CN107998447A - Conformal performance radiotherapy tissue equivalent compensation glue and its preparation method and application - Google Patents
Conformal performance radiotherapy tissue equivalent compensation glue and its preparation method and application Download PDFInfo
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- CN107998447A CN107998447A CN201711389759.3A CN201711389759A CN107998447A CN 107998447 A CN107998447 A CN 107998447A CN 201711389759 A CN201711389759 A CN 201711389759A CN 107998447 A CN107998447 A CN 107998447A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
- A61L27/165—Rubbers
Abstract
The present invention relates to a kind of conformal performance radiotherapy tissue equivalent compensation glue and its preparation method and application; including uncured layer and cured layer; the outer layer covers matcoveredn of uncured layer and cured layer; uncured layer and cured layer are made of identical raw material components, and the raw material components of uncured layer and cured layer are calculated by weight as：70 90 parts of liquid rubber, 8 12 parts of epoxy soybean oil acrylate, 35 parts of ethoxyethoxyethyl acrylate, 3 0.2 0.8 parts of pyrroles's phenyl titanocenes of double 2,6 difluoros.Preparation method of the present invention is simple, applying step is easily operated, liquid rubber, epoxy soybean oil acrylate is used to compensate glue soft comfortable for the tissue equivalent that raw material is prepared, it is good with the skin attachement degree of patient, it can effectively prevent the generation of cavity, reduce the secondary buildup effect of high-energy ray, and it can be molded according to the irradiated site situation of patient, repeatable accuracy is high, can ensure the accurate of tissue resorption dosage, reduces radioreaction.
Description
Technical field
The present invention relates to a kind of conformal performance radiotherapy tissue equivalent compensation glue and its preparation method and application, belong to medical supplies
Technical field.
Background technology
Radiotherapy has stepped into be accurately positioned, accurately at present as one for the treatment of three big main means of malignant tumour
Plan, " three essence " epoch accurately treated, up to radiotherapy terminates since considering to prepare to implement radiotherapy to a patient, Mei Yibu
All stress refinements are true, main accurate and irradiation tissue resorption dosage accurate including positional precision.
Radiotherapy external exposure mainly uses the x-ray and high energy e+e- collisions of high energy, these high-energy rays are all deposited into human body
A dosage built-up areas, since the dose curve slope before dosage built-up areas is larger and related to ray energy, even
The energy of high-energy X-ray more large surface dosage is lower, clinically avoids using this section as far as possible for this as uniform formation's absorbent
The calculating of amount, but the section for using the dose curve behind built-up areas relatively flat carries out tissue resorption Rapid Dose Calculation, exists for this
Treatment superficial tumor or the irradiation of superficial target area use tissue equivalent's indemnity often, ensure the uniform standard of tissue resorption dosage
Really, such as after breast modified radical mastectomy, cutaneum carcinoma, each position bias tumour, Cervical metastasis radiotherapy.
The tissue equivalent's indemnity used at present has paraffin, vaseline, water pocket, special silica gel, shaping compensation film etc., has certainly
System, have commercialization, be covered in human body and show, exist cannot fit like a glove firmly with patient skin very much, became uneven equivalent depth
It is uncertain, repeatability is too poor etc., simultaneously for patient's bodily form curved surface, postoperative scar, tumour shape it is irregular when, usually occur
Tissue equivalent's indemnity adherence is bad to there is cavity, and numerous studies show that the presence of cavity not only influences cavity center and corresponds to skin
The dosage deposition on surface, can also sink a certain range of skin surface outside around center until border and the dosage of shallow layer tissue
Product impacts, and must be avoided in Clinical practice tissue equivalent indemnity for this.
At present, tissue equivalent's indemnity is avoided to have using the method for hollow cavity：
(1) the fixation band of molded tissue equivalent compensation film.Although cavity can be reduced by increasing certain external force, for
Patient skin show to have curvature, scar after the operation, tumour uneven etc. this method cannot effectively eliminate, or even increase cavity.
(2) indemnity of the personalized printing patient of patient's outer contour rebuild using 3D printing technique according to CT.The technology
Material used is resin and silica gel, and there are certain hardness, patient comfort is not high, while each repeated positioning will during radiotherapy
Good fit is sought, otherwise increases cavity on the contrary, and it is not short to make the used time.
The content of the invention
The purpose of the present invention is to solve easily form cavity during existing tissue equivalent's indemnity use to influence to put
A kind of the problem for the treatment of radiation response, there is provided conformal performance radiotherapy tissue equivalent compensation glue and its preparation method and application.
