CN102430020A - Process method for homogenizing easily-layered paste in production of compound arisaema analgesic paste - Google Patents
Process method for homogenizing easily-layered paste in production of compound arisaema analgesic paste Download PDFInfo
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- CN102430020A CN102430020A CN2011104102693A CN201110410269A CN102430020A CN 102430020 A CN102430020 A CN 102430020A CN 2011104102693 A CN2011104102693 A CN 2011104102693A CN 201110410269 A CN201110410269 A CN 201110410269A CN 102430020 A CN102430020 A CN 102430020A
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- Prior art keywords
- creme
- paste
- tray
- layering
- production
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- 238000004519 manufacturing process Methods 0.000 title claims abstract description 20
- 238000000034 method Methods 0.000 title claims abstract description 19
- 150000001875 compounds Chemical class 0.000 title claims abstract description 12
- 241000489492 Arisaema Species 0.000 title abstract description 3
- 230000000202 analgesic effect Effects 0.000 title abstract 2
- 239000000843 powder Substances 0.000 claims abstract description 17
- 239000003814 drug Substances 0.000 claims abstract description 14
- 229940079593 drug Drugs 0.000 claims abstract description 10
- 238000003756 stirring Methods 0.000 claims abstract description 10
- 238000010438 heat treatment Methods 0.000 claims abstract description 4
- 238000001816 cooling Methods 0.000 claims description 15
- 238000000265 homogenisation Methods 0.000 claims description 11
- 239000009959 nanxing Substances 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 9
- 239000002674 ointment Substances 0.000 claims description 7
- 239000000758 substrate Substances 0.000 claims description 7
- 239000002671 adjuvant Substances 0.000 claims description 6
- 239000011229 interlayer Substances 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims description 3
- 238000004062 sedimentation Methods 0.000 claims description 3
- 239000012257 stirred material Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000463 material Substances 0.000 abstract description 8
- 239000011159 matrix material Substances 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 238000003475 lamination Methods 0.000 description 4
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 230000004927 fusion Effects 0.000 description 3
- 238000007726 management method Methods 0.000 description 3
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 2
- RSWGJHLUYNHPMX-ONCXSQPRSA-N abietic acid Chemical compound C([C@@H]12)CC(C(C)C)=CC1=CC[C@@H]1[C@]2(C)CCC[C@@]1(C)C(O)=O RSWGJHLUYNHPMX-ONCXSQPRSA-N 0.000 description 2
- 238000004378 air conditioning Methods 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- 229940057995 liquid paraffin Drugs 0.000 description 2
- 229960001047 methyl salicylate Drugs 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 229940099259 vaseline Drugs 0.000 description 2
- LSPHULWDVZXLIL-UHFFFAOYSA-N (+/-)-Camphoric acid Chemical class CC1(C)C(C(O)=O)CCC1(C)C(O)=O LSPHULWDVZXLIL-UHFFFAOYSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- 241000717739 Boswellia sacra Species 0.000 description 1
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 1
- 239000005770 Eugenol Substances 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 239000004863 Frankincense Substances 0.000 description 1
- DPMGVDIWDTYPMP-UHFFFAOYSA-N Hypaconitine Natural products COCC12CCC(OC)C3(CN(C)C1)C4CC5(O)C(OC)C(O)C(CC(OC)C23)(OC(=O)C)C4C5OC(=O)c6ccccc6 DPMGVDIWDTYPMP-UHFFFAOYSA-N 0.000 description 1
- 241001057584 Myrrha Species 0.000 description 1
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 1
- 241000238370 Sepia Species 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 239000010238 camphora Substances 0.000 description 1
- 229940025250 camphora Drugs 0.000 description 1
- 239000000498 cooling water Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229960002217 eugenol Drugs 0.000 description 1
- FIDOCHXHMJHKRW-GKVQVCCJSA-N hypaconitine Chemical compound O([C@H]1[C@]2(O)C[C@H]3[C@]45[C@@H](OC)CC[C@@]6([C@H]4[C@@H](OC)[C@H]([C@@](OC(C)=O)([C@H]31)[C@@H](O)[C@H]2OC)[C@H]5N(C)C6)COC)C(=O)C1=CC=CC=C1 FIDOCHXHMJHKRW-GKVQVCCJSA-N 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 229940056211 paraffin Drugs 0.000 description 1
- 238000012913 prioritisation Methods 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
The process method for homogenizing easily layered paste in the production of the compound arisaema analgesic paste comprises the following steps: heating and melting matrix and auxiliary materials of the paste, adding fine drug powder, and stirring to obtain uniform paste; uniformly and separately placing the paste into a plurality of shallow trays; the temperature of the third step is rapidly reduced, so that the settling speed of the medicinal powder is reduced and the medicinal powder is solidified; fourthly, segmenting the solidified paste: dividing the paste in each tray into a plurality of strips according to the same specification and the same shape; fifthly, numbering all the paste strips separated from each shallow tray respectively according to the same numbering mode; sixthly, putting the paste material in each shallow tray with the same number into blocks to form each group; and (4) stirring the paste materials in each group by a stirrer respectively, and uniformly mixing the paste materials by a film machine for production of the next process. The invention thoroughly solves the problem of layering of the paste, obtains the paste with various homogenized components, and solves the problem which can not be solved in the production in the field for a long time.
Description
Technical field
The present invention relates to a kind of pharmaceutical technology of medicine for external use, be specifically related to make in a kind of compound Nanxing pain paste production the process that is prone to layering creme homogenization.
Background technology
Unguentum occupies very great share in medicine for external use; Relate to substrate and drug powder in the creme of this type unguentum mostly; The unguentum of some oil-soluble substrate particularly is in its production process, when substrate, adjuvant and drug powder mix homogeneously under molten condition; Progressively run into the phenomenon that substrate, adjuvant and drug powder layering that the deposition because of drug powder causes cause the paste medicine density unevenness through regular meeting under the state of cooling, conventional art is difficult to address this problem.And this lamination problem can directly influence the uniform distribution of medicine in substrate, and then influences product quality.
In production practices, pharmaceutical industry has been tested various schemes, does not all find the ideal solution that solves unguentum creme lamination problem.
Summary of the invention
In order to overcome the problems referred to above of prior art; The purpose of this invention is to provide and make the process that is prone to layering creme homogenization in a kind of compound Nanxing pain paste production; This method can thoroughly solve the lamination problem that is prone to the layering creme, obtains the creme of various component homogenization.
The technical scheme of accomplishing the foregoing invention task is: make the process that is prone to layering creme homogenization in a kind of compound Nanxing pain paste production, it is characterized in that step is following:
⑴. substrate, adjuvant and the drug powder of unguentum are put into the agitated reactor that has interlayer in order, and heating is stirred, and obtains the creme of mix homogeneously; (continue the logical cooling water temperature of agitated reactor interlayer under the stirring, reduce about the temperature to 50 ℃ of fusion creme; )
⑵. the even creme branch that step ⑴ is obtained is put in several trays, increases area of dissipation;
⑶. each tray is placed on rapidly in the freezer, and the creme that branch is placed in each tray is lowered the temperature rapidly, reduces the medicated powder sedimentation velocity, and it is solidified;
Branch is placed on the creme that has solidified in each tray to be cut apart: be divided into some sticks to the creme in each tray according to same specification, same shape;
(4). according to same numbering, all creme sticks that are partitioned in each tray are numbered respectively (for example, the creme stick in first tray is numbered 1,2,3,4 from left to right Then the creme stick in second tray is numbered 1,2,3,4 equally from left to right Creme stick in the 3rd tray is numbered 1,2,3,4 equally from left to right ...);
(5). the creme stick of same numbering in each tray is put into together, forms each group respectively;
(6). after the creme in each group stirred material respectively and make its mix homogeneously through medical membrane machine through mixer, be used for the production of subsequent processing.
Further improvement of the present invention has following prioritization scheme:
Between step ⑴ and step ⑵, can be provided with step ⑴-1: with the creme cooling of mix homogeneously, its cooling extent is as the criterion with the flowability that does not influence creme;
" with the creme cooling of mix homogeneously " of said step ⑴-1 is the mode that adopts agitated reactor outer setting water-cooled interlayer, in the water flowing cooling, creme do not stopped to stir;
Step (2) described " creme to branch is placed in each tray is lowered the temperature rapidly, and it is solidified ", be to adopt the mode that reduces ambient temperature is carried out: promptly, the tray that branch is placed with creme is placed in the cooling chamber, adopts air-conditioning to lower the temperature to cooling chamber.
Process of the present invention can thoroughly solve the lamination problem that is prone to the layering creme, obtains the unguentum raw material of various component homogenization.Tradition prejudice is thought; Creme in the same agitated reactor is further divided into groups, can constitute some " inferior batches ", and violate the regulation of pharmaceutical production management; The present invention has overcome this traditional prejudice; Said step ⑸ and step ⑹'s cuts apart stick, numbering group respectively, is in same batch creme in the agitated reactor, to carry out, and each group of step (6) is respectively organized creme through what mixer obtained respectively simultaneously; With divide in the same agitated reactor successively emit respectively organize creme, in batch management, have no the difference of internal.The regulation that meets the pharmaceutical production management, the while has solved the problem of non-uniform of easy layering creme again, has solved this area and has produced a medium-term and long-term insurmountable difficult problem.
The specific embodiment
Embodiment 1, the production technology of compound Nanxing pain paste.
Product adjuvant: Colophonium, paraffin, vaseline, liquid Paraffin, methyl salicylate.
Raw material: Chinese crude drug fine powder (containing Arisaema Cum Bile, Radix Aconiti, Flos Caryophylli, Cortex Cinnamomi, the Radix Angelicae Dahuricae, Herba Asari, Rhizoma Chuanxiong, Radix Cynanchi Paniculati, Olibanum (system), Myrrha (processed), Camphora, Borneolum Syntheticum).
Characteristics: adjuvant fusing back adds the Chinese crude drug fine powder, and creme is emitted, and the Chinese crude drug fine powder is prone to deposition in cooling procedure, and layering takes place, and the upper strata is that pale brown color, lower floor are sepia.
Process:
⑴: get Colophonium earlier and be positioned in the material-compound tank, be heated to (about 130 ℃ of temperature) after the complete fusion, gradation adds paraffin, vaseline, continues heated and stirred to all fusions (about 95 ℃ of temperature), stops heating.Add liquid paraffin, stir, treat that temperature camphorates when being cooled to about 60 ℃, Borneolum Syntheticum, be stirred to whole dissolvings, add methyl salicylate, under stirring, slowly add medicated powder, fully stirred blowing 30 minutes.(purpose: 1, make a jar interior medicated powder mix homogeneously; 2, reduce temperature, increase viscosity, reduce the medicated powder sedimentation velocity).
⑵, ⑶: accelerate rate of cooling.Measure: 1, branch dish dress increases area of dissipation.2, increase air-conditioning.
⑷, ⑸, ⑹, ⑺: with after the creme sabot cooling, every dish is divided into ten equal portions, and every dish gets wherein that the portion of same label stirs material when stirring material, and ten/a collection of during short card is large quantities of evenly; Evenly the back is with the medical membrane machine extruding for the material artificial mixed of stirring, and remix guarantees that material is even.
Technique effect: all creme appearance luster are consistent, through measuring eugenol, hypaconitine content in the creme, prove that creme is even.
Claims (5)
1. make the process that is prone to layering creme homogenization in a compound Nanxing pain paste production, it is characterized in that step is following:
⑴. substrate, adjuvant and the drug powder of unguentum are put into agitated reactor in order, and heating is stirred, and obtains uniform creme;
⑵. the even creme branch that step ⑴ is obtained is put in several trays, increases area of dissipation;
⑶. the creme to branch is placed in each tray is lowered the temperature rapidly, reduces the medicated powder sedimentation velocity, and it is solidified;
⑷. branch is placed on the creme that has solidified in each tray cuts apart: be divided into some sticks to the creme in each tray according to same specification, same shape;
⑸. according to same numbering, all creme sticks that are partitioned in each tray are numbered respectively;
⑹. the creme stick of same numbering in each tray is put into together, forms each group respectively;
⑺. after the creme in each group stirred material respectively and make its mix homogeneously through medical membrane machine through mixer, be used for the production of subsequent processing.
2. make the process that is prone to layering creme homogenization in the compound Nanxing pain paste production according to claim 1; It is characterized in that; Between step ⑴ and step ⑵, can be provided with step ⑴-1: with the creme cooling of mix homogeneously, its cooling extent is as the criterion with the flowability that does not influence creme.
3. make the process that is prone to layering creme homogenization in the compound Nanxing pain paste production according to claim 2, it is characterized in that the cooling of step ⑴-1 is to cool to about 50 ℃.
4. make the process that is prone to layering creme homogenization in the said compound Nanxing pain paste production according to claim 1; It is characterized in that; " with the creme cooling of mix homogeneously " of said step ⑴-1; Be the mode that adopts agitated reactor outer setting water-cooled interlayer: in the water flowing cooling, creme is not stopped to stir.
5. according to making the process that is prone to layering creme homogenization in the described compound Nanxing pain paste production of one of claim 1-4; It is characterized in that; Step ⑶ described " creme to branch is placed in each tray is lowered the temperature rapidly, and it is solidified " is to adopt the mode that reduces ambient temperature is carried out.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104102693A CN102430020A (en) | 2011-12-12 | 2011-12-12 | Process method for homogenizing easily-layered paste in production of compound arisaema analgesic paste |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104102693A CN102430020A (en) | 2011-12-12 | 2011-12-12 | Process method for homogenizing easily-layered paste in production of compound arisaema analgesic paste |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102430020A true CN102430020A (en) | 2012-05-02 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011104102693A Pending CN102430020A (en) | 2011-12-12 | 2011-12-12 | Process method for homogenizing easily-layered paste in production of compound arisaema analgesic paste |
Country Status (1)
| Country | Link |
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| CN (1) | CN102430020A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108042762A (en) * | 2017-12-28 | 2018-05-18 | 贵州东仪医疗器械有限公司 | A kind of pharmaceutical composition for treating pain, patch and its preparation method and application |
-
2011
- 2011-12-12 CN CN2011104102693A patent/CN102430020A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 沈雪梅主编: "《中药制剂学》", 31 May 2006, 中国医药科技出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108042762A (en) * | 2017-12-28 | 2018-05-18 | 贵州东仪医疗器械有限公司 | A kind of pharmaceutical composition for treating pain, patch and its preparation method and application |
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Application publication date: 20120502 |