CN102949534B - Traditional Chinese medicine for treating cervical spondylosis and preparation method thereof - Google Patents
Traditional Chinese medicine for treating cervical spondylosis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine for treating cervical spondylosis and a preparation method thereof. The traditional Chinese medicine for treating cervical spondylosis is prepared from the following raw materials, by weight: 20-35 parts of Bauhinia championii, 15-30 parts of fissistigma polyanthum, 10-30 parts of garden balsam stem, 10-25 parts of Cissus pteroclada Hayata, 5-15 parts of Ardisia crenata, 5-15 parts of Rubus parvifolius and 5-15 parts of Herba sarcandrae. Compared with the prior art, main medicines of Bauhinia championii, fissistigma polyanthum and garden balsam stem have main effects of dispelling wind and dampness, and promoting blood circulation; auxiliary medicines of Cissus pteroclada Hayata, Ardisia crenata, Rubus parvifolius and Herba sarcandrae have auxiliary functions of clearing heat, detoxifying and reliving swelling; and the three main medicines and four auxiliary medicines are combined to play roles of dispelling wind and dampness, promoting blood circulation to remove blood stasis, and dredging collateral channels. The formula is simple and has synergistic effect of each medicine, good effect on the treatment of cervical disease, and little toxic effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to Chinese medicine for the treatment of cervical spondylosis and preparation method thereof, belong to technical field of Chinese medicines.
Background technology
The approach for the treatment of cervical spondylosis mainly contains at present: the therapies such as herbal treatment, modus operandi, traction, acupuncture and massage.Wherein, possess that toxic and side effects is little, effect comparatively the herbal treatment of distinguishing feature become one of important channel for the treatment of cervical spondylosis, as the publication number patent of invention that is CN101618200, a kind of Dressed plaster of specially treating cervical spondylosis is disclosed, formula is that to select Herba zephyranthis grandiflorae, Radix Notoginseng, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Scorpio, Scolopendra, Radix Gentianae Macrophyllae, Fructus Capsici be monarch drug, inrigorating qi and promoting blood circulation pain relieving; Herba Saussureae Involueratae, Caulis Spatholobi, Cortex Magnoliae Officinalis, Herba Pyrolae, Os Tigris, Squama Manis, Pyritum, Cortex erythrinae are ministerial drug, expelling wind and cold, promoting the flow of QI in the collateral by warming the meridian; The Radix Rehmanniae, Herba Chrysosplenii Macrophylli, Cortex Phellodendri, Concha Ostreae, Radix Achyranthis Bidentatae, Radix Morindae Officinalis, charred Cortex Eucommiae are assistant, invigorating the liver and kidney, suppressing the hyperactive liver to relieve the wind syndrome; Radix Puerariae, Radix Platycodonis, Fructus Chaenomelis, Rhizoma Alismatis, Rhizoma Zingiberis be for making, to prevent that the product of nourishing from producing damp and hot fraud, again can clearing away heat and promoting diuresis, and detumescence, relaxes the property of medicine; Make each efficacy of drugs produce synergism said medicine combination, thereby there is the effect of good treatment cervical spondylosis.But foregoing invention medicament composing prescription Raw medicine is more, the processing of each crude drug is also comparatively complicated.
Summary of the invention
The technical problem to be solved in the present invention is to provide Chinese medicine of the treatment cervical spondylosis that a kind of prescription is simple, therapeutic effect is good and preparation method thereof.
The Chinese medicine for the treatment of cervical spondylosis of the present invention, by weight, it is made by the crude drug of following weight parts:
20～35 parts of Caulis Bauhihiae Championiis, 15～30 parts of Caulis Fissistigmatiss (Caulis Fissistigmatis), 10～30 parts of Herba speranskiae tuberculataes, 10～25 parts of Cissus pteroclada Hayatas, 5～15 parts of Radix Ardisiae Crenataes, 5～15 parts of Herba Rubi parvifolii (Rubus Parvifolius L.), 5～15 parts of Herba Sarcandraes.
