CN108042417A - 一种抗敏组合物 - Google Patents

一种抗敏组合物 Download PDF

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CN108042417A
CN108042417A CN201711313653.5A CN201711313653A CN108042417A CN 108042417 A CN108042417 A CN 108042417A CN 201711313653 A CN201711313653 A CN 201711313653A CN 108042417 A CN108042417 A CN 108042417A
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composition
commercially available
extract
antiallergic
inflammatory agent
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Foshan Jucheng Biochemical Technology Research and Development Co Ltd
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Foshan Jucheng Biochemical Technology Research and Development Co Ltd
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Abstract

本发明提供了一种抗敏组合物，包括中药混合物，抗炎剂，保湿剂，防腐剂，抗氧化剂的成分，其中抗炎剂能有效抑制炎症因子的分泌，并有效抗炎，达到抗敏的目的；抗氧化剂能保护细胞膜的脂质免受过氧化，减轻炎症反应，间接起到抗敏作用；重要混合物能提高细胞活性，加强肌肤的健康。且本发明抗敏组合物，有效帮助肌肤抵抗敏感物质的侵袭，提高细胞活性，发挥抗炎抗敏功效，并将其应用在化妆品中，能赋予化妆品良好的保湿、滋润、美白、抗敏效果。

Description

一种抗敏组合物
技术领域
本发明涉及化妆品领域，具体涉及一种抗敏组合物。
背景技术
敏感性皮肤是一种问题性皮肤，任何肤质中都可能有敏感性肌肤。就如同各种肤质都可能有老化肤质，痘痘肤质等。敏感肌肤看上去皮肤较薄，容易过敏，脸上的红血丝明显。皮肤容易受环境因素、季节变化及面部保养品刺激，但更多的是由于使用了激素类的化妆品导致成为敏感肌肤，并可能伴有全身的皮肤敏感。因为皮肤细胞受损而使皮肤的免疫力下降，角质层变薄导致皮肤滋润度不够，最终导致肌肤的屏障功能过于薄弱，无法抵御外界刺激，接着皮肤的神经纤维由于经常受到外界刺激，过于亢奋，从而易于产生泛红，发热，瘙痒、刺痛，红疹等不适现象的产生，这一类通常是由于肌肤接触了激素类的东西。
目前化妆品行业正在逐渐朝着崇尚绿色、回归自然的方向发展，现今的消费者也对化妆品的安全性特别关注，特别是敏感肌肤对化妆品提出了更高的要求，消费者倾向于使用天然、无刺激的产品。因此，开发具有显著功效、安全的天然抗敏组合物，并将其应用在化妆品中已经成为化妆品研发的重点之一。
发明内容
本发明的目的在于提供一种抗敏组合物，并将其应用在化妆品中，赋予化妆品显著的效果。
为了达到上述目的，本发明提供如下的技术方案：
一种抗敏组合物，包括如下质量份的组分：
其中，抗炎剂包括褐藻多糖、雪莲黄酮、水溶性脱乙酰壳多糖、氧化苦参碱中的一种或一种以上。
进一步地，所述的组合物包括如下质量份的组分：
其中，抗炎剂包括褐藻多糖、雪莲黄酮、水溶性脱乙酰壳多糖、氧化苦参碱中的一种或一种以上。
更进一步地，所述的组合物包括如下质量份的组分：
其中，抗炎剂包括褐藻多糖、雪莲黄酮、水溶性脱乙酰壳多糖、氧化苦参碱中的一种或一种以上。
另外，所述的中药混合物包括市售的抗坏血酸及其衍生物、微量元素锌、茶叶提取物、银杏提取物、白术提取物中的两种或两种以上；
所述抗炎剂包括市售的褐藻多糖、雪莲黄酮、水溶性脱乙酰壳多糖、氧化苦参碱中的一种或一种以上；
所述的保湿剂包括市售的红藻提取物、橙花提取物、玫瑰提取液、透明质酸钠、乳酸钠、甘油中的一种或一种以上；
所述的抗氧化剂包括市售的五味子木脂素、姜黄根提取物、二丁基羟基甲苯、维生素E及其衍生物中的一种或一种以上；
所述的防腐剂包括苯甲酸钠、山梨酸钾、苯氧乙醇、羟苯甲酯中的一种或一种以上。
本发明的抗敏组合物可应用于化妆品，也可作为添加剂用于皮肤外用药剂中。
与现有技术相比，本发明具有的有益效果如下：
(1)添加抗炎剂，能有效抑制炎症因子的分泌，提供的雪莲黄酮有解毒作用，并有效抗炎；褐藻多糖能清除自由基、有抗菌保湿活性，能令肌肤更加健康，达到抗敏的目的；
(2)添加抗氧化剂，保护细胞膜的脂质免受过氧化，减轻炎症反应，其中提供的五味子木脂素具有显著的清除自由基作用，降低氧化损伤，间接起到抗敏作用；
(3)本发明抗敏组合物，有效帮助肌肤抵抗敏感物质的侵袭，提高细胞活性，发挥抗炎抗敏功效，并将其应用在化妆品中，能赋予化妆品良好的保湿、滋润、美白、抗敏效果。
具体实施方式
以下结合具体实施例对本发明作进一步阐述。
实施例1
抗敏组合物的制备：
将2克银杏提取物、2.5克白术提取物、13克雪莲黄酮、6.5克红藻提取物、2克姜黄根提取物、0.5克苯氧乙醇和73.5克去离子水置于混合器中，搅拌混合均匀，即可得到抗敏组合物。
人体斑贴实验
组织30名志愿者按照《化妆品卫生规范》(2007版)记载的人体皮肤斑贴实验规范，测试本发明实施例1所制得的抗敏组合物，结果如表1所示。
表1
实施例2
抗敏面膜的制备：
取78.7％去离子水、10％丙二醇、0.15％透明汉生胶、0.15％透明质酸钠、0.1％水解透明质酸、0.2％卡波姆、0.2％霍霍巴蜡PEG-120酯类加入乳化锅内并升温至80℃，然后搅拌直至溶液呈透明均一，然后保温30分钟后搅拌降温至40℃；然后向溶液中加入10％抗敏组合物和0.5％苯氧乙醇搅拌均匀，冷却即可。
实施例3
抗敏膏霜的制备：
将8％甘油、0.5％卡波姆、0.2％黄原胶、1.5％鲸蜡硬脂基葡糖苷和68.6％去离子水混合均匀，加热至82℃，搅拌保温30min至完全溶解，得水相；同时将2％辛基十二醇肉豆蔻酸酯、2％牛油果树果脂、3％聚二甲基硅氧烷加热至82℃，保温25-35分钟，得油相；将水相和油相混合均匀，在80℃下均质乳化15min，脱泡；降温至45℃，再加入14％抗敏组合物和0.2％苯氧乙醇混合均匀，冷却出料。
实施例4
抗敏乳液的制备：
取60.1％去离子水、2.5％甘油、0.05％氢化卵磷脂、6％甜菜碱、0.05％黄原胶、0.2％聚丙烯酸、0.2％乙基己基甘油、0.1％生育酚混合加热至80℃后，搅拌均匀，得水相；将4％角鲨烷、4％聚二甲基硅氧烷、3％鲸蜡硬脂醇、0.6％异壬酸异壬酯、0.5％双-二甘油多酰基己二酸酯-2、0.4％PEG-45硬脂酸酯混合加热至80℃，搅拌均匀，得油相；将油相抽入水相中，在真空条件下均质5分钟；搅拌降温至40℃，加入18％抗敏组合物和0.3％苯氧乙醇，搅拌均匀，冷却即可。
实施例5
抗炎功效试验
主要材料：小鼠巨噬细胞系RAW264.7(来源于中国医学科学院基础医学研究所细胞资源中心)、实施例1抗敏组合物、实施例2抗敏面膜、实施例3抗敏膏霜、实施例4抗敏乳液、小鼠前列腺素E2(PGE2)ELISA检测试剂盒、小鼠肿瘤坏死因子-α(TNF-α)ELISA检测试剂盒、脂多糖(LPS)。
方法：(1)用MTT法检测抗敏组合物对RAW264.7细胞生长的影响，调整RAW264.7细胞密度至5x104/mL，接种于96孔细胞培养板中，每孔1000μL，置于37℃、5％CO2细胞培养箱中培养24h。培养结束后吸出细胞板中的培养基，处理组中分别加入浓度为500μg/mL生物200μL含抗敏组合物培养基、面膜、膏霜、乳液稀释液，空白对照组加入等体积的无血清培养基，继续培育24h，每组3个复孔。24h后，每组加入20μL的MTT溶液，继续培育4h后，取出96孔板，吸出孔内液体，加入150μL的DMSO，震荡5min后于490nm处测定吸光度(A)值，计算细胞的存活率。存活率＝药物组平均A值/空白对照组平均A值。
(2)对脂多糖(LPS)刺激RAW264.7细胞释放PGE2的影响，分别为对照组(无血清培养基)，抗敏组合物组(100μg/mL的抗敏组合物及1μg/mL的LPS)，面膜组(100μg/mL的面膜及1μg/mL的LPS)，膏霜组(100μg/mL的膏霜及1μg/mL的LPS)，乳液组(100μg/mL的乳液及1μg/mL的LPS)，细胞培养和方法与(1)同，于LPS刺激18h后收集细胞上清液，按照ELISA试剂盒说明书要求进行PGE2检测，计算抑制率，记为抑制率1。
(3)对LPS刺激RAW264.7细胞释放TNF-a的影响，分别为对照组(无血清培养基)，抗敏组合物组(100μg/mL的抗敏组合物及1μg/mL的LPS)，面膜组(100μg/mL的面膜及1μg/mL的LPS)，膏霜组(100μg/mL的膏霜及1μg/mL的LPS)，乳液组(100μg/mL的乳液及1μg/mL的LPS)，LPS刺激18h后收集细胞上清，按ELISA试剂盒说明书操作要求进行TNF-a检测，计算抑制率，记为抑制率2。
实验结果如下表2。
表2
组别 存活率(％) 抑制率1(％) 抑制率2(％)
抗敏组合物 104.2 92.5 89.3
抗敏面膜 102.4 90.2 88.6
抗敏膏霜 102.8 91.2 88.9
抗敏乳液 103.2 91.6 89.1
空白对照组 101.2 35.1 33.2
由表2中存活率的数据分析可知，抗敏组合物、面膜、膏霜和乳液无细胞毒作用，成分温和、不刺激；从抑制率1和抑制率2的数据分析可知，说明了抗敏组合物能有效抑制细胞炎症因子的释放，将其应用在化妆品面膜、膏霜和乳液中，能赋予化妆品良好的抗炎功效。
实施例6
抗敏功效验证
方法：透明质酸酶活性抑制实验；
原理：为当过敏原初次侵入机体时，机体产生抗体IgE，过敏原再次入侵机体时，与致敏细胞表面的IgE抗体相结合，发生FceRI交联.从而启动活化信号，引发信号传导，使胞内透明质酸酶在内的多种酶活化，此过程被称为过敏反应。透明质酸是组织基质中限制水分和其它胞外物质扩散的成分，被透明质酸酶水解后，细胞间则变为非粘性，引起细胞脱颗粒和合成的新介质渗出，发挥生物效应。因此，可以利用透明质酸没活性抑制率来判断抗敏活性，透明质酸酶活性抑制率越高则反映该成分的抗敏效果越强，反之则越弱。
实验步骤：在试管中加入0.1mL 0.25mmo1/L-1CaC12溶液和0.5mL透明质酸酶液，37℃保温培养20min，分9组实验，分别加入0.5mL实施例1抗敏组合物、实施例2抗敏面膜、实施例3抗敏膏霜、实施例4抗敏乳液，37℃保温培养20min；加入0.5mL透明质酸钠液，37℃保温30min；然后常温静置5min，加入0.4mo1/L-1NaOH溶液0.1mL和乙酞丙酮溶液0.5mL，沸水浴中加热反应15min后立刻冰浴5min；再加入1.0mL埃尔利希试剂并用3.0mL无水乙醇进行稀释，放置20min后进行显色，测定其吸光度值，代入下式计算抑制率。
试中：A为对照溶液吸光度(用醋酸缓冲液代替样品溶液)；
B为空白对照溶液吸光度值(用醋酸缓冲液代替样品溶液及酶液)；
C为受试样品溶液吸光度值；
D为试样空白溶液吸光度值(用醋酸缓冲液代替酶液)。
结果如下表3。
表3
由表3数据分析可知，抗敏组合物具有显著的抗敏作用，将其应用在化妆品面膜、膏霜、乳液中，能赋予化妆品优异的抗敏功效。
以上实施例仅表明本发明的几种实施例，其描述较为具体和详细，但并不能因此而理解为对本发明专利的限制范围。应当指出的是：任何从事本专业的技术人员，都有能力利用已揭示的技术内容，对其作出一些更动或修饰，成为等同变化的等效实施例。根据本发明技术实质，对本发明进行简单修改、等同变化与修饰，均属于本发明技术方案的范围内。

Claims (10)

1.一种抗敏组合物，其特征在于组分和含量为：
以上均为质量份；
其中，抗炎剂包括褐藻多糖、雪莲黄酮、水溶性脱乙酰壳多糖、氧化苦参碱中的一种或一种以上。
2.如权利要求1所述的组合物，其特征在于组分和含量为：
以上均为质量份；
其中，抗炎剂包括褐藻多糖、雪莲黄酮、水溶性脱乙酰壳多糖、氧化苦参碱中的一种或一种以上。
3.如权利要求2所述的组合物，其特征在于组分和含量为：
以上均为质量份；
其中，抗炎剂包括褐藻多糖、雪莲黄酮、水溶性脱乙酰壳多糖、氧化苦参碱中的一种或一种以上。
4.如权利要求1所述的组合物，其特征在于：
所述的中药混合物包括市售的抗坏血酸及其衍生物、微量元素锌、茶叶提取物、银杏提取物、白术提取物中的两种或两种以上；
所述抗炎剂包括市售的褐藻多糖、雪莲黄酮、水溶性脱乙酰壳多糖、氧化苦参碱中的一种或一种以上；
所述的保湿剂包括市售的红藻提取物、橙花提取物、玫瑰提取液、透明质酸钠、乳酸钠、甘油中的一种或一种以上；
所述的抗氧化剂包括市售的五味子木脂素、姜黄根提取物、二丁基羟基甲苯、维生素E及其衍生物中的一种或一种以上；
所述的防腐剂包括苯甲酸钠、山梨酸钾、苯氧乙醇、羟苯甲酯中的一种或一种以上。
5.如权利要求2所述的组合物，其特征在于：
所述的中药混合物包括市售的抗坏血酸及其衍生物、微量元素锌、茶叶提取物、银杏提取物、白术提取物中的两种或两种以上；
所述抗炎剂包括市售的褐藻多糖、雪莲黄酮、水溶性脱乙酰壳多糖、氧化苦参碱中的一种或一种以上；
所述的保湿剂包括市售的红藻提取物、橙花提取物、玫瑰提取液、透明质酸钠、乳酸钠、甘油中的一种或一种以上；
所述的抗氧化剂包括市售的五味子木脂素、姜黄根提取物、二丁基羟基甲苯、维生素E及其衍生物中的一种或一种以上；
所述的防腐剂包括苯甲酸钠、山梨酸钾、苯氧乙醇、羟苯甲酯中的一种或一种以上。
6.如权利要求3所述的组合物，其特征在于：
所述的中药混合物包括市售的抗坏血酸及其衍生物、微量元素锌、茶叶提取物、银杏提取物、白术提取物中的两种或两种以上；
所述抗炎剂包括市售的褐藻多糖、雪莲黄酮、水溶性脱乙酰壳多糖、氧化苦参碱中的一种或一种以上；
所述的保湿剂包括市售的红藻提取物、橙花提取物、玫瑰提取液、透明质酸钠、乳酸钠、甘油中的一种或一种以上；
所述的抗氧化剂包括市售的五味子木脂素、姜黄根提取物、二丁基羟基甲苯、维生素E及其衍生物中的一种或一种以上；
所述的防腐剂包括苯甲酸钠、山梨酸钾、苯氧乙醇、羟苯甲酯中的一种或一种以上。
7.如权利要求1所述的组合物的应用，其特征在于可用于化妆品。
8.如权利要求2所述的组合物的应用，其特征在于可用于化妆品。
9.如权利要求3所述的组合物的应用，其特征在于可用于化妆品。
10.如权利要求1～3任一项所述的组合物的应用，其特征在于可作为添加剂用于皮肤外用药剂中。
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CN111388376A (zh) * 2020-04-20 2020-07-10 广西诗琳茉莉生物科技集团有限公司 一种茉莉草本抗敏舒缓面膜及其制备方法
CN113855620A (zh) * 2021-11-24 2021-12-31 安赛搏(重庆)生物技术有限公司 含有天山雪莲细胞培养物的组合物及其制备方法与应用

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CN111388376A (zh) * 2020-04-20 2020-07-10 广西诗琳茉莉生物科技集团有限公司 一种茉莉草本抗敏舒缓面膜及其制备方法
CN111388376B (zh) * 2020-04-20 2022-06-21 广西诗琳茉莉生物科技集团有限公司 一种茉莉草本抗敏舒缓面膜及其制备方法
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Application publication date: 20180518