CN1080545A - Nose liniment and preparation technology thereof - Google Patents
Nose liniment and preparation technology thereof Download PDFInfo
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- CN1080545A CN1080545A CN 93117965 CN93117965A CN1080545A CN 1080545 A CN1080545 A CN 1080545A CN 93117965 CN93117965 CN 93117965 CN 93117965 A CN93117965 A CN 93117965A CN 1080545 A CN1080545 A CN 1080545A
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- bulbus allii
- rhizoma
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Nose liniment and preparation technology thereof, its prescription is made up of ten Six-element Chinese medicines such as Bulbus Allii, Flos Magnoliae, the Radix Angelicae Dahuricae, Radix Puerariaes.Preparation method is that medical material is cleaned, and sterilization through diafiltration, enzymolysis, mixing, adds Mel and forms through cryoconcentration in medicinal liquid.The present invention can be used for treating flu, chronic simple rhinitis and allergic rhinitis clinical.Treat by putting on the skin in the nostril, treat rapid-actionly, good effect particularly can be cured nasal obstruction rapidly.Do not have obvious adverse reaction after the medication, medication is carried all very convenient, is worthy of popularization.
Description
The present invention relates to a kind of novel Chinese patent medicine external and put nasal preparation on the skin, with and application in disease such as treatment flu etc.
Flu is one of a kind of global commonly encountered diseases, frequently-occurring disease, the medical scholars of countries in the world are in order to capture the anti-difficulty that cures cold, once did and appear bigger effort, it is with a long history that Chinese medicine prevention is caught a cold, existing detailed record in the Gu doctor nationality before bimillennium.The modern Chinese medicine clinical practice has confirmed that also Chinese medicine is more satisfactory for the curative effect of flu, no matter but be Chinese medicinal formulae or Chinese patent medicine, for oral medicine, rapid inadequately substantially through gastrointestinal absorption, and large usage quantity.Existing Western medicine such as chemical anti-virus formulation, immune formulation, immunostimulant, to putting out or suppress the cold virus of one or more types, certain specific aim or timeliness are all arranged, and the gesture ferociousness to breaking out, plant the cold virus attack that form variation is not surveyed, often be difficult to again prove effective.
The object of the present invention is to provide a kind of external to put nose liniment and the preparation technology thereof of nose approach on the skin with diseases such as treatment flu, this medicine has stronger inhibitory action to multiple pathogenic bacteria and the virus that causes catching a cold, Signs is improved rapidly, and consumption is little, and therapeutic effect is remarkable.
Nose liniment of the present invention is a raw material with the Chinese medicine medical material, processes through diafiltration, enzymolysis, extraction, and its prescription is by weight percentage:
Bulbus Allii 50-73 Flos Magnoliae 1-5 Radix Angelicae Dahuricae 2-6
Radix Puerariae 2-6 Ramulus Cinnamomi 2-6 Herba Ephedrae 2-6
Herba Schizonepetae 2-10 Rhizoma Chuanxiong 1-5 Rhizoma Zingiberis Recens 1-5
Fructus Jujubae 1-5 Herba Asari 1-5 Rhizoma Et Radix Notopterygii 1-5
Radix Saposhnikoviae 2-6 white peony root 2-6 Radix Glycyrrhizae 2-6
Mel 5-20
This property of medicine shape is a light brown viscous liquid, the feeble QI suffering, and tool is garlicky, the sweet acid of distinguishing the flavor of.
Preparation process of the present invention is as follows:
A, the material Flos Magnoliae of getting it filled, the Radix Angelicae Dahuricae, Radix Puerariae, Ramulus Cinnamomi, Herba Ephedrae, Herba Schizonepetae, Rhizoma Chuanxiong, Rhizoma Zingiberis Recens, Fructus Jujubae, Herba Asari, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae, white peony root, Radix Glycyrrhizae, etc. 14 flavors, clean sterilization, mix homogeneously, put in the diafiltration jar, add 5 times of amount distilled waters at normal temperatures, diafiltration 4 hours gets percolate;
B, get Bulbus Allii, go to cut into slices behind the crust, put and use the distilled water enzymolysis in the extraction pot, leave standstill, centrifugal filtration, cryoconcentration gets enzymolysis solution;
C, get 70% concentration ethanol that the Bulbus Allii slag adds 3 times of amounts and extract, filtered and recycled ethanol, medicinal liquid centrifugal filtration, cryoconcentration, concentrated solution;
D, above-mentioned three kinds of extracting solution are mixed, and add Mel and be stirred to evenly, put placement under the low temperature, centrifugal filtration, cryoconcentration to crude drug content is 1.43g/ml concentration.
