CN108042762A - A kind of pharmaceutical composition for treating pain, patch and its preparation method and application - Google Patents
A kind of pharmaceutical composition for treating pain, patch and its preparation method and application Download PDFInfo
- Publication number
- CN108042762A CN108042762A CN201711454775.6A CN201711454775A CN108042762A CN 108042762 A CN108042762 A CN 108042762A CN 201711454775 A CN201711454775 A CN 201711454775A CN 108042762 A CN108042762 A CN 108042762A
- Authority
- CN
- China
- Prior art keywords
- parts
- weight
- patch
- pain
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8884—Arisaema, e.g. Jack in the pulpit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A kind of pharmaceutical composition for treating pain, patch and its preparation method and application, belong to pharmaceutical technology field.The pharmaceutical composition includes：Radix Aconiti, unprocessed Arisaema erubescens, myrrh, frankincense, turmeric, Chinese cassia tree and Rhizoma Chuanxiong.The pharmaceutical composition for pain the interpretation of the cause, onset and process of an illness and primary symptom and set, it is warming channel and expelling cold with expelling wind and activating blood flow, remove obstruction in channels to relieve pain based on, all medicine phases 5 are opposed each other and yet also complement each other so that numbness hinders logical, and pain disappears.The diseases such as the pharmaceutical composition can greatly improve acute lumbar muscle sprain, arthritis and osteoarthritis, the periarthritis of shoulderjoint, pain in waist and lower extremities and prolapse of nucleus pulposus of lumbar spine, neck is ached, cervical spondylosis and myotenositis are pain caused.It is rapid-action, high efficiency.After patient uses the patch, pain is significantly slowed or disappeared, and has preferable therapeutic effect.
Description
Technical field
The present invention relates to pharmaceutical technology field, and more particularly to a kind of pharmaceutical composition for treating pain, patch and its system
Preparation Method and purposes.
Background technology
The aseptic inflammations such as acute lumbar muscle sprain, discitis, sciatica, cervical vertebra pain, scapulohumeral periarthritis pain, osteoarthrosis pain and
Prolapse of nucleus pulposus of lumbar spine etc. is common disease, frequently-occurring disease clinically.In addition to medicine for oral administration, affected part externally applied drug is also most basic most normal
Therapy.
The content of the invention
The first object of the present invention is to provide a kind of pharmaceutical composition for treating pain, the activity of the pharmaceutical composition into
Pain can effectively be treated by dividing.
The second object of the present invention is to provide a kind of patch for treating pain, which is easy to use, and can treat
Relevant pain disease, it is rapid-action.
The third object of the present invention is to provide a kind of preparation method for the patch for treating pain, and the preparation method is simply easy
Row.
The fourth object of the present invention is that providing a kind of pharmaceutical composition of above-mentioned treatment pain is preparing treatment pain
Purposes in drug, which plays the effect for the treatment of pain by the synergistic effect between multicomponent, to pain
Associated conditions tool has a better effect.
The present invention is solved its technical problem and is realized using following technical scheme.
The present invention proposes a kind of pharmaceutical composition for treating pain, pharmaceutical composition count in parts by weight including：
14~18 parts of Radix Aconiti, 14~18 parts of unprocessed Arisaema erubescens, 6~10 parts of myrrh, 6~10 parts of frankincense, turmeric 14~18
14~18 parts of part, 14~18 parts of Chinese cassia tree and Rhizoma Chuanxiong.
A kind of preparation method for the patch for treating pain, including：
By 14~18 parts by weight of Radix Aconiti, 14~18 parts by weight of unprocessed Arisaema erubescens, 6~10 parts by weight of myrrh, 6~10 weight of frankincense
Amount part, 14~18 parts by weight of turmeric, 14~18 parts by weight of Chinese cassia tree and 14~18 parts by weight of Rhizoma Chuanxiong are mixed to form pharmaceutical composition,
Pharmaceutical composition is used into reflux extraction extraction, is concentrated to give medicinal extract of the relative density for 1.05-1.2；
Medicinal extract 4-6 parts by weight, far-infared ceramic powder 12-18 parts by weight and patch substrate 50-65 parts by weight are mixed to get
Medicament.
A kind of patch for treating pain, is mainly made by the preparation method of the patch for the treatment of pain.
A kind of purposes of pharmaceutical composition of above-mentioned treatment pain in the drug for preparing treatment pain.
Compared with prior art, the beneficial effects of the invention are as follows：
In pharmaceutical composition and patch that present disclosure provides, the interpretation of the cause, onset and process of an illness and primary symptom for pain and set, lived with wind-dispelling
Blood, it is warming channel and expelling cold, remove obstruction in channels to relieve pain based on, all medicine phases 5 are opposed each other and yet also complement each other so that numbness hinders logical, and pain disappears.
Inventor's research shows that the pharmaceutical composition enables to wind-cold-dampness arthralgia arthralgia to alleviate or disappear, clinic examination
It tests and shows that the pharmaceutical composition can greatly improve acute lumbar muscle sprain, arthritis and osteoarthritis, the periarthritis of shoulderjoint, waist-leg
The diseases such as pain and prolapse of nucleus pulposus of lumbar spine, neck are ached, cervical spondylosis and myotenositis are pain caused.It is rapid-action, high efficiency.Patient
After the patch, pain is significantly slowed or disappeared, and has preferable therapeutic effect.
Description of the drawings
It, below will be to required use in embodiment in order to illustrate more clearly of the technical solution of embodiment of the present invention
Attached drawing be briefly described, it should be understood that the following drawings illustrates only certain embodiments of the present invention, therefore is not to be seen as
It is the restriction to scope, it for those of ordinary skill in the art, without creative efforts, can be with root
Other relevant attached drawings are obtained according to these attached drawings.
