CN108024522A - Etv2及其用途 - Google Patents

Etv2及其用途 Download PDF

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Publication number
CN108024522A
CN108024522A CN201680024200.8A CN201680024200A CN108024522A CN 108024522 A CN108024522 A CN 108024522A CN 201680024200 A CN201680024200 A CN 201680024200A CN 108024522 A CN108024522 A CN 108024522A
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CN
China
Prior art keywords
human
etv2
human animal
cells
blastocyst
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680024200.8A
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English (en)
Chinese (zh)
Inventor
D·J·加里
M·G·加里
T·拉斯穆森
N·小谷野中川
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Minnesota System
Original Assignee
University of Minnesota System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Minnesota System filed Critical University of Minnesota System
Publication of CN108024522A publication Critical patent/CN108024522A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877—Techniques for producing new mammalian cloned embryos
    • C12N15/8778—Swine embryos
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0604—Whole embryos; Culture medium therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A01K2267/025—Animal producing cells or organs for transplantation

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Microbiology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201680024200.8A 2015-03-03 2016-03-03 Etv2及其用途 Pending CN108024522A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562127330P 2015-03-03 2015-03-03
US62/127,330 2015-03-03
PCT/US2016/020768 WO2016141234A1 (en) 2015-03-03 2016-03-03 Etv2 and uses thereof

Publications (1)

Publication Number Publication Date
CN108024522A true CN108024522A (zh) 2018-05-11

Family

ID=56848633

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680024200.8A Pending CN108024522A (zh) 2015-03-03 2016-03-03 Etv2及其用途

Country Status (15)

Country Link
US (2) US11673928B2 (https=)
EP (1) EP3264891A4 (https=)
JP (1) JP2018506984A (https=)
KR (1) KR102684690B1 (https=)
CN (1) CN108024522A (https=)
AU (1) AU2016226087A1 (https=)
BR (1) BR112017018932A2 (https=)
CA (1) CA2978457A1 (https=)
CL (1) CL2017002226A1 (https=)
IL (1) IL254241A0 (https=)
MX (1) MX2017011345A (https=)
PH (1) PH12017501589A1 (https=)
RU (1) RU2017132331A (https=)
SG (1) SG11201707151YA (https=)
WO (1) WO2016141234A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10897880B2 (en) 2015-06-30 2021-01-26 Regents Of The University Of Minnesota Humanized heart muscle
US11673928B2 (en) 2015-03-03 2023-06-13 Regents Of The University Of Minnesota Genetically modified pig cells with an inactivated Etv2 gene
US12089574B2 (en) 2015-06-30 2024-09-17 Regents Of The University Of Minnesota Humanized skeletal muscle

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7265988B2 (ja) * 2017-02-03 2023-04-27 コーネル ユニヴァーシティー 安定な３次元血管およびそれを形成するための方法

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WO1997025412A1 (en) 1996-01-09 1997-07-17 The Regents Of The University Of California Ungulate embryonic stem-like cells, methods of making and using the cells to produce transgenic ungulates
US5994619A (en) 1996-04-01 1999-11-30 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus Production of chimeric bovine or porcine animals using cultured inner cell mass cells
CN1241210A (zh) 1996-10-11 2000-01-12 得克萨斯农业及机械体系综合大学 产生原生殖细胞和转基因动物物种的方法
US20050039222A1 (en) * 2001-10-24 2005-02-17 Kiyoshi Habu Sgrf gene-modified non-human animals
US20040133931A1 (en) 2003-01-08 2004-07-08 Gavin William G. Method and system for fusion and activation following nuclear transfer in reconstructed embryos
US20050125853A1 (en) * 2002-03-22 2005-06-09 St. Jude Children's Resarch Hospital Method for generating genetically modified animals
CA2488725A1 (en) 2002-07-03 2004-01-15 Su Qian Agouti-related protein deficient cells, non-human transgenic animals and methods of selecting compounds which regulate energy metabolism
GB2398784B (en) 2003-02-26 2005-07-27 Babraham Inst Removal and modification of the immunoglobulin constant region gene cluster of a non-human mammal
US20060008451A1 (en) 2004-07-06 2006-01-12 Michigan State University In vivo methods for effecting tissue specific differentiation of embryonic stem cells
JP5425641B2 (ja) 2007-01-11 2014-02-26 ユニバーシティー オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション 尿路病状の処置のための筋由来細胞ならびにその作製および使用の方法
US20100107263A1 (en) * 2007-01-20 2010-04-29 Boehringer Ingelheim International Gmbh & Co., Kg C-reactive protein (crp) knockout mouse
JPWO2008102602A1 (ja) 2007-02-22 2010-05-27 国立大学法人 東京大学 Ｂｌａｓｔｏｃｙｓｔｃｏｍｐｌｅｍｅｎｔａｔｉｏｎを利用した臓器再生法
JP5688788B2 (ja) 2008-02-22 2015-03-25 国立大学法人 東京大学 遺伝子改変による致死性表現型を持つ動物の繁殖用ファウンダー動物作製法
GB2490443B8 (en) 2008-08-22 2014-08-13 Univ Tokyo Organ regeneration method utilizing iPS cell and blastocyst complementation
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CA2762584A1 (en) 2009-05-20 2010-11-25 Cardio3 Biosciences S.A. Pharmaceutical composition for the treatment of heart diseases
AU2012249390B2 (en) 2011-04-27 2017-03-30 Amyris, Inc. Methods for genomic modification
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US9862929B2 (en) 2011-11-18 2018-01-09 Kyoto University Method of inducing differentiation from pluripotent stem cells to skeletal muscle cells
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US20140115728A1 (en) 2012-10-24 2014-04-24 A. Joseph Tector Double knockout (gt/cmah-ko) pigs, organs and tissues
US11377639B2 (en) 2013-11-15 2022-07-05 Wisconsin Alumni Research Foundation Lineage reprogramming to induced cardiac progenitor cells (iCPC) by defined factors
BR112016024945A2 (pt) 2014-04-28 2017-10-24 Recombinetics Inc edição de gene multiplex em suínos
KR102684690B1 (ko) 2015-03-03 2024-07-15 리젠츠 오브 더 유니버시티 오브 미네소타 Etv2 및 그의 용도
RU2018103093A (ru) 2015-06-30 2019-07-31 Реджентс Оф Зэ Юниверсити Оф Миннесота Гуманизированная скелетная мышца
WO2017004388A1 (en) 2015-06-30 2017-01-05 Regents Of The University Of Minnesota Humanized heart muscle
EP3367785A4 (en) 2015-10-27 2019-08-14 Regents of the University of Minnesota COMPOSITIONS AND METHODS FOR CHIMERIC EMBRYO-ASSISTED ORGAN PRODUCTION
CN108125943A (zh) 2018-01-17 2018-06-08 云南省第二人民医院 前胡醇当归脂作为制备抗动脉粥样硬化药物的应用

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11673928B2 (en) 2015-03-03 2023-06-13 Regents Of The University Of Minnesota Genetically modified pig cells with an inactivated Etv2 gene
US10897880B2 (en) 2015-06-30 2021-01-26 Regents Of The University Of Minnesota Humanized heart muscle
US12089574B2 (en) 2015-06-30 2024-09-17 Regents Of The University Of Minnesota Humanized skeletal muscle

Also Published As

Publication number Publication date
US20180037620A1 (en) 2018-02-08
MX2017011345A (es) 2018-04-24
CL2017002226A1 (es) 2018-07-27
WO2016141234A1 (en) 2016-09-09
PH12017501589A1 (en) 2018-02-05
AU2016226087A1 (en) 2017-10-26
US20230365638A1 (en) 2023-11-16
JP2018506984A (ja) 2018-03-15
RU2017132331A (ru) 2019-04-03
KR102684690B1 (ko) 2024-07-15
EP3264891A4 (en) 2018-09-05
SG11201707151YA (en) 2017-09-28
BR112017018932A2 (pt) 2018-07-31
EP3264891A1 (en) 2018-01-10
IL254241A0 (en) 2017-10-31
KR20170121262A (ko) 2017-11-01
US11673928B2 (en) 2023-06-13
CA2978457A1 (en) 2016-09-09

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