CN108025091A - 固体脂质磁共振纳米粒子及其制备方法和应用 - Google Patents

固体脂质磁共振纳米粒子及其制备方法和应用 Download PDF

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Publication number
CN108025091A
CN108025091A CN201680047521.XA CN201680047521A CN108025091A CN 108025091 A CN108025091 A CN 108025091A CN 201680047521 A CN201680047521 A CN 201680047521A CN 108025091 A CN108025091 A CN 108025091A
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magnetic resonance
nano particle
solid lipid
preparation
resonance nano
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孙继红
袁弘
刘菲
陈少青
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Zhejiang University ZJU
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Zhejiang University ZJU
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes

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  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

本发明公开了一种固体脂质磁共振纳米粒子及其制备方法和应用，该纳米粒子以单硬脂酸甘油酯为脂质材料，通过十八胺与磁共振对比剂钆喷替酸葡胺复合，海藻糖作为冻干保护剂，制备肠道易吸收的脂质纳米粒。本发明在原有固体脂质纳米粒制备方法的基础上进行优化，制备得到的纳米粒子的水溶性良好、粒径均一，延长了纳米粒中钆喷替酸葡胺的释放时间，并降低了材料对乳腺癌细胞的毒性，提高了MR成像的驰豫效率。

Description

PCT国内申请，说明书已公开。

Claims (26)

  1. PCT国内申请，权利要求书已公开。
CN201680047521.XA 2015-09-10 2016-08-12 固体脂质磁共振纳米粒子及其制备方法和应用 Pending CN108025091A (zh)

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CN201510573829.5A CN106692992B (zh) 2015-09-10 2015-09-10 固体脂质磁共振纳米粒子及其制备方法和应用
CN2015105738295 2015-09-10
PCT/CN2016/094834 WO2017041609A1 (zh) 2015-09-10 2016-08-12 固体脂质磁共振纳米粒子及其制备方法和应用

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CN108025091A true CN108025091A (zh) 2018-05-11

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CN201680047521.XA Pending CN108025091A (zh) 2015-09-10 2016-08-12 固体脂质磁共振纳米粒子及其制备方法和应用

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116173188A (zh) * 2023-02-07 2023-05-30 浙江大学 口服glp-1类似物固体脂质纳米粒及其制备方法和应用

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110585121B (zh) * 2019-10-18 2023-07-25 武汉布润脑医学科技有限责任公司 替莫唑胺核磁共振可视化可注射水凝胶、制备方法及用途

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008006535A2 (en) * 2006-07-10 2008-01-17 Medigene Ag Use of a cationic colloidal preparation for the diagnosis and treatment of ocular diseases
CN101129336A (zh) * 2007-07-24 2008-02-27 浙江大学 一种脂质纳米粒的制备方法
WO2009018332A1 (en) * 2007-08-01 2009-02-05 Alnylam Pharmaceuticals, Inc. Single-stranded and double-stranded oligonucleotides comprising a metal-chelating ligand
CN101496906A (zh) * 2009-02-19 2009-08-05 浙江大学 含磁共振对比剂的脂质纳米粒及其制备方法和应用
CN103990151A (zh) * 2014-06-09 2014-08-20 北京大学 一种磁共振成像造影剂及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101637612A (zh) * 2008-07-31 2010-02-03 上海交通大学医学院附属仁济医院 呼吸道磁共振喷雾造影剂及其制备方法
CN102078624B (zh) * 2010-12-23 2012-07-25 华东理工大学 一种高效载钆脂质体制剂及其制备方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008006535A2 (en) * 2006-07-10 2008-01-17 Medigene Ag Use of a cationic colloidal preparation for the diagnosis and treatment of ocular diseases
CN101129336A (zh) * 2007-07-24 2008-02-27 浙江大学 一种脂质纳米粒的制备方法
WO2009018332A1 (en) * 2007-08-01 2009-02-05 Alnylam Pharmaceuticals, Inc. Single-stranded and double-stranded oligonucleotides comprising a metal-chelating ligand
CN101496906A (zh) * 2009-02-19 2009-08-05 浙江大学 含磁共振对比剂的脂质纳米粒及其制备方法和应用
CN103990151A (zh) * 2014-06-09 2014-08-20 北京大学 一种磁共振成像造影剂及其制备方法和应用

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
JIHONG SUN等: "Development of Nanoparticle-Based Magnetic Resonance Colonography", 《MAGNETIC RESONANCE IN MEDICINE 》 *
TAO WU等: "Bimodal visualization of colorectal uptake of nanoparticles in dimethylhydrazine-treated mice", 《WORLD J GASTROENTEROL》 *
孙继红: "基于固体脂质体纳米粒的新型磁共振大肠成像方法的建立", 《中国博士学位论文全文数据库 医药卫生科技辑》 *
王毅翔等: "新型磁共振造影剂研究动态", 《国外医学.临床放射学分册》 *
袁弘: "固体脂质纳米粒口服药物载体经胃肠道转运的研究", 《中国博士学位论文全文数据库 医药卫生科技辑》 *
陈智金: "用于肝癌早期诊断生物可降解型纳米粒分子显影对比剂的研究", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116173188A (zh) * 2023-02-07 2023-05-30 浙江大学 口服glp-1类似物固体脂质纳米粒及其制备方法和应用
CN116173188B (zh) * 2023-02-07 2023-12-01 浙江大学 口服glp-1类似物固体脂质纳米粒及其制备方法和应用

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CN106692992A (zh) 2017-05-24
CN106692992B (zh) 2019-08-23
WO2017041609A1 (zh) 2017-03-16

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Application publication date: 20180511