KR20140108942A - Composition of herbal medicine for improving implantation - Google Patents
Composition of herbal medicine for improving implantation Download PDFInfo
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- KR20140108942A KR20140108942A KR1020130022860A KR20130022860A KR20140108942A KR 20140108942 A KR20140108942 A KR 20140108942A KR 1020130022860 A KR1020130022860 A KR 1020130022860A KR 20130022860 A KR20130022860 A KR 20130022860A KR 20140108942 A KR20140108942 A KR 20140108942A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Abstract
The invention provides a mixed extract of herbal medicines and a pharmaceutical composition or health functional food containing the same as an active ingredient. The herbal composition-mixed extract enhances the intrauterine implantation of embryos in the case of repeated abortion and in vitro fertilization, thereby improving the pregnancy rate and preventing or treating infertility.
Description
The present invention relates to a pharmaceutical composition for enhancing an implantability and a functional food containing the mixed extract of a medicinal herb as an active ingredient, and more particularly, to a composition and a health functional food for enhancing intrauterine implantation of a fertilized egg to enhance pregnancy.
Infertility is a condition in which a pregnant woman can not get pregnant within a year despite the fact that she wants to get pregnant through normal marital life after marriage. According to clinical reasons, male factor, ovulation factor, tubal and peritoneal factor, cervix and uterine factor, Factor, nutrition and metabolic factor.
In vitro fertilization-embryo transfer, a method of infertility treatment, was first attempted by Edward in 1965 and has been widely used in the treatment of infertility since 1978 by Steptoe and Edwards, Many studies and developments have been made to increase the success rate of in vitro fertilization. Although many studies have been carried out on the in vitro culture of embryos, the pregnancy rate did not improve significantly. The success rate of in vitro fertilization has been reported to vary from 5 to 25%, depending on the researcher. Even if successful, about 30% of pregnancies are terminated by abortion and 5% of ectopic pregnancies are reported. Recent studies have shown that the pregnancy rate does not increase in spite of the development of ovarian induction agent, improvement of ovarian induction method, and improvement of fertilization rate and ovulation rate of the ovary. According to Edward, the embryo implantation rate 10-15%, which is relatively low. Therefore, the main research interest and limitation of improvement of pregnancy rate in assisted reproductive technology such as in vitro fertilization is in the field of endometrial implantation of embryo.
In addition, failure to conceive is also a major cause of recurrent miscarriage. Even if the embryo's stable implantation is interrupted due to anatomical problems in the uterus, abortion may occur repeatedly, but other hormone abnormalities, immunological factors, and other unknown causes may prevent the embryo from implanting into the endometrium It can not be maintained even after the implantation has been done and the abortion may occur repeatedly.
Therefore, in the case of repeated abortion and in vitro fertilization, it is necessary to study the herbal medicine which can help to improve the pregnancy rate.
Disclosure of the Invention The present invention has been conceived to solve the above-mentioned problems, and provides a pharmaceutical composition for enhancing intrauterine implantation of fertilized eggs containing a mixed extract of herbal medicines as an active ingredient and a health functional food.
However, the technical problem to be solved by the present invention is not limited to the above-mentioned problems, and other matters not mentioned can be clearly understood by those skilled in the art from the following description.
The present invention relates to a method for enhancing the intrauterine growth of embryos including Suseo extract, Lycopersicon esculentum Extract, Rhododendron Rhizoma Extract, Rhododendron Rhizoma Extract, Lycopersicon esculentum Extract, Gum Extract, Ginger Extract, Dermatophyte Extract, Provides a mixed extract of herbal medicines.
In one embodiment of the present invention, the herbal mixture extract may contain 250 to 500 parts by weight of the extract of Sasao, 250 to 500 parts by weight of the extract, 250 to 500 parts by weight of the extract, 100 to 150 parts by weight of a mushroom extract, 100 parts by weight of a dermis extract, 100 parts by weight of a sine extract, 50 parts by weight of a crude oil extract, 50 parts by weight of a crass extract, And 50 parts by weight of a soil extract.
In another embodiment of the present invention, the herbal mixed extract is extracted with an extraction solvent selected from water, C1-C4 alcohol or a mixture thereof.
The present invention provides a pharmaceutical composition for enhancing intrauterine implantation of embryos containing the herbal composition-mixed extract as an active ingredient.