Fig. 1 is the structure diagram for the patch that the specific embodiment of the invention provides；
Fig. 2 is the structure diagram of release film in Fig. 1.
Icon：100- patches；110- nonwoven layers；120- release films；122- arc tearable mouths；122a- circular arcs.
Specific embodiment
It, below will be in the embodiment of the present invention to make the purpose, technical scheme and advantage of the embodiment of the present invention clearer
Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, builds according to normal condition or manufacturer
The condition of view carries out.Reagents or instruments used without specified manufacturer is the conventional production that can be obtained by commercially available purchase
Product.
A kind of pharmaceutical composition for treating pain, pharmaceutical composition count in parts by weight including：
14~18 parts of Radix Aconiti, 14~18 parts of unprocessed Arisaema erubescens, 6~10 parts of myrrh, 6~10 parts of frankincense, turmeric 14~18
14~18 parts of part, 14~18 parts of Chinese cassia tree and Rhizoma Chuanxiong.
In an embodiment of the present invention, count in parts by weight, Radix Aconiti is 15~17 parts, unprocessed Arisaema erubescens are 15~17
Part, myrrh are 7~9 parts, frankincense is 7~9 parts, turmeric is 15~17 parts, Chinese cassia tree is 15~17 parts and Rhizoma Chuanxiong is 15~17
Part.
In an embodiment of the present invention, count in parts by weight, Radix Aconiti is 16.2 parts, unprocessed Arisaema erubescens are 16.2 parts,
Myrrh is 8 parts, frankincense is 8 parts, turmeric is 16.2 parts, Chinese cassia tree is 16.2 parts and Rhizoma Chuanxiong is 16.2 parts.
In the pharmaceutical formulation that present embodiment provides, using Radix Aconiti as monarch drug in a prescription.Traditional Chinese medicine side solves, through cloud：" wet three gas of chill
It is miscellaneous extremely, combined into numbness ".Numbness person, numbness resistance is obstructed, not general rule pain.Needed in treatment expelling wind and activating blood flow, it is warming channel and expelling cold, remove obstruction in channels to relieve pain.Its
In, Radix Aconiti is pungent, bitter, temperature；The thoughts of returning home, liver,kidney,spleen warp；It is warming channel and expelling cold with dispelling wind and eliminating dampness, external application burst heavily fortified point dispel corruption the effect of.
" rhizome of Chinese monkshood, temperate-dryness downlink, property dredge the sharp power very victory opened the pass natural fibre line of meat rapidly, dispel cold-dampness " (《Changsha medicine solution》), scattered exopathogen is it
Person's character with rhizome of Chinese monkshood person, takes it to walk the residual air let out, and is apt into channels and collaterals, and power can dredge chronic cloudy three and tremble with fear, really panacea.《Compendium of Materia Medica》Meaning
Its " main main strong wind of energy " and be monarch drug in a prescription.
In the pharmaceutical formulation, Chinese cassia tree, Rhizoma Chuanxiong, frankincense, myrrh and turmeric are ministerial drug.Chinese cassia tree, it is pungent, sweet, hot；Return kidney, spleen,
The heart, Liver Channel；The effect of fire is supporing yang with spreading, guiding fire to origin, warming meridian, eliminating cold to stop pain.《Pharmacological property class is bright》Cloud " guiding yang-energy,
The gas of harmonizing nutrient QI and difensive QI, makes qi and blood pass through, and all cold-evil stagnate, and obstructed tremble with fear of blood vessels is brushed lightly, and all cards of blood stasis, a surname leads hundred medicines, the dry blood of drum
Gas, then strong muscle and bone, Xuemaitong ".Rhizoma Chuanxiong, acrid in flavour and warm in nature, fragrance is walked to alter；Return liver, courage, pericardium channel；With promoting blood circulation property gas, warm promoting blood circulation,
The effect of wind-expelling pain-stopping.Wardrobe mesh thereon, outer thorough fur, pass through the sea of blood, takes up four limbs, and it is flat to walk blood, and has " gas medicine in blood "
Title.Frankincense, pungent, bitter, temperature；The thoughts of returning home, liver, the spleen channel；The fragrant profit of its pungent-warm, can the promoting the circulation of qi in blood, there is relaxing tendons and activating collaterals, swelling and pain relieving
The effect of.Myrrh, it is bitter, it puts down；The thoughts of returning home, liver, the spleen channel；It is strong that its hardship lets out power, has the effect of promoting blood circulation to remove blood stasis, swelling and pain relieving.Frankincense and
Myrrh compatibility, mutual reinforcement between is uses, and qi and blood is taken into account, and the Liao Dynasty is knowingly followed the example of a wrongdoer to be rapid.Turmeric, pungent, bitter, temperature；Return liver, the spleen channel；With blood-breaking,
The effect of inducing meastruation to relieve menalgia.Five medicines cooperation monarch drug in a prescription strengthen dispelling wind and eliminating dampness, it is warming channel and expelling cold, remove obstruction in channels to relieve pain.
In the pharmaceutical formulation, unprocessed Arisaema erubescens are adjutant.Unprocessed Arisaema erubescens, it is bitter, acrid in flavour and warm in nature；Return lung, liver, the spleen channel；Its is pungent alter it is kind
It dissipates, has effects that dispel pathogenic wind and remove dampness, dissipates blood detumescence.The medicine coordinates monarch drug in a prescription and ministerial drug that can strengthen dispelling wind and eliminating dampness, warming channel and expelling cold, detumescence
Analgesic.