The present invention adopts the following technical scheme that：A kind of conformal performance radiotherapy tissue equivalent compensation glue, including uncured layer and solid
Change layer, the outer layer covers matcoveredn of the uncured layer and cured layer, the uncured layer and cured layer use identical original
Material component is made, and the raw material components of uncured layer and cured layer are calculated by weight as：70-90 parts of liquid rubber, epoxy soybean
Oily acrylate 8-12 parts, 3-5 parts of ethoxyethoxyethyl acrylate, the fluoro- 3- pyrroles's phenyl titanocenes of double 2,6- bis-
0.2-0.8 parts.
Further, the thickness of the cured layer is 3-15mm.
Further, the thickness of the uncured layer is 0.1-20mm.
Further, the protective layer is made of medical PVC material.
Further, the density of tissue equivalent's compensation glue is 1~1.1g/cm3。
Further, the thickness of the protective layer is 0.2-0.5mm.
A kind of preparation method of conformal performance radiotherapy tissue equivalent compensation glue：Include the following steps：
(1) 70-90 parts of liquid rubbers are taken in parts by weight first under lucifuge state, 3- is sequentially added under stirring
Bis- fluoro- 3- of the double 2,6- of 5 parts of ethoxyethoxyethyl acrylate, 8-12 parts of epoxy soybean oil acrylates and 0.2-0.8 parts
Pyrroles's phenyl titanocenes, after being sufficiently stirred 1-1.5h, bubble removing is removed after mixture is sufficiently stirred 1-1.5h；
(2) mixture is placed in die body, cures 2-10min under the conditions of natural light and form cured layer；
(3) mixture is smeared above cured layer and forms uncured layer；
(4) layer protective layer is wrapped up in the outside of uncured layer and cured layer.
Further, empty the bubble in mixture using vacuum pumping 2-5min in the step (1).
A kind of application of conformal performance radiotherapy tissue equivalent compensation glue：By the surface of uncured layer and patient contact,
Wavelength is to be cured under the mercury vapor lamp of 400nm, and hardening time 2-5min, forms complete with patient's therapentic part bodily form
Identical tissue equivalent's compensation glue.
Using liquid rubber as flexible composition in the present invention, epoxy soybean oil acrylate is light-cured resin, passes through adjusting
Ratio between light-cured resin and liquid rubber changes the hardness of material, ensures flexible, and comfort level is good, then passes through work
Property diluent adjust component compatibility and system viscosity, ensure the stability of colloid, then photopolymerization is triggered by photoinitiator, play
Molding effect.
Preparation method of the present invention is simple, and step is easily operated, uses liquid rubber, epoxy soybean oil acrylate as raw material
The tissue equivalent's compensation glue soft comfortable being prepared, it is good with the skin attachement degree of patient, it can effectively prevent cavity
Generation, reduces the secondary buildup effect of high-energy ray, and can be molded according to the irradiated site situation of patient, repeatable accuracy
Height, can ensure the accurate of tissue resorption dosage, reduce radioreaction.
Brief description of the drawings
Fig. 1 is the structure diagram of the present invention
Reference numeral：Protective layer 1, uncured layer 2, cured layer 3.
Embodiment
The present invention is further detailed below in conjunction with specific embodiment.
Embodiment 1：
A kind of conformal performance radiotherapy tissue equivalent compensation glue, including uncured layer and cured layer, uncured layer and cured layer
Outer layer covers matcoveredn, the thickness of cured layer is 3mm, and the thickness of uncured layer is 0.1mm, and protective layer uses medical PVC material
Material is made, and the thickness of protective layer is 0.2mm, and uncured layer and cured layer are made of identical raw material components, uncured layer and
The raw material components of cured layer are calculated by weight as：70 parts of liquid rubber, 12 parts of epoxy soybean oil acrylate, ethoxy ethoxy
0.2 part of the fluoro- 3- pyrroles's phenyl titanocenes of 3 parts of base ethyl propylene acid esters, double 2,6- bis-.
A kind of preparation method of conformal performance radiotherapy tissue equivalent compensation glue：Include the following steps：
(1) 70 parts of liquid rubbers are taken in parts by weight first under lucifuge state, 3 parts of second are sequentially added under stirring
The fluoro- cyclopentadienyls of 3- pyrroles's phenyl two of the double 2,6- bis- of epoxide ethoxyethyl acrylate, 12 parts of epoxy soybean oil acrylates and 0.2 part
Titanium, after being sufficiently stirred 1.5h, the bubble in mixture is removed using vacuum pump；
(2) mixture is placed in die body, cures 2min under the conditions of natural light and form cured layer；
(3) mixture is smeared above cured layer and forms uncured layer；
(4) layer protective layer is wrapped up in the outside of uncured layer and cured layer, is preserved again under the conditions of lucifuge after sealing.