The present invention also provides a health functional food for enhancing fertilization of embryos containing the herbal composition-mixed extract as an active ingredient. In one embodiment of the present invention, the health functional food is a health functional beverage.
The mixed extract of herbal medicines according to the present invention, the pharmaceutical composition containing the herb extract as an active ingredient, and the health functional food improve the intrauterine implantation of embryos and prevent or treat infertility and improve the pregnancy rate.
Figure 1 shows the individual distribution of each patient for the null hypothesis.
Figure 2 shows a histogram for the null hypothesis.
Herbal medicine mixed extract
The present invention provides a mixed extract of herbal medicines for enhancing intrauterine implantation of embryos.
The medicinal herbs of the present invention include sewage, sardine, sardine, sardine, shiitake, mackerel, ginger, dermis, sine, sour oil, poultry and soil.
The medicinal herbs used in the present invention will be described in more detail as follows:
(1) sewage
Hashuo is the root of Polygonum multiflorum Thunb., A perennial chronic herb that belongs to the Polygonaceae family (Polygonaceae). In the sewage, there is an enemy sewage and a back sewer, and it can be used without discrimination in the present invention. The sewage sludge may be purchased commercially or directly grown.
(2) Liquorice
White roots are dried medicines (Korea) by removing the roots or junks of Atractylodes japonica Koidzumi or Atractylodes macrocephala Koidzumi. The bagasse may be purchased commercially or directly grown.
(3)
熟地 黄 (熟地黄) is rooted in the root of geohang (黄黄) is dried herbal medicine means. The safflower can be purchased commercially or directly grown.
(4)
The 膠 주 주 (膠 膠 膠 膠 膠 膠 膠 膠 膠 膠 아...................................... The main ingredient is gelatin. The above-mentioned glue may be purchased commercially or directly grown.
(5) Amino Acids
Mountain medicine refers to the roots of ducks (Dioscorea japonica) or duck (Disocorea batatas) belonging to the family Dioscoreaceae. The luciferase can be purchased commercially or directly grown.
(6)
Eucommia ulmoides Oliver is a medicinal herb that has dried the bark of the bark of Eucommia ulmoides Oliver. The luciferase can be purchased commercially or directly grown.
(7) ginger
Ginger (ginger) is a root of the perennial plant with ginger tree ginger ginger. The ginger may be purchased commercially or directly grown.
(8) Dermis
Dandelion (筒皮) is the mature peel of the citrus unshiu Markovich or related plants in Korea. The dermis may be purchased commercially or directly grown.
(9) Signs
Sane (砂仁) is a herbaceous herb plant belonging to the ginger and Yangchunsa (Amanum villosum LOUR. The sign may be purchased from the market or directly grown.
(10)
Sukyu (吳茱萸) is a medicinal product made from the fruit of a deciduous arboresa of a dicotyledonous plant, The sour milk can be purchased commercially or directly grown.
(11) The crest
Pagoda is a medicinal herb that has dried the fruit of a year-old plant (psoralea corylifolia L.), an annual plant belonging to the soybean family. The digger can be purchased commercially or directly grown.
(12) Tosser
Dodder (兎 子 子) is an annual plant belonging to the filamentous fungus. The soil can be purchased from the market or directly grown.
Preparation method of herbal extracts
The herbal mixed extract of the present invention is preferably, but not limited to, prepared by a manufacturing method comprising the following steps:
(1) removing foreign matter mixed in the herbal medicines and washing them;
(2) extracting the extract by adding an extraction solvent to the mixture of the herbal medicines;
(3) concentrating the extract under reduced pressure;
(4) filtering the concentrate; And
(5) drying the filtered extract.
The washing of step (1) is preferably repeated one to five times.
The extraction of the step (2) can be performed by shaking extraction, Soxhlet extraction, or a reflux extraction method, but is not limited thereto.
As the extraction solvent, water, C1-C4 alcohol or a mixture thereof can be used. The extraction solvent is preferably extracted by adding an extraction solvent of 3 to 10 times the total weight of the herbal medicine preparation.
The hydrothermal pressure extraction is preferably performed at a pressure of 1.1 to 2 atm, more preferably at a pressure of 1.2 to 1.5 atm.
In addition, the temperature during hydrothermal extraction is preferably 60 to 100 ° C, more preferably 80 to 100 ° C. The extraction time is preferably 2 to 24 hours, and the extraction time is preferably 1 to 5 times.
