CN108030952A - 一种新型生物纤维止血材料及其制备方法 - Google Patents

一种新型生物纤维止血材料及其制备方法 Download PDF

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CN108030952A
CN108030952A CN201711417207.9A CN201711417207A CN108030952A CN 108030952 A CN108030952 A CN 108030952A CN 201711417207 A CN201711417207 A CN 201711417207A CN 108030952 A CN108030952 A CN 108030952A
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陈益德
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Abstract

本发明公开的属于生物医药止血材料技术领域，具体为一种新型生物纤维止血材料及其制备方法，该新型生物纤维止血材料包括如下组成成分：聚乙烯醇：60‑70份；纤维蛋白原：20‑25份；明胶：15‑20份；枫香叶提取物：8‑10份；凝血材料：2‑3份和止血药物：4‑6份，该新型生物纤维止血材料的制备方法包括如下步骤：S1：溶胀；S2：溶解：将纤维蛋白原采用0.8％‑1.0％的氯化钠溶液进行溶解；S3：混合：将聚乙烯醇、明胶、纤维蛋白原、枫香叶提取物、凝血材料和止血药物搅拌均匀，保温，静置，静置时间为10‑12小时；S4：纺丝，具有促进血液凝固的功效，有一定的粘接性，生物安全性高，该发明还具有凝血、加快伤口的愈合、消炎的功效。

Description

一种新型生物纤维止血材料及其制备方法
技术领域
本发明涉及生物医药止血材料技术领域，具体为一种新型生物纤维止血材料及其制备方法。
背景技术
出血是外壳手术和外伤中最常见、最难控制的问题之一，特别是中央脏器的出血，如肝脏、脾脏和肾脏的破裂出血，直接威胁人的生命，有效的止血是外科手术、外伤止血中急需解决的主要问题，基本方法有加热止血、机械止血和化学止血，止血对于手术的成功和患者的安危起着相当大的作用。现有的止血方式只对创面起物理保护作用，功能和效果单一，止血效果不好，为此，我们提出一种新型生物纤维止血材料及其制备方法。
发明内容
本发明的目的在于提供一种新型生物纤维止血材料及其制备方法，以解决上述背景技术中提出的现有的止血方式只对创面起物理保护作用，功能和效果单一，止血效果不好的问题。
为实现上述目的，本发明提供如下技术方案：一种新型生物纤维止血材料，该新型生物纤维止血材料包括如下组成成分：
聚乙烯醇：60-70份；纤维蛋白原：20-25份；明胶：15-20份；枫香叶提取物：8-10份；凝血材料：2-3份和止血药物：4-6份。
优选的，所述凝血材料为纳米二氧化硅和蒙脱石中的至少一种。
优选的，所述止血药物为黄柏和马勃，且黄柏和马勃之间的分量比1:2。
优选的，所述枫香叶提取物是由枫香叶经乙醇溶液浸提而成的浓缩液。
一种新型生物纤维止血材料的制备方法，该新型生物纤维止血材料的制备方法包括如下步骤：
S1：溶胀：将聚乙烯醇和明胶分别置于两个容器内，加热，使得聚乙烯醇和明胶溶胀溶解；
S2：溶解：将纤维蛋白原采用0.8％-1.0％的氯化钠溶液进行溶解；
S3：混合：将聚乙烯醇、明胶、纤维蛋白原、枫香叶提取物、凝血材料和止血药物搅拌均匀，保温，静置，静置时间为10-12小时；
S4：纺丝：采用纺丝装置对混合后的原液进行纺丝，喷出纤维丝，并将纤维丝制作成纤维网或纤维带。
优选的，所述步骤S2中的溶解温度为40-55摄氏度。
优选的，所述步骤S3中搅拌温度为65-85摄氏度。
与现有技术相比，本发明的有益效果是：该发明提出的一种新型生物纤维止血材料及其制备方法，具有促进血液凝固的功效，有一定的粘接性，生物安全性高，该发明还具有凝血、加快伤口的愈合、消炎的功效。
附图说明
图1为本发明制备方法流程图。
具体实施方式
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
本发明提供一种新型生物纤维止血材料，该新型生物纤维止血材料包括如下组成成分：
聚乙烯醇：60-70份；纤维蛋白原：20-25份；明胶：15-20份；枫香叶提取物：8-10份，所述枫香叶提取物是由枫香叶经乙醇溶液浸提而成的浓缩液；凝血材料：2-3份，所述凝血材料为纳米二氧化硅和蒙脱石中的至少一种；止血药物：4-6份，所述止血药物为黄柏和马勃，且黄柏和马勃之间的分量比1:2。
请参阅图1，该发明还提供一种新型生物纤维止血材料的制备方法：
实施例1
该新型生物纤维止血材料的制备方法包括如下步骤：
S1：溶胀：将聚乙烯醇和明胶分别置于两个容器内，加热，使得聚乙烯醇和明胶溶胀溶解；
S2：溶解：将纤维蛋白原采用1.0％的氯化钠溶液进行溶解，溶解温度为55摄氏度；
S3：混合：将聚乙烯醇、明胶、纤维蛋白原、枫香叶提取物、凝血材料和止血药物搅拌均匀，搅拌温度为85摄氏度，保温，静置，静置时间为12小时；
S4：纺丝：采用纺丝装置对混合后的原液进行纺丝，喷出纤维丝，并将纤维丝制作成纤维网或纤维带。
在本实施例中，聚乙烯醇：61份；纤维蛋白原：20份；明胶：16份；枫香叶提取物：10份，所述枫香叶提取物是由枫香叶经乙醇溶液浸提而成的浓缩液；凝血材料：3份，所述凝血材料为纳米二氧化硅和蒙脱石中的至少一种；止血药物：6份，所述止血药物为黄柏和马勃，且黄柏和马勃之间的分量比1:2。
实施例2
该新型生物纤维止血材料的制备方法包括如下步骤：
S1：溶胀：将聚乙烯醇和明胶分别置于两个容器内，加热，使得聚乙烯醇和明胶溶胀溶解；
S2：溶解：将纤维蛋白原采用0.8％的氯化钠溶液进行溶解，溶解温度为40摄氏度；
S3：混合：将聚乙烯醇、明胶、纤维蛋白原、枫香叶提取物、凝血材料和止血药物搅拌均匀，搅拌温度为65摄氏度，保温，静置，静置时间为10小时；
S4：纺丝：采用纺丝装置对混合后的原液进行纺丝，喷出纤维丝，并将纤维丝制作成纤维网或纤维带。
在本实施例中，聚乙烯醇：68份；纤维蛋白原：21份；明胶：16份；枫香叶提取物：8份，所述枫香叶提取物是由枫香叶经乙醇溶液浸提而成的浓缩液；凝血材料：3份，所述凝血材料为纳米二氧化硅和蒙脱石中的至少一种；止血药物：4份，所述止血药物为黄柏和马勃，且黄柏和马勃之间的分量比1:2。
实施例3
该新型生物纤维止血材料的制备方法包括如下步骤：
S1：溶胀：将聚乙烯醇和明胶分别置于两个容器内，加热，使得聚乙烯醇和明胶溶胀溶解；
S2：溶解：将纤维蛋白原采用0.9％的氯化钠溶液进行溶解，溶解温度为47.5摄氏度；
S3：混合：将聚乙烯醇、明胶、纤维蛋白原、枫香叶提取物、凝血材料和止血药物搅拌均匀，搅拌温度为75摄氏度，保温，静置，静置时间为11小时；
S4：纺丝：采用纺丝装置对混合后的原液进行纺丝，喷出纤维丝，并将纤维丝制作成纤维网或纤维带。
在本实施例中，聚乙烯醇：65份；纤维蛋白原：22.5份；明胶：17.5份；枫香叶提取物：9份，所述枫香叶提取物是由枫香叶经乙醇溶液浸提而成的浓缩液；凝血材料：2.5份，所述凝血材料为纳米二氧化硅和蒙脱石中的至少一种；止血药物：5份，所述止血药物为黄柏和马勃，且黄柏和马勃之间的分量比1:2。
尽管已经示出和描述了本发明的实施例，对于本领域的普通技术人员而言，可以理解在不脱离本发明的原理和精神的情况下可以对这些实施例进行多种变化、修改、替换和变型，本发明的范围由所附权利要求及其等同物限定。

Claims (7)

1.一种新型生物纤维止血材料，其特征在于：该新型生物纤维止血材料包括如下组成成分：
聚乙烯醇：60-70份；纤维蛋白原：20-25份；明胶：15-20份；枫香叶提取物：8-10份；凝血材料：2-3份和止血药物：4-6份。
2.根据权利要求1所述的一种新型生物纤维止血材料及其制备方法，其特征在于：所述凝血材料为纳米二氧化硅和蒙脱石中的至少一种。
3.根据权利要求1所述的一种新型生物纤维止血材料及其制备方法，其特征在于：所述止血药物为黄柏和马勃，且黄柏和马勃之间的分量比1:2。
4.根据权利要求1所述的一种新型生物纤维止血材料及其制备方法，其特征在于：所述枫香叶提取物是由枫香叶经乙醇溶液浸提而成的浓缩液。
5.一种新型生物纤维止血材料的制备方法，其特征在于：该新型生物纤维止血材料的制备方法包括如下步骤：
S1：溶胀：将聚乙烯醇和明胶分别置于两个容器内，加热，使得聚乙烯醇和明胶溶胀溶解；
S2：溶解：将纤维蛋白原采用0.8％-1.0％的氯化钠溶液进行溶解；
S3：混合：将聚乙烯醇、明胶、纤维蛋白原、枫香叶提取物、凝血材料和止血药物搅拌均匀，保温，静置，静置时间为10-12小时；
S4：纺丝：采用纺丝装置对混合后的原液进行纺丝，喷出纤维丝，并将纤维丝制作成纤维网或纤维带。
6.根据权利要求5所述的一种新型生物纤维止血材料的制备方法，其特征在于：所述步骤S2中的溶解温度为40-55摄氏度。
7.根据权利要求5所述的一种新型生物纤维止血材料的制备方法，其特征在于：所述步骤S3中搅拌温度为65-85摄氏度。
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CN103083449A (zh) * 2013-01-17 2013-05-08 延安大学 一种止血药物及其制备方法
CN104721878A (zh) * 2015-04-07 2015-06-24 广州市电纺生物科技有限公司 一种止血材料的制备方法
CN104888267A (zh) * 2015-05-25 2015-09-09 浙江华峰氨纶股份有限公司 一种医用止血氨纶纤维织物及其制备方法
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CN1157355A (zh) * 1996-10-21 1997-08-20 山西省化学纤维研究所 止血纤维组成及其气体牵伸法纺丝工艺
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Application publication date: 20180515