This pharmaceutical formulation is set for the pain interpretation of the cause, onset and process of an illness and primary symptom, warming channel and expelling cold with expelling wind and activating blood flow, remove obstruction in channels to relieve pain based on, it is all
Medicine phases 5, oppose each other and yet also complement each other so that numbness hinders logical, and pain disappears.
Inventor's research shows that the pharmaceutical composition enables to wind-cold-dampness arthralgia arthralgia to alleviate or disappear, clinic examination
It tests and shows that the pharmaceutical composition can greatly improve acute lumbar muscle sprain, arthritis and osteoarthritis, the periarthritis of shoulderjoint, waist-leg
The diseases such as pain and prolapse of nucleus pulposus of lumbar spine, neck are ached, cervical spondylosis and myotenositis are pain caused.
Present embodiment also provides a kind of preparation method for the patch 100 for treating pain, including：
By 14~18 parts by weight of Radix Aconiti, 14~18 parts by weight of unprocessed Arisaema erubescens, 6~10 parts by weight of myrrh, 6~10 weight of frankincense
Amount part, 14~18 parts by weight of turmeric, 14~18 parts by weight of Chinese cassia tree and 14~18 parts by weight of Rhizoma Chuanxiong are mixed to form pharmaceutical composition,
Pharmaceutical composition is used into reflux extraction extraction, is concentrated to give medicinal extract of the relative density for 1.05-1.2；
Medicinal extract 4-6 parts by weight, far-infared ceramic powder 12-18 parts by weight and patch substrate 50-65 parts by weight are mixed to get
Medicament.
Wherein, medicinal extract includes following preparation process：
According to solid-liquid ratio 1:Pharmaceutical composition is mixed infiltration with ethanol solution by 5~8, then adds in pharmaceutical composition weight
5~7 times of ethanol solution obtain mixed liquor, mixed liquor is subjected to first time refluxing extraction under 70-90 DEG C of temperature conditionss
Obtain the first extracting solution and the dregs of a decoction.In certain embodiments of the present invention, the time of infiltration is 20-40min or 25-
35min.Before pharmaceutical composition mixes infiltration with ethanol solution, first each component of pharmaceutical composition is crushed, 40 mesh sieves is crossed and takes
Fine powder is conducive to improve the dissolution rate of effective substance, extraction efficiency is improved, to be further ensured that the drug effect of the medicament.
The dregs of a decoction are mixed with ethanol solution and carries out second of refluxing extraction and obtains the second extracting solution, by the first extracting solution and the
Two extracting solutions mixing after be concentrated to give under 75-85 DEG C of water bath condition relative density be 1.05-1.2 medicinal extract, second time
The ethanol solution and the weight ratio of pharmaceutical composition that stream extraction adds in are 4-6:1.Wherein, the volume fraction of ethanol solution is
80-90% or 85%.It is extracted using this method simply, convenient for control.
Wherein, it is 20-28 that patch substrate, which includes weight ratio,：22-27：30-38：3-5：The rubber of 4-7, rosin, oxidation
Zinc, lanolin and vaseline.Alternatively, rubber, rosin, zinc oxide, the weight ratio of lanolin and vaseline are 22-25：23-
25：32-35：3-4：5-6.
Stickup can be realized in the patch substrate of present embodiment under light pressure, and vaseline is as patch substrate to wound
With lubrication and protective effect, and be conducive to remove.A kind of component of the lanolin as patch substrate, can make pharmaceutical composition
Active ingredient is absorbed rapidly by mucous membrane and skin, and lanolin has adhesive force, and property is stablized, and can enhance the water absorbing capacity of patch substrate
Power is not easy rancid.
Far-infared ceramic powder can absorb amount of heat and be converted, and reflect 8~14 microns received by human body
Far infrared wave, this far infrared wave act on patient part, and local heating can be made to promote blood circulation and play the role of the scattered stasis of blood.
Further, in certain embodiments of the present invention, first by far-infared ceramic powder 12-18 parts by weight and borneol
After the mixing of 0.5-0.7 parts by weight, then with medicinal extract, patch substrate it is mixed to get medicament.
Borneol, it is pungent, it is bitter, it is cool；The thoughts of returning home, spleen, lung channel；Have effects that declare key, tonneau, analgesic, borneol is closed with unprocessed Arisaema erubescens
Make for assistant.Far-infared ceramic powder is first mixed with borneol, is conducive to be uniformly mixed with medicinal extract and patch substrate.
Further, after far-infared ceramic powder is mixed with borneol, when being mixed with medicinal extract, patch substrate, further include with
The auxiliary material mixing of 17-22 parts by weight, it is 2-4 that auxiliary material, which includes weight ratio,： 4-6：4-6：The menthol of 1-3, camphor, wintergreen and
Azone.
Menthol is used for local analgesia, antipruritic, is shared with camphor, can enhance antipruritic effect.Wintergreen, which has, promotes blood
Xun Huan, analgesic, anti-inflammatory effect.Azone has the Transdermal absorption effect for promoting drug.
Further, in certain embodiments of the present invention, obtained medicament is coated on to the surface of release film 120
On, it then covers upper nonwoven layer 110 and can obtain patch first product.Patch first product is cut, seals, patch 100 can be obtained.
The preparation method of the patch of the treatment pain of embodiment of the present invention, it is simple and practicable, it is workable, it can be larger
Degree avoids effective component from being destroyed, and remains the content of active principle in medicament, so as to ensure drug effect.
Present embodiment further includes a kind of patch 100 for treating pain, by the preparation of the patch 100 of above-mentioned treatment pain
Method is made.
