CN107998447B - Conformal radiotherapy tissue equivalent compensation glue and preparation method and application thereof - Google Patents
Conformal radiotherapy tissue equivalent compensation glue and preparation method and application thereof Download PDFInfo
- Publication number
- CN107998447B CN107998447B CN201711389759.3A CN201711389759A CN107998447B CN 107998447 B CN107998447 B CN 107998447B CN 201711389759 A CN201711389759 A CN 201711389759A CN 107998447 B CN107998447 B CN 107998447B
- Authority
- CN
- China
- Prior art keywords
- layer
- tissue equivalent
- parts
- equivalent compensation
- conformal radiotherapy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
- A61L27/165—Rubbers
Abstract
The invention relates to conformal radiotherapy tissue equivalent compensation glue and a preparation method and application thereof, wherein the conformal radiotherapy tissue equivalent compensation glue comprises an uncured layer and a cured layer, the outer layers of the uncured layer and the cured layer are wrapped by protective layers, the uncured layer and the cured layer are prepared from the same raw material components, and the raw material components of the uncured layer and the cured layer are as follows in parts by weight: 70-90 parts of liquid rubber, 8-12 parts of epoxidized soybean oil acrylate, 3-5 parts of ethoxy ethyl acrylate and 0.2-0.8 part of bis (2, 6-difluoro-3-pyrrolylphenyl) titanocene. The preparation method is simple, the application steps are easy to operate, the tissue equivalent compensation adhesive prepared by using the liquid rubber and the epoxidized soybean oil acrylate as raw materials is soft and comfortable, the skin of a patient is well jointed, the generation of a cavity can be effectively prevented, the secondary building effect of high-energy rays is reduced, the tissue equivalent compensation adhesive can be formed according to the irradiation part condition of the patient, the repetition precision is high, the accuracy of tissue absorbed dose can be ensured, and the radiation reaction is reduced.
Description
Technical Field
The invention relates to conformal radiotherapy tissue equivalent compensation glue and a preparation method and application thereof, belonging to the technical field of medical supplies.
Background
Radiotherapy, as one of the three main means for treating malignant tumor, has been introduced in the "three-essence" era of precise positioning, precise planning and precise treatment, and each step is required to be precise from the beginning of radiotherapy preparation for a patient to the end of radiotherapy, mainly including the precision of position precision and the precision of absorbed dose of irradiated tissue.
The external radiation of radiotherapy mainly adopts high-energy X rays and high-energy electron rays, the high-energy X rays enter a human body and have a dose built-up area, the slope of a dose curve before the dose built-up area is larger and is related to the energy of the rays, even the energy of the high-energy X rays is larger, the surface dose is lower, therefore, the section is avoided being used as the calculation of the uniform tissue absorbed dose clinically, the tissue absorbed dose is calculated by adopting a section with a relatively flat dose curve after the built-up area, therefore, tissue equivalent compensators are frequently used for the radiation of a superficial tumor or a superficial target area, and the uniformity and the accuracy of the tissue absorbed dose are ensured, such as the improvement of breast cancer, the radical treatment of skin cancer, eccentric tumors of each part, cervical metastatic tumors and the like.
The tissue equivalent compensators adopted at present comprise paraffin, vaseline, water sac, special silica gel, formed compensation films and the like, are self-made and commercially available, and cover on a human body to show that the tissue equivalent compensators are too hard to be completely matched with the skin of a patient, have uncertain equivalent depth with uneven thickness, too poor repeatability and the like, and can often generate cavities due to poor adhesion of the tissue equivalent compensators when the body shape of the patient is curved, scars after operation and irregular tumor appearance.
Currently, methods for avoiding the use of hollow cavities for tissue equivalent compensators include:
(1) and forming a fixing band of the tissue equivalent compensation film. Although the cavity can be reduced by adding a certain external force, the method can not effectively eliminate the curved surface of the skin of a patient, the postoperative scar, the uneven tumor and the like, and even increase the cavity.
(2) And (3) the 3D printing technology is adopted to print the compensators of the patient according to the outline of the patient reconstructed by the CT. The used material of this technique is resin and silica gel, has certain hardness, and patient's comfort level is not high, and the while is repeated during radiotherapy to be put the position at every turn and is required to laminate well, otherwise increases the cavity on the contrary to it is not short during the preparation.
Disclosure of Invention
The invention aims to solve the problem that a cavity is easily formed in the use process of the conventional tissue equivalent compensator to influence the radiation effect of radiotherapy, and provides conformal radiotherapy tissue equivalent compensation glue, and a preparation method and application thereof.