Nose liniment of the present invention, its principal character chemical constituent is a cinnamic acid, Herba Ephedrae is salty and garlicin etc.Adopt thin layer chromatography to carry out discrimination test.When differentiating the Cortex cinnamomi japonici (Ramulus Cinnamomi) component, exploring with normal hexane-ether-glacial acetic acid (5: 5: 0.1) through test of many times is developing solvent, differentiates cinnamic acid.When differentiating the Herba Ephedrae component, select for use n-butyl alcohol-glacial acetic acid-water (8: 2: 1) to be developing solvent, differentiate ephedrine.When differentiating the Bulbus Allii component, select for use hexane-benzene (9: 1) to be developing solvent, differentiate garlicin.More than the discriminating of three kinds of compositions have good separating effect, the advantage that method is easy.
Preparation process of the present invention, its main extraction process is without organic solvent, and is with low cost, safe and effective, and extraction and preparation process are all very simple, are suitable for pharmaceutical factory large-scale production.
The real difficulty of pharmacodynamics of the present invention shows: this product can obviously strengthen humoral immunization, enhancing body resistance.Can reduce the animal capillary permeability, reduce and ooze out and swelling, antiinflammatory action is preferably arranged, recover promoting, symptoms such as control nasal obstruction watery nasal discharge, sneeze are significant; Extracorporeal bacteria inhibitor test shows, to hemophilus influenza, and staphylococcus aureus, pneumonia is to coccus, and beta hemolytic streptococcus, bacillus pyocyaneus etc. all have strong bacteriostasis, and be especially better to hemophilus influenza and beta hemolytic streptococcus fungistatic effect; Suppress the virus test and show that external have direct killing action to influenza virus, in the animal body influenza virus is had inhibitory action.In route of administration and virus and the medicinal liquid and inoculating cell footpath, back all suppresses virus fully behind the herpes simplex virus elder generation infection cell.Reaction to fever in rabbits due to typhoid fever-the pay part cold triple vaccine also has certain effect.
The toxicologic study of this product shows: it is 392.0 ± 29.7mg/Kg that the acute toxicity test gets mice LD50.Be equivalent to 230 times of clinical consumptions.Long term toxicity test divides four groups of observations with 80 rats, is coated with nasal administration, and in continuous 4 weeks, the big-and-middle small dose group of result is to body weight, general situation, and routine blood test, hepatic and renal function, electrocardiogram and pathological anatomy histological examination do not find that all untoward reaction and toxic change.Local toxicity is observed, and after 4 weeks of continuous and local medication, does not find tangible local untoward reaction, and pathological section nasal mucosa and submucous tissue also show no obvious abnormalities.Show this product short-term, long-term, local application, safe and effective, no obvious toxicity and toxic pathological changes can be for clinical uses.
This product stability test shows that after content changed, places 2-6 month when placing 1 month, content tended towards stability, and differentiates and all be negative that relative density and pH value are almost constant, and be more stable.Content was more stable after the accelerated stability experiment showed placement 1,2, March, differentiated that item is negative, and relative density and pH value are more stable.This product character is a light brown viscous liquid, the feeble QI rate, and the tool Bulbus Allii is smelt, the sweet acid of distinguishing the flavor of.
Clinical verification of the present invention shows: this product is in treatment anemofrigid cold 567 examples, and wherein 453 examples are organized in treatment, matched group 114 examples (positive control drug is an infusion for treating coryza of wind cold type).The total effective rate of treatment group as a result is 93.06%, total obvious effective rate is 69.10%, the matched group total effective rate is 92.98%, total obvious effective rate is 69.30%, learn by statistics and handle the P value all greater than 0.05, two groups total effective rate and total obvious effective rate there was no significant difference are described, therapeutic equivalence, but nose liniment to nasal obstruction and the total effective rate of watery nasal discharge apparently higher than infusion for treating coryza of wind cold type (P＜0.01), total obvious effective rate and infusion for treating coryza of wind cold type to nasal obstruction and headache compare, and difference has highly significant (P＜0.01 or 0.051), and it is fast than infusion for treating coryza of wind cold type that the medicine chief puts the onset time of nasal obstruction on the skin, thereby on the whole, nose liniment is better than infusion for treating coryza of wind cold type to the curative effect of flu.