Specifically, patch 100 further includes nonwoven layer 110 and release film 120, and medicament is adhered to release film 120, non-woven fabrics
Layer 110, which is attached at release film 120, has the surface of medicament, and release film 120 is provided with arc tearable mouth 122.
In use, release film 120 is torn off nonwoven layer 110, since release film 120 has arc tearable mouth 122, then may be used
Relatively easily to tear off release film 120, at this moment the release film 120 with medicament can be directed at affected part periphery, utilize release film
Patch matter matrix and skin attachement in medicament on 120.Due to carrying medicament on release film 120, medicament has treatment to affected part
Effect.
In the present embodiment, arc tearable mouth 122 is set along the width of release film 120.Arc tearable mouth 122 is by more
A circular arc 122a compositions.The opening direction of adjacent circular arc 122a is oppositely arranged.In the present embodiment, adjacent circular arc 122a is opened
To the left, one to the right for one, mouth.
Set-up mode in this way can utilize involve power between adjacent circular arc 122a, easily tear release film 120
From nonwoven layer 110.
Present embodiment further includes a kind of purposes of pharmaceutical composition for treating pain in the drug for preparing treatment pain.
Further, antalgesic includes acute lumbar muscle sprain, arthritis and osteoarthritis, the periarthritis of shoulderjoint, pain in waist and lower extremities
And the diseases such as prolapse of nucleus pulposus of lumbar spine, neck are ached, cervical spondylosis and myotenositis are pain caused.
The feature and performance of the present invention are described in further detail with reference to embodiments.
Embodiment 1
The present embodiment provides a kind of patch 100 for treating pain, the medicament in the patch 100 is counted in parts by weight including leaching
20 parts of 5 parts of cream, 15 parts of far-infared ceramic powder, 0.6 part of borneol, 60 parts of patch substrate and auxiliary material.
Wherein, medicinal extract includes following preparation process：
Pharmaceutical composition is smashed it through into 40 mesh sieves, pharmaceutical composition includes：16.2 parts by weight of Radix Aconiti, unprocessed Arisaema erubescens
16.2 parts by weight, 8 parts by weight of myrrh, 8 parts by weight of frankincense, 16.2 parts by weight of turmeric, 16.2 parts by weight of Chinese cassia tree and Rhizoma Chuanxiong 16.2
Parts by weight.
The ethanol solution that pharmaceutical composition and volume fraction after sieving are 85% is taken according to solid-liquid ratio 1:5 mixing infiltrations
30min, 5 times of ethanol solution (volume fraction 85%) for then adding in pharmaceutical composition weight obtain mixed liquor, will mix
Liquid carries out first time refluxing extraction 1h under 80 DEG C of temperature conditionss and obtains the first extracting solution and the dregs of a decoction.By the dregs of a decoction and ethanol solution
(volume fraction 85%) mixing carries out second of refluxing extraction 30min and obtains the second extracting solution, by the first extracting solution and second
The medicinal extract that relative density is 1.1 is concentrated to give after extracting solution mixing under 80 DEG C of water bath condition, second of refluxing extraction adds in
Ethanol solution and pharmaceutical composition weight ratio be 4:1.
It is 20 that patch substrate, which includes weight ratio,：23：35：3：4 rubber, rosin, zinc oxide, lanolin and vaseline.
It is 2 that auxiliary material, which includes weight ratio,：5：5：2 menthol, camphor, wintergreen and azone.
The preparation method of the patch 100 includes：After above-mentioned far-infared ceramic powder is mixed with borneol, then with medicinal extract, patch
Agent matrix and auxiliary material are mixed to get medicament, and medicament is coated on release film 120, then cover upper nonwoven layer 110 and are pasted
Agent first product cuts patch first product, and sealing can obtain patch 100.
Embodiment 2
The present embodiment provides a kind of patch 100 for treating pain, the medicament in the patch 100 is counted in parts by weight including leaching
18 parts of 4.5 parts of cream, 12 parts of far-infared ceramic powder, 0.5 part of borneol, 55 parts of patch substrate and auxiliary material.
Wherein, medicinal extract includes following preparation process：
Pharmaceutical composition is smashed it through into 40 mesh sieves, pharmaceutical composition includes：14 parts by weight of Radix Aconiti, unprocessed Arisaema erubescens 14
Parts by weight, 7.5 parts by weight of myrrh, 7 parts by weight of frankincense, 14 parts by weight of 14 parts by weight of turmeric, 14 parts by weight of Chinese cassia tree and Rhizoma Chuanxiong.
The ethanol solution that pharmaceutical composition and volume fraction after sieving are 80% is taken according to solid-liquid ratio 1:8 mixing infiltrations
20min, 7 times of ethanol solution (volume fraction 80%) for then adding in pharmaceutical composition weight obtain mixed liquor, will mix
Liquid carries out first time refluxing extraction 50min under 70 DEG C of temperature conditionss and obtains the first extracting solution and the dregs of a decoction.By the dregs of a decoction and ethyl alcohol
Solution (volume fraction 80%) mixing carries out second of refluxing extraction 25min and obtains the second extracting solution, by the first extracting solution and
The medicinal extract that relative density is 1.05, second of refluxing extraction are concentrated to give after the mixing of second extracting solution under 85 DEG C of water bath condition
The ethanol solution of addition and the weight ratio of pharmaceutical composition are 5:1.
It is 25 that patch substrate, which includes weight ratio,：22：30：4：5 rubber, rosin, zinc oxide, lanolin and vaseline.
It is 4 that auxiliary material, which includes weight ratio,：4：6：1 menthol, camphor, wintergreen and azone.
The preparation method of the patch 100 includes：After above-mentioned far-infared ceramic powder is mixed with borneol, then with medicinal extract, patch
Agent matrix and auxiliary material are mixed to get medicament, and medicament is coated on release film 120, then cover upper nonwoven layer 110 and are pasted
Agent first product cuts patch first product, and sealing can obtain patch 100.
Embodiment 3
The present embodiment provides a kind of patch 100 for treating pain, the medicament in the patch 100 is counted in parts by weight including leaching
20 parts of 4 parts of cream, 14 parts of far-infared ceramic powder, 0.6 part of borneol, 50 parts of patch substrate and auxiliary material.
Wherein, medicinal extract includes following preparation process：
Pharmaceutical composition is smashed it through into 40 mesh sieves, pharmaceutical composition includes：15 parts by weight of Radix Aconiti, unprocessed Arisaema erubescens
14.5 parts by weight, 6 parts by weight of myrrh, 7.5 parts by weight of frankincense, 15 weight of 14.5 parts by weight of turmeric, 14 parts by weight of Chinese cassia tree and Rhizoma Chuanxiong
Measure part.
The ethanol solution that pharmaceutical composition and volume fraction after sieving are 90% is taken according to solid-liquid ratio 1:6 mixing infiltrations
40min, 6 times of ethanol solution (volume fraction 90%) for then adding in pharmaceutical composition weight obtain mixed liquor, will mix
Liquid carries out first time refluxing extraction 55min under 70 DEG C of temperature conditionss and obtains the first extracting solution and the dregs of a decoction.By the dregs of a decoction and ethyl alcohol
Solution (volume fraction 90%) mixing carries out second of refluxing extraction 30min and obtains the second extracting solution, by the first extracting solution and
The medicinal extract that relative density is 1.2, second of refluxing extraction are concentrated to give after the mixing of second extracting solution under 75 DEG C of water bath condition
The ethanol solution of addition and the weight ratio of pharmaceutical composition are 6:1.
It is 28 that patch substrate, which includes weight ratio,：25：38：5：7 rubber, rosin, zinc oxide, lanolin and vaseline.
It is 3 that auxiliary material, which includes weight ratio,：6：4：3 menthol, camphor, wintergreen and azone.
The preparation method of the patch 100 includes：After above-mentioned far-infared ceramic powder is mixed with borneol, then with medicinal extract, patch
Agent matrix and auxiliary material are mixed to get medicament, and medicament is coated on release film 120, then cover upper nonwoven layer 110 and are pasted
Agent first product cuts patch first product, and sealing can obtain patch 100.
Embodiment 4
The present embodiment provides a kind of patch 100 for treating pain, the medicament in the patch 100 is counted in parts by weight including leaching
17 parts of 6 parts of cream, 13 parts of far-infared ceramic powder, 0.6 part of borneol, 52 parts of patch substrate and auxiliary material.
Wherein, medicinal extract includes following preparation process：
Pharmaceutical composition is smashed it through into 40 mesh sieves, pharmaceutical composition includes：17 parts by weight of Radix Aconiti, unprocessed Arisaema erubescens 17
Parts by weight, 10 parts by weight of myrrh, 8.5 parts by weight of frankincense, 17 parts by weight of 17 parts by weight of turmeric, 17 parts by weight of Chinese cassia tree and Rhizoma Chuanxiong.
The ethanol solution that pharmaceutical composition and volume fraction after sieving are 85% is taken according to solid-liquid ratio 1:7 mixing infiltrations
50min, 5 times of ethanol solution (volume fraction 85%) for then adding in pharmaceutical composition weight obtain mixed liquor, will mix
Liquid carries out first time refluxing extraction 50min under 75 DEG C of temperature conditionss and obtains the first extracting solution and the dregs of a decoction.By the dregs of a decoction and ethyl alcohol
Solution (volume fraction 85%) mixing carries out second of refluxing extraction 30min and obtains the second extracting solution, by the first extracting solution and
The medicinal extract that relative density is 1.15, second of refluxing extraction are concentrated to give after the mixing of second extracting solution under 80 DEG C of water bath condition
The ethanol solution of addition and the weight ratio of pharmaceutical composition are 5:1.
It is 22 that patch substrate, which includes weight ratio,：27：32：4：7 rubber, rosin, zinc oxide, lanolin and vaseline.
It is 3 that auxiliary material, which includes weight ratio,：5：5：2 menthol, camphor, wintergreen and azone.
The preparation method of the patch 100 includes：After above-mentioned far-infared ceramic powder is mixed with borneol, then with medicinal extract, patch
Agent matrix and auxiliary material are mixed to get medicament, and medicament is coated on release film 120, then cover upper nonwoven layer 110 and are pasted
Agent first product cuts patch first product, and sealing can obtain patch 100.
Embodiment 5
The present embodiment provides a kind of patch 100 for treating pain, the medicament in the patch 100 is counted in parts by weight including leaching
22 parts of 5.5 parts of cream, 18 parts of far-infared ceramic powder, 0.7 part of borneol, 58 parts of patch substrate and auxiliary material.
Wherein, medicinal extract includes following preparation process：
Pharmaceutical composition is smashed it through into 40 mesh sieves, pharmaceutical composition includes：16.5 parts by weight of Radix Aconiti, unprocessed Arisaema erubescens
16 parts by weight, 7 parts by weight of myrrh, 9 parts by weight of frankincense, 16 parts by weight of 15 parts by weight of turmeric, 15 parts by weight of Chinese cassia tree and Rhizoma Chuanxiong.
The ethanol solution that pharmaceutical composition and volume fraction after sieving are 85% is taken according to solid-liquid ratio 1:5 mixing infiltrations
30min, 6 times of ethanol solution (volume fraction 85%) for then adding in pharmaceutical composition weight obtain mixed liquor, will mix
Liquid carries out first time refluxing extraction 1h under 80 DEG C of temperature conditionss and obtains the first extracting solution and the dregs of a decoction.By the dregs of a decoction and ethanol solution
(volume fraction 85%) mixing carries out second of refluxing extraction 30min and obtains the second extracting solution, by the first extracting solution and second
The medicinal extract that relative density is 1.1 is concentrated to give after extracting solution mixing under 80 DEG C of water bath condition, second of refluxing extraction adds in
Ethanol solution and pharmaceutical composition weight ratio be 5:1.
It is 24 that patch substrate, which includes weight ratio,：24：35：3：5 rubber, rosin, zinc oxide, lanolin and vaseline.
It is 2 that auxiliary material, which includes weight ratio,：4：5：3 menthol, camphor, wintergreen and azone.
The preparation method of the patch 100 includes：After above-mentioned far-infared ceramic powder is mixed with borneol, then with medicinal extract, patch
Agent matrix and auxiliary material are mixed to get medicament, and medicament is coated on release film 120, then cover upper nonwoven layer 110 and are pasted
Agent first product cuts patch first product, and sealing can obtain patch 100.
Embodiment 6
The present embodiment provides a kind of patch 100 for treating pain, the medicament in the patch 100 is counted in parts by weight including leaching
21 parts of 4.2 parts of cream, 16 parts of far-infared ceramic powder, 0.5 part of borneol, 65 parts of patch substrate and auxiliary material.
Wherein, medicinal extract includes following preparation process：
Pharmaceutical composition is smashed it through into 40 mesh sieves, pharmaceutical composition includes：18 parts by weight of Radix Aconiti, unprocessed Arisaema erubescens 18
Parts by weight, 9 parts by weight of myrrh, 10 parts by weight of frankincense, 18 parts by weight of 18 parts by weight of turmeric, 18 parts by weight of Chinese cassia tree and Rhizoma Chuanxiong.
The ethanol solution that pharmaceutical composition and volume fraction after sieving are 85% is taken according to solid-liquid ratio 1:5 mixing infiltrations
30min, 6 times of ethanol solution (volume fraction 85%) for then adding in pharmaceutical composition weight obtain mixed liquor, will mix
Liquid carries out first time refluxing extraction 1h under 80 DEG C of temperature conditionss and obtains the first extracting solution and the dregs of a decoction.By the dregs of a decoction and ethanol solution
(volume fraction 85%) mixing carries out second of refluxing extraction 30min and obtains the second extracting solution, by the first extracting solution and second
The medicinal extract that relative density is 1.1 is concentrated to give after extracting solution mixing under 80 DEG C of water bath condition, second of refluxing extraction adds in
Ethanol solution and pharmaceutical composition weight ratio be 5:1.
It is 26 that patch substrate, which includes weight ratio,：23：34：4：5 rubber, rosin, zinc oxide, lanolin and vaseline.
It is 2 that auxiliary material, which includes weight ratio,：4：4：1 menthol, camphor, wintergreen and azone.
The preparation method of the patch 100 includes：After above-mentioned far-infared ceramic powder is mixed with borneol, then with medicinal extract, patch
Agent matrix and auxiliary material are mixed to get medicament, and medicament is coated on release film 120, then cover upper nonwoven layer 110 and are pasted
Agent first product cuts patch first product, and sealing can obtain patch 100.
Embodiment 7
The present embodiment provides a kind of patch 100 for treating pain, the medicament in the patch 100 is counted in parts by weight including leaching
19 parts of 5.2 parts of cream, 17 parts of far-infared ceramic powder, 54 parts of patch substrate and auxiliary material.
Wherein, medicinal extract includes following preparation process：
Pharmaceutical composition is smashed it through into 40 mesh sieves, pharmaceutical composition includes：15.5 parts by weight of Radix Aconiti, unprocessed Arisaema erubescens
15 parts by weight, 8.5 parts by weight of myrrh, 6 parts by weight of frankincense, 15 weight of 15.5 parts by weight of turmeric, 14.5 parts by weight of Chinese cassia tree and Rhizoma Chuanxiong
Measure part.
The ethanol solution that pharmaceutical composition and volume fraction after sieving are 85% is taken according to solid-liquid ratio 1:5 mixing infiltrations
30min, 5 times of ethanol solution (volume fraction 85%) for then adding in pharmaceutical composition weight obtain mixed liquor, will mix
Liquid carries out first time refluxing extraction 1h under 80 DEG C of temperature conditionss and obtains the first extracting solution and the dregs of a decoction.By the dregs of a decoction and ethanol solution
(volume fraction 85%) mixing carries out second of refluxing extraction 30min and obtains the second extracting solution, by the first extracting solution and second
The medicinal extract that relative density is 1.1 is concentrated to give after extracting solution mixing under 80 DEG C of water bath condition, second of refluxing extraction adds in
Ethanol solution and pharmaceutical composition weight ratio be 5:1.
It is 27 that patch substrate, which includes weight ratio,：24：34：3：5 rubber, rosin, zinc oxide, lanolin and vaseline.
It is 2 that auxiliary material, which includes weight ratio,：5：4：1 menthol, camphor, wintergreen and azone.
The preparation method of the patch 100 includes：Above-mentioned far-infared ceramic powder is mixed with medicinal extract, patch substrate and auxiliary material
Medicament is obtained, medicament is coated on release film 120, upper nonwoven layer 110 is then covered and obtains patch first product, by patch first product
Cutting, sealing, can obtain patch 100.