The invention adopts the following technical scheme: the tissue equivalent compensation glue for conformal radiotherapy comprises an uncured layer and a cured layer, wherein the outer layers of the uncured layer and the cured layer are wrapped by a protective layer, the uncured layer and the cured layer are made of the same raw material components, and the raw material components of the uncured layer and the cured layer are as follows in parts by weight: 70-90 parts of liquid rubber, 8-12 parts of epoxidized soybean oil acrylate, 3-5 parts of ethoxy ethyl acrylate and 0.2-0.8 part of bis (2, 6-difluoro-3-pyrrolylphenyl) titanocene.
Further, the thickness of the cured layer is 3 to 15mm.
Further, the thickness of the uncured layer is 0.1 to 20 mm.
Furthermore, the protective layer is made of medical PVC materials.
Further, the density of the tissue equivalent compensation glue is 1-1.1 g/cm3。
Further, the thickness of the protective layer is 0.2-0.5 mm.
A preparation method of conformal radiotherapy tissue equivalent compensation glue comprises the following steps: the method comprises the following steps:
(1) taking 70-90 parts of liquid rubber by weight in a light-shielding state, sequentially adding 3-5 parts of ethoxy ethyl acrylate, 8-12 parts of epoxy soybean oil acrylate and 0.2-0.8 part of bis-2, 6-difluoro-3-pyrrolyl phenyl titanocene in a stirring state, fully stirring for 1-1.5h, fully stirring the mixture for 1-1.5h, and removing bubbles;
(2) placing the mixture in a mold body, and curing for 2-10min under natural light conditions to form a cured layer;
(3) coating the mixture on the solidified layer to form an uncured layer;
(4) and a protective layer is wrapped outside the uncured layer and the cured layer.
Further, in the step (1), a vacuum pump is adopted to pump for 2-5min to completely remove air bubbles in the mixture.
The application of the conformal radiotherapy tissue equivalent compensation glue comprises the following steps: contacting the surface of the uncured layer with the skin of a patient, curing under an artificial sun lamp with the wavelength of 400nm for 2-5min to form the tissue equivalent compensation glue which is completely matched with the body shape of the part to be treated of the patient.
According to the invention, the liquid rubber is used as a flexible component, the epoxy soybean oil acrylate is used as a light-cured resin, the hardness of the material is changed by adjusting the proportion between the light-cured resin and the liquid rubber, the flexibility and the comfort are ensured, the component compatibility and the system viscosity are adjusted by an active diluent, the stability of colloid is ensured, and the light polymerization is initiated by a photoinitiator, so that the forming effect is achieved.
The preparation method is simple, the steps are easy to operate, the tissue equivalent compensation adhesive prepared by adopting the liquid rubber and the epoxidized soybean oil acrylate as raw materials is soft and comfortable, the skin of a patient is well jointed, the generation of a cavity can be effectively prevented, the secondary building effect of high-energy rays is reduced, the forming can be carried out according to the irradiation part condition of the patient, the repetition precision is high, the accuracy of tissue absorbed dose can be ensured, and the radiation reaction is reduced.
Drawings
FIG. 1 is a schematic structural view of the present invention
Reference numerals: protective layer 1, uncured layer 2, cured layer 3.
Detailed Description
The present invention will be further described with reference to specific examples.
Example 1:
the utility model provides a conformal radiotherapy tissue equivalent compensation glue, includes uncured layer and cured layer, the outer parcel of uncured layer and cured layer has the protective layer, and the thickness of cured layer is 3mm, and the thickness of uncured layer is 0.1mm, and the protective layer adopts medical PVC material to make, and the thickness of protective layer is 0.2mm, and uncured layer and cured layer adopt the same raw materials component, and the raw materials component of uncured layer and cured layer is counted according to the part by weight: 70 parts of liquid rubber, 12 parts of epoxidized soybean oil acrylate, 3 parts of ethoxy ethyl acrylate and 0.2 part of bis (2, 6-difluoro-3-pyrrolylphenyl) titanocene.
A preparation method of conformal radiotherapy tissue equivalent compensation glue comprises the following steps: the method comprises the following steps:
(1) taking 70 parts of liquid rubber according to parts by weight in a light-shielding state, sequentially adding 3 parts of ethoxy ethyl acrylate, 12 parts of epoxy soybean oil acrylate and 0.2 part of bis 2, 6-difluoro-3-pyrrolylphenyl titanocene in a stirring state, fully stirring for 1.5h, and removing bubbles in the mixture by using a vacuum pump;
(2) placing the mixture in a mold body, and curing for 2min under natural light conditions to form a cured layer;
(3) coating the mixture on the solidified layer to form an uncured layer;
(4) and a protective layer is wrapped on the outer sides of the uncured layer and the cured layer, and the protective layer is sealed and then stored in a dark condition.