Preferably, the weight portion of above-mentioned each crude drug is:
20～30 parts of Caulis Bauhihiae Championiis, 15～25 parts of Caulis Fissistigmatiss (Caulis Fissistigmatis), 10～20 parts of Herba speranskiae tuberculataes, 10～20 parts of Cissus pteroclada Hayatas, 5～10 parts of Radix Ardisiae Crenataes, 5～10 parts of Herba Rubi parvifolii (Rubus Parvifolius L.), 10～15 parts of Herba Sarcandraes.
Best, the weight portion of above-mentioned each crude drug is:
25 parts of Caulis Bauhihiae Championiis, 20 parts of Caulis Fissistigmatiss (Caulis Fissistigmatis), 15 parts of Herba speranskiae tuberculataes, 10 parts of Cissus pteroclada Hayatas, 8 parts of Radix Ardisiae Crenataes, 10 parts of Herba Rubi parvifolii (Rubus Parvifolius L.), 12 parts of Herba Sarcandraes.
In prescription of the present invention,
Caulis Bauhihiae Championii is the dry rattan of leguminous plant Caulis Bauhiniae Championii Bauhinia championii (Benth.) Benth..The traditional Chinese medical science has expelling wind and removing dampness, promoting blood circulation and stopping pain, and spleen invigorating is regulated the flow of vital energy.Strong doctor Wei Tongtiaolong road Huo Lu, the poison that dispels the wind, except noxious dampness; For sending out prosperous (rheumatic ostalgia), take by force and grip (fracture), in mind pain (stomachache).
Caulis Fissistigmatis (Caulis Fissistigmatis), for annonaceae plant is spent more the dry rattan of Radix Fissistigmatis Oldhamii Fissistigma polyanthum (Hook.f.et Thoms.) Merr..Traditional Chinese medical science wind-damp dispelling, bone and muscle strengthening, promoting blood circulation and stopping pain.Strong doctor Tong Longlu fire road, the poison that dispels the wind, promoting blood flow to regulate menstruation; For sending out prosperous (rheumatic ostalgia), Carnis Gallus domesticus atrophy, strangles stupid watt of grandfather (poliomyelitis sequela), menoxenia, and woods must sting phase (traumatic injury), in mind pain (stomachache).
Herba speranskiae tuberculatae: wind-damp dispelling, invigorate blood circulation, relaxing muscles and tendons, pain relieving.Dispelling the wind and dampness pathogens pain, sprain and contusion wound, innominate toxic swelling.
Cissus pteroclada Hayata is the dry rattan of vitaceae Cissus pteroclada Hayata Cissus pteroclada Hayata.Strong doctor's fire-through path, the poison that dispels the wind, except noxious dampness, promoting blood circulation and detumescence; For sending out prosperous (rheumatic ostalgia), fiber crops are smeared (numb limbs and tense tendons), and woods must sting phase (traumatic injury), live and invite Yin's (cervical spondylosis), the Ba Yin of nation (scapulohumeral periarthritis), A Yimi (dysentery), ruthless Yin's (furuncle).
Radix Ardisiae Crenatae is the dry root of fund cattle plant Radix Ardisiae Crenatae Ardisia crenata Sims.Traditional Chinese medical science removing toxic substances and promoting subsidence of swelling, promoting blood circulation and stopping pain, expelling wind and removing dampness.Zhuan Yitiaolong road Huo Lu, heat clearing away poison, the poison that dispels the wind, except noxious dampness, reducing swelling and alleviating pain; For sending out prosperous (rheumatic ostalgia), woods must sting phase (traumatic injury), and capital Yin (dysmenorrhea) spits blood, and pain (stomachache), has a headache in mind, goods cigarette mother (cigarette pain), soldier frost fire person of outstanding talent (diphtheria), erysipelas.
Herba Rubi parvifolii (Rubus Parvifolius L.) is the dry aerial parts of rosaceous plant Herba Rubi parvifolii (Rubus Parvifolius L.) Rubus parvi folius L..Traditional Chinese medicine blood circulation promoting detumescence, heat-clearing and toxic substances removing, wind-damp dispelling.Strong doctor Tong Longlu, dredging water passages, heat clearing away poison, eliminating stasis to stop pain.
Herba Sarcandrae is the dry Herb of Chloranthaceae plant plait Corallium Japonicum Kishinouye Sarcandra glabra (Thunb.) Nakai.Clearing away heat and cooling blood, the speckle removing of invigorating blood circulation, dispelling wind and removing obstruction in the collateral; For heat in blood purpura, purpura, rheumatic arthralgia, traumatic injury.
Above-mentioned Chinese medicine preparation can be ointment, patch or gel, preferably makes patch.
The preparation method of the Chinese medicine for the treatment of cervical spondylosis of the present invention is: take Caulis Bauhihiae Championii 20～35 weight portions, Caulis Fissistigmatis (Caulis Fissistigmatis) 15～30 weight portions, Herba speranskiae tuberculatae 10～30 weight portions, Cissus pteroclada Hayata 10～25 weight portions, Radix Ardisiae Crenatae 5～15 weight portions, Herba Rubi parvifolii (Rubus Parvifolius L.) 5～15 weight portions and Herba Sarcandrae 5～15 weight portions, pulverize, decoct with water, collect medicinal liquid, be condensed into the extractum that at 65～70 ℃, relative density is 1.15～1.20, dry, be ground into after powder, by existing conventional method, make ointment, patch or gel.
Concrete preparation method is: take Caulis Bauhihiae Championii, Caulis Fissistigmatis (Caulis Fissistigmatis), Herba speranskiae tuberculatae, Cissus pteroclada Hayata, Radix Ardisiae Crenatae, Herba Rubi parvifolii (Rubus Parvifolius L.) and Herba Sarcandrae, be crushed to 10～20 orders, decoct with water 1～2 time, each 1～2h that decocts, filters, and collects medicinal liquid, be condensed into the extractum that at 65～70 ℃, relative density is 1.15～1.20, vacuum drying, is ground into 50～80 object medicated powder, and then makes ointment, patch or gel by existing conventional method.
The concrete grammar when medicated powder after pulverizing obtained above is further made to patch is: medicated powder and sodium polyacrylate, sodium carboxymethyl cellulose, kieselguhr, gelatin, dimethyl sulfoxide, propylene glycol and water are placed in coating machine, mix homogeneously under 55～60 ℃ of conditions, be coated with afterwards, cut, obtain.
The proportioning of above-mentioned medicated powder and sodium polyacrylate, sodium carboxymethyl cellulose, kieselguhr, gelatin, dimethyl sulfoxide, propylene glycol and water is same as the prior art.Particularly, by weight percentage, be generally: medicated powder 5%～15%, sodium polyacrylate 15%～25%, sodium carboxymethyl cellulose 5%～15%, kieselguhr 10%～15%, gelatin 10%～18%, dimethyl sulfoxide 8%～15%, propylene glycol 8%～12%, glycerol 5%～8%, water 2.5%～8%, and the summation of each component is 100%.Preferred percentage by weight is: medicated powder 8%, sodium polyacrylate 20%, sodium carboxymethyl cellulose 12%, kieselguhr 13%, gelatin 15%, dimethyl sulfoxide 10%, propylene glycol 10%, glycerol 6%, water 6%.
The using method of the patch making is as stated above: patch is directly affixed on to affected part, and paste every day one, within 15 days, is a course for the treatment of.Patients with mild general 1～2 course for the treatment of, severe patient is general, and can reach good therapeutic effect 3～6 courses for the treatment of.
Compared with prior art, the present invention adopts local characteristic medical material to carry out prescription, and take Caulis Bauhihiae Championii, Caulis Fissistigmatis (Caulis Fissistigmatis) and Herba speranskiae tuberculatae is principal agent, the dehumidifying of main attack Eradicates wind, the effect of invigorating blood circulation; With Cissus pteroclada Hayata, Radix Ardisiae Crenatae, Herba Rubi parvifolii (Rubus Parvifolius L.) and Herba Sarcandrae, for assisting a ruler in governing a country medical material, play the assosting effects such as heat clearing away, removing toxic substances, detumescence; With above-mentioned three taste principal agents and the mutual compatibility of four taste accessory drugss, play altogether the effect of expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling, dredging the meridian, can synergism between simple and each taste medicine of prescription, treatment cervical spondylosis is had to good effect, and toxic and side effects is little.
The specific embodiment
With specific embodiment, the invention will be further described below, but the present invention is not limited to these embodiment.
Embodiment 1
1) take Caulis Bauhihiae Championii 100g, Caulis Fissistigmatis (Caulis Fissistigmatis) 80g, Herba speranskiae tuberculatae 60g, Cissus pteroclada Hayata 40g, Radix Ardisiae Crenatae 32g, Herba Rubi parvifolii (Rubus Parvifolius L.) 40g and Herba Sarcandrae 48g, be crushed to 10 orders, decoct with water 2 times and (add the water extraction 2h of 6 times of crude drug weight the 1st time, add the water extraction 2h of 4 times of raw material weights the 2nd time), filter, merge medicinal liquid, medicinal liquid is condensed into the extractum that at 65 ℃, relative density is 1.20, vacuum drying, is ground into 60 object medicated powder;
2) take step 1) medicated powder 32g, the sodium polyacrylate 80g, sodium carboxymethyl cellulose 48g, kieselguhr 56g, gelatin 60g, dimethyl sulfoxide 40g, propylene glycol 40g, glycerol 24g, the water 10g that make, be placed in mix homogeneously under 60 ℃ of conditions of coating machine, with curtain coating technology, evenly coat on backing layer, the about 2mm of coating layer thickness, dry, cover separate paper, cut into the area of 100mm * 50mm, obtain transdermal patch.
Embodiment 2
1) take Caulis Bauhihiae Championii 120g, Caulis Fissistigmatis (Caulis Fissistigmatis) 120g, Herba speranskiae tuberculatae 40g, Cissus pteroclada Hayata 100g, Radix Ardisiae Crenatae 40g, Herba Rubi parvifolii (Rubus Parvifolius L.) 60g and Herba Sarcandrae 32g, be crushed to 10 orders, decoct with water 2 times and (add the water extraction 2h of 6 times of crude drug weight the 1st time, add the water extraction 1h of 4 times of raw material weights the 2nd time), filter, merge medicinal liquid, medicinal liquid is condensed into the extractum that at 65 ℃, relative density is 1.15, vacuum drying, is ground into 50 object medicated powder;
2) by the total amount of 400g, take step 1) the medicated powder 60g that makes, then take account for total amount 18% sodium polyacrylate, account for total amount 15% sodium carboxymethyl cellulose, account for total amount 10% kieselguhr, account for total amount 10% gelatin, account for total amount 10% dimethyl sulfoxide, account for total amount 12% propylene glycol, account for total amount 7% glycerol, account for the water of total amount 8%, be placed in mix homogeneously under 55 ℃ of conditions of coating machine, with curtain coating technology, evenly coat on backing layer, the about 2mm of coating layer thickness, dry, cover separate paper, cut into the area of 100mm * 50mm size, obtain transdermal patch.
Embodiment 3
1) take Caulis Bauhihiae Championii 80g, Caulis Fissistigmatis (Caulis Fissistigmatis) 100g, Herba speranskiae tuberculatae 120g, Cissus pteroclada Hayata 80g, Radix Ardisiae Crenatae 60g, Herba Rubi parvifolii (Rubus Parvifolius L.) 20g and Herba Sarcandrae 40g, be crushed to 20 orders, the water extraction 2h that adds 8 times of crude drug weight, filter, collect medicinal liquid, medicinal liquid is condensed into the extractum that at 70 ℃, relative density is 1.15, and vacuum drying, is ground into 60 object medicated powder;
2) by the total amount of 400g, take step 1) the medicated powder 28g that makes, then take account for total amount 25% sodium polyacrylate, account for total amount 5% sodium carboxymethyl cellulose, account for total amount 12% kieselguhr, account for total amount 18% gelatin, account for total amount 15% dimethyl sulfoxide, account for total amount 8% propylene glycol, account for total amount 5% glycerol, account for the water of total amount 5%, be placed in mix homogeneously under 60 ℃ of conditions of coating machine, with curtain coating technology, evenly coat on backing layer, the about 2mm of coating layer thickness, dry, cover separate paper, cut into the area of 100mm * 50mm size, obtain transdermal patch.
Embodiment 4
1) take Caulis Bauhihiae Championii 140g, Caulis Fissistigmatis (Caulis Fissistigmatis) 60g, Herba speranskiae tuberculatae 80g, Cissus pteroclada Hayata 60g, Radix Ardisiae Crenatae 20g, Herba Rubi parvifolii (Rubus Parvifolius L.) 40g and Herba Sarcandrae 60g, be crushed to 10 orders, decoct with water 2 times and (add the water extraction 2h of 5 times of crude drug weight the 1st time, add the water extraction 2h of 5 times of raw material weights the 2nd time), filter, merge medicinal liquid, medicinal liquid is condensed into the extractum that at 65 ℃, relative density is 1.15, vacuum drying, is ground into 80 object medicated powder;
2) by the total amount of 400g, take step 1) the medicated powder 32g that makes, then take account for total amount 20% sodium polyacrylate, account for total amount 12% sodium carboxymethyl cellulose, account for total amount 13% kieselguhr, account for total amount 15% gelatin, account for total amount 10% dimethyl sulfoxide, account for total amount 10% propylene glycol, account for total amount 6% glycerol, account for the water of total amount 6%, be placed in mix homogeneously under 55 ℃ of conditions of coating machine, with curtain coating technology, evenly coat on backing layer, the about 2mm of coating layer thickness, dry, cover separate paper, cut into the area of 100mm * 50mm size, obtain transdermal patch.
For verifying the effect of Chinese medicine of the present invention, applicant has carried out clinical experiment in the People's Hospital, Wuzhou:
1, case selection
Selecting tcm diagnosis cervical spondylosis is standard: patient's limb is soft weak, weak with it; Neck-shoulder pain, upper limb numbness, often with headache, dizziness, tinnitus, muscle of upper extremity atrophy.As above symptom, can confirm.
Year May in October, 2010 to 2011, altogether 260 Patients with Cervical Spondylopathies are carried out to clinical observation treatment, wherein male patient is 140,120 of female patients, the age is between 35～55 years old.
2, Therapeutic Method
The transdermal patch that uses embodiment 1 to make, spreads on the position of cervical vertebra ache outward, presses steadily, and paste every day one, and every subsides are pasted 10 hours, and a little position of staggering while at every turn sticking, sticks before falling asleep evening.Within 15 days, be a course for the treatment of, treat 3 courses for the treatment of.
3, efficacy assessment standard
Cure: the symptoms such as the swollen discomfort of cervical region acid, numb hand and foot, headache, dizziness disappear completely, and cervical muscle is without anxiety, without tenderness, and head and neck activity freely.With nothing recurrence in anti-three months.
Effective: cervical vertebra ache and related symptoms disappear substantially, only when fatigue or Changes in weather, there is mild, but do not affect daily life and work.
Effective: related symptoms makes moderate progress, but the state of an illness is stable not, drug withdrawal has recurrence after a period of time, and counterweight physical exertion has impact.
Invalid: symptom is without changing or changing not obvious.
4, therapeutic effect
Through 3 course of therapy, cure 176 examples, account for 68%; Effective 37 examples, account for 14%; Effective 20 examples, account for 8%; Invalid 27 examples, account for 10%, and total effective rate accounts for 90%.
Through observing, during whole treatment, patient is without obvious adverse reaction.
Claims (6)
1. a Chinese medicine for the treatment of cervical spondylosis, is characterized in that: by weight, it is made by the crude drug of following weight parts:
20～35 parts of Caulis Bauhihiae Championiis, 15～30 parts of Caulis Fissistigmatiss, 10～30 parts of Herba speranskiae tuberculataes, 10～25 parts of Cissus pteroclada Hayatas, 5～15 parts of Radix Ardisiae Crenataes, 5～15 parts of Herba Rubi parvifolii, 5～15 parts of Herba Sarcandraes.
2. the Chinese medicine for the treatment of cervical spondylosis according to claim 1, is characterized in that: the weight portion of each crude drug is:
20～30 parts of Caulis Bauhihiae Championiis, 15～25 parts of Caulis Fissistigmatiss, 10～20 parts of Herba speranskiae tuberculataes, 10～20 parts of Cissus pteroclada Hayatas, 5～10 parts of Radix Ardisiae Crenataes, 5～10 parts of Herba Rubi parvifolii, 10～15 parts of Herba Sarcandraes.
3. the Chinese medicine for the treatment of cervical spondylosis according to claim 2, is characterized in that: the weight portion of each crude drug is:
25 parts of Caulis Bauhihiae Championiis, 20 parts of Caulis Fissistigmatiss, 15 parts of Herba speranskiae tuberculataes, 10 parts of Cissus pteroclada Hayatas, 8 parts of Radix Ardisiae Crenataes, 10 parts of Herba Rubi parvifolii, 12 parts of Herba Sarcandraes.
4. according to the Chinese medicine of the treatment cervical spondylosis described in any one in claim 1～3, it is characterized in that: described Chinese medicine preparation is ointment, patch or gel.
5. treat the preparation method of the Chinese medicine of cervical spondylosis, it is characterized in that: take Caulis Bauhihiae Championii 20～35 weight portions, Caulis Fissistigmatis 15～30 weight portions, Herba speranskiae tuberculatae 10～30 weight portions, Cissus pteroclada Hayata 10～25 weight portions, Radix Ardisiae Crenatae 5～15 weight portions, Herba Rubi parvifolii 5～15 weight portions and Herba Sarcandrae 5～15 weight portions, pulverize, decoct with water, collect medicinal liquid, be condensed into the extractum that at 65～70 ℃, relative density is 1.15～1.20, dry, be ground into after powder, by existing conventional method, make ointment, patch or gel.
6. preparation method according to claim 5, it is characterized in that: after gained extract powder is broken into powder, be placed in coating machine with sodium polyacrylate, sodium carboxymethyl cellulose, kieselguhr, gelatin, dimethyl sulfoxide, glycerol propylene glycol and water, mix homogeneously under 55～60 ℃ of conditions, be coated with afterwards, cut, obtain patch.
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Address after: 278 No. 543100 the Guangxi Zhuang Autonomous Region Wuzhou City Longwei District Dragon Avenue southwest Wei Zhen Patentee after: GUANGXI JIAJIN PHARMACEUTICAL CO., LTD. Address before: 278 No. 543100 the Guangxi Zhuang Autonomous Region Cangwu Long Wei County of Wuzhou City, southwest of the town road Patentee before: Guangxi Jiajin Pharmaceutical Co., Ltd. |
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Denomination of invention: Chinese Medicine for treating cervieal vertebra disease and its preparation method Effective date of registration: 20200313 Granted publication date: 20140402 Pledgee: Cangwu rural credit cooperative association| Wuzhou Urban Rural Credit Cooperative Association Pledgor: GUANGXI JIAJIN PHARMACEUTICAL Co.,Ltd. Registration number: Y2020450000009 |