Model case
Case one: Hao * *, the woman, 42 years old, May 3 in 1992 was first visits.The patient headache, nasal obstruction, snivel, aching of the whole body discomfort, antiperspirant, itching throat occur after suffering from cold before conscious 1 day.Check: ordinary circumstance is fair, and spirit is poor slightly, pharyngeal mild hyperaemia, and the both sides tonsil is little, cardiopulmonary (-), WBC:7800/mm
3, N:72%, the L:28% body of the tongue is light red, thin white fur of tongue, stringy pulse.Diagnosis: the traditional Chinese medical science: anemofrigid cold, doctor trained in Western medicine: medium-sized flu, give nose liniment and put nose on the skin, 3-4 time/day, advise patient's polydipsia boiled water simultaneously, take a good rest.Symptoms such as headache in first day, nasal obstruction, watery nasal discharge obviously alleviate behind the medicine, and second day all disease eliminated substantially behind the medicine, and sick the announcement fully recovered.
Case two: hole * *, the male 26 years old, goes to a doctor the date: on June 1st, 1992.Main suit's heating, aversion to cold, headache 1 day, nasal obstruction, snivel, 38.3 ℃ of body temperature, pharyngeal congestion, the tonsil II is ° big, light red tongue, white and thin fur, wiry and frequent pulse; Chemical examination: peripheral blood WBC1100/mm
3,, N:70%, L:30%, Chest X-rays is normal, uses behind the nose liniment 24 hours, and body temperature is reduced to 37.2 ℃, and symptoms such as nasal obstruction, headache, aversion to cold obviously alleviate, and body temperature is normal after 48 hours, and malaise symptoms disappears.Check hemogram: WBC:7000/mm
3, N:69%, L:31%, the sick announcement fully recovered.
This product is used for the treatment of chronic simple rhinitis 267 examples in addition, wherein 197 examples are organized in treatment, (positive control drug is a phinamide to matched group 70 examples, pharmacy two factories in Foshan produce), the total effective rate of treatment group as a result is 82.74%, and the matched group total effective rate is relatively P＜0.01 of 67.14%, two group of total effective rate, significant differences is arranged, and the treatment group is better than matched group.It is 30.46% that total obvious effective rate is organized in treatment, the total obvious effective rate of matched group is 32.86%, two groups are compared there was no significant difference (P＞0.05), to the total effective rate of nasal obstruction and to the total effective rate of watery nasal discharge, sneeze and total two groups of there was no significant differences of obvious effective rate (P＞0.05), but total obvious effective rate to nasal obstruction, two groups have significant difference (P＞0.05), illustrate that the treatment group is better than matched group to the curative effect of primary disease nasal obstruction symptom.
Model case:
Case one: Du * *, man, 38 years old, workman, first visit on May 12 in 1992.Nasal obstruction, watery nasal discharge, sneeze 15 years.Treating symptom repeatedly still can not continue to alleviate toposcopy: nasal mucosa chronic congestion, swelling, middle nasal meatus's olfactory cleft, no purulent secretion.Symptom is at present: nasal obstruction +++, rhinocnesmus+, watery nasal discharge ++, sneeze+, headache ++.The treatment of use nose liniment, beginning onset in about 1 minute, disease transference cure after 5 minutes, and can keep curative effect about 4 hours, and one week of continuous use, transference cures such as nasal obstruction, rhinocnesmus, sneeze, watery nasal discharge, nasal mucosa hyperemia alleviates, and concha nasalis swelling disappears.
Case two: health * *, the man, 30 years old, in first visit on June 18 in 92 year.Suffer from chronic rhinitis 5 years, nasal obstruction is obvious, and normal sense is breathed and is obstructed, the influence sleep, and the time decreased sense of smell arranged, the time heavy when light, secretions is based on white, the time sneeze is arranged, it is obvious to meet cold reception wind.Toposcopy: nose left and right sides onychauxis, a little hyperemia of mucosa, right nasal meatus is unobstructed, and not seeing has obvious secretions, and red tip of the tongue tongue is white, rolling pulse.Medication beginning in 1 minute onset, nasal obstruction obviously alleviates, but just the time spent nasal discharge increases, and sneeze increases the weight of, and adheres to that medication to the began to alleviate in three days, medication to the seven days, all diseases disappear substantially, and nose does not have secretions.Toposcopy changes not obviously, and the state of an illness is faced control in the recent period.