Example 2:
the utility model provides a conformal radiotherapy tissue equivalent compensation glue, includes uncured layer and cured layer, the outer parcel of uncured layer and cured layer has the protective layer, the thickness of cured layer is 10mm, the thickness of uncured layer is x-xmm, the protective layer adopts medical PVC material to make, the thickness of protective layer is 0.5mm, uncured layer and cured layer adopt the same raw materials component to make, the raw materials component of uncured layer and cured layer is counted according to the part by weight: 85 parts of liquid rubber, 10.5 parts of epoxidized soybean oil acrylate, 4.5 parts of ethoxy ethyl acrylate and 0.5 part of bis-2, 6-difluoro-3-pyrrolylphenyl titanocene.
A preparation method of conformal radiotherapy tissue equivalent compensation glue comprises the following steps: the method comprises the following steps:
(1) taking 85 parts of liquid rubber according to parts by weight in a light-shielding state, sequentially adding 4.5 parts of ethoxy ethyl acrylate, 10.5 parts of epoxy soybean oil acrylate and 0.5 part of bis-2, 6-difluoro-3-pyrrolylphenyl titanocene in a stirring state, fully stirring for 1h, and removing bubbles in the mixture by using a vacuum pump;
(2) placing the mixture in a mold body, and curing for 8min under natural light conditions to form a cured layer;
(3) coating the mixture on the solidified layer to form an uncured layer;
(4) and a protective layer is wrapped on the outer sides of the uncured layer and the cured layer, and the protective layer is sealed and then stored in a dark condition.
Example 3:
the utility model provides a conformal radiotherapy tissue equivalent compensation glue, includes uncured layer and cured layer, the outer parcel of uncured layer and cured layer has the protective layer, and the thickness of cured layer is 15mm, and the thickness of uncured layer is 20mm, and the protective layer adopts medical PVC material to make, and the thickness of protective layer is 0.2mm, and uncured layer and cured layer adopt the same raw materials component, and the raw materials component of uncured layer and cured layer is counted according to the part by weight: 90 parts of liquid rubber, 8 parts of epoxidized soybean oil acrylate, 5 parts of ethoxy ethyl acrylate and 0.8 part of bis (2, 6-difluoro-3-pyrrolylphenyl) titanocene.
A preparation method of conformal radiotherapy tissue equivalent compensation glue comprises the following steps: the method comprises the following steps:
(1) taking 90 parts by weight of liquid rubber in a light-shielding state, sequentially adding 5 parts of ethoxy ethyl acrylate, 8 parts of epoxy soybean oil acrylate and 0.8 part of bis 2, 6-difluoro-3-pyrrolyl phenyl titanocene in a stirring state, fully stirring for 1h, and removing bubbles in the mixture by using a vacuum pump;
(2) placing the mixture in a mold body, and curing for 10min under natural light conditions to form a cured layer;
(3) coating the mixture on the solidified layer to form an uncured layer;
(4) and a protective layer is wrapped on the outer sides of the uncured layer and the cured layer, and the protective layer is sealed and then stored in a dark condition.
The conformal radiotherapy tissue equivalent compensation glue prepared in the second embodiment is used for clinical effect test, and the method comprises the following steps:
selecting 50 patients needing radiation therapy after improved radical treatment of breast cancer, randomly dividing into a control group and a test group, respectively covering the existing 30cm 0.3cm tissue equivalent compensator in the current market and the conformal radiotherapy tissue equivalent compensation glue with the same specification prepared by the invention on the skin surface of the local chest wall needing irradiation of the patient before CT simulation, fixing the body membrane, then carrying out CT scanning, transmitting the image to a treatment planning system, delineating the target area and the endangered organ, simultaneously delineating the cavity between the compensator and the skin, and adopting 6MV X-ray
The design of the intensity modulation plan is carried out, DT is 50Gy/25fx, and the average cavity number (cavities) is compared
) Average maximum cavity volume (cavity Vmax, unit: ml), sub-cavity skin spot dose variability (spot dose S), patient interrogation for compensator comfort during radiation delivery, and observation of patient chest wall skin pigmentationThe results are shown in Table 1, together with the skin reactions within 2 weeks after radiation therapy.
