CN1080537A - The goods of protect against osteoporosis and method for making thereof - Google Patents
The goods of protect against osteoporosis and method for making thereof Download PDFInfo
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- CN1080537A CN1080537A CN 92105338 CN92105338A CN1080537A CN 1080537 A CN1080537 A CN 1080537A CN 92105338 CN92105338 CN 92105338 CN 92105338 A CN92105338 A CN 92105338A CN 1080537 A CN1080537 A CN 1080537A
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Abstract
A kind of goods of protect against osteoporosis, these goods contain the extract of the fruit of Umbelliferae Cnidium Cusson plant Fructus Cnidii, and this extract has and stops sclerotin further to be lost and promote new osteoplastic effect.Be to prevent and treat osteoporotic ideal medicament at present, these goods can be made medicine or health product.
Description
The present invention relates to treat the goods and the method for making thereof of osteoporosis.
Treatment to osteoporosis has in recent years become one of heat subject, along with the aging of population with to going deep into that osteoporosis is understood, makes prevention and treatment of osteoporosis become a problem that develops rapidly.Present this disease has 200,000,000 patients approximately in the whole world, expect the year two thousand twenty also with double, and 1/3～1/2 menopausal women will suffer from this disease.The most frequently used medicine has estrogen, progestogen, calcitonin and bisphosphonates at present, and their effect mainly is to stop sclerotin further to be lost, and is very little to the formation effect of bone.Several new therapies stimulate sclerotin to form the commitment that all is in research as adopting somatomedin and parathyroid hormone, on this basis and the product of design also comes out.Some Chinese medicine preparation of domestic research how to mend " kidney ", are aided with and replenish calcium preparation and Vit D etc., and the present curative effect of this based article is still very not satisfactory.Chinese scholars is all at the specific drug of being devoted to seek the treatment osteoporosis at present.
Task of the present invention is a kind of goods that contain natural materials of development, and it can stop further losing of sclerotin, and the sclerotin of having lost is also had the effect of the formation that promotes new bone, has low toxicity, efficient, the advantage that untoward reaction is few.
The approach that solves this task is to make this based article contain the extract of the fruit Fructus Cnidii of Chinese medicine samphire cnidium monnieri.
Fructus cnidii extract has and stops sclerotin further to lose and promote new osteoplastic effect to promote alcium and phosphor metabolization, promote that blood calcium is converted into bone calcium, make loose osseous tissue become fine and close, and can eliminate the various clinical uncomfortable disease due to the osteoporosis.There is no report with Fructus cnidii extract treatment osteoporosis domestic and foreign literature.
Fructus cnidii extract comprises the goods that obtain with following SOME METHODS extraction:
1. get Fructus Cnidii 50g and pulverize, soaked 1 hour, in flask, decoct repeatedly three times, each half an hour with distilled water 300ml; Collect medicinal liquid.Filter and remove residue, low pressure concentrate, the lyophilization powdered, and 4 ℃ of refrigerators are preserved standby.
2. get Fructus Cnidii and clay into power,, collect pure immersion, concentrate when being blackish green oily liquid and cool off with 95% alcohol dipping, percolation, add 10% potassium hydroxide solution, constantly jolting or stirring make the grease saponification, add the water gaging dilution again, left standstill about 1 day, and promptly got the volume crystallization, sucking filtration gets coarse crystallization about 4%.
3. get Fructus Cnidii and be milled to powdery, with 0.5% sodium hydroxide solution heating extraction, extracting solution, gets total coumarins and accounts for 4% again with acetone treatment with acid neutralization back gained precipitate.
4. get Fructus Cnidii and be milled to powdery, extract with 95% reflow of alcohol, extracting solution is placed after-filtration, and being concentrated into does not have the alcohol flavor, the reuse Petroleum ether extraction, and extracting solution is separated out a large amount of colourless column crystallizations after placing, and is osthole through identifying this crystallization, and recovery rate is 0.8%.
5. will carry out vapor distillation behind the Fructus Cnidii fruit porphyrize, the distillate petroleum ether extraction is told petroleum ether, uses anhydrous Na2SO4 dehydration, filters and concentrates, and obtains the oily liquids that yellow has special fragrance, and yield is 2%.Through further isolation identification, confirm to contain four kinds of chemical compounds, i.e. osthole (Osthol), bergapton (Bexga pten), sagittol (β-Eudesmol) and borneol acetate (Bornylacetate);
The effective ingredient that adopts above 1～4 method to extract is mainly following composition through isolation identification:
Palmic acid (Palmiticacid), osthole (Osthol), cupreol (β-Sitosterol), bergapton (bergapten), isopimpinellin (isopimpinellin), xanthotoxol (xanthotoxol), xanthotoxin (xanthotoxin) and ammidin (imperatorin), α-Oleum Pini bicyclic hydrocarbons, lauro lene (Camphene), bornival (Bornyl isoualerate) etc.
Get the above semi-finished product that make by 1～5 method, make solvent with ethanol, propylene glycol and distilled water (ratio 1: 1: 2), and add about stabilizing agent and accent PH to 7.2～7.4, make every peace bottle 5ml by the production technology of injection and contain osthole or volatile oil 50～100mg;
The semi-finished product that make by above-mentioned 1～5 method also can be by the processing technology of conventional tablet, capsule, electuary, drop pill, granule, makes every or whenever comprise the preparation of the effective ingredient about 0.5～10g respectively.
The present invention still can be applied to osteoporotic control as health-care products by other approach, as making health beverage by following three kinds of methods:
1. Fructus Cnidii is ground into powder,, is applied to market as health promoting wine with 24 hours after-filtration of 20～60 degree steeping in wine bubbles;
2. Fructus Cnidii is ground into powder, makes decoct or extractum, make health beverage again with the decocting in water alcohol deposition method;
3. after active ingredient of the present invention being extracted, be made into oral liquid and be supplied in market.
If calcium preparation and vitamin D are added in the said extracted liquid, then can improve the curative effect of these product, the synthetic blood calcium that makes shifts to bone calcium because the Fructus Cnidii extracting solution has the new bone of promotion, thus add calcium preparation, the deficiency that then can replenish blood calcium, and improve curative effect.Calcium preparation is calcium gluconate, calcium lactate or calcium phosphate preferably, also can adopt calcium chloride, calcium carbonate, calcium hydrogen phosphate, calcium levulinate or activated calcium.Vitamin D can promote small intestinal to calcium and phosphatic absorption with increase their mobilization from bone, illustrate on evidence that in addition vitamin D has certain direct effect to kidney, can in the heavily absorption of proximal convoluted tubule its storage capacity be increased by strengthening calcium and phosphate, vitamin D is α preferably, 25 dihydroxy vitamin d3s also can adopt other to contain the preparation of vitamin D.
When using this product, Fructus cnidii extract can be made preparation separately, also can add calcium preparation and vitamin D and form compound preparation, the dosage form of said preparation can be used as injection, tablet, capsule, electuary, drop pill, also can be made into other dosage form.
This product also can be used as health-care products such as beverage, health promoting wine or oral liquid.
Claims (10)
1, a kind of goods of protect against osteoporosis is characterized in that these goods contain the extract of the fruit Fructus Cnidii of Umbelliferae Cnidium Cusson plant cnidium monnieri (Cnidum monnieri (L.) Cusson).
2, goods as claimed in claim 1 is characterized in that Fructus cnidii extract comprises Fructus Cnidii total coumarins, osthole, bergapton, cupreol, isopimpinellin, xanthotoxol, xanthotoxin, ammidin and α-Oleum Pini bicyclic hydrocarbons, lauro lene, bornival.
3, as claim 1,2 described goods, it is characterized in that containing calcium preparation.
4, as claim 1,2,3 described goods, it is characterized in that containing vitamin D.
5, produce as the described goods of claim 1～4, it is characterized in that this class extract is decoct or the extractum by making with traditional extracting technique of Chinese medicine, and make tablet, electuary, capsule, granule or beverage with this.
6, produce as the described goods of claim 1～4, it is characterized in that this class extract is by alcohol dipping, percolation, collect alcoholic solution, concentrate, cooling adds technology such as 10% potassium hydroxide solution saponification again and makes coarse crystallization, and makes injection, tablet, electuary, capsule with this crystallization.
7, produce as the described goods of claim 1～4, it is characterized in that this class extract is with 0.5% sodium hydroxide solution heating extraction, reuse acid neutralization is to obtain after the acetone treatment.And make injection, electuary, tablet, capsule, granule with this extract.
8, produce as the described goods of claim 1～4, it is characterized in that this class extract is to extract with 95% reflow of alcohol, filter, concentrate back reuse Petroleum ether extraction and obtain.And make injection, electuary, tablet, capsule, granule with this extract.
9, produce as the described goods of claim 1～4, it is characterized in that this class extract is to collect it with steam distillation to wave method oil, distillate reuse petroleum ether extraction, tells petroleum ether.Use anhydrous Na2SO4 dehydration, filtration, concentrated making.And make injection, electuary, tablet, capsule, granule with this extracting solution.
10,, it is characterized in that these goods can be made into health promoting wine, beverage or oral liquid as right 1～9 described goods.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN92105338A CN1041991C (en) | 1992-07-01 | 1992-07-01 | Products and preparing process for curing osteo porosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN92105338A CN1041991C (en) | 1992-07-01 | 1992-07-01 | Products and preparing process for curing osteo porosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1080537A true CN1080537A (en) | 1994-01-12 |
| CN1041991C CN1041991C (en) | 1999-02-10 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN92105338A Expired - Fee Related CN1041991C (en) | 1992-07-01 | 1992-07-01 | Products and preparing process for curing osteo porosis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1041991C (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004089389A1 (en) * | 2003-04-11 | 2004-10-21 | Nuliv Biomedicine Inc. | Pharmaceutical composition for prevention and treatment of osteoporosis and its preparation |
| CN101164557B (en) * | 2006-10-18 | 2011-04-20 | 科达制药股份有限公司 | Medical composition for preventing and/or treating bone matrix's loss |
| US20110160298A1 (en) * | 2008-03-07 | 2011-06-30 | Chen Chao Hsiang | Pharmaceutical composition for prevention and/or treatment of bone loss |
| CN102727487A (en) * | 2011-04-14 | 2012-10-17 | 河北医科大学 | Novel application of 8-methoxsalen to prevention and treatment of osteoporosis for post-menopause women |
| CN105030863A (en) * | 2015-08-20 | 2015-11-11 | 陈鹏 | Fructus cnidii extract and anti-tumor application thereof |
| CN106668001A (en) * | 2015-11-10 | 2017-05-17 | 上海中医药大学附属龙华医院 | Application of cnidium lactone to preparation of osteoportic fracture drugs |
-
1992
- 1992-07-01 CN CN92105338A patent/CN1041991C/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004089389A1 (en) * | 2003-04-11 | 2004-10-21 | Nuliv Biomedicine Inc. | Pharmaceutical composition for prevention and treatment of osteoporosis and its preparation |
| CN101164557B (en) * | 2006-10-18 | 2011-04-20 | 科达制药股份有限公司 | Medical composition for preventing and/or treating bone matrix's loss |
| US20110160298A1 (en) * | 2008-03-07 | 2011-06-30 | Chen Chao Hsiang | Pharmaceutical composition for prevention and/or treatment of bone loss |
| US20110166217A1 (en) * | 2008-03-07 | 2011-07-07 | Chen Chao Hsiang | Pharmaceutical composition for prevention and/or treatment of bone loss |
| CN102727487A (en) * | 2011-04-14 | 2012-10-17 | 河北医科大学 | Novel application of 8-methoxsalen to prevention and treatment of osteoporosis for post-menopause women |
| CN102727487B (en) * | 2011-04-14 | 2015-08-26 | 河北医科大学 | The novelty teabag of 8-methoxyposoralen in control postmenopausal osteoporosis |
| CN105030863A (en) * | 2015-08-20 | 2015-11-11 | 陈鹏 | Fructus cnidii extract and anti-tumor application thereof |
| CN106668001A (en) * | 2015-11-10 | 2017-05-17 | 上海中医药大学附属龙华医院 | Application of cnidium lactone to preparation of osteoportic fracture drugs |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1041991C (en) | 1999-02-10 |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C15 | Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993) | ||
| OR01 | Other related matters | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |