CN109705806A - A kind of cancer radiation therapy compensates the production method of glue with tissue - Google Patents
A kind of cancer radiation therapy compensates the production method of glue with tissue Download PDFInfo
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- CN109705806A CN109705806A CN201811614221.2A CN201811614221A CN109705806A CN 109705806 A CN109705806 A CN 109705806A CN 201811614221 A CN201811614221 A CN 201811614221A CN 109705806 A CN109705806 A CN 109705806A
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- styrene
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- maleic anhydride
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- radiation therapy
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Abstract
The present invention provides a kind of production method of cancer radiation therapy tissue compensation glue, comprising the following steps: is S1, that 100:2:12~14:3~7 weigh solid paraffin, low density polyethylene (LDPE), styrene-maleic anhydride copolymer and crospovidone according to mass ratio；S2, styrene-maleic anhydride copolymer and crospovidone are mixed, and it is added 1,4- dioxane azeotropic, it is cooled to 10~20 DEG C again, keeps 30~40min, adds hydroxylamine hydrochloride and sodium methoxide reaction, add toluene azeotropic 5h, filtering, filter residue ether, water clean, and are dried under vacuum to constant weight up to synergist；S3, by solid paraffin, low density polyethylene (LDPE) and synergist mixing injection molding, molding, demould up to cancer radiation therapy tissue compensate glue.Production method proposed by the present invention, easy to operate, one-pass molding, the tissue compensation glue produced can be applied in cancer radiation therapy, good with the compactness of skin.
Description
Technical field
The present invention relates to the productions of medical material technical field more particularly to a kind of cancer radiation therapy tissue compensation glue
Method.
Background technique
Cancer is that normal regulation is lost due to body cell, disease caused by hyper-proliferative.The cell of hyper-proliferative claims
Cancer cell, cancer cell can often invade surrounding tissue, in addition can be transferred to through body-internal-circulation system and/or lymphatic system body other
Part.At present the therapeutic modality of cancer include operative treatment, chemotherapy, radiotherapy or it is several combine, wherein about
70% cancer patient needs to undergo radiotherapy in the therapeutic process of cancer, so therapeutic process of the radiotherapy in cancer
In play a crucial role.In radiation therapy process, high-energy ray after entering human body there are a dosage built-up areas,
Dosage behind built-up areas is only the actual dose for acting on human body.Due to one of the depth-dose distribution characteristic of different-energy ray
It is exactly to increase and field dose decline with ray energy, maximum dose point depth and percentage depth dose (maximum dose point) increase
Add, from surface to maximum dose, point depth is dosage built-up areas, when causing superficial tumor tune to radiate by force due to this characteristic, superficial
Projected dose is not achieved in target dose.Tissue indemnity would generally be used to be modified in superficial target area thus, to guarantee to radiate
Dosage it is accurate and uniform.But tissue indemnity used at present usually selects paraffin, vaseline to be made, these materials are not
Easily mixing, and the compactness for the tissue indemnity and skin made is undesirable, causes to deposit between tissue indemnity and skin
In gap, high-energy ray is caused to cause secondary buildup effect to skin, aggravates the damage of skin.Based on the deficiencies of the prior art,
The present invention proposes a kind of production method of cancer radiation therapy tissue compensation glue.
Summary of the invention
The purpose of the present invention is to solve the making materials of existing tissue indemnity to be not easy to mix, tissue obtained compensates
The problem of compactness of object and skin is undesirable, causes high-energy ray to cause secondary buildup effect to skin, aggravates skin injury,
And a kind of cancer radiation therapy proposed compensates the production method of glue with tissue.
In order to achieve the above object, the present invention is achieved by the following technical programs:
A kind of cancer radiation therapy compensates the production method of glue with tissue, comprising the following steps:
It S1, is that 100:2:12~14:3~7 weigh solid paraffin, low density polyethylene (LDPE), styrene-Malaysia according to mass ratio
Acid anhydride copolymer and crospovidone, it is spare；
Styrene-maleic anhydride copolymer and crospovidone are mixed, and Isosorbide-5-Nitrae-dioxane are added by S2, at room temperature
After 1~2h of azeotropic, 35~40 DEG C first are down to the cooling rate of 2 DEG C/min, then be down to 10~20 with the cooling rate of 1 DEG C/min
DEG C, 30~40min is kept after temperature is down to 10~20 DEG C, adds hydroxylamine hydrochloride and sodium methoxide reacts 8~10h, filter, then
Toluene azeotropic 5h is added, filtering, filter residue is cleaned 2~3 times with ether, then is washed with water 2~3 times, is dried under vacuum to constant weight to obtain the final product
Synergist；
S3, the synergist that the weighed solid paraffin of step S1, low density polyethylene (LDPE) and step S2 are prepared are added
Into mixer, after mixing, be added in mold, then it is cured molding, demould up to cancer radiation therapy group darning
Repay glue.
Preferably, the solid paraffin, low density polyethylene (LDPE), styrene-maleic anhydride copolymer and crospovidone
Mass ratio is 100:2:13:5.
Preferably, in step S2, the addition quality of the Isosorbide-5-Nitrae-dioxane is the 20 of styrene-maleic anhydride copolymer
Times, the addition quality of the hydroxylamine hydrochloride is 0.45~0.48 times of styrene-maleic anhydride copolymer, and the sodium methoxide adds
Enter 0.4~0.42 times that quality is styrene-maleic anhydride copolymer.
Preferably, the styrene-maleic anhydride copolymer is atactic styrene-maleic anhydride copolymer, 25 DEG C of density
It is 1.581 for 1.27g/ml, refractive index n20/D.
Preferably, in step S2, the vacuum drying temperature is 55~60 DEG C.
Production method proposed by the present invention, advantage is compared with prior art:
1, production method proposed by the present invention, easy to operate, one-pass molding, first by styrene-maleic anhydride copolymer and
Crospovidone is reacted, then is carried out mixing with solid paraffin and low density polyethylene (LDPE), injection molding, solidification, demoulded and have to obtain the final product
The tissue of good sticking nature compensates glue, can be applied in cancer radiation therapy, can solve without cumbersome multilayered structure
Traditional group is knitted between indemnity and skin there are gap, and high-energy ray is caused to cause secondary buildup effect to skin, aggravates skin
The problem of damage.
2, synergist used in the present invention is first by the styrene-maleic anhydride copolymer and crospovidone of rational proportion
The azeotropic in Isosorbide-5-Nitrae-dioxane, then cool down and hydroxylamine hydrochloride is added and sodium methoxide is reacted, azeotropic is then carried out in toluene
And obtain, the synergist obtained after reaction can either promote solid paraffin and low-density poly- due to the doping of crospovidone
The mixing of ethylene simplifies production stage, shortens the production cycle, and can guarantee the compactness between tissue compensation glue and skin, warp
Experiments have shown that synergist after crospovidone doping can auxiliary solid paraffin and low density polyethylene (LDPE) significantly reduce radiation and control
Damage of the high-energy ray to skin in treatment.
Specific embodiment
Combined with specific embodiments below the present invention is made further to explain.
Embodiment 1
A kind of cancer radiation therapy proposed by the present invention compensates the production method of glue with tissue, comprising the following steps:
It S1, is that weigh solid paraffin, low density polyethylene (LDPE), phenylethylene-maleic anhydride total by 100:2:12:3 according to mass ratio
Polymers and crospovidone, it is spare, the styrene-maleic anhydride copolymer be atactic styrene-maleic anhydride copolymer, 25
DEG C density is 1.27g/ml, and refractive index n20/D is 1.581；
Styrene-maleic anhydride copolymer and crospovidone are mixed, and styrene-maleic acid are added by S2, at room temperature
After 20 times of anhydride copolymer quality of Isosorbide-5-Nitrae-dioxane azeotropic 2h, be first down to 35 DEG C with the cooling rate of 2 DEG C/min, then with 1 DEG C/
The cooling rate of min is down to 10 DEG C, keeps 40min after temperature is down to 10 DEG C, adds styrene-maleic anhydride copolymer matter
The hydroxylamine hydrochloride of 0.45 times of amount and 0.4 times of styrene-maleic anhydride copolymer quality of sodium methoxide react 10h, and filtering adds
Toluene azeotropic 5h, filtering, filter residue is cleaned 2 times with ether, then is washed with water 3 times, is dried under vacuum to constant weight in 60 DEG C up to synergistic
Agent；
S3, the synergist that the weighed solid paraffin of step S1, low density polyethylene (LDPE) and step S2 are prepared are added
Into mixer, after mixing, be added in mold, then it is cured molding, demould up to cancer radiation therapy group darning
Repay glue.
Embodiment 2
A kind of cancer radiation therapy proposed by the present invention compensates the production method of glue with tissue, comprising the following steps:
It S1, is that weigh solid paraffin, low density polyethylene (LDPE), phenylethylene-maleic anhydride total by 100:2:13:5 according to mass ratio
Polymers and crospovidone, it is spare, the styrene-maleic anhydride copolymer be atactic styrene-maleic anhydride copolymer, 25
DEG C density is 1.27g/ml, and refractive index n20/D is 1.581；
Styrene-maleic anhydride copolymer and crospovidone are mixed, and styrene-maleic acid are added by S2, at room temperature
After 20 times of anhydride copolymer quality of Isosorbide-5-Nitrae-dioxane azeotropic 1h, be first down to 40 DEG C with the cooling rate of 2 DEG C/min, then with 1 DEG C/
The cooling rate of min is down to 15 DEG C, keeps 30min after temperature is down to 15 DEG C, adds styrene-maleic anhydride copolymer matter
The hydroxylamine hydrochloride of 0.47 times of amount and 0.41 times of styrene-maleic anhydride copolymer quality of sodium methoxide react 9h, and filtering adds
Toluene azeotropic 5h, filtering, filter residue is cleaned 3 times with ether, then is washed with water 3 times, is dried under vacuum to constant weight in 55 DEG C up to synergistic
Agent；
S3, the synergist that the weighed solid paraffin of step S1, low density polyethylene (LDPE) and step S2 are prepared are added
Into mixer, after mixing, be added in mold, then it is cured molding, demould up to cancer radiation therapy group darning
Repay glue.
Embodiment 3
A kind of cancer radiation therapy proposed by the present invention compensates the production method of glue with tissue, comprising the following steps:
It S1, is that weigh solid paraffin, low density polyethylene (LDPE), phenylethylene-maleic anhydride total by 100:2:14:7 according to mass ratio
Polymers and crospovidone, it is spare, the styrene-maleic anhydride copolymer be atactic styrene-maleic anhydride copolymer, 25
DEG C density is 1.27g/ml, and refractive index n20/D is 1.581；
Styrene-maleic anhydride copolymer and crospovidone are mixed, and styrene-maleic acid are added by S2, at room temperature
After 20 times of anhydride copolymer quality of Isosorbide-5-Nitrae -1~2h of dioxane azeotropic, 40 DEG C first are down to the cooling rate of 2 DEG C/min, then with 1
DEG C/cooling rate of min is down to 20 DEG C, 30min is kept after temperature is down to 20 DEG C, adds styrene-maleic anhydride copolymer
The hydroxylamine hydrochloride and 0.42 times of styrene-maleic anhydride copolymer quality of sodium methoxide that 0.48 times of amount of substance react 8h, filter, then
Toluene azeotropic 5h is added, filtering, filter residue is cleaned 3 times with ether, then is washed with water 2 times, is dried under vacuum to constant weight in 55 DEG C to obtain the final product
Synergist；
S3, the synergist that the weighed solid paraffin of step S1, low density polyethylene (LDPE) and step S2 are prepared are added
Into mixer, after mixing, be added in mold, then it is cured molding, demould up to cancer radiation therapy group darning
Repay glue.
Comparative example 1
A kind of cancer radiation therapy proposed by the present invention compensates the production method of glue with tissue, comprising the following steps:
It is that 100:2 weighs solid paraffin and low density polyethylene (LDPE) is added in mixer according to mass ratio, after mixing,
Be added in mold, then it is cured molding, demould up to cancer radiation therapy tissue compensate glue.
Comparative example 2
A kind of cancer radiation therapy proposed by the present invention compensates the production method of glue with tissue, comprising the following steps:
It S1, is that 100:2:12 weighs solid paraffin, low density polyethylene (LDPE) and styrene-maleic anhydride copolymer according to mass ratio
Object, spare, the styrene-maleic anhydride copolymer is atactic styrene-maleic anhydride copolymer, and 25 DEG C of density are 1.27g/
Ml, refractive index n20/D are 1.581；
20 times of styrene-maleic anhydride copolymer quality are added into styrene-maleic anhydride copolymer by S2, at room temperature
Isosorbide-5-Nitrae-dioxane azeotropic 2h after, be first down to 35 DEG C with the cooling rate of 2 DEG C/min, then drop with the cooling rate of 1 DEG C/min
To 10 DEG C, 40min is kept after temperature is down to 10 DEG C, adds 0.45 times of styrene-maleic anhydride copolymer quality of hydrochloric acid
Azanol and 0.4 times of styrene-maleic anhydride copolymer quality of sodium methoxide react 10h, and filtering adds toluene azeotropic 5h, mistake
Filter, filter residue is cleaned 2 times with ether, then is washed with water 3 times, is dried under vacuum to constant weight in 60 DEG C up to synergist；
S3, the synergist that the weighed solid paraffin of step S1, low density polyethylene (LDPE) and step S2 are prepared are added
Into mixer, after mixing, be added in mold, then it is cured molding, demould up to cancer radiation therapy group darning
Repay glue.
Comparative example 3
A kind of cancer radiation therapy proposed by the present invention compensates the production method of glue with tissue, comprising the following steps:
It S1, is that 100:2:3 weighs solid paraffin, low density polyethylene (LDPE) and crospovidone according to mass ratio, it is spare；
S2, at room temperature, after Isosorbide-5-Nitrae-dioxane azeotropic 2h is added into crospovidone, first with the cooling speed of 2 DEG C/min
Degree is down to 35 DEG C, then is down to 10 DEG C with the cooling rate of 1 DEG C/min, keeps 40min after temperature is down to 10 DEG C, adds hydrochloric acid
Azanol and sodium methoxide react 10h, and filtering adds toluene azeotropic 5h, filter, filter residue is cleaned 2 times with ether, then washes with water 3
It is secondary, constant weight is dried under vacuum in 60 DEG C up to synergist；The addition quality of the 1,4- dioxane, hydroxylamine hydrochloride and sodium methoxide
It is identical in quality with the addition in embodiment 1；
S3, the synergist that the weighed solid paraffin of step S1, low density polyethylene (LDPE) and step S2 are prepared are added
Into mixer, after mixing, be added in mold, then it is cured molding, demould up to cancer radiation therapy group darning
Repay glue.
Choosing 200 superficial tumors needs the patient of radiotherapy, and being divided between 4 groups, every group has statistical significance, the
One group use embodiment 1 produce obtain tissue compensation glue as patient radiation treatment when dosage compensation, second group use pair
The compensation of dosage, the tissue that third group is produced using comparative example 2 when the tissue compensation glue that ratio 1 produces is treated as patient radiation
The compensation of dosage when glue is treated as patient radiation is compensated, the 4th group of tissue for using comparative example 3 to produce compensates glue as patient
The compensation of dosage when radiotherapy.It is irradiated with 4~6MV X-ray, and determines dermoreaction, dermoreaction criterion
Are as follows: I degree, skin there is erythema, slight pigmentation itches or falls off；II degree, dry skin dermatitis, skin black furfur in the form of sheets；
III degree, moisture dermatitis, local edema, bubble are formed, and have diffusate, rotten to the corn, excoriation, pain；IV degree, skin ulcer, office
Portion's ulcer necrosis.Dermoreaction determines that result see the table below.
| I degree of ratio | II degree of ratio | III degree of ratio | IV degree of ratio | |
| First group | 56 | 44 | 0 | 0 |
| Second group | 26 | 50 | 16 | 8 |
| Third group | 32 | 56 | 8 | 4 |
| 4th group | 44 | 48 | 6 | 2 |
Dermoreaction is one of postoperative most common complication of superficial tumor radiotherapy, is added with after tissue equivalent's indemnity
Skin surface dosage can be improved, but also aggravated dermoreaction in various degree.When x-ray bombardment, tissue equivalent's indemnity and skin
If there is gap between skin, high-energy ray generates secondary buildup effect in gap, skin injury is aggravated, if skin injury is tight
Weight, influences treatment process, leads to that expected therapeutic effect is not achieved, eventually lead to cancer return.
First group as the result is shown (obtained tissue equivalent's glue is produced using embodiment 1) of above-mentioned experiment is carried out radiation and controlled
After treatment the damage of patient's skin compared with second and third, it is four groups small, patient skin damage is zero for III degree and IV degree of ratio, and I degree of ratio
Example occupies 50% or more；Second group (is not added styrene-maleic anhydride copolymer and crospovidone is raw in tissue equivalent's glue
Producing obtained tissue equivalent's glue) injury tolerance that carries out patient's skin after radiotherapy is heavier, and I degree of ratio only has 26%, and III degree
The summation damaged with IV degree has reached 24%；Third group (does not add the group that crospovidone produces in tissue compensation glue
Knit equivalent glue) or the 4th group (i.e. tissue compensation glue in do not add the tissue etc. that styrene-maleic anhydride copolymer produces
Effect glue) degree of injury of patient skin makes moderate progress compared to second group, but also has a certain distance compared to first group；It is real
It tests the result shows that styrene-maleic anhydride copolymer and crospovidone in tissue equivalent's glue of the present invention can be with auxiliary solid stones
Wax and low density polyethylene (LDPE) significantly reduce damage of the high-energy ray to skin in radiotherapy.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (5)
1. the production method that a kind of cancer radiation therapy compensates glue with tissue, which comprises the following steps:
It S1, is that 100:2:12~14:3~7 weigh solid paraffin, low density polyethylene (LDPE), phenylethylene-maleic anhydride according to mass ratio
Copolymer and crospovidone, it is spare；
Styrene-maleic anhydride copolymer and crospovidone are mixed, and Isosorbide-5-Nitrae-dioxane azeotropic 1 are added by S2, at room temperature
After~2h, 35~40 DEG C first are down to the cooling rate of 2 DEG C/min, then be down to 10~20 DEG C with the cooling rate of 1 DEG C/min, to
Temperature keeps 30~40min after being down to 10~20 DEG C, adds hydroxylamine hydrochloride and sodium methoxide reacts 8~10h, filtering adds
Toluene azeotropic 5h, filtering, filter residue is cleaned 2~3 times with ether, then is washed with water 2~3 times, is dried under vacuum to constant weight up to synergistic
Agent；
S3, the weighed solid paraffin of step S1, low density polyethylene (LDPE) and step the S2 synergist being prepared are added to it is close
In mill, after mixing, be added in mold, then it is cured molding, demould up to cancer radiation therapy tissue compensate glue.
2. the production method that a kind of cancer radiation therapy according to claim 1 compensates glue with tissue, which is characterized in that institute
The mass ratio for stating solid paraffin, low density polyethylene (LDPE), styrene-maleic anhydride copolymer and crospovidone is 100:2:13:
5。
3. the production method that a kind of cancer radiation therapy according to claim 1 compensates glue with tissue, which is characterized in that step
In rapid S2, the addition quality of the Isosorbide-5-Nitrae-dioxane is 20 times of styrene-maleic anhydride copolymer, the hydroxylamine hydrochloride
0.45~0.48 times that quality is styrene-maleic anhydride copolymer is added, the addition quality of the sodium methoxide is styrene-horse
0.4~0.42 times for carrying out acid anhydride copolymer.
4. a kind of cancer radiation therapy according to claim 1 or 2 or 3 compensates the production method of glue, feature with tissue
It is, the styrene-maleic anhydride copolymer is atactic styrene-maleic anhydride copolymer, and 25 DEG C of density are 1.27g/ml,
Refractive index n20/D is 1.581.
5. the production method that a kind of cancer radiation therapy according to claim 1 compensates glue with tissue, which is characterized in that step
In rapid S2, the vacuum drying temperature is 55~60 DEG C.
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| CN201811614221.2A CN109705806B (en) | 2018-12-27 | 2018-12-27 | Production method of tissue compensation glue for cancer radiotherapy |
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