TABLE 1 statistical table of clinical trials
As shown in Table 1, the test group using the tissue equivalent compensation gel for conformal radiotherapy has good comfort for patients, basically eliminates the cavity between the tissue equivalent compensation gel and the skin of the patients, has uniform dose distribution and high accuracy, obviously reduces severe skin reaction, and has good effect.
Claims (9)
1. The equivalent compensation glue for conformal radiotherapy tissues is characterized in that: the protective layer comprises an uncured layer (2) and a cured layer (3), wherein the protective layer (1) is wrapped on the outer layer of the uncured layer (2) and the cured layer (3), the uncured layer (2) and the cured layer (3) are made of the same raw material components, and the raw material components of the uncured layer (2) and the cured layer (3) are as follows in parts by weight: 70-90 parts of liquid rubber, 8-12 parts of epoxidized soybean oil acrylate, 3-5 parts of ethoxy ethyl acrylate and 0.2-0.8 part of bis (2, 6-difluoro-3-pyrrolylphenyl) titanocene.
2. The conformal radiotherapy tissue equivalent compensation glue of claim 1, wherein: the thickness of the cured layer (3) is 3-15mm.
3. The conformal radiotherapy tissue equivalent compensation glue of claim 1, wherein: the thickness of the uncured layer (2) is 0.1-20 mm.
4. The conformal radiotherapy tissue equivalent compensation glue of claim 1, wherein: the protective layer (1) is made of medical PVC materials.
5. The conformal radiotherapy tissue equivalent compensation glue of claim 1, wherein: density of the tissue equivalent compensation gelThe degree of the reaction is 1 to 1.1g/cm3。
6. The conformal radiotherapy tissue equivalent compensation glue of claim 1, wherein: the thickness of the protective layer (1) is 0.2-0.5 mm.
7. The method for preparing tissue equivalent compensation glue for conformal radiotherapy according to claim 1, wherein the method comprises the following steps: the method comprises the following steps:
(1) taking 70-90 parts of liquid rubber by weight in a light-resistant state, sequentially adding 3-5 parts of ethoxy ethyl acrylate, 8-12 parts of epoxy soybean oil acrylate and 0.2-0.8 part of bis-2, 6-difluoro-3-pyrrolyl phenyl titanocene in a stirring state, fully stirring the mixture for 1-1.5h, and removing bubbles;
(2) placing the mixture in a mold body, and curing for 2-10min under natural light conditions to form a cured layer;
(3) coating the mixture on the solidified layer to form an uncured layer;
(4) and a protective layer is wrapped outside the uncured layer and the cured layer.
8. The method for preparing tissue equivalent compensation glue for conformal radiotherapy according to claim 7, wherein the method comprises the following steps: and (2) pumping for 2-5min by using a vacuum pump in the step (1) to completely discharge bubbles in the mixture.
9. Use of the tissue equivalent compensation gel for conformal radiotherapy according to claim 1, wherein: the surface of the uncured layer (2) is contacted with the skin of a patient, and is cured under an artificial sun lamp with the wavelength of 400nm for 2-5min to form the tissue equivalent compensation adhesive which is completely matched with the body shape of the part to be treated of the patient.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711389759.3A CN107998447B (en) | 2017-12-21 | 2017-12-21 | Conformal radiotherapy tissue equivalent compensation glue and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711389759.3A CN107998447B (en) | 2017-12-21 | 2017-12-21 | Conformal radiotherapy tissue equivalent compensation glue and preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107998447A CN107998447A (en) | 2018-05-08 |
| CN107998447B true CN107998447B (en) | 2020-12-15 |
Family
ID=62060288
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711389759.3A Active CN107998447B (en) | 2017-12-21 | 2017-12-21 | Conformal radiotherapy tissue equivalent compensation glue and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107998447B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109705806B (en) * | 2018-12-27 | 2020-12-15 | 杭州恒煜医疗科技有限公司 | Production method of tissue compensation glue for cancer radiotherapy |
| CN113416022B (en) * | 2021-06-30 | 2022-04-26 | 西安中核核仪器股份有限公司 | Gamma detector energy response compensation material and use method thereof |
| CN113679958B (en) * | 2021-08-02 | 2023-03-24 | 无锡恒成医疗科技股份有限公司 | Equivalent tissue compensator and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH095521A (en) * | 1995-06-21 | 1997-01-10 | Teijin Ltd | Optical compensating film and liquid crystal display device |
| CN203291395U (en) * | 2013-06-14 | 2013-11-20 | 中国人民解放军第四军医大学 | A thermoplastic tissue compensation composite fixing film |
| CN103842457A (en) * | 2011-09-30 | 2014-06-04 | 3M创新有限公司 | A conformable coating and composition |
| CN104945574A (en) * | 2015-05-19 | 2015-09-30 | 北京化工大学 | Preparation method of elastomer material |
| CN105664377A (en) * | 2016-01-26 | 2016-06-15 | 成都博瑞三文科技有限公司 | Personalized silicone rubber equivalent compensation body membrane and preparation method thereof |
| CN106039598A (en) * | 2016-06-30 | 2016-10-26 | 北京启麟科技有限公司 | Tissue equivalent replenisher for radiotherapy and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6565604B2 (en) * | 2000-12-05 | 2003-05-20 | F & E Gesellschaft Fur Bekleidungs-Innovation Gmbh & Co. Kg | Symmetrical breast prosthesis |
-
2017
- 2017-12-21 CN CN201711389759.3A patent/CN107998447B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH095521A (en) * | 1995-06-21 | 1997-01-10 | Teijin Ltd | Optical compensating film and liquid crystal display device |
| CN103842457A (en) * | 2011-09-30 | 2014-06-04 | 3M创新有限公司 | A conformable coating and composition |
| CN203291395U (en) * | 2013-06-14 | 2013-11-20 | 中国人民解放军第四军医大学 | A thermoplastic tissue compensation composite fixing film |
| CN104945574A (en) * | 2015-05-19 | 2015-09-30 | 北京化工大学 | Preparation method of elastomer material |
| CN105664377A (en) * | 2016-01-26 | 2016-06-15 | 成都博瑞三文科技有限公司 | Personalized silicone rubber equivalent compensation body membrane and preparation method thereof |
| CN106039598A (en) * | 2016-06-30 | 2016-10-26 | 北京启麟科技有限公司 | Tissue equivalent replenisher for radiotherapy and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107998447A (en) | 2018-05-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107998447B (en) | Conformal radiotherapy tissue equivalent compensation glue and preparation method and application thereof | |
| CN106039598B (en) | Radiotherapy tissue equivalent indemnity and preparation method thereof | |
| CN103285527B (en) | Apparatus and method for immobilizing patients for breast radiation therapy | |
| CN105664377B (en) | A kind of personalization silica gel equivalent compensation body film and preparation method thereof | |
| Chiu et al. | Three-dimensional printer-aided casting of soft, custom silicone boluses (SCSBs) for head and neck radiation therapy | |
| US8219354B2 (en) | Bolus for radiotherapy and method for determining the shape of such a bolus | |
| Wiebe et al. | Customized vaginal vault brachytherapy with computed tomography imaging-derived applicator prototyping | |
| CN108187242A (en) | Personalized silica gel indemnity for adjusting target of prophylactic radiotherapy dosage and preparation method thereof | |
| Kowalik et al. | Individual applicator for brachytherapy for various sites of superficial malignant lesions | |
| Wang et al. | The clinical application of 3D-printed boluses in superficial tumor radiotherapy | |
| Park et al. | Development and dosimetric assessment of a patient-specific elastic skin applicator for high-dose-rate brachytherapy | |
| CN112552661B (en) | Plastic tissue compensation glue and preparation method thereof | |
| CN205924729U (en) | A organize equivalent compensation arrangement for cancer radiation therapy | |
| CN110769896B (en) | Method, apparatus and system for manufacturing patient-specific soft filler for radiation therapy | |
| CN110882490A (en) | Preparation method and application method of individualized compensation film | |
| CN211158198U (en) | Tissue compensation membrane | |
| Wang et al. | 3D-printed bolus ensures the precise postmastectomy chest wall radiation therapy for breast cancer | |
| CN209529927U (en) | A kind of equivalent tissue compensation block | |
| CN214181487U (en) | Compensation mould for radiotherapy after breast cancer operation | |
| CN214181488U (en) | Compensation mould for radiotherapy of superficial tumor on head surface | |
| Scherf et al. | Individualized mould-based high-dose-rate brachytherapy for perinasal skin tumors: technique evaluation from a dosimetric point of view | |
| CN112957619A (en) | Method for producing tissue compensation film and tissue compensation film | |
| KR20190122637A (en) | Bolus for radiotheraphy in cancer and preparing method thereof | |
| CN113679958B (en) | Equivalent tissue compensator and preparation method thereof | |
| Zhang et al. | Application value of 3D-printed Bolus in radiotherapy after radical mastectomy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |