CN108026584B - 非小细胞肺癌诊断用蛋白质生物标志物组及利用其的非小细胞肺癌诊断方法 - Google Patents

非小细胞肺癌诊断用蛋白质生物标志物组及利用其的非小细胞肺癌诊断方法 Download PDF

Info

Publication number
CN108026584B
CN108026584B CN201580083066.4A CN201580083066A CN108026584B CN 108026584 B CN108026584 B CN 108026584B CN 201580083066 A CN201580083066 A CN 201580083066A CN 108026584 B CN108026584 B CN 108026584B
Authority
CN
China
Prior art keywords
biomarker
lung cancer
protein
small cell
cell lung
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201580083066.4A
Other languages
English (en)
Chinese (zh)
Other versions
CN108026584A (zh
Inventor
金润东
石民京
郑钟河
E·卡蒂柳斯
D·A·齐基
R·M·奥斯特罗夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aptamer Sciences Inc
Original Assignee
Aptamer Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aptamer Sciences Inc filed Critical Aptamer Sciences Inc
Publication of CN108026584A publication Critical patent/CN108026584A/zh
Application granted granted Critical
Publication of CN108026584B publication Critical patent/CN108026584B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57423Specifically defined cancers of lung
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4737C-reactive protein
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/7056Selectin superfamily, e.g. LAM-1, GlyCAM, ELAM-1, PADGEM
    • G01N2333/70564Selectins, e.g. CD62
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/988Lyases (4.), e.g. aldolases, heparinase, enolases, fumarase

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201580083066.4A 2015-09-11 2015-09-11 非小细胞肺癌诊断用蛋白质生物标志物组及利用其的非小细胞肺癌诊断方法 Active CN108026584B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/KR2015/009552 WO2017043679A1 (en) 2015-09-11 2015-09-11 Protein biomarker panel for detecting non-small cell lung cancer and method for diagnosing a non-small cell lung cancer by the use thereof

Publications (2)

Publication Number Publication Date
CN108026584A CN108026584A (zh) 2018-05-11
CN108026584B true CN108026584B (zh) 2021-12-10

Family

ID=58239995

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580083066.4A Active CN108026584B (zh) 2015-09-11 2015-09-11 非小细胞肺癌诊断用蛋白质生物标志物组及利用其的非小细胞肺癌诊断方法

Country Status (4)

Country Link
JP (1) JP6857185B2 (enExample)
KR (2) KR102087373B1 (enExample)
CN (1) CN108026584B (enExample)
WO (1) WO2017043679A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7548903B2 (ja) * 2018-11-20 2024-09-10 ヴェンタナ メディカル システムズ, インク. 形態学的特徴およびバイオマーカー発現のために細胞サンプルを調製および分析するための方法およびシステム
TWI758670B (zh) * 2018-12-24 2022-03-21 奎克生技光電股份有限公司 健康風險評估方法
CN110333341A (zh) * 2019-07-04 2019-10-15 浙江理工大学 一种基于蛋白质芯片技术鉴别丝织品文物样的方法
US12499535B2 (en) 2020-01-24 2025-12-16 The Regents Of The University Of California Retinal disease biomarker prediction by stacking slices of 3D OCT image to reshape into 2D image and applying trained feature extractor and CNN
WO2023130049A1 (en) * 2021-12-30 2023-07-06 Somalogic Operating Co., Inc. Next-generation sequencing for protein measurement
WO2024173602A2 (en) * 2023-02-14 2024-08-22 The Regents Of The University Of California Systems and methods for automated diagnosis of disease related risk factors in 3d biomedical imaging
WO2025166038A1 (en) * 2024-02-02 2025-08-07 Illumina, Inc. Improved aptamer detection techniques
CN119064600B (zh) * 2024-11-04 2025-01-24 中国科学院生物物理研究所 用于非小细胞肺癌诊断的细胞外囊泡生物标志物及其应用
CN119595908B (zh) * 2024-12-13 2025-10-17 四川大学华西医院 金属离子介导的dna功能纳米机器开关用于双标志物同时检测的分析方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010030697A1 (en) * 2008-09-09 2010-03-18 Somalogic, Inc. Lung cancer biomarkers and uses thereof
WO2011015602A2 (en) * 2009-08-04 2011-02-10 Biosystems International Sas Lung cancer biomarkers
CN102084000A (zh) * 2008-02-01 2011-06-01 总医院有限公司 微泡在医学疾病和病况的诊断、预后以及治疗中的用途
WO2013033019A1 (en) * 2011-08-31 2013-03-07 University Of Utah Research Foundation Methods for determining the integrity of a biological sample
WO2013062515A2 (en) * 2011-10-24 2013-05-02 Somalogic, Inc. Lung cancer biomarkers and uses thereof
WO2013152989A2 (en) * 2012-04-10 2013-10-17 Eth Zurich Biomarker assay and uses thereof for diagnosis, therapy selection, and prognosis of cancer
CN103797131A (zh) * 2011-06-16 2014-05-14 卡里斯生命科学卢森堡控股有限责任公司 生物标志物组合物和方法
CN103874770A (zh) * 2011-08-08 2014-06-18 卡里斯生命科学卢森堡控股有限责任公司 生物标志物组合物和方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1354890B1 (en) * 2000-12-28 2007-08-08 Shionogi & Co., Ltd. Chordin-like polypeptides and dna thereof
WO2009036123A1 (en) * 2007-09-11 2009-03-19 Cancer Prevention And Cure, Ltd. Method of identifying biomarkers in human serum indicative of pathologies of human lung tissues
ES2703714T3 (es) * 2009-03-12 2019-03-12 Cancer Prevention & Cure Ltd Métodos de identificación, evaluación, prevención y terapia de enfermedades pulmonares y kits de los mismos, incluida la identificación, evaluación, prevención y terapia de enfermedades en base al género
SG168431A1 (en) * 2009-07-23 2011-02-28 Univ Singapore Cancer biomarker and the use thereof
CA2791905A1 (en) * 2010-03-01 2011-09-09 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Biomarkers for theranostics
JP5905003B2 (ja) * 2010-07-09 2016-04-20 ソマロジック・インコーポレーテッド 肺癌バイオマーカーとその使用
AU2011380023B2 (en) 2011-10-24 2015-03-26 Hewlett-Packard Development Company, L.P. Fluid ejection devices and methods thereof

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102084000A (zh) * 2008-02-01 2011-06-01 总医院有限公司 微泡在医学疾病和病况的诊断、预后以及治疗中的用途
WO2010030697A1 (en) * 2008-09-09 2010-03-18 Somalogic, Inc. Lung cancer biomarkers and uses thereof
WO2011015602A2 (en) * 2009-08-04 2011-02-10 Biosystems International Sas Lung cancer biomarkers
CN103797131A (zh) * 2011-06-16 2014-05-14 卡里斯生命科学卢森堡控股有限责任公司 生物标志物组合物和方法
CN103874770A (zh) * 2011-08-08 2014-06-18 卡里斯生命科学卢森堡控股有限责任公司 生物标志物组合物和方法
WO2013033019A1 (en) * 2011-08-31 2013-03-07 University Of Utah Research Foundation Methods for determining the integrity of a biological sample
WO2013062515A2 (en) * 2011-10-24 2013-05-02 Somalogic, Inc. Lung cancer biomarkers and uses thereof
CN103890586A (zh) * 2011-10-24 2014-06-25 私募蛋白质体公司 肺癌生物标记及其用途
WO2013152989A2 (en) * 2012-04-10 2013-10-17 Eth Zurich Biomarker assay and uses thereof for diagnosis, therapy selection, and prognosis of cancer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
A Novel Serum 4-microRNA Signature for Lung Cancer Detection;Ernest Nadal et al;《Scientific Reports》;20150723;第05卷(第12464期);第1-9页 *

Also Published As

Publication number Publication date
CN108026584A (zh) 2018-05-11
KR20180036787A (ko) 2018-04-09
KR102087373B1 (ko) 2020-03-10
WO2017043679A1 (en) 2017-03-16
JP6857185B2 (ja) 2021-04-14
KR102078310B1 (ko) 2020-02-19
KR20200020958A (ko) 2020-02-26
JP2018528441A (ja) 2018-09-27

Similar Documents

Publication Publication Date Title
CN108026584B (zh) 非小细胞肺癌诊断用蛋白质生物标志物组及利用其的非小细胞肺癌诊断方法
JP5701212B2 (ja) 肺癌バイオマーカーとその使用
KR101921945B1 (ko) 폐암 바이오마커 및 그것의 용도
CN103415624B (zh) 胰腺癌生物标记及其用途
CN102985819B (zh) 肺癌生物标记及其用途
US20120143805A1 (en) Cancer Biomarkers and Uses Thereof
US20220065872A1 (en) Lung Cancer Biomarkers and Uses Thereof
HK1229002A (en) Lung cancer biomarkers and uses thereof
HK1229002A1 (en) Lung cancer biomarkers and uses thereof
HK1229003A1 (en) Pancreatic cancer biomarkers and uses thereof
HK1229002B (en) Lung cancer biomarkers and uses thereof
HK1229003B (zh) 胰腺癌生物标记及其用途

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant