CN104689122B - A kind of medicament for the treatment of pruritus vulvae - Google Patents
A kind of medicament for the treatment of pruritus vulvae Download PDFInfo
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- CN104689122B CN104689122B CN201510124580.XA CN201510124580A CN104689122B CN 104689122 B CN104689122 B CN 104689122B CN 201510124580 A CN201510124580 A CN 201510124580A CN 104689122 B CN104689122 B CN 104689122B
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Abstract
The present invention relates to a kind of medicament for the treatment of pruritus vulvae, it is made up of the material of following weight portion: Herba Jussiaeae Repentis 10-20 part, Radix Caesalpiniae Radicis 5-15 part, Herba cypripedii japonici 1-10 part, clammy hopseedbush leaf 5-15 part, Herba Orostachyos 5-15 part, Radix Aerio Fici Microcarpae 10-20 part, Herba hylotelephii erythrosticti flower 1-10 part, Herba Solani Lyrati 10-20 part, Herba Laggerae Alatae 5-15 part, Ampelopsis cantoniensis （Hook. et Arn.） Planch. var. grossedentata Hand.-Mazz. 10-20 part, Elsholtzia eriostachya Benth. (Aphanochilus eriostachya Benth, Elsholtzia pusilla Banth) 1-10 part, Herba lygodii 10-20 part, Herba asplenii trichomanis 10-20 part, father-in-law's ripple 1-10 part, Flos Osmanthi Fragrantis branch 5-15 part, cyperi rhizoma 10-20 part, Herba Vernoniae Patulae 10-20 part, Herba Salviae Plebeiae 5-15 part, Radix Glycyrrhizae 1-10 part, Herba Chrysopogonis Aciculati 5-15 part, Herba Hyperici 5-15 part.Medicament of the present invention is for pruritus vulvae determined curative effect, and safety is high, is worth applying clinically.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of medicament for the treatment of pruritus vulvae.
Background technology
Pruritus vulvae is common gynecological disease, is pudendum because infusorian, mycete, pubic louse, scabies, pinworm etc. cause special infection, or stimulates because of malnutrition, chronic eczema, drug allergy, chemicals and local is unclean, menstrual period are unhygienic etc. caused by factor.Clinical common external genital pruritus, increased the weight of night or edible irritable food.Pruritus vulvae onset urgency, the course of disease are grown, are easily recurred, and when pruritus is serious, the many uneasy in either sitting or lying of patient, have a strong impact on live and work.
For a long time, doctor trained in Western medicine is clinical takes the composite treatments such as infection, and the course for the treatment of is long, untoward reaction is comparatively large, and not easily cure, curative effect is not fully up to expectations.And Chinese medicine therapy is experienced for treatment pruritus vulvae.Pruritus vulvae is attributed to " pudendal pruritus " category by Chinese medicine, think its with damp and hot, malicious, worm is relevant.Pudendal pruritus person, endogenous cause of ill internal organs are deficient, and hepatic and renal function is not normal, the common perineum local damage of exopathogenic factor, and leukorrhagia urine stops amassing, and wet and accumulate and heat-dissipating, parasite caused by accumulation of damp-heat in the body, and insect poison corrodes, then cause vulvodynia unbearably.Because Chinese medicine therapy is various informative, comprise oral, washout and intravaginal medication etc., and untoward reaction being little, easy, economy, no pain, is therefore easily that extensive patients accepts.
Summary of the invention
The object of this invention is to provide a kind of medicament for the treatment of pruritus vulvae.
In order to realize object of the present invention, the invention provides a kind of medicament for the treatment of pruritus vulvae, it is made up of the material of following weight portion: Herba Jussiaeae Repentis 10-20 part, Radix Caesalpiniae Radicis 5-15 part, Herba cypripedii japonici 1-10 part, clammy hopseedbush leaf 5-15 part, Herba Orostachyos 5-15 part, Radix Aerio Fici Microcarpae 10-20 part, Herba hylotelephii erythrosticti flower 1-10 part, Herba Solani Lyrati 10-20 part, Herba Laggerae Alatae 5-15 part, Ampelopsis cantoniensis （Hook. et Arn.） Planch. var. grossedentata Hand.-Mazz. 10-20 part, Elsholtzia eriostachya Benth. (Aphanochilus eriostachya Benth, Elsholtzia pusilla Banth) 1-10 part, Herba lygodii 10-20 part, Herba asplenii trichomanis 10-20 part, father-in-law's ripple 1-10 part, Flos Osmanthi Fragrantis branch 5-15 part, cyperi rhizoma 10-20 part, Herba Vernoniae Patulae 10-20 part, Herba Salviae Plebeiae 5-15 part, Radix Glycyrrhizae 1-10 part, Herba Chrysopogonis Aciculati 5-15 part, Herba Hyperici 5-15 part.
