CN108014314A - 一种风湿寒痹酊及其制备方法 - Google Patents

一种风湿寒痹酊及其制备方法 Download PDF

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CN108014314A
CN108014314A CN201711374047.4A CN201711374047A CN108014314A CN 108014314 A CN108014314 A CN 108014314A CN 201711374047 A CN201711374047 A CN 201711374047A CN 108014314 A CN108014314 A CN 108014314A
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王继彩
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Abstract

本发明属于中药技术领域，具体涉及一种风湿寒痹酊及其制备方法。该酊剂配方为细辛3g、威灵仙10‑20g、杜仲10‑15g、川牛膝10‑15g、寻骨风10‑15g、乌梢蛇10‑15g、徐长卿10‑15g、松节10‑15g、羌活10‑15g、独活10‑15g、干姜10‑15g、川芎10‑15g、红花15‑20g、土鳖虫10‑15g、俾筋草10‑15g、元胡15‑20g、桂枝10‑15g、冰片3‑5g、甘草5‑9g。本发明制备的酊剂能够有效的治疗风湿寒痹症，药效快，依从性强，且对肠胃无刺激作用。

Description

一种风湿寒痹酊及其制备方法
技术领域
本发明属于中药技术领域，具体涉及一种风湿寒痹酊及其制备方法。
背景技术
风湿寒痹又称痛痹，是以寒邪为主而导致的以肢体关节冷痛、疼痛较剧，得热痛减为主要临床特征的风湿病。寒痹首见于《内经》，《灵枢·寿夭刚柔》又言：“寒痹之为病也，留而不去，时痛而皮不仁”。寒痹的病因病机，中医认为，内因多由于脏腑功能失调、正气不足或寒自内生，外因多因严冬涉水、步履冰雪，久居寒湿之地等，基本病机为感受寒邪，或内生寒邪，痹阻于肢体关节经络，气血运行不畅而致痹。风湿寒痹的病位为肢体关节肌肉经络，可涉及肾、肝、脾等脏腑，该病一年四季均可发生，多发于冬季，发病可见于任何年龄，女性多于男性。
中国专利申请CN201310672606.5提供了一种用于治疗风湿寒痹证的中药，该中药服用后对胃肠刺激较大，加重了病人的肠胃负担。
发明内容
针对现有技术存在的问题，本发明提供了一种风湿寒痹酊。
本发明还提供了一种风湿寒痹酊的制备方法。
本发明为了实现上述目的所采用的技术方案为：
本发明提供了一种风湿寒痹酊，包括以下原料药：细辛3g、威灵仙10-20g、杜仲10-15g、川牛膝10-15g、寻骨风10-15g、乌梢蛇10-15g、徐长卿10-15g、松节10-15g、羌活10-15g、独活10-15g、干姜10-15g、川芎10-15g、红花15-20g、土鳖虫10-15g、俾筋草10-15g、元胡15-20g、桂枝10-15g、冰片3-5g、甘草5-9g。
本发明还提供了一种上述风湿寒痹酊的制备方法，包括以下步骤：
（1）首先将乌梢蛇、土鳖虫研磨成粉，然后加入由卵磷脂、甘油、水及醋酸钙组成的混合溶液，搅拌浸泡24h，得混合粉备用；
（2）将其他原料药及上述混合粉中加入白酒3000mL，浸泡7d过滤即可。
优选的，所述混合溶液每L含有卵磷脂0.2g、甘油20mL、醋酸钙0.5g及余量的水。
上述混合溶液同乌梢蛇及土鳖虫混合粉的质量比为1：1。
优选的，所述白酒为42°以上。
本发明制备的酊剂的使用方法为：将制备的酊剂涂抹于患处即可。
本发明的有益效果为：本发明制备的酊剂能够有效的治疗风湿寒痹症，药效快，依从性强，且对肠胃无刺激作用。
具体实施方式
下面通过实施例对本发明进行进一步的阐述，应该明白的是，下述说明仅是为了解释本发明，并不对其内容进行限定。
实施例1
一种风湿寒痹酊，配方为：细辛3g、威灵仙10g、杜仲15g、川牛膝10g、寻骨风10g、乌梢蛇15g、徐长卿12g、松节15g、羌活10g、独活15g、干姜15g、川芎12g、红花15g、土鳖虫10g、俾筋草15g、元胡20g、桂枝15g、冰片3g、甘草5g。
制备方法如下：
（1）首先将乌梢蛇、土鳖虫研磨成粉，然后加入同质量的由卵磷脂、甘油、水及醋酸钙组成的混合溶液，搅拌浸泡24h，得混合粉备用；
所述混合溶液每L含有卵磷脂0.2g、甘油20mL、醋酸钙0.5g及余量的水；
（2）将其他原料药及上述混合粉中加入56°白酒3000mL，浸泡7d过滤即可。
实施例2
一种风湿寒痹酊，配方为：细辛3g、威灵仙20g、杜仲10g、川牛膝15g、寻骨风15g、乌梢蛇12g、徐长卿15g、松节10g、羌活15g、独活10g、干姜15g、川芎15g、红花20g、土鳖虫15g、俾筋草10g、元胡15g、桂枝10g、冰片5g、甘草9g。
制备方法同实施例1。
实施例3
一种风湿寒痹酊，配方同实施例1。
制备方法如下：将各原料按照重量份混合后，直接加入56℃白酒3000mL，浸泡7d过滤即可。
（一）临床实验数据
2015-2016年期间，来我诊所就诊的痛经严重的患者共计有152名；
疗效标准如下：
痊愈：症状全部消失，功能活动恢复正常。
显效：全部症状消失或主要症状消失，关节功能活动基本恢复，能参加正常工作和劳动；
有效：主要症状基本消失，主要关节基本功能恢复或有明显进步，生活不能自理转为能自理；
无效：和治疗前比较，各方面均无进步。
本发明对152例患者进行临床跟踪治疗，年龄为32-76 岁患者，病程最长者达32年，使用本发明制备的中药组合物最长的2个疗程后，总有效率（包括痊愈，显著及有效的人数）为96%。
同时，值得注意的是，本发明初期采用的制备方法为实施例3制备的酊剂，该制剂使用时，患者中出现瘙痒、过敏等症状，经过发明人大量的实验及实践操作后，采用实施例1及实施例2制备的酊剂症状明显减轻，且酊剂的储存时间也延长。
（二）典型病例
1、许某，女，56岁，于2016年来我诊所就诊，膝关节反复疼痛已达11年，逢寒冷及潮湿的季节，疼痛加重，痛处发凉，关节屈伸不利，步履困难，舌苔薄白，脉沉细，经诊断，关节肿胀，触之不温，诊断为风湿寒痹；涂抹本发明实施例2提供的酊剂，涂抹于患处，每天3次，早中晚各一次，涂抹后可适当进行按摩，然后医嘱注意保暖，涂抹5d后，疼痛感明显减轻，继续涂抹1个月后，疼痛消失，经医院检查，血沉等指标均正常，随访半年无复发。
2、叶某，男，35岁，于2015年来我诊所就诊，叶某就职于冷库工作，近半年关节反复疼痛，双手指间关节肿胀，活动受限，且遇阴冷天气，疼痛加剧，舌苔薄白，经检查，血沉等均异常，经诊断为风湿寒痹；涂抹本发明实施例1提供的酊剂，涂抹于患处，7d后，自述疼痛感减轻，且双手关节肿胀较来诊时明显减轻，活动范围有所改善，继续使用15d后，症状基本消失，医院复查血沉正常，但类风湿因子仍为阳性，继续使用10d后，复查类风湿因子转阴，达到医学痊愈，巩固治疗10d，随访1年无复发。

Claims (5)

1.一种风湿寒痹酊，其特征在于，包括以下原料药：细辛3g、威灵仙10-20g、杜仲10-15g、川牛膝10-15g、寻骨风10-15g、乌梢蛇10-15g、徐长卿10-15g、松节10-15g、羌活10-15g、独活10-15g、干姜10-15g、川芎10-15g、红花15-20g、土鳖虫10-15g、俾筋草10-15g、元胡15-20g、桂枝10-15g、冰片3-5g、甘草5-9g。
2.一种如权利要求1所述的风湿寒痹酊的制备方法，其特征在于，包括以下步骤：
（1）首先将乌梢蛇、土鳖虫研磨成粉，然后加入由卵磷脂、甘油、水及醋酸钙组成的混合溶液，搅拌浸泡24h，得混合粉备用；
（2）将其他原料药及上述混合粉中加入白酒3000mL，浸泡7d过滤即可。
3.根据权利要求2所述的制备方法，其特征在于，所述混合溶液每L含有卵磷脂0.2g、甘油20mL、醋酸钙0.5g及余量的水。
4.根据权利要求3所述的制备方法，其特征在于，所述混合溶液同乌梢蛇及土鳖虫混合粉的质量比为1：1。
5.根据权利要求2所述的制备方法，其特征在于，所述白酒为42°以上。
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CN105596583A (zh) * 2014-11-02 2016-05-25 刘继银 一种泡制药酒
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112023015A (zh) * 2020-09-29 2020-12-04 江西中医药大学 一种止痛穴位贴及其制备方法

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Application publication date: 20180511