This product is used for the treatment of 47 routine allergic rhinitises, the result shows after a treatment course of treatment (all around), obvious effective rate is 25.53%, total effective rate is 74.47%, patient's nasal obstruction, watery nasal discharge, sneeze symptom and nasal cavity sign are improved in various degree, the state of an illness is alleviated in various degree, thereby thinks that this medicine has the effect of treatment of allergic rhinitis.This medicine instant effect in addition, to the average onset time of having a stuffy nose be 3.36 minutes, help alleviating rapidly local symptom, and do not have obvious adverse reaction.
Model case:
Open * *, man, 34 years old, first visit on May 5 in 92 year.Suffering from allergic rhinitis outbreak throughout the year often had sneeze, snivel more than 4 years, and morning is obvious.Each sneeze continuously has the secretions that weighs clearly to flow out constantly more than 10 times immediately, and is swollen slightly with rhinocnesmus and skin of ala nasi.To norfloxacin allergy.Toposcopy: each concha nasalis is all little, and the mucosa color is light, and has little water wet.Nasal septum right avertence.Pale tongue with thin fur is white, stringy and rolling pulse.Be diagnosed as chronic allergic rhinitis, to the nose liniment treatment, sneeze after the first medication, snivel increases the weight of to some extent, and a little time can be alleviated.Behind the continuous use 10 days, the frequent sneeze of every morning, watery nasal discharge almost disappear, and other symptom also alleviates.When adhering to that medication finished to the course of treatment, idol has sneeze or rhinocnesmus, toposcopy: the nasal membrane color is light and water is wet alleviates before the treatment, and the patient is comparatively satisfied.
The Therapeutic Method that this product is concrete is as follows: with putting the nose agent on the skin cotton rod is stained with a little medicinal liquid, inserts nostril 1 centimeters, evenly be applied to the nasal cavity perisporium, after waiting to be coated with two nasal cavities, press on one side the Renzhong acupoint gently, on one side with nose dark air-breathing 2-3 time, the nasal obstruction heavier person that has a headache, after being coated with for the first time, drink one glass of hot water, repaste once then is coated with once every half an hour, wait to have a stuffy nose after the remission, be coated with 3-4 every day.
Modern medicine study is observed, and nasal cavity applied medicine is not limited only to treat nose diseases.In recent years, find that many medicines through after the Nasal Mucosa Absorption, can enter the body circulation rapidly, the effect of performance whole body therapeutic is put the nose agent on the skin and is put the characteristics that nose has new wound from the pharmacy of enzymolysis low temperature on the skin to external.Meet the principle that the differential diagnosis in tcm opinion is controlled, have the tcm characteristic of " inner disease outer treat ".By smearing of nasal cavity, brought into play hot loosing and reached the unique effect of sensible cold expelling thoroughly.Practical studies confirms also that the present invention has and suppresses pathogenic bacterium and antiinflammatory action preferably; Can obviously strengthen humoral immunization, the enhancing body low resistance; Can reduce the animal capillary permeability, reduce and ooze out swelling, and the resisiting influenza virus effect.Clinical research shows that further the present invention is to flu, and rhinitis etc. have therapeutical effect preferably, and using dosage is little, and are rapid-action, good effect.Nasal cavity applied medicine is simple and easy to do, no obvious adverse reaction, thereby its clinical use value is arranged, be worthy of popularization.
Claims (4)
1, nose liniment is characterized in that it is that following Chinese medicine medical material processes through diafiltration, enzymolysis, extraction, and its prescription is by weight percentage:
Bulbus Allii 50-73 Flos Magnoliae 1-5 Radix Angelicae Dahuricae 2-6
Radix Puerariae 2-6 Ramulus Cinnamomi 2-6 Herba Ephedrae 2-6
Herba Schizonepetae 2-10 Rhizoma Chuanxiong 1-5 Rhizoma Zingiberis Recens 1-5
Fructus Jujubae 1-5 Herba Asari 1-5 Rhizoma Et Radix Notopterygii 1-5
Radix Saposhnikoviae 2-6 white peony root 2-6 Radix Glycyrrhizae 2-6
Mel 5-20
This property of medicine shape is a light brown viscous liquid, the feeble QI suffering, and tool is garlicky, and it is sweet to distinguish the flavor of; Its principal character chemical constituent is cinnamic acid, ephedrine and garlicin.
2, the preparation technology of nose liniment according to claim 1 is characterized in that realizing as follows:
A, get it filled material Flos Magnoliae, the Radix Angelicae Dahuricae, Radix Puerariae, Ramulus Cinnamomi, Herba Ephedrae, Herba Schizonepetae, Rhizoma Chuanxiong, Rhizoma Zingiberis Recens, Fructus Jujubae, Herba Asari, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae, white peony root, Radix Glycyrrhizae are cleaned, sterilization, mix homogeneously, put in the diafiltration jar, add 5 times of amount distilled waters at normal temperatures, diafiltration 4 hours gets percolate;
B, get Bulbus Allii, go to cut into slices behind the crust, put and use the distilled water enzymolysis in the extraction pot, leave standstill, centrifugal filtration, cryoconcentration gets enzymolysis solution;
C, get 70% concentration ethanol that the Bulbus Allii slag adds 3 times of amounts and extract, filtered and recycled ethanol, medicinal liquid centrifugal filtration, cryoconcentration, concentrated solution;
D, above-mentioned three kinds of extracting solution are mixed, and add Mel and be stirred to evenly, put placement under the low temperature, centrifugal filtration, cryoconcentration to crude drug content is 1.43g/ml concentration, and is canned.
3, nose liniment as claimed in claim 1 is characterized in that adopting thin layer chromatography to carry out discrimination test, and when differentiating the Cortex cinnamomi japonici (Ramulus Cinnamomi) component, adopting normal hexane-ether-glacial acetic acid (5: 5: 0.1) is developing solvent, differentiates cinnamic acid.When differentiating the Herba Ephedrae component, select for use n-butyl alcohol-glacial acetic acid-water (8: 2: 1) to be developing solvent, differentiate ephedrine.When differentiating the Bulbus Allii component, select for use hexane-benzene (9: 1) to be developing solvent, differentiate garlicin.
4, nose liniment as claimed in claim 1, its feature said preparation can be used for treating diseases such as flu, chronic simple rhinitis, allergic rhinitis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93117965 CN1025478C (en) | 1993-09-29 | 1993-09-29 | Nose liniment and preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93117965 CN1025478C (en) | 1993-09-29 | 1993-09-29 | Nose liniment and preparing process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1080545A true CN1080545A (en) | 1994-01-12 |
| CN1025478C CN1025478C (en) | 1994-07-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93117965 Expired - Fee Related CN1025478C (en) | 1993-09-29 | 1993-09-29 | Nose liniment and preparing process |
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| Country | Link |
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| CN (1) | CN1025478C (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1899593B (en) * | 2006-07-17 | 2012-07-11 | 刘树平 | Powder for treating common cold and its preparing method |
| CN103463254A (en) * | 2013-08-26 | 2013-12-25 | 荣成市科学技术情报研究所 | Traditional Chinese medicine composition for treating allergic rhinitis |
| CN103830355A (en) * | 2014-02-28 | 2014-06-04 | 田易玲 | Black cumin seed oil nose drop and preparation method thereof |
| CN103948898A (en) * | 2014-05-15 | 2014-07-30 | 张士金 | Chinese herbal medicine for treating wind-cold and preparation method thereof |
| CN106110248A (en) * | 2016-07-15 | 2016-11-16 | 杨小玲 | A kind of specially cure cold, the Chinese herbal medicine of rhinitis |
| CN106260991A (en) * | 2015-06-08 | 2017-01-04 | 杜乃龙 | A kind of diet therapy formula controlling cureless cold nasal obstruction |
-
1993
- 1993-09-29 CN CN 93117965 patent/CN1025478C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1899593B (en) * | 2006-07-17 | 2012-07-11 | 刘树平 | Powder for treating common cold and its preparing method |
| CN103463254A (en) * | 2013-08-26 | 2013-12-25 | 荣成市科学技术情报研究所 | Traditional Chinese medicine composition for treating allergic rhinitis |
| CN103830355A (en) * | 2014-02-28 | 2014-06-04 | 田易玲 | Black cumin seed oil nose drop and preparation method thereof |
| CN103830355B (en) * | 2014-02-28 | 2016-03-09 | 徐凌川 | Oleum Nigellae nasal drop and preparation method thereof |
| CN103948898A (en) * | 2014-05-15 | 2014-07-30 | 张士金 | Chinese herbal medicine for treating wind-cold and preparation method thereof |
| CN106260991A (en) * | 2015-06-08 | 2017-01-04 | 杜乃龙 | A kind of diet therapy formula controlling cureless cold nasal obstruction |
| CN106110248A (en) * | 2016-07-15 | 2016-11-16 | 杨小玲 | A kind of specially cure cold, the Chinese herbal medicine of rhinitis |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1025478C (en) | 1994-07-20 |
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