CN108012528A - 调控短链脱氢酶活性的组合物和方法 - Google Patents

调控短链脱氢酶活性的组合物和方法 Download PDF

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Publication number
CN108012528A
CN108012528A CN201680034932.5A CN201680034932A CN108012528A CN 108012528 A CN108012528 A CN 108012528A CN 201680034932 A CN201680034932 A CN 201680034932A CN 108012528 A CN108012528 A CN 108012528A
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alkyl
disease
inhibitor
study subject
aryl
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Inventor
S·D·马科维茨
J·瑞达
Y·Y·张
M·安特科扎克
J·K·V·威尔森
B·A·波斯纳
W·格林丽
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Texas System Council, University of
Case Western Reserve University
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Case Western Reserve University
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    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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CN201680034932.5A 2015-04-14 2016-04-14 调控短链脱氢酶活性的组合物和方法 Pending CN108012528A (zh)

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US201562147305P 2015-04-14 2015-04-14
US62/147,305 2015-04-14
PCT/US2016/027549 WO2016168472A1 (en) 2015-04-14 2016-04-14 Compositions and methods of modulating short-chain dehydrogenase activity

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US (4) US20180118756A1 (enExample)
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JP (1) JP2018511616A (enExample)
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AU (1) AU2016248080A1 (enExample)
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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11690847B2 (en) 2016-11-30 2023-07-04 Case Western Reserve University Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof
CN116457014A (zh) * 2020-10-23 2023-07-18 莱兰斯坦福初级大学评议会 通过抑制前列腺素降解酶15-pgdh提升线粒体生物合成和功能
CN116507626A (zh) * 2020-05-20 2023-07-28 罗迪奥治疗公司 调节短链脱氢酶活性的组合物和方法
WO2023143432A1 (zh) * 2022-01-28 2023-08-03 赛诺哈勃药业（成都）有限公司 一种调控15-pgdh活性的化合物及其制备方法
US11718589B2 (en) 2017-02-06 2023-08-08 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase
WO2023198141A1 (zh) * 2022-04-13 2023-10-19 赛诺哈勃药业（成都）有限公司 一种调控15-pgdh活性的化合物及其制备方法
WO2024099429A1 (zh) * 2022-11-11 2024-05-16 赛诺哈勃药业（成都）有限公司 一种调控15-pgdh活性的化合物及其制备方法
WO2024104317A1 (zh) * 2022-11-14 2024-05-23 武汉人福创新药物研发中心有限公司 抑制15-pgdh的化合物及其用途
WO2024240086A1 (zh) * 2023-05-19 2024-11-28 成都倍特药业股份有限公司 一种调控15-pgdh活性的化合物及其制备方法
US12336982B2 (en) 2018-11-21 2025-06-24 Rodeo Therapeutics Corporation Compositions and methods of modulating short-chain dehydrogenase activity

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2838533T (pt) 2012-04-16 2017-11-22 Univ Texas Composições e métodos de modulação da atividade de 15-pgdh
US9801863B2 (en) 2012-04-16 2017-10-31 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for modulating hematopoietic stem cells and hematopoiesis
AU2014342811B2 (en) 2013-10-15 2019-01-03 Board Of Regents Of The University Of Texas System Compositions and methods of modulating short-chain dehydrogenase activity
AU2016229918B2 (en) 2015-03-08 2020-10-29 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for treating fibrosis
AU2017300377B2 (en) * 2016-07-18 2022-04-21 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for promoting neurogenesis and inhibiting nerve cell death
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WO2019195565A1 (en) * 2018-04-04 2019-10-10 Case Western Reserve University Compositions and methods for treating renal injury
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