Embodiment 2：
A kind of conformal performance radiotherapy tissue equivalent compensation glue, including uncured layer and cured layer, uncured layer and cured layer
Outer layer covers matcoveredn, the thickness of cured layer is 10mm, and the thickness of uncured layer is x-xmm, and protective layer uses medical PVC material
Material is made, and the thickness of protective layer is 0.5mm, and uncured layer and cured layer are made of identical raw material components, uncured layer and
The raw material components of cured layer are calculated by weight as：85 parts of liquid rubber, 10.5 parts of epoxy soybean oil acrylate, ethyoxyl second
0.5 part of the fluoro- 3- pyrroles's phenyl titanocenes of 4.5 parts of epoxide ethyl propylene acid esters, double 2,6- bis-.
A kind of preparation method of conformal performance radiotherapy tissue equivalent compensation glue：Include the following steps：
(1) 85 parts of liquid rubbers are taken in parts by weight first under lucifuge state, 4.5 parts are sequentially added under stirring
The fluoro- 3- pyrroles's phenyl of the double 2,6- bis- of ethoxyethoxyethyl acrylate, 10.5 parts of epoxy soybean oil acrylates and 0.5 part
Titanocenes, after being sufficiently stirred 1h, the bubble in mixture is removed using vacuum pump；
(2) mixture is placed in die body, cures 8min under the conditions of natural light and form cured layer；
(3) mixture is smeared above cured layer and forms uncured layer；
(4) layer protective layer is wrapped up in the outside of uncured layer and cured layer, is preserved again under the conditions of lucifuge after sealing.
Embodiment 3：
A kind of conformal performance radiotherapy tissue equivalent compensation glue, including uncured layer and cured layer, uncured layer and cured layer
Outer layer covers matcoveredn, the thickness of cured layer is 15mm, and the thickness of uncured layer is 20mm, and protective layer uses medical PVC material
Material is made, and the thickness of protective layer is 0.2mm, and uncured layer and cured layer are made of identical raw material components, uncured layer and
The raw material components of cured layer are calculated by weight as：90 parts of liquid rubber, 8 parts of epoxy soybean oil acrylate, ethoxy ethoxy
0.8 part of the fluoro- 3- pyrroles's phenyl titanocenes of 5 parts of base ethyl propylene acid esters, double 2,6- bis-.
A kind of preparation method of conformal performance radiotherapy tissue equivalent compensation glue：Include the following steps：
(1) 90 parts of liquid rubbers are taken in parts by weight first under lucifuge state, 5 parts of second are sequentially added under stirring
The fluoro- cyclopentadienyls of 3- pyrroles's phenyl two of the double 2,6- bis- of epoxide ethoxyethyl acrylate, 8 parts of epoxy soybean oil acrylates and 0.8 part
Titanium, after being sufficiently stirred 1h, the bubble in mixture is removed using vacuum pump；
(2) mixture is placed in die body, cures 10min under the conditions of natural light and form cured layer；
(3) mixture is smeared above cured layer and forms uncured layer；
(4) layer protective layer is wrapped up in the outside of uncured layer and cured layer, is preserved again under the conditions of lucifuge after sealing.
The conformal performance radiotherapy tissue equivalent compensation glue that Example two is prepared carries out clinical effectiveness inspection, and method is such as
Under：
The patient of radiotherapy is needed after 50 breast modified radical mastectomies of selection, is randomly divided into control group and test group,
Before CT simulations, respectively using prepared by existing 30cm*30cm*0.3cm tissue equivalents indemnity currently on the market and the present invention
The conformal performance radiotherapy tissue equivalent compensation glue of same size be covered in the local chest wall cutaneous surface that patient need to be irradiated, body film is consolidated
CT scan is carried out after fixed, and image is sent to treatment planning systems, drawing target outline is with while jeopardizing organ, sketching out compensation
Cavity between thing and skin, using 6MV x-rays
Carry out adjusting strong plan design, DT=50Gy/25fx, compares average cavity number (cavity), average maximum cavity
Volume (cavity Vmax, unit：Ml), skin dose point otherness (dose point S) under cavity, inquires during radiation therapy delivery patient to mending
Repay thing and use comfort, observe the dermoreaction situation in 2 weeks after patient's chest wall cutaneous pigmentation situation and radiotherapy, as a result
As shown in table 1.
1 clinical test statistical form of table
As shown in table 1, test group is good using the conformal performance radiotherapy tissue equivalent compensation glue patient comfort of the present invention, base
Originally the cavity between patient skin is eliminated, dosage is evenly distributed, accuracy is high, hence it is evident that reduce severe skin reaction, effect
Well.
Claims (9)
- A kind of 1. conformal performance radiotherapy tissue equivalent compensation glue, it is characterised in that：Including uncured layer（2）And cured layer（3）, it is described Uncured layer（2）And cured layer（3）Outer layer covers matcoveredn（1）, the uncured layer（2）And cured layer（3）Using phase Same raw material components are made, uncured layer（2）And cured layer（3）Raw material components be calculated by weight as：Liquid rubber 70-90 Part, 8-12 parts of epoxy soybean oil acrylate, 3-5 parts of ethoxyethoxyethyl acrylate, the fluoro- 3- pyrroles's benzene of double 2,6- bis- 0.2-0.8 parts of base titanocenes.
- 2. conformal performance radiotherapy tissue equivalent compensation glue as claimed in claim 1, it is characterised in that：The cured layer（3）Thickness Spend for 3-15mm.
- 3. conformal performance radiotherapy tissue equivalent compensation glue as claimed in claim 1, it is characterised in that：The uncured layer（2）'s Thickness is 0.1-20mm.
- 4. conformal performance radiotherapy tissue equivalent compensation glue as claimed in claim 1, it is characterised in that：The protective layer（1）Using Medical PVC material is made.
- 5. conformal performance radiotherapy tissue equivalent compensation glue as claimed in claim 1, it is characterised in that：The tissue equivalent compensates glue Density be 1~1.1 g/cm3。
- 6. conformal performance radiotherapy tissue equivalent compensation glue as claimed in claim 1, it is characterised in that：The protective layer（1）Thickness Spend for 0.2-0.5mm.
- 7. the preparation method of the conformal performance radiotherapy tissue equivalent compensation glue described in claim 1, it is characterised in that：Including following step Suddenly：（1）Take 70-90 parts of liquid rubbers in parts by weight first under lucifuge state, 3-5 parts are sequentially added under stirring Ethoxyethoxyethyl acrylate, 8-12 part epoxy soybean oil acrylate and 0.2-0.8 parts of bis- fluoro- 3- pyrroles of double 2,6- Phenyl titanocenes, bubble removing is removed after mixture is sufficiently stirred 1-1.5h；（2）Mixture is placed in die body, cures 2-10min under the conditions of natural light and forms cured layer；（3）Mixture is smeared above cured layer and forms uncured layer；（4）Layer protective layer is wrapped up in the outside of uncured layer and cured layer.
- 8. the preparation method of conformal performance radiotherapy tissue equivalent compensation glue as claimed in claim 7, it is characterised in that：The step （1）It is middle to empty the bubble in mixture using vacuum pumping 2-5min.
- 9. the application of the conformal performance radiotherapy tissue equivalent compensation glue described in claim 1, it is characterised in that：By uncured layer（2） Surface and patient contact, wavelength be 400nm mercury vapor lamp under cured, hardening time 2-5min, shape Glue is compensated into the tissue equivalent to fit like a glove with patient's therapentic part bodily form.
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| CN201711389759.3A CN107998447B (en) | 2017-12-21 | 2017-12-21 | Conformal radiotherapy tissue equivalent compensation glue and preparation method and application thereof |
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| CN201711389759.3A CN107998447B (en) | 2017-12-21 | 2017-12-21 | Conformal radiotherapy tissue equivalent compensation glue and preparation method and application thereof |
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| CN107998447A true CN107998447A (en) | 2018-05-08 |
| CN107998447B CN107998447B (en) | 2020-12-15 |
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| CN109705806A (en) * | 2018-12-27 | 2019-05-03 | 杭州恒煜医疗科技有限公司 | A kind of cancer radiation therapy compensates the production method of glue with tissue |
| CN113416022A (en) * | 2021-06-30 | 2021-09-21 | 西安中核核仪器有限公司 | Gamma detector energy response compensation material and use method thereof |
| CN113679958A (en) * | 2021-08-02 | 2021-11-23 | 无锡恒成医疗科技股份有限公司 | Equivalent tissue compensator and preparation method thereof |
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