It is preferable to use a vacuum decompression concentrator or a vacuum rotary evaporator for the decompression concentration in the step (3). In step (3), the extract is preferably concentrated to a solid content of 40% or more.
The drying in step (5) may be performed by vacuum drying, vacuum drying, boiling drying, spray drying or freeze drying, but is not limited thereto.
Pharmaceutical composition for implantation promotion
The present invention provides a pharmaceutical composition for enhancing intrauterine implantation of embryos containing the herbal composition-mixed extract as an active ingredient. Therefore, the pharmaceutical composition of the present invention helps pregnancy and exhibits the effect of preventing or treating infertility.
In order to exhibit a pharmacologically effective pharmacological effect, the herbal mixture-containing extract is preferably contained in an amount of 0.1 to 50% by weight based on the total weight of the pharmaceutical composition of the present invention, but is not limited thereto.
The pharmaceutical composition of the present invention may be orally administered in a form such as solid or liquid at the time of actual clinical administration. In the case of formulation, it may be prepared using diluents or excipients such as fillers, extenders, binders, wetting agents, disintegrating agents and surfactants which are usually used.
Solid formulations for oral administration include tablets, pills, powders, granules, capsules, and the like, and such solid preparations can be prepared by incorporating into the pharmaceutical composition of the present invention at least one or more excipients such as starch, calcium carbonate, sucrose, lactose And gelatin. In addition to simple excipients, lubricants such as magnesium, stearide, and talc may also be used.
Liquid preparations for oral administration include suspensions, solutions, emulsions and syrups. Various excipients such as wetting agents, sweeteners, fragrances and preservatives may be included in addition to water and liquid paraffin, which are commonly used simple diluents. have.
The dosage of the pharmaceutical composition of the present invention varies depending on the condition and the weight of the patient, the degree of disease, the type of drug, the administration route and the period, and can be appropriately selected by those skilled in the art. However, for the desired effect, the extract of the present invention is preferably administered at 0.0001 to 100 mg / kg per day. The administration may be carried out once a day or divided into several doses. However, the scope of the present invention is not limited to these dosages.
The pharmaceutical composition of the present invention can be used in combination with other therapeutic methods such as acupuncture treatment or moxibustion treatment to promote intrauterine implantation of fertilized eggs.
Health functional food for conception improvement
The present invention provides a health functional food for enhancing intrauterine implantation of a fertilized egg containing the herbal composition-mixed extract as an active ingredient.
The health functional food of the present invention can enhance the intrauterine implantation of embryos to improve the pregnancy success rate or the pregnancy success rate of IVF in patients with repeated abortion.
The health functional food of the present invention can be used as it is or in combination with other food or food ingredients, and can be suitably used according to conventional methods.
The content of the active ingredient may be suitably determined according to the intended use (prevention, health or therapeutic treatment). In general, the herbal medicinal herbal extract of the present invention may be added in an amount of 0.01 to 15% by weight based on the total weight of the food during the manufacture of food or beverage.
There is no particular limitation on the kind of the health functional food of the present invention. Examples of health functional foods to which the herbal medicine mixed extract of the present invention can be added include beverages, gums, vitamin complexes, and drinks, and include health functional foods in the conventional sense. The health functional food is most preferably a health functional drink which is easy to take.
The health functional beverage of the present invention may contain various flavors or natural carbohydrates as an additional ingredient such as ordinary beverages. Examples of the natural carbohydrate include monosaccharides such as glucose, fructose and the like; Disaccharides such as maltose, sucrose and the like; And polysaccharides, for example, conventional sugars such as dextrin, cyclodextrin and the like, and sugar alcohols such as xylitol, sorbitol and erythritol. Flavoring agents (saccharin, aspartame, etc.) other than those described above may also be used.
The health functional food of the present invention can be used as a nutritional supplement, a vitamin, a mineral (electrolyte), a flavor such as a synthetic flavor and a natural flavor, a colorant and an enhancer (cheese, chocolate etc.), a pectic acid and its salt, , Organic acids, protective colloid thickeners, pH adjusting agents, stabilizers, preservatives, glycerin, alcohols, carbonating agents used in carbonated drinks, and the like.
Example
Hereinafter, preferred embodiments of the present invention will be described in order to facilitate understanding of the present invention. However, the following examples are provided only for the purpose of easier understanding of the present invention, and the present invention is not limited by the following examples.
< Example 1> Preparation of herbal medicine extract
I purchased it from a distributor of Han, Hwasoo, Baekwoo, Sukjihwang, Mitcheon, Sangjak, Quail, Ginger, Dermis, Sign, After washing each medicinal material, 10 to 20 g of Sasao, 10 to 20 g of Sake ginger, 10 to 20 g of Sake ginger, 8 to 12 g of astringent ginger, 5 to 10 g of Acanthaceae, 4 to 6 g of ginger, 4 g of ginger, 4 g of dermis , 4 g of sine, 2 g of sour milk, 2 g of puffer, and 2 g of soil were placed in an extraction container, and 5 L of water was added and extracted at 100 ° C for 2 hours. The resulting solution was cooled at room temperature, filtered through filter paper, and concentrated under reduced pressure using a vacuum rotary evaporator to obtain a mixed extract of two herbal medicines (330 cc). The same method was used to obtain additional herbal medicine mixed extracts.
< Example 2> Confirmation of the effect of implantation enhancement of herbal composition mixed extract composition
1. Outline of experiment
We used the medical records of 13 patients who had more than two repeat abortion experiences or who were scheduled for in vitro treatment among patients who visited Ina Medical Center (Seocho-gu, Seoul) from August 4, 2011 to January 15, 2013.
2. Treatment contents
The herbal mixed extract prepared according to Example 1 was orally administered to the patients three times per day at 110 cc (corresponding to 330 cc per day, twice a day) at one time. Patients who were scheduled to undergo an in vitro procedure were to be taken for one month after the procedure.
3. Evaluation Method
We confirmed that the pregnancy was maintained for more than 20 weeks, and if the pregnancy was not maintained before 20 weeks, it was regarded as a miscarriage. The thirteen patients were assigned to the nursing hypothesis that the administration of the herbal medicine mixed extract prepared in Example 1 had no effect on the implantation, and the corresponding sample T test (pair T test) was performed.
4. Results
The success and maintenance of pregnancy of the 13 patients are described in Table 1 below. 0 for no conception and 1 for successful pregnancy.
[Table 1]
Table 2 below shows the mean, standard deviation, and standard error of the mean for prescriptions and prescriptions of the 13 patients.
[Table 2]
For the above results, the 95% confidence interval (CI) of the mean difference was (-1.073, -0.619). In the T-test of the mean difference, the T-value was -8.12, and the calculated P-value was 0.000. Therefore, it can be concluded that the rejection of the null hypothesis is rejected and it is effective for implantation and maintenance of pregnancy when the herbal medicine mixed extract of the present invention is administered.
Figure 1 shows the individual distribution of each patient for the null hypothesis, and Figure 2 shows the histogram for the null hypothesis.
< Formulation example >
The herbal mixed extracts prepared in Example 1 were used for the preparation of the following formulation examples and preparative examples.
<Pharmaceutical preparations>
(1) Formulation Example 1: Preparation of powder
Herbal medicine mixed extract 2 g
Lactose 1 g
The above components are mixed and packed in airtight bags to prepare powders.
(2) Formulation Example 2: Preparation of tablets
Herbal medicine mixed extract 100 mg
Corn starch 100 mg
Lactose 100 mg
Magnesium stearate 2 mg
After mixing the above components, tablets are prepared by tableting by a conventional method for producing tablets.
(3) Formulation Example 3: Preparation of capsules
Herbal medicine mixed extract 100 mg
Corn starch 100 mg
Lactose 100 mg
Magnesium stearate 2 mg
After mixing the above components, they are filled into gelatin capsules by a conventional method for producing gelatin to prepare tablets.
(4) Formulation Example 4: Preparation of liquid preparation
Herbal medicine mixed extract 100 mg
10g per isomerization
Mannitol 5 g
Purified water quantity
Each component was added to and dissolved in purified water according to a conventional method for preparing a liquid preparation, the components were mixed, purified water was added, and the solution was filled in an ampule and sterilized to prepare a liquid preparation.
<Health functional drinks>
(1) Production Example 1
To 1000 ml of purified water prepared by sterilization, 3.6 g of the herbal mixture-mixed extract was added. 1000 mg of citric acid, 2 g of plum concentrate, 100 g of oligosaccharide and 1 g of taurine were added, and the mixture was heated at 85 캜 for about 60 minutes and heated. The resulting solution was filtered and sterilized in a sterilized 2 L container, sealed and then stored in a refrigerator to prepare a health functional beverage of the present invention.
(2) Production example 2
0.4 g of the herbal composition-mixed extract was dissolved in 100 ml of a soft beverage syrup such as cider.
(3) Production example 3
The preparation was carried out in the same manner as in Preparation Example 1, except that 0.25 g of the herbal mixed extract was added to 100 ml of various kinds of spot drinks.
(4) Production example 4
Except that 0.15 g of the mixed extract of Chinese medicine was added to 100 ml of beverage prepared by using juice of various fruits, vegetables, seaweeds, beans, natural medicines, etc. or its extract concentrate (apple juice, tomato juice, kelp juice or ginseng juice) Were prepared in the same manner as in Preparation Example 1.
(5) Production example 5
The preparation was carried out in the same manner as in Preparation Example 1, except that 0.5 g of the herbal mixed extract was added to 100 ml of the fatigue disintegrant drink.
(6) Production example 6
The preparation was carried out in the same manner as in Preparation Example 1, except that 0.5 g of the herbal mixed extract was added to 100 ml of the alcoholic beverage.
It will be understood by those skilled in the art that the foregoing description of the present invention is for illustrative purposes only and that those of ordinary skill in the art can readily understand that various changes and modifications may be made without departing from the spirit or essential characteristics of the present invention. will be. It is therefore to be understood that the above-described embodiments are illustrative in all aspects and not restrictive.
Claims (6)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020130022860A KR20140108942A (en) | 2013-03-04 | 2013-03-04 | Composition of herbal medicine for improving implantation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020130022860A KR20140108942A (en) | 2013-03-04 | 2013-03-04 | Composition of herbal medicine for improving implantation |
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| KR20140108942A true KR20140108942A (en) | 2014-09-15 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104548051A (en) * | 2015-02-03 | 2015-04-29 | 潍坊医学院 | Traditional Chinese medicine preparation for treating habitual abortion |
| WO2017095011A1 (en) * | 2015-12-02 | 2017-06-08 | 동국대학교 경주캠퍼스 산학협력단 | Composition for preventing and treating premature ovarian failure, containing evodia rutaecarpa bentham extract having protective activity against ovotoxicity |
| WO2017111529A1 (en) * | 2015-12-24 | 2017-06-29 | 동국대학교 경주캠퍼스 산학협력단 | Ovulation and implantation herbal medicine extract having implantation enhancing effect, and use of same |
| JPWO2020218295A1 (en) * | 2019-04-26 | 2020-10-29 | ||
| US10835564B2 (en) | 2015-12-02 | 2020-11-17 | Dongguk University Gyeongju Campus Industry-Academy Cooperation Foundation | Composition for preventing and treating premature ovarian failure, containing Evodia rutaecarpa bentham extract having protective activity against ovotoxicity |
-
2013
- 2013-03-04 KR KR1020130022860A patent/KR20140108942A/en not_active Application Discontinuation
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104548051A (en) * | 2015-02-03 | 2015-04-29 | 潍坊医学院 | Traditional Chinese medicine preparation for treating habitual abortion |
| WO2017095011A1 (en) * | 2015-12-02 | 2017-06-08 | 동국대학교 경주캠퍼스 산학협력단 | Composition for preventing and treating premature ovarian failure, containing evodia rutaecarpa bentham extract having protective activity against ovotoxicity |
| US10835564B2 (en) | 2015-12-02 | 2020-11-17 | Dongguk University Gyeongju Campus Industry-Academy Cooperation Foundation | Composition for preventing and treating premature ovarian failure, containing Evodia rutaecarpa bentham extract having protective activity against ovotoxicity |
| WO2017111529A1 (en) * | 2015-12-24 | 2017-06-29 | 동국대학교 경주캠퍼스 산학협력단 | Ovulation and implantation herbal medicine extract having implantation enhancing effect, and use of same |
| JPWO2020218295A1 (en) * | 2019-04-26 | 2020-10-29 | ||
| WO2020218295A1 (en) * | 2019-04-26 | 2020-10-29 | サントリーホールディングス株式会社 | Method for producing beverage |
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