CA2982784A1 - Compositions and methods of modulating short-chain dehydrogenase activity - Google Patents

Compositions and methods of modulating short-chain dehydrogenase activity Download PDF

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Publication number
CA2982784A1
CA2982784A1 CA2982784A CA2982784A CA2982784A1 CA 2982784 A1 CA2982784 A1 CA 2982784A1 CA 2982784 A CA2982784 A CA 2982784A CA 2982784 A CA2982784 A CA 2982784A CA 2982784 A1 CA2982784 A1 CA 2982784A1
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Canada
Prior art keywords
subject
inhibitor
disease
alkyl
administered
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Abandoned
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CA2982784A
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English (en)
French (fr)
Inventor
Sanford D. Markowitz
Joseph READY
Yongyou Zhang
Monika ANTCZAK
James K.V. Willson
Bruce A. Posner
William Greenlee
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Case Western Reserve University
University of Texas System
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Case Western Reserve University
University of Texas System
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Publication of CA2982784A1 publication Critical patent/CA2982784A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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  • Health & Medical Sciences (AREA)
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  • Dermatology (AREA)
  • Cardiology (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
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  • Hematology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Developmental Biology & Embryology (AREA)
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  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
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CA2982784A 2015-04-14 2016-04-14 Compositions and methods of modulating short-chain dehydrogenase activity Abandoned CA2982784A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562147305P 2015-04-14 2015-04-14
US62/147,305 2015-04-14
PCT/US2016/027549 WO2016168472A1 (en) 2015-04-14 2016-04-14 Compositions and methods of modulating short-chain dehydrogenase activity

Publications (1)

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CA2982784A1 true CA2982784A1 (en) 2016-10-20

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CA2982784A Abandoned CA2982784A1 (en) 2015-04-14 2016-04-14 Compositions and methods of modulating short-chain dehydrogenase activity

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US (4) US20180118756A1 (enExample)
EP (1) EP3283074A4 (enExample)
JP (1) JP2018511616A (enExample)
CN (1) CN108012528A (enExample)
AU (1) AU2016248080A1 (enExample)
CA (1) CA2982784A1 (enExample)
HK (1) HK1250651A1 (enExample)
WO (1) WO2016168472A1 (enExample)

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PT2838533T (pt) 2012-04-16 2017-11-22 Univ Texas Composições e métodos de modulação da atividade de 15-pgdh
US9801863B2 (en) 2012-04-16 2017-10-31 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for modulating hematopoietic stem cells and hematopoiesis
AU2014342811B2 (en) 2013-10-15 2019-01-03 Board Of Regents Of The University Of Texas System Compositions and methods of modulating short-chain dehydrogenase activity
AU2016229918B2 (en) 2015-03-08 2020-10-29 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for treating fibrosis
AU2017300377B2 (en) * 2016-07-18 2022-04-21 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for promoting neurogenesis and inhibiting nerve cell death
EP3548035A4 (en) 2016-11-30 2020-07-22 Case Western Reserve University COMBINATIONS OF 15-PGDH INHIBITORS WITH CORCOSTEROIDS AND / OR TNF INHIBITORS AND THEIR USES
CN110573154A (zh) 2017-02-06 2019-12-13 卡斯西部储备大学 调节短链脱氢酶活性的组合物和方法
US11426420B2 (en) 2017-04-07 2022-08-30 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for treating coronary disorders
WO2019195565A1 (en) * 2018-04-04 2019-10-10 Case Western Reserve University Compositions and methods for treating renal injury
EA202191422A1 (ru) * 2018-11-21 2021-10-21 Кейс Вестерн Ризерв Юниверсити Композиции и способы модулирования активности короткоцепочечной дегидрогеназы
JP7532385B2 (ja) 2019-01-31 2024-08-13 杏林製薬株式会社 １５－ｐｇｄｈ阻害薬
GB2599292A (en) * 2019-06-11 2022-03-30 Univ Leland Stanford Junior Methods of rejuvenating aged tissue by inhibiting 15-hydroxyprostaglandin dehydrogenase (15-PGDH)
AU2021224268A1 (en) * 2020-02-21 2022-09-15 Case Western Reserve University Compositions and methods for treating renal injury
PE20230777A1 (es) * 2020-05-20 2023-05-09 Rodeo Therapeutics Corp Composiciones y metodos para modular la actividad de deshidrogenasas de cadena corta
WO2022087631A1 (en) * 2020-10-23 2022-04-28 The Board Of Trustees Of The Leland Stanford Junior University Elevation of mitochondrial biogenesis and function by inhibition of prostaglandin degrading enzyme 15-pgdh
AU2021396543A1 (en) * 2020-12-09 2023-07-06 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of prostaglandin degrading enzyme 15-pgdh to improve joint structure and function
US20250154162A1 (en) * 2022-01-28 2025-05-15 Scinnohub Pharmaceutical Co., Ltd. Compound for regulating and controlling 15-pgdh activity and preparation method therefor
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