Test example
Situation is observed with reference to clinical application, the patch provided the embodiment of the present invention 1 carries out in terms of pain is treated
Evaluation.
Case selection：
During being chosen in October, 2016~2017 year November, frustrated in the soft tissue of the first affiliated hospital of Yunnan University of Traditional Chinese Medicine
Hinder patient 72, rheumatoid arthritis patients 72 and periarthritis of shoulderjoint patient 72.
Therapeutic regimen：
Patient sticks the patch of the embodiment of the present invention 1 in affected part, once a day, is replaced daily, during replacement
Affected part need to be cleaned up.
As a result count：After one week, follow-up statistics is carried out to the service condition of patient, result is recorded in table 1.
1 patient's result of table counts
The patch of the treatment pain of the embodiment of the present invention be can be seen that from the result of upper table for soft tissue injury, rheumatism
Pain caused by arthritis and the periarthritis of shoulderjoint is respectively provided with preferable therapeutic effect.
In conclusion pharmaceutical composition and patch that embodiment of the present invention provides, enable to wind-cold-dampness arthralgia arthritis
Pain is alleviated or disappears, and clinical test shows that the pharmaceutical composition can greatly improve acute lumbar muscle sprain, arthritis and Bones and joints
The diseases such as inflammation, the periarthritis of shoulderjoint, pain in waist and lower extremities and prolapse of nucleus pulposus of lumbar spine, neck are ached, cervical spondylosis and myotenositis are pain caused.
It is rapid-action, high efficiency.After patient uses the patch, pain is significantly slowed or disappeared, and has preferable therapeutic effect.
Embodiments described above is part of the embodiment of the present invention, instead of all the embodiments.The reality of the present invention
The detailed description for applying example is not intended to limit the scope of claimed invention, but is merely representative of the selected implementation of the present invention
Example.Based on the embodiments of the present invention, those of ordinary skill in the art are obtained without creative efforts
Every other embodiment, belongs to the scope of protection of the invention.
Claims (10)
1. a kind of pharmaceutical composition for treating pain, which is characterized in that described pharmaceutical composition count in parts by weight including：
14~18 parts of Radix Aconiti, 14~18 parts of unprocessed Arisaema erubescens, 6~10 parts of myrrh, 6~10 parts of frankincense, 14~18 parts of turmeric, Chinese cassia tree
14~18 parts and 14~18 parts of Rhizoma Chuanxiong.
2. the pharmaceutical composition for the treatment of pain according to claim 1, which is characterized in that count in parts by weight, the life
Monkshood is 15~17 parts, the unprocessed Arisaema erubescens are 15~17 parts, the myrrh is 7~9 parts, the frankincense is 7~9 parts, described
Turmeric is 15~17 parts, the Chinese cassia tree is 15~17 parts and the Rhizoma Chuanxiong is 15~17 parts.
3. a kind of use of pharmaceutical composition for the treatment of pain as claimed in claim 1 or 2 in the drug for preparing treatment pain
On the way.
4. a kind of preparation method for the patch for treating pain, which is characterized in that including：
By 14~18 parts by weight of Radix Aconiti, 14~18 parts by weight of unprocessed Arisaema erubescens, 6~10 parts by weight of myrrh, 6~10 weight of frankincense
Part, 14~18 parts by weight of turmeric, 14~18 parts by weight of Chinese cassia tree and 14~18 parts by weight of Rhizoma Chuanxiong are mixed to form pharmaceutical composition, will
Described pharmaceutical composition uses reflux extraction extraction, is concentrated to give medicinal extract of the relative density for 1.05-1.2；
The medicinal extract 4-6 parts by weight, far-infared ceramic powder 12-18 parts by weight and patch substrate 50-65 parts by weight are mixed to get
Medicament.
5. the preparation method of the patch for the treatment of pain according to claim 4, which is characterized in that the medicinal extract includes following
Preparation process：
According to solid-liquid ratio 1:Described pharmaceutical composition is mixed infiltration with ethanol solution by 5~8, then adds in described pharmaceutical composition
5~7 times of ethanol solution of weight obtains mixed liquor, and the mixed liquor is carried out for the first time under 70-90 DEG C of temperature conditionss
Refluxing extraction obtains the first extracting solution and the dregs of a decoction, and the dregs of a decoction are mixed with ethanol solution and carries out second of refluxing extraction and obtains the
Two extracting solutions are concentrated to give after mixing first extracting solution and second extracting solution under 75-85 DEG C of water bath condition
Relative density is the medicinal extract of 1.05-1.2, the ethanol solution that second of refluxing extraction adds in and the medicine group
The weight ratio for closing object is 4-6:1.
6. the preparation method of the patch for the treatment of pain according to claim 4, which is characterized in that the patch substrate includes
Weight ratio is 20-28：22-27：30-38：3-5：Rubber, rosin, zinc oxide, lanolin and the vaseline of 4-7.
7. the preparation method of the patch for the treatment of pain according to claim 4, which is characterized in that first the far infrared is made pottery
After porcelain powder 12-18 parts by weight are mixed with borneol 0.5-0.7 parts by weight, then with the medicinal extract, the patch substrate it is mixed to get medicine
Agent.
8. the preparation method of the patch for the treatment of pain according to claim 7, which is characterized in that by the far-infrared ceramic
After powder is mixed with the borneol, when being mixed with the medicinal extract, the patch substrate, the auxiliary material with 17-22 parts by weight is further included
Mixing, it is 2-4 that the auxiliary material, which includes weight ratio,：4-6：4-6：Menthol, camphor, wintergreen and the azone of 1-3.
9. a kind of patch for treating pain, which is characterized in that the patch of pain is treated by claim 4-8 any one of them
Preparation method is made.
10. it is according to claim 9 treatment pain patch, which is characterized in that the patch further include nonwoven layer and
Release film, the medicament are adhered to the release film, and the nonwoven layer, which is attached at the release film, has the surface of medicament, institute
It states release film and is provided with arc tearable mouth.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711454775.6A CN108042762A (en) | 2017-12-28 | 2017-12-28 | A kind of pharmaceutical composition for treating pain, patch and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711454775.6A CN108042762A (en) | 2017-12-28 | 2017-12-28 | A kind of pharmaceutical composition for treating pain, patch and its preparation method and application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108042762A true CN108042762A (en) | 2018-05-18 |
Family
ID=62128694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711454775.6A Pending CN108042762A (en) | 2017-12-28 | 2017-12-28 | A kind of pharmaceutical composition for treating pain, patch and its preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108042762A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108567766A (en) * | 2018-06-05 | 2018-09-25 | 史锐 | A kind of ventilation patch and preparation method thereof |
| CN115154567A (en) * | 2022-07-05 | 2022-10-11 | 王祥峰 | Preservative-free multi-purpose traditional Chinese medicine formula for promoting blood circulation and removing blood stasis |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101040903A (en) * | 2006-08-03 | 2007-09-26 | 武汉正午阳光医药生物科技有限公司 | Farinfrared emplastrum |
| CN102430020A (en) * | 2011-12-12 | 2012-05-02 | 江苏南星药业有限责任公司 | Process method for leading easily-layered paste material to be uniform in production of compound south-star pain relieving paste |
| CN105770734A (en) * | 2016-03-17 | 2016-07-20 | 邢健昆 | Traditional Chinese medicine composition for treating joint sore symptoms of osteoarthritis through external use |
-
2017
- 2017-12-28 CN CN201711454775.6A patent/CN108042762A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101040903A (en) * | 2006-08-03 | 2007-09-26 | 武汉正午阳光医药生物科技有限公司 | Farinfrared emplastrum |
| CN102430020A (en) * | 2011-12-12 | 2012-05-02 | 江苏南星药业有限责任公司 | Process method for leading easily-layered paste material to be uniform in production of compound south-star pain relieving paste |
| CN105770734A (en) * | 2016-03-17 | 2016-07-20 | 邢健昆 | Traditional Chinese medicine composition for treating joint sore symptoms of osteoarthritis through external use |
Non-Patent Citations (1)
| Title |
|---|
| 耀持等: "复方南星止痛膏治疗腰椎间盘突出症临床观察", 《上海中医药杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108567766A (en) * | 2018-06-05 | 2018-09-25 | 史锐 | A kind of ventilation patch and preparation method thereof |
| CN115154567A (en) * | 2022-07-05 | 2022-10-11 | 王祥峰 | Preservative-free multi-purpose traditional Chinese medicine formula for promoting blood circulation and removing blood stasis |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100560124C (en) | A kind of plaster for the treatment of bone matrix hyperplasia and pain and preparation method thereof | |
| CN101347536B (en) | External-use preparation for treating traumatic injury | |
| CN102631513B (en) | Medicinal plaster for removing stasis, eliminating stagnation and relieving swelling and preparation method thereof | |
| CN102526406B (en) | Traditional Chinese medicine plaster for treating cervical spondylotic radiculopathy and preparation method thereof | |
| CN104758690A (en) | Traditional Chinese medicinal preparation for treating pre-operative anesthesia and preparation method of traditional Chinese medicinal preparation | |
| CN108042762A (en) | A kind of pharmaceutical composition for treating pain, patch and its preparation method and application | |
| CN111388532B (en) | Skin scraping oil with effects of eliminating dampness, dispelling cold, warming middle-jiao and relieving pain and preparation method thereof | |
| CN106620622A (en) | Moxibustion composition and preparation method and application thereof | |
| CN109464517A (en) | Clearing heat and detoxicating paediatrics external application massage ointment formula, the method and application for preparing ointment | |
| CN105561270A (en) | Analgesic Chinese herbal medicine for external application and preparation method thereof | |
| CN101269191B (en) | Externally applied medicament for treating hepatopathy | |
| CN105055755A (en) | External traditional Chinese medicine plaster for treating prolapse of lumbar intervertebral disc | |
| CN103961618A (en) | Plaster for treating pains caused by wind-cold damp pathogens | |
| CN208726315U (en) | A kind of external use plaster | |
| CN103656001A (en) | Compound medicine for treating osteoproliferation | |
| CN1141105C (en) | Cancer curing medicine liquid | |
| CN107982363A (en) | Chinese medicine composition for swelling and pain relieving | |
| CN102406789B (en) | Plaster for treating cervical spondylosis | |
| CN105560537A (en) | Medicine composition for treating osteoartritis and preparation method thereof | |
| CN106620040A (en) | Drug for treating cervical spondylosis | |
| CN101485868A (en) | Pharmaceutical composition for dispersing swelling and relieving pain and preparation method thereof | |
| CN1157199C (en) | Chinese medicine for treating hyperosteogeny, arthritis and herniation of cervical disc and prolapse of lumbar intervertebral disc and administration device thereof | |
| CN102764344B (en) | Ointment containing basil essential oil, almond oil and grape seed oil for treating acne and preparation method thereof | |
| CN102949534B (en) | Traditional Chinese medicine for treating cervical spondylosis and preparation method thereof | |
| CN103356951A (en) | Traditional Chinese medicine composition for treating cardiac insufficiency |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |