体为催化剂,加入无机碱,芳香仲醇发生碳碳键氧化裂解,得到有机酸。本发明氧化效率高,产品收率高;以空气或氧气作为氧源,经济、环保,具有很好的应用前景。
Description
技术领域
本发明涉及到一种芳香仲醇氧化裂解制备有机酸的方法。
背景技术
有机酸是一种重要的化合物,广泛应用于食品、溶剂、医药合成中间体等。传统有机酸主要是通过伯醇氧化,或者烃类氧化,或者醛类的氧化得到。脂肪醇氧化制备脂肪酸是有机合成中非常重要的反应之一,同时也非常具有挑战性。传统的伯醇氧化方法制备酸,使用计量的高锰酸钾、二氧化锰、三氧化铬、次氯酸钠等氧化剂氧化,该方法会副产大量的无机氧化物或盐,污染严重。
芳香仲醇是一类容易得到的原料。目前芳香仲醇氧化主要生成酮。本发明的目的是发展一种芳香仲醇氧化裂解直接制备有机酸的方法。本方法采用氧气为氧源,在铜基催化剂作用下,芳香仲醇高效的转化到有机酸,具有很好的应用前景。
发明内容
本发明提供一种芳香仲醇氧化裂解制备酸的方法。
本发明所采用的技术方案为:
一种芳香仲醇氧化裂解制备有机酸的方法:
以空气或氧气为氧源,以铜盐和有机配体为催化剂,加入无机碱,芳香仲醇发生碳碳键氧化裂解,得到有机酸。
为了使得催化剂与底物充分接触,需要加入溶剂,使催化剂和底物溶解,使其能够充分的接触与反应。有些醇室温为固体,需加入有机溶剂使其溶解。所用溶剂为甲苯、邻二甲苯、乙腈、二氯甲烷、二甲基亚砜中的一种或者两种以上;反应过程中进行搅拌。
所述芳香仲醇的结构式为产物有机酸的结构式为
其中,R为苯基、萘基、吡啶、噻吩、呋喃,或含有取代基的苯基、萘基、吡啶、噻吩、呋喃;
所述取代基为OCH3、F、Cl、Br、I、NO2、CH3中的一种、两种或三种以上,取代基的个数为1-7个。
所述铜盐中铜离子的价态为一价或者二价,阴离子为醋酸跟、硫酸根、硝酸根、氯、溴或碘;
铜盐选自醋酸铜、硫酸铜、硝酸铜、氯化铜、氯化亚铜、溴化铜、溴化亚铜、碘化亚铜。
为了调控铜金属的催化性能,需要引入一些有机配体来调控其电子性质,所述有机配体为含氧和氮的化合物;
优选的有机配体结构如下:
本体系需要加入一定量的无机碱来促进该反应,所述无机碱为KOH、NaOH、LiOH、LiOH、K2CO3、Na2CO3或Cs2CO3中的一种或两种以上。
所述芳香仲醇氧化所用氧源为空气或氧气,氧源中氧气分压为0.1-2MPa。
反应温度为30-150℃;反应时间为0.5-48h。
无机碱与底物芳香仲醇的摩尔比为0.5-2。
以金属铜计,铜盐为底物芳香仲醇的0.1-10mol%;有机配体与铜盐的摩尔比为0.5-2。
本发明将上述催化剂用于芳香仲醇氧化制备有机酸,具体操作过程如下:将催化剂和醇加入到反应釜中,再加入适量溶剂,密闭反应釜,通入一定压力的空气或氧气,搅拌下升至一定温度,反应一定时间后,冷却。
本发明的有益效果为:
催化剂体系简单、高效,副产物少,副产物为苯乙酮,催化剂用量少。
具体实施方式
下面通过具体实施例对本发明进行说明,但本发明实施不局限于这些实施例:
实施例1-18:将0.5mmol 1-苯乙醇,0.025mmol硝酸铜,0.025mmol邻菲罗琳配体,1mmol KOH,2mL溶剂加入到30mL反应釜中,密闭反应釜,通入一定压力的空气或氧气,搅拌下升至一定温度,反应一定时间后,冷却,离心分离催化剂。所得样品定性分析采用气相色谱-质谱联用技术,定量分析由气相色谱实现,结果见表1。
表1反应条件优化
分析表1中结果可知,催化分子氧氧化1-苯乙醇到苯甲酸的较佳溶剂二甲基亚砜,优化条件为0.8MPa氧气分压,90℃,12h,1-苯乙醇的转化率为96%,苯甲酸的选择性为97%。
实施例19-29,将0.5mmol 1-苯乙醇,一定量的催化剂和邻菲罗琳配体,1mmolKOH,2mL二甲基亚砜加入到30mL反应釜中,密闭反应釜,通入0.8MPa氧气,搅拌下升至90℃,反应12h后,冷却。所得样品定性分析采用气相色谱-质谱联用技术,定量分析由气相色谱实现,结果见表2。
表2不同铜盐对催化反应的影响
分析表2中结果可知,随着硝酸铜的增加,1-苯乙醇的转化率和苯甲酸的选择性先增加后减小,优化值5mol%。其它铜盐也有较好的催化效果。
实施例30-34,将0.5mmol 1-苯乙醇,0.01mol硝酸铜,一定量的有机配体,1mmolKOH,2mL二甲基亚砜苯加入到30mL反应釜中,密闭反应釜,通入0.8MPa氧气,搅拌下升至90℃,反应12h后,冷却。所得样品定性分析采用气相色谱-质谱联用技术,定量分析由气相色谱实现,结果见表3。
表3有机配体对催化反应的影响
分析表3中结果可知,有机配体对反应的有着重要影响,影响催化活性和反应的选择性。
实施例35-41,将0.5mmol 1-苯乙醇,0.025mol硝酸铜,0.025mol的邻菲罗琳,一定量的碱,2mL二甲基亚砜加入到30mL反应釜中,密闭反应釜,通入0.8MPa氧气,搅拌下升至90℃,反应12h后,冷却。所得样品定性分析采用气相色谱-质谱联用技术,定量分析由气相色谱实现,结果见表4。
表4碱对催化反应的影响
分析表4中结果可知,碱对反应有明显的促进作用,强键KOH,NaOH表现出更好的效果。
实施例42-53,将0.5mmol芳香仲醇,0.025mol硝酸铜,0.025mol的邻菲罗琳,1mmolKOH,2mL二甲基亚砜加入到30mL反应釜中,密闭反应釜,通入0.8MPa氧气,搅拌下升至90℃,反应12h后,冷却。所得样品定性分析采用气相色谱-质谱联用技术,定量分析由气相色谱实现,结果见表5。
表5不同芳香仲醇氧化
分析表5中结果可知,其它芳香仲醇也能实现高效率的转化为相应的有机酸。
产品的定性采用气相色谱-质谱分析,并和标准样品的保留时间进行比对;定量用内标法气相色谱分析。
转化率=(转化醇的摩尔数/投入醇的摩尔数)×100%
选择性=(酸的摩尔数/转化醇的摩尔数)×100%
本发明方法氧化效率高,所用氧源为分子氧,环保、绿色、成本低,具有很好的应用前景。
Claims (10)
1.一种芳香仲醇氧化裂解制备有机酸的方法,其特征在于:
以空气或氧气为氧源,以铜盐和有机配体为催化剂,加入无机碱,芳香仲醇发生碳碳键氧化裂解,得到有机酸。
2.根据权利要求1所述的方法,其特征在于:反应中加入溶剂,所用溶剂为甲苯、邻二甲苯、乙腈、二氯甲烷、二甲基亚砜中的一种或者两种以上;反应过程中进行搅拌。
3.根据权利要求1所述的方法,其特征在于:
所述芳香仲醇的结构式为产物有机酸的结构式为
其中,R为苯基、萘基、吡啶、噻吩、呋喃,或含有取代基的苯基、萘基、吡啶、噻吩、呋喃;
所述取代基为OCH3、F、Cl、Br、I、NO2、CH3中的一种、两种或三种以上,取代基的个数为1-7个。
4.根据权利要求1所述的方法,其特征在于:所述铜盐中铜离子的价态为一价或者二价,阴离子为醋酸跟、硫酸根、硝酸根、氯、溴或碘;
铜盐选自醋酸铜、硫酸铜、硝酸铜、氯化铜、氯化亚铜、溴化铜、溴化亚铜、碘化亚铜。
5.根据权利要求1所述的方法,其特征在于:
所述有机配体为含氧和氮的化合物;
优选的有机配体结构如下:
6.根据权利要求1所述的方法,其特征在于:
所述无机碱为KOH、NaOH、LiOH、LiOH、K2CO3、Na2CO3或Cs2CO3中的一种或两种以上。
7.根据权利要求1所述的方法,其特征在于:所述芳香仲醇氧化所用氧源为空气或氧气,氧源中氧气分压为0.1-2MPa。
8.根据权利要求1所述的方法,其特征在于:反应温度为30-150℃;反应时间为0.5-48h。
9.根据权利要求1所述的方法,其特征在于:无机碱与底物芳香仲醇的摩尔比为0.5-2。
10.根据权利要求1所述的方法,其特征在于:以金属铜计,铜盐为底物芳香仲醇的0.1-10mol%;有机配体与铜盐的摩尔比为0.5-2。
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CN110483356A (zh) * | 2019-08-28 | 2019-11-22 | 上海克琴科技有限公司 | 一种铜配合物促进的视黄醛的合成方法 |
CN114907196A (zh) * | 2021-02-09 | 2022-08-16 | 赣南医学院 | 通过芳基取代邻二醇氧化裂解制备羰基化合物的方法 |
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CN110483356A (zh) * | 2019-08-28 | 2019-11-22 | 上海克琴科技有限公司 | 一种铜配合物促进的视黄醛的合成方法 |
CN114907196A (zh) * | 2021-02-09 | 2022-08-16 | 赣南医学院 | 通过芳基取代邻二醇氧化裂解制备羰基化合物的方法 |
CN114907196B (zh) * | 2021-02-09 | 2024-01-05 | 赣南医学院 | 通过芳基取代邻二醇氧化裂解制备羰基化合物的方法 |
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