Preferably, the medicament for the treatment of pruritus vulvae of the present invention is made up of the material of following weight portion: Herba Jussiaeae Repentis 15 parts, Radix Caesalpiniae Radicis 10 parts, Herba cypripedii japonici 8 parts, clammy hopseedbush leaf 12 parts, Herba Orostachyos 10 parts, Radix Aerio Fici Microcarpae 15 parts, Herba hylotelephii erythrosticti spend 5 parts, Herba Solani Lyrati 15 parts, Herba Laggerae Alatae 10 parts, Ampelopsis cantoniensis （Hook. et Arn.） Planch. var. grossedentata Hand.-Mazz. 12 parts, Elsholtzia eriostachya Benth. (Aphanochilus eriostachya Benth, Elsholtzia pusilla Banth) 5 parts, Herba lygodii 15 parts, Herba asplenii trichomanis 15 parts, Weng Bo 8 parts, 10 parts, Flos Osmanthi Fragrantis branch, cyperi rhizoma 12 parts, Herba Vernoniae Patulae 15 parts, Herba Salviae Plebeiae 10 parts, 8 parts, Radix Glycyrrhizae, Herba Chrysopogonis Aciculati 10 parts, Herba Hyperici 12 parts.
More preferably, described medicament can be tablet, dispersible tablet, capsule, soft capsule, ointment, lotion or decoction.
The present invention also provides the purposes of compositions in the medicine of preparation treatment pruritus vulvae, described compositions is made up of the material of following weight portion: Herba Jussiaeae Repentis 10-20 part, Radix Caesalpiniae Radicis 5-15 part, Herba cypripedii japonici 1-10 part, clammy hopseedbush leaf 5-15 part, Herba Orostachyos 5-15 part, Radix Aerio Fici Microcarpae 10-20 part, Herba hylotelephii erythrosticti flower 1-10 part, Herba Solani Lyrati 10-20 part, Herba Laggerae Alatae 5-15 part, Ampelopsis cantoniensis （Hook. et Arn.） Planch. var. grossedentata Hand.-Mazz. 10-20 part, Elsholtzia eriostachya Benth. (Aphanochilus eriostachya Benth, Elsholtzia pusilla Banth) 1-10 part, Herba lygodii 10-20 part, Herba asplenii trichomanis 10-20 part, father-in-law's ripple 1-10 part, Flos Osmanthi Fragrantis branch 5-15 part, cyperi rhizoma 10-20 part, Herba Vernoniae Patulae 10-20 part, Herba Salviae Plebeiae 5-15 part, Radix Glycyrrhizae 1-10 part, Herba Chrysopogonis Aciculati 5-15 part, Herba Hyperici 5-15 part.
Preferably, described compositions is made up of the material of following weight portion: Herba Jussiaeae Repentis 15 parts, Radix Caesalpiniae Radicis 10 parts, Herba cypripedii japonici 8 parts, clammy hopseedbush leaf 12 parts, Herba Orostachyos 10 parts, Radix Aerio Fici Microcarpae 15 parts, Herba hylotelephii erythrosticti spend 5 parts, Herba Solani Lyrati 15 parts, Herba Laggerae Alatae 10 parts, Ampelopsis cantoniensis （Hook. et Arn.） Planch. var. grossedentata Hand.-Mazz. 12 parts, Elsholtzia eriostachya Benth. (Aphanochilus eriostachya Benth, Elsholtzia pusilla Banth) 5 parts, Herba lygodii 15 parts, Herba asplenii trichomanis 15 parts, Weng Bo 8 parts, 10 parts, Flos Osmanthi Fragrantis branch, cyperi rhizoma 12 parts, Herba Vernoniae Patulae 15 parts, Herba Salviae Plebeiae 10 parts, 8 parts, Radix Glycyrrhizae, Herba Chrysopogonis Aciculati 10 parts, Herba Hyperici 12 parts.
More preferably, described medicine can be tablet, dispersible tablet, capsule, soft capsule, ointment, lotion or decoction.
In the present compositions, Herba Laggerae Alatae, cyperi rhizoma, Radix Aerio Fici Microcarpae are monarch drug; Herba Jussiaeae Repentis, Herba cypripedii japonici, Elsholtzia eriostachya Benth. (Aphanochilus eriostachya Benth, Elsholtzia pusilla Banth), Herba Chrysopogonis Aciculati, Ampelopsis cantoniensis （Hook. et Arn.） Planch. var. grossedentata Hand.-Mazz. are ministerial drug; Radix Caesalpiniae Radicis, clammy hopseedbush leaf, Herba Orostachyos, Herba hylotelephii erythrosticti flower, Herba Solani Lyrati, Herba lygodii, Herba asplenii trichomanis, Weng Bo, Flos Osmanthi Fragrantis branch, Herba Vernoniae Patulae, Herba Salviae Plebeiae, Herba Hyperici are adjuvant drug; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, for making medicine.
Medicament of the present invention, from integral status, giving consideration to both the incidental and fundamental, asks Yin Zhiben.Full side becomes clearing away heat-damp and promoting diuresis altogether, the merit of removing toxic substances, killing parasites for relieving itching of dispeling the wind, and has the effect of convergence leukorrhagia stopping, tonifying speen and tonifying kidney concurrently, and has certain antiinflammatory action, body's immunity can be increased, for pruritus vulvae determined curative effect, safety is high, is worth applying clinically.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modification that the present invention carries out.Unless otherwise stated, the percent in the present invention is percetage by weight.
The preparation of embodiment lotion of the present invention
Take Herba Jussiaeae Repentis 150 grams, Radix Caesalpiniae Radicis 100 grams, Herba cypripedii japonici 80 grams, clammy hopseedbush leaf 120 grams, Herba Orostachyos 100 grams, Radix Aerio Fici Microcarpae 150 grams, Herba hylotelephii erythrosticti spends 50 grams, Herba Solani Lyrati 150 grams, Herba Laggerae Alatae 100 grams, Ampelopsis cantoniensis （Hook. et Arn.） Planch. var. grossedentata Hand.-Mazz. 120 grams, Elsholtzia eriostachya Benth. (Aphanochilus eriostachya Benth, Elsholtzia pusilla Banth) 50 grams, Herba lygodii 150 grams, Herba asplenii trichomanis 150 grams, 80 grams, father-in-law's ripple, 100 grams, Flos Osmanthi Fragrantis branch, cyperi rhizoma 120 grams, Herba Vernoniae Patulae 150 grams, Herba Salviae Plebeiae 100 grams, 80 grams, Radix Glycyrrhizae, Herba Chrysopogonis Aciculati 100 grams, Herba Hyperici 120 grams, add 25000 ml waters, to soak after 2 hours in the flask that condensing tube is housed reflux 3 hours, then filter, obtain lotion of the present invention.
The curative effect of experimental example medicament of the present invention
1 data and method
1.1 physical data
This group pruritus vulvae patient 100 example.The conscious pruritus vulvae of patient, skin of vulva is seen in gynecologial examination and vaginal mucosa is congested, color is red, and secretions amount is many, yellow skin, frowziness.100 routine patients are divided into treatment group 50 example and matched group 50 example.Wherein treatment group age 20-48 year, average 37.1 years old; Married 34 examples, unmarried 16 examples; The course of disease 1 month-2 years, average 3.5 months.Minimum 18-45 year at matched group age, average 36.9 years old; Married 35 examples, unmarried 15 examples; The course of disease 1 month-3 years, average 3.6 months.Two groups of patients, at the equal not statistically significant of the difference of above-mentioned each side (p > 0.05), have comparability.
1.2 Therapeutic Method
Treatment group uses lotion of the present invention.Prepare lotion of the present invention according to method described in embodiment before using, be down to after the suitable temperature of body sense, pour in clean basin for each 400 milliliters until medicinal liquid, washing pudendum, demibain 30 minutes, treats 1 every day.
Matched group uses JIEERYIN XIYE (authentication code: the accurate word Z10930008 of traditional Chinese medicines, Sichuan Enwei Pharmaceutical Co., Ltd. produces).First prepare the washing liquid (namely getting milliliter mixing of washing liquid 10 milliliters of warm water to 100) of 10% concentration, delivered to vagina deep washing vagina with irrigator, and clean pudendum, every day 1 time.Two groups was all a course for the treatment of with 7 days, continuously 3 courses for the treatment of of treatment, and in case of menstrual period then stop, clean period proceeds after 3 days to treat.Treatments period avoids spicy food, and keeps pudendum cleaning dry.
1.3 criterion of therapeutical effect
Recovery from illness: pruritis disappears, skin of vulva color recovers normal, and vaginal mucosa is without hyperemia, and secretions reduces, and free from extraneous odour, color is normal.
Take a turn for the better: pruritis alleviates, vaginal mucosa is without congested or light flushing, and secretions reduces, and color is normal.
Invalid: before and after treatment, pruritis and examination per vagina are all not improved.
1.4 statistical analysis
Adopt the capable statistical analysis of SPSS15.0 software.Enumeration data adopts x
2inspection.With p < 0.05 for difference has statistical significance.
2 results
After treating 3 courses for the treatment of, two groups of clinical efficacies relatively in table 1.
The comparison of table 1 liang group clinical efficacy
Note: compare with matched group, * p<0.05
Table 1 shows, and the efficient difference of two groups has statistical significance (p < 0.05).This shows that the clinical efficacy for the treatment of group is better than matched group, pharmaceutical treatment pruritus vulvae Be very effective of the present invention.
Claims (1)
1. treat the lotion of pruritus vulvae for one kind, it is characterized in that being made up by following method of following material: take Herba Jussiaeae Repentis 150 grams, Radix Caesalpiniae Radicis 100 grams, Herba cypripedii japonici 80 grams, clammy hopseedbush leaf 120 grams, Herba Orostachyos 100 grams, Radix Aerio Fici Microcarpae 150 grams, Herba hylotelephii erythrosticti spends 50 grams, Herba Solani Lyrati 150 grams, Herba Laggerae Alatae 100 grams, Ampelopsis cantoniensis （Hook. et Arn.） Planch. var. grossedentata Hand.-Mazz. 120 grams, Elsholtzia eriostachya Benth. (Aphanochilus eriostachya Benth, Elsholtzia pusilla Banth) 50 grams, Herba lygodii 150 grams, Herba asplenii trichomanis 150 grams, 80 grams, father-in-law's ripple, 100 grams, Flos Osmanthi Fragrantis branch, cyperi rhizoma 120 grams, Herba Vernoniae Patulae 150 grams, Herba Salviae Plebeiae 100 grams, 80 grams, Radix Glycyrrhizae, Herba Chrysopogonis Aciculati 100 grams, Herba Hyperici 120 grams, add 25000 ml waters, to soak after 2 hours in the flask that condensing tube is housed reflux 3 hours, then filter, obtain.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510124580.XA CN104689122B (en) | 2015-03-20 | 2015-03-20 | A kind of medicament for the treatment of pruritus vulvae |
| CN201510464560.7A CN104958616A (en) | 2015-03-20 | 2015-03-20 | Medicine for treating pruritus vulvae |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510124580.XA CN104689122B (en) | 2015-03-20 | 2015-03-20 | A kind of medicament for the treatment of pruritus vulvae |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510464560.7A Division CN104958616A (en) | 2015-03-20 | 2015-03-20 | Medicine for treating pruritus vulvae |
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| CN104689122A CN104689122A (en) | 2015-06-10 |
| CN104689122B true CN104689122B (en) | 2015-11-04 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510464560.7A Pending CN104958616A (en) | 2015-03-20 | 2015-03-20 | Medicine for treating pruritus vulvae |
| CN201510124580.XA Expired - Fee Related CN104689122B (en) | 2015-03-20 | 2015-03-20 | A kind of medicament for the treatment of pruritus vulvae |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510464560.7A Pending CN104958616A (en) | 2015-03-20 | 2015-03-20 | Medicine for treating pruritus vulvae |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102293967A (en) * | 2011-09-22 | 2011-12-28 | 郭心仪 | Medicine for treating eczema |
| CN103550559A (en) * | 2013-11-01 | 2014-02-05 | 王晓梅 | Preparation method of traditional Chinese medicine (TCM) lotion for treating carbuncle on back caused by overeating dried gingers |
-
2015
- 2015-03-20 CN CN201510464560.7A patent/CN104958616A/en active Pending
- 2015-03-20 CN CN201510124580.XA patent/CN104689122B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102293967A (en) * | 2011-09-22 | 2011-12-28 | 郭心仪 | Medicine for treating eczema |
| CN103550559A (en) * | 2013-11-01 | 2014-02-05 | 王晓梅 | Preparation method of traditional Chinese medicine (TCM) lotion for treating carbuncle on back caused by overeating dried gingers |
Non-Patent Citations (1)
| Title |
|---|
| 中药治疗外阴瘙痒症临床探讨;白居正;《中国现代药物应用》;20100531;第04卷(第09期);第136-137页 * |
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| Publication number | Publication date |
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| CN104689122A (en) | 2015-06-10 |
| CN104958616A (en) | 2015-10-07 |
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Inventor after: Li Mingying Inventor before: Li Fujun |
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Effective date of registration: 20150911 Address after: 274100, Heze County, Shandong province Dingtao Road station section B Dingtao County family planning service station Applicant after: Li Mingying Address before: 071000 No. 6 Chaoyang South Street, Hebei, Baoding Applicant before: Li Fujun |
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