CN107997855A - 3D porous supports method for establishing model, device and preparation system - Google Patents
3D porous supports method for establishing model, device and preparation system Download PDFInfo
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- CN107997855A CN107997855A CN201711239691.0A CN201711239691A CN107997855A CN 107997855 A CN107997855 A CN 107997855A CN 201711239691 A CN201711239691 A CN 201711239691A CN 107997855 A CN107997855 A CN 107997855A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2/2846—Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y70/00—Materials specially adapted for additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
Abstract
A kind of 3D porous supports method for establishing model, device and preparation system provided by the invention, are related to medicine technology field.The 3D porous supports method for establishing model is included according to bone lesion or defect CT images data, obtain the bone density distribution of outline data and stent to be built corresponding each pixel in CT images data of stent to be built, select the primitive of the topological structure type of minimal structure, and structural motif and outline data generation uniform porosity initial support model based on the topological classification chosen, the porosity of each structural motif and pore size in initial support model are adjusted using the bone density distribution of corresponding each pixel, to generate the 3D porous support models of the corresponding class cancellous bone of stent to be built.The porous support printed according to the 3D porous supports model of class cancellous bone, meets the bionical micro-structure of bone defect position biomechanics characteristic, meets the cell growth microenvironment such as migration, differentiation and propagation of cell.
Description
Technical field
The present invention relates to medicine technology field, in particular to a kind of 3D porous supports method for establishing model, device and
Preparation system.
Background technology
In field of orthopaedics, osseous lesion, bone defect ten caused by many reasons such as severe trauma, bone tumour, osteomyelitis
Divide common.Currently used bone renovating material includes autologous bone and metal prostheses.Autologous bone adds the wound and pain of patient；
There is the problems such as loosening, stress shielding in metal prostheses.Therefore, artificial bone substitute materials repairing bone defect becomes medicine emphasis.System
Standby bioactivity, porous stenter to implant body defect, carrier is provided for cell growth, propagation and differentiation, formed it is new with oneself
The tissue or organ that body function and anatomic form are adapted, achieve the purpose that gentrify diseased region, have important society
Can benefit.Current porous support preparation method is unsatisfactory, although can accomplish to meet lesion, defect area in shape
Personalized shape, but can not realize the class cancellous bone loose structure for meeting biomechanical properties in bones feature, it can not provide and people's bone photo
Same biomechanics characteristic and the microenvironment of cell growth.
The content of the invention
It is an object of the invention to provide a kind of 3D porous supports method for establishing model, device and preparation system, to change
The kind above problem.
To achieve these goals, the technical solution that the embodiment of the present invention uses is as follows：
In a first aspect, the embodiment of the present invention provides a kind of 3D porous supports method for establishing model, the described method includes：According to
The outline data of CT images data and the stent to be built being obtained ahead of time, obtains the stent to be built in the CT images data
In corresponding each pixel bone density distribution；Structural motif and the outline data based on the topological classification chosen in advance
Generate initial support model；The hole to the initial support model is distributed using the bone density of corresponding each pixel
Rate and pore size are adjusted, to generate the 3D porous support models of the corresponding class cancellous bone of the stent to be built.
Second aspect, the embodiment of the present invention provide a kind of 3D porous supports model foundation device, and described device includes：Obtain
Module, for the outline data according to CT images data and the stent to be built being obtained ahead of time, obtains the stent to be built and exists
The bone density distribution of corresponding each pixel in the CT images data；Module is built, for based on the topology chosen in advance
The structural motif of type and outline data generation initial support model；Module is adjusted, it is described corresponding each for utilizing
The bone density distribution of pixel is adjusted the initial support model, to generate the corresponding class spongiosa of the stent to be built
The 3D porous support models of bone.
The third aspect, the embodiment of the present invention provide a kind of 3D porous supports model preparation system, and the system comprises 3D to beat
Print machine and modeling terminal, the 3D printer are electrically connected with the modeling terminal, the system comprises：The modeling terminal,
Outline data for the stent to be built being obtained ahead of time according to CT images data and acquisition, obtains the stent to be built in institute
State the bone density distribution of corresponding each pixel in CT images data；The modeling terminal, is additionally operable to based on choosing in advance
The structural motif of topological classification and outline data generation initial support model；The modeling terminal, is additionally operable to using described
The bone density distribution of corresponding each pixel is adjusted the initial support model, and the generation stent to be built corresponds to
Class cancellous bone 3D porous supports model and send to the 3D printer；The 3D printer, for more according to the 3D
Hole stent model printing generation class cancellous bone 3D porous supports.
Compared with prior art, a kind of 3D porous supports method for establishing model provided in an embodiment of the present invention, passes through basis
The outline data of CT images data and stent to be built, it is corresponding every in the CT images data to obtain the stent to be built
The bone density distribution of a pixel, recycles the bone density of corresponding each pixel to be distributed to being generated according to outline data
Initial support model be adjusted, to generate the 3D porous support models of the class cancellous bone of per-sonalization structures gradient.So that root
The porous support printed according to 3D porous supports model meets the bionical micro-structure of the biomechanics characteristic at bone defect position, meanwhile, also
It can meet the cell growth microenvironment such as migration, differentiation and breeding of osteocyte.
To enable the above objects, features and advantages of the present invention to become apparent, preferred embodiment cited below particularly, and coordinate
Appended attached drawing, is described in detail below.
Brief description of the drawings
In order to illustrate the technical solution of the embodiments of the present invention more clearly, below will be to needed in the embodiment attached
Figure is briefly described, it will be appreciated that the following drawings illustrate only certain embodiments of the present invention, therefore be not construed as pair
The restriction of scope, for those of ordinary skill in the art, without creative efforts, can also be according to this
A little attached drawings obtain other relevant attached drawings.
Fig. 1 shows a kind of schematic diagram for 3D porous supports model preparation system that present pre-ferred embodiments provide.
Fig. 2 is the block diagram that terminal is modeled in Fig. 1.
Fig. 3 shows a kind of flow chart for 3D porous supports method for establishing model that present pre-ferred embodiments provide.
Fig. 4 is the sub-step flow chart of step S103 in Fig. 3.
Fig. 5 shows the schematic diagram of a part of loose structure of initial support model provided in an embodiment of the present invention.
Fig. 6 is a kind of structure diagram of the structural motif of topological classification provided in an embodiment of the present invention.
Fig. 7 is the sub-step flow chart of step S105 in Fig. 3.
Fig. 8 shows that a kind of function module for 3D porous supports model foundation device that present pre-ferred embodiments provide is shown
It is intended to.
Fig. 9 is the function sub-modules schematic diagram that module is adjusted in Fig. 8.
Icon：100-3D porous support model preparation systems；111- memories；112- processors；113- communication units；
200-3D porous support model foundation devices；201- extraction modules；202- generation modules；203- acquisition modules；204- builds mould
Block；205- adjusts module；2051- determination sub-modules；2052- calculating sub modules；2053- adjusts submodule；2054- builds submodule
Block；206- sending modules；300- models terminal；400-3D printers；10- structural motifs；The first sides of 11-；The second sides of 12-；13-
Vertex；20- loose structures.
Embodiment
Below in conjunction with attached drawing in the embodiment of the present invention, the technical solution in the embodiment of the present invention is carried out clear, complete
Ground describes, it is clear that described embodiment is only part of the embodiment of the present invention, instead of all the embodiments.Usually exist
The component of the embodiment of the present invention described and illustrated in attached drawing can be arranged and designed with a variety of configurations herein.Cause
This, the detailed description of the embodiment of the present invention to providing in the accompanying drawings is not intended to limit claimed invention below
Scope, but it is merely representative of the selected embodiment of the present invention.Based on the embodiment of the present invention, those skilled in the art are not doing
Go out all other embodiments obtained on the premise of creative work, belong to the scope of protection of the invention.
It should be noted that：Similar label and letter represents similar terms in following attached drawing, therefore, once a certain Xiang Yi
It is defined, then it further need not be defined and explained in subsequent attached drawing in a attached drawing.Meanwhile of the invention real
In the description for applying example, term " first ", " second " etc. are only used for distinguishing description, and it is not intended that indicating or implying relatively important
Property.
The 3D modeling softwares such as Mimics, Simpleware, Amira widely used at present can be according to medicine such as CT/MRI
Image carries out three-dimensional reconstruction to anatomical structure, disclosure satisfy that the personalized geometry appearance feature modeling of bone defect healing requirement will
Ask.But inventor has found the uniform porosity porous stent structure of the porous support printed using 3D printer 400, can not realize
Class cancellous bone is emulated, and biomechanics characteristic and cell growth microenvironment and people's bone are inconsistent.Cause using effect bad.
In order to realize that the porous support 3D printed meets the biomechanics characteristic at bone defect position, meet moving for cell
The microenvironment of the cell growths such as shifting, differentiation and propagation, precisely repairs for bone defect and provides strong instrument.The embodiment of the present invention
Provide a kind of 3D porous supports method for establishing model, device and preparation system.Please refer to Fig.1, the porous branch of 3D as shown in Figure 1
Frame model preparation system 100 includes modeling terminal 300 and 3D printer 400, and modeling terminal 300 is connected with 3D printer 400.
Alternatively, it is PC (personal computer, PC), tablet electricity that the modeling terminal 300, which may be, but not limited to,
Brain, intelligent terminal, notebook tablet computer etc..
Please refer to Fig.2, Fig. 2 is the block diagram of the modeling terminal 300.It is porous that the modeling terminal 300 includes 3D
Stent model establishes device 200, memory 111, processor 112, communication unit 113.
The memory 111, processor 112 and 113 each element of communication unit are directly or indirectly electrical between each other
Connection, to realize the transmission of data or interaction.For example, these elements can pass through one or more communication bus or letter between each other
Number line, which is realized, to be electrically connected.The 3D porous supports model foundation device 200 include it is at least one can be with software or firmware
(firmware) form is stored in the memory 111 or is solidificated in the operating system (operating of modeling terminal 300
System, OS) in software function module.The processor 112 is used to perform the executable mould stored in the memory 111
Block, such as software function module included by the 3D porous supports model foundation device 200 and computer program etc..
Wherein, the memory 111 may be, but not limited to, random access memory (Random Access
Memory, RAM), read-only storage (Read Only Memory, ROM), programmable read only memory (Programmable
Read-Only Memory, PROM), erasable read-only memory (Erasable Programmable Read-Only
Memory, EPROM), electricallyerasable ROM (EEROM) (Electric Erasable Programmable Read-Only
Memory, EEPROM) etc..Wherein, memory 111 is used for storage program and voice data, and the processor 112 is receiving
After execute instruction, described program is performed.
The communication unit 113 is used to establish between the modeling terminal 300 and 3D printer 400 by the network
Communication connection, and for passing through the network transceiving data.The communication unit 113 can also connect with CT images harvester
Connect, for just receiving the CT images data of CT images harvester collection.
The 3D printer 400 is connected with the modeling terminal 300, the stl exported for receiving the modeling terminal 300
The model of form, and printed.To generate the 3D porous supports that user builds in modeling terminal 300.
First embodiment
Fig. 3 is refer to, is that the 3D for being applied to the modeling terminal 300 shown in Fig. 1 that present pre-ferred embodiments provide is porous
The flow chart of stent model method for building up.The 3D porous supports method for establishing model comprises the following steps：
Step S101, extracts organizational boundary's profile of lesion region or defect area from the CT images data of acquisition in advance.
Above-mentioned CT images data can directly be received by modeling terminal 300 from CT images harvester, can also be advance
Import the modeling terminal 300.The CT images data can include Ipsilateral region CT images data and with Ipsilateral region phase
For the CT images data in the symmetrical side region of human body axis.For example, affected part is located at left knee, then the CT images number obtained
According to the CT images data and the CT images data of right knee area corresponding with left knee that can include left knee region.
Above-mentioned lesion region may be, but not limited to, due to severe trauma, bone tumour, osteomyelitis, bone necrosis,
Bone tissue lesion region caused by Bone and joint trauma etc..Above-mentioned absent region can be the region for occurring bone tissue missing.The two
Difference lies in CT images data the corresponding CT values of lesion region bone tissue can be extracted in lesion region, and in absent region
Extraction CT values corresponding less than missing bone tissue.
In present pre-ferred embodiments, from the lesion region of CT images extracting data personalization or the group of defect area
Boundary profile is knitted, to generate the outline data of lesion region or defect area.Alternatively, when the tissue side of extraction lesion region
, can be directly from the corresponding CT images extracting data of lesion region during boundary's profile.When organizational boundary's wheel of extraction absent region
When wide, with reference to the CT images data of the absent region and with absent region relative to the symmetrical side normal bone of human body axis
The CT images data in region are extracted.It should be noted that human skeleton is symmetrical along human body central axes, under normal circumstances relatively
The CT values of the normal bone tissues of title are essentially identical.
Step S102, the outline data of the stent to be built is generated according to organizational boundary's profile.
Above-mentioned stent to be built can be the 3D for needing to be fabricated to replace the bone tissue of lesion region or defect area
Porous support.Above-mentioned outline data can be the profile parameters of the macro geometry of the stent to be built.According to the tissue side
Boundary's profile generates the outline data of stent to be built, so that stent to be built in shape can be with replacing region bone tissue
Border agree with.Stent to be built is set to possess personalized exterior geometric shape to meet bone defect formalness scrambling.
Step S103, according to CT images data and the outline data for the stent to be built being obtained ahead of time, structure is treated described in acquisition
Build the bone density distribution of stent corresponding each pixel in the CT images data.
In embodiments of the present invention, can be obtained in CT images data in organizational boundary corresponding with outline data profile
Each pixel, determined and each position pair of stent to be built further according to the correspondence of outline data and organizational boundary's profile
The pixel answered.And the corresponding multiple bone densities of stent to be built are obtained according to the correspondence pixel and are distributed.As one kind
Embodiment, can be with as shown in figure 4, step S103 may comprise steps of：
Sub-step S1031, the outline data of the stent to be built previously generated according to CT images data and acquisition, obtains institute
State the CT values of stent to be built corresponding each pixel in the CT images data.
In embodiments of the present invention, can be by obtaining the corresponding organizational boundary's profile of outline data from CT images data
The CT values of each interior pixel.Alternatively, when the stent to be built is the bone tissue for replacing lesion region, directly
The CT values of each pixel in the corresponding organizational boundary's profile of outline data are obtained in the CT images data in Ipsilateral region.Work as institute
When to state stent to be built be the bone tissue for replacing defect area, then from symmetrical relative to human body axis with Ipsilateral region
The CT values of each corresponding pixel of outline data are obtained in the CT images data in side normal bone tissues region.
Sub-step S1032, according to the CT values of corresponding each pixel, using interpolation method, calculates described corresponding
The bone density distribution of each pixel.
Above-mentioned CT values can characterize the bone density of correspondence position.Above-mentioned CT images data can include multiple levels, can
Include multiple CT values to extract each level.Even if the spacing between two levels is near again, the area between two levels
CT values in domain also can not be obtained completely, therefore, it is necessary to obtain corresponding CT Distribution values according to the corresponding CT values of each pixel,
It is distributed to be obtained according to CT Distribution values as the corresponding bone density of the pixel.
As a kind of embodiment, since the X of CT images data, Y-direction resolution ratio and Z-direction resolution ratio are inconsistent, because
This, selects the CT values of all pixels by carrying out the resolution ratio such as interpolation calculation X, Y, Z-direction to Z-direction, is calculated with will pass through
All CT values gone out calculate any pixel bone density distribution of lesion region or defect area.
Step S104, structural motif 10 and outline data generation initial support based on the topological classification chosen in advance
Model.
Said structure primitive 10 is the minimal structure body for having identical topological structure.Several press topological structure size successively
The structural motif 10 of equal-difference arrangement forms initial support model.For example, a part of porous knot of the initial support model shown in Fig. 5
The schematic diagram of structure 20.Above-mentioned loose structure 20 is then to be arranged as the structural motif 10 of the topological classification shown in several Fig. 6 by equal difference
Row composition.Alternatively, all structural motifs 10 horizontal, vertical successively, layer in the space that outline data surrounds is arranged in equal difference array
(for example, being arranged along X, Y, Z-direction equal difference array), to build generation initial support model.The size of each structural motif 10
Data can be determined according to the basic point coordinate and the primitive length of side of structural motif 10.Connect example, the length of side bag of structural motif 10 in Fig. 6
Include first in 11 length and second 12 length, it can be represented respectively：Half length of the bone trabecula being modeled, thickness.
When the length on the first side 11 is a, the size of structural motif 10 is 2a+b when the length on the second side 12 is b.Said structure primitive 10
Basic point can be preassigned structural motif 10 a node, by upper example, a vertex 13 by the lower left corner in Fig. 6 is
Default to be set to basic point, all structural motifs 10 for building the initial support model are equal on the corresponding vertex 13 in the lower left corner
For its corresponding basic point.The 10 corresponding length of side of structural motif is to be determined according to the size of the structural motif 10 of selection.It is above-mentioned each
The position of structural motif 10 can be determined by its corresponding basic point coordinate.
In embodiments of the present invention, can be described initial from building after the building of the initial support model is completed
The primitive coordinate of a structural motif 10 is selected to be arranged to starting point coordinate, such as starting point coordinate in the structural motif 10 of stent model
It is arranged to (0,0,0).Again using dimension data as arithmetic progression tolerance, the basic point for calculating all structural motifs 10 successively is sat
Mark.Specifically, X, Y, Z-direction equal difference array computation can be utilized to obtain.Connect example, selected structural motif 10 is length of side a,
B is 1, then the base with 10 adjacent six structural motifs 10 of structural motif as starting point can be obtained according to above-mentioned computation rule
Point coordinates is (- 3,0,0), (3,0,0), (0, -3,0), (0,3,0), (0,0, -3), (0,0,3).
Step S105, adjusts the initial support model using the bone density distribution of corresponding each pixel
It is whole, to generate the 3D porous support models of the corresponding class cancellous bone of the stent to be built.
In embodiments of the present invention, can be obtained according to the basic point coordinate of each structural motif 10 in initial support model
Take corresponding bone density to be distributed, be distributed further according to corresponding bone density to each structure base in the initial support model
The 12 length b in 11 length a and second of member 10 corresponding first is adjusted, i.e., its porosity and pore size is carried out
Adjustment.As a kind of embodiment, step S105 can be with as shown in fig. 7, comprises following steps：
Sub-step S1051, determines the corresponding bone density distribution of each structural motif 10.
In embodiments of the present invention, its correspondence in CT images data is obtained according to the basic point coordinate of each structural motif 10
Pixel.According to the corresponding bone density distribution of the pixel, determine that the 10 corresponding bone density of structural motif is distributed.
Sub-step S1052, is distributed, meter according to the dimension data of each structural motif 10 and the corresponding bone density
Calculate each 10 corresponding bone density value of structural motif.
In embodiments of the present invention, the structural motif 10 is obtained in corresponding bone according to the dimension data of structural motif 10
Corresponding bone density value in Density Distribution.
Sub-step S1053, is adjusted the structural motif 10 according to the bone density value, to obtain the structure base
Dimension data after the adjustment of member 10.
In embodiments of the present invention, described in being calculated by using each 10 corresponding bone density value of structural motif
The adjustment dimension data of structural motif 10.Can be that corresponding structural motif is used as using bone density value as a kind of embodiment
The weighted term of the 10 primitive length of side, is weighted each primitive length of side of all structural motifs 10, to obtain structure
Dimension data after the adjustment of primitive 10.
Sub-step S1054, according to the dimensional parameters after the adjustment, builds the 3D porous supports model.
In embodiments of the present invention, dimension data and pre-set dimension data after each adjustment of structural motif 10 are judged successively
Size, when the structural motif 10 adjustment after dimension data exceed pre-set dimension data when, according to the structural motif
Dimension data after 10 adjustment builds corresponding STL models；The dimension data after structural motif 10 adjusts is no more than pre-
When dimension data is set, then the corresponding STL models of the structural motif 10 are not built, emulate osteoporosis.Above-mentioned structure corresponds to
STL models can be exceeded to pre-set the 10 corresponding node coordinate of structural motif of dimension data according to dimension data, utilize
Tri patch surface construction rule, generates the corresponding STL models of each structural motif 10, and then by generating all STL models
Form the 3D porous supports model.It can make the composition 3D porous supports model that there is class cancellous bone through the above way
Characteristic, realizes and the true of bone trabecula distribution is presented.Create the form, size and porosity in the hole of the 3D porous supports model
Make the cell growth microenvironment such as the migration for meeting cell, differentiation and propagation.
Above-mentioned node coordinate can be the coordinate for the multiple boundary points for characterizing 10 position of structural motif.For example, structural motif
10 be Fig. 6, then is the node of structural motif 10 with all apex angles, and the corresponding position of apex angle is then node coordinate.Node is sat
Mark can carry out calculating acquisition according to the dimension data after corresponding basic point coordinate and adjustment.
Step S106, the 3D porous support models of generation are sent to 3D printer 400.
In the embodiment of the present invention, the 3D porous support models of generation are sent to 3D printer 400 to print correspondence
Porous support.Bioactivity processing is carried out to the 3D porous supports, you can it is more to prepare biologically active class cancellous bone
Hole stent.
Second embodiment
Fig. 8 is refer to, is that the 3D for being applied to the modeling terminal 300 shown in Fig. 1 that present pre-ferred embodiments provide is porous
Stent model establishes device 200, and 3D porous support model foundations device 200 includes：Extraction module 201, generation module 202, obtain
Modulus block 203, structure module 204 and adjustment module 205.
Extraction module 201, for extracting organizational boundary's profile of lesion region or defect area from the CT images data.
In embodiments of the present invention, the step S101 can be performed by extraction module 201.
Generation module 202, the outline data of the stent to be built is generated according to organizational boundary's profile.
In embodiments of the present invention, the step S102 can be performed by generation module 202.
Acquisition module 203, for the outline data according to CT images data and the stent to be built being obtained ahead of time, obtains institute
State the bone density distribution of stent to be built corresponding each pixel in the CT images data.
In embodiments of the present invention, the step S103, sub-step S1031 and sub-step S1032 can be by acquisition moulds
Block 203 performs.
Module 204 is built, for based on the structural motif 10 chosen in advance and outline data generation initial support mould
Type.
In embodiments of the present invention, the step S104 can be performed by structure module 204.
Module 205 is adjusted, for being distributed using the bone density of corresponding each pixel to the initial support mould
Type is adjusted, to generate the 3D porous support models of the corresponding class cancellous bone of the stent to be built.
In embodiments of the present invention, the step S105 can be performed by adjustment module 205.As shown in figure 9, the adjustment
Module 205 can include：
Determination sub-module 2051, for determining the corresponding bone density distribution of each structural motif 10.
In embodiments of the present invention, the sub-step S1051 can be performed by determination sub-module 2051.
Calculating sub module 2052, for the dimension data according to each structural motif 10 and the corresponding bone density
Distribution, calculates each 10 corresponding bone density value of structural motif.
In embodiments of the present invention, the sub-step S1052 can be performed by calculating sub module 2052.
Submodule 2053 is adjusted, for being adjusted according to the bone density value to the structural motif 10, to obtain
State the dimension data after structural motif 10 adjusts.
In embodiments of the present invention, the sub-step S1053 can be performed by adjustment submodule 2053.
Submodule 2054 is built, for according to the dimensional parameters after the adjustment, building the 3D porous supports model.
In embodiments of the present invention, the sub-step S1054 can be performed by structure submodule 2054.
Sending module 206, for sending the 3D porous support models of generation to 3D printer 400.
In embodiments of the present invention, the step S106 can be performed by sending module 206.
In conclusion a kind of 3D porous supports method for establishing model, device and preparation system provided in an embodiment of the present invention,
By the outline data according to CT images data and stent to be built, the stent to be built is obtained in the CT images data
The bone density distribution of corresponding each pixel, recycles the bone density of corresponding each pixel to be distributed to according to profile
The initial support model of data generation is adjusted, to generate the 3D porous support moulds of the class cancellous bone of per-sonalization structures gradient
Type.So as to meet bionical micro- knot of the biomechanics characteristic at bone defect position according to the porous support that 3D porous supports model prints
Structure, meets the cell growth microenvironment such as migration, differentiation and breeding of osteocyte.
In several embodiments provided herein, it should be understood that disclosed apparatus and method, can also pass through
Other modes are realized.Device embodiment described above is only schematical, for example, flow chart and block diagram in attached drawing
Show the devices of multiple embodiments according to the present invention, method and computer program product architectural framework in the cards,
Function and operation.At this point, each square frame in flow chart or block diagram can represent the one of a module, program segment or code
Part, a part for the module, program segment or code include one or more and are used for realization holding for defined logic function
Row instruction.It should also be noted that at some as in the implementation replaced, the function that is marked in square frame can also with different from
The order marked in attached drawing occurs.For example, two continuous square frames can essentially perform substantially in parallel, they are sometimes
It can perform in the opposite order, this is depending on involved function.It is it is also noted that every in block diagram and/or flow chart
The combination of a square frame and block diagram and/or the square frame in flow chart, can use function or the dedicated base of action as defined in performing
Realize, or can be realized with the combination of specialized hardware and computer instruction in the system of hardware.
In addition, each function module in each embodiment of the present invention can integrate to form an independent portion
Point or modules individualism, can also two or more modules be integrated to form an independent part.
If the function is realized in the form of software function module and is used as independent production marketing or in use, can be with
It is stored in a computer read/write memory medium.Based on such understanding, technical scheme is substantially in other words
The part to contribute to the prior art or the part of the technical solution can be embodied in the form of software product, the meter
Calculation machine software product is stored in a storage medium, including some instructions are used so that a computer equipment (can be
People's computer, server, or network equipment etc.) perform all or part of step of each embodiment the method for the present invention.
And foregoing storage medium includes：USB flash disk, mobile hard disk, read-only storage (ROM, Read-Only Memory), arbitrary access are deposited
Reservoir (RAM, Random Access Memory), magnetic disc or CD etc. are various can be with the medium of store program codes.
It should be noted that herein, relational terms such as first and second and the like are used merely to a reality
Body or operation are distinguished with another entity or operation, are deposited without necessarily requiring or implying between these entities or operation
In any this actual relation or order.Moreover, term " comprising ", "comprising" or its any other variant are intended to
Non-exclusive inclusion, so that process, method, article or equipment including a series of elements not only will including those
Element, but also including other elements that are not explicitly listed, or further include as this process, method, article or equipment
Intrinsic key element.In the absence of more restrictions, the key element limited by sentence "including a ...", it is not excluded that
Also there are other identical element in process, method, article or equipment including the key element.
The foregoing is only a preferred embodiment of the present invention, is not intended to limit the invention, for the skill of this area
For art personnel, the invention may be variously modified and varied.Within the spirit and principles of the invention, that is made any repaiies
Change, equivalent substitution, improvement etc., should all be included in the protection scope of the present invention.It should be noted that：Similar label and letter exists
Similar terms is represented in following attached drawing, therefore, once being defined in a certain Xiang Yi attached drawing, is then not required in subsequent attached drawing
It is further defined and is explained.
The above description is merely a specific embodiment, but protection scope of the present invention is not limited thereto, any
Those familiar with the art the invention discloses technical scope in, change or replacement can be readily occurred in, should all be contained
Cover within protection scope of the present invention.Therefore, protection scope of the present invention answers the scope of the claims of being subject to.
Claims (10)
- A kind of 1. 3D porous supports method for establishing model, it is characterised in that the described method includes：According to CT images data and the outline data for the stent to be built being obtained ahead of time, the stent to be built is obtained in the CT The bone density distribution of corresponding each pixel in image data；Structural motif and outline data generation initial support model based on the topological classification chosen in advance；The initial support model is adjusted using the bone density distribution of corresponding each pixel, with described in generation The 3D porous support models of the corresponding class cancellous bone of stent to be built.
- 2. the method as described in claim 1, it is characterised in that utilize the bone density distribution pair of corresponding each pixel The initial support model is adjusted, to generate the 3D porous support models of the corresponding class cancellous bone of the stent to be built Step includes：Determine the corresponding bone density distribution of each structural motif；According to the dimension data of each structural motif and the corresponding bone density distribution, each structural motif is calculated Corresponding bone density value；The structural motif is adjusted according to the bone density value, to obtain the size number after the structural motif adjustment According to；According to the dimensional parameters after the adjustment, the 3D porous supports model is built.
- 3. method as claimed in claim 2, it is characterised in that described to determine that the corresponding bone of each structural motif is close The step of degree distribution, includes：The basic point coordinate of each structural motif is obtained according to the dimension data of the structural motif and initial support model；The bone density distribution corresponding with the structural motif is determined according to the basic point coordinate.
- 4. method as claimed in claim 2 or claim 3, it is characterised in that the 3D porous supports model includes multiple STL models, The dimensional parameters according to after the adjustment, the step of building the 3D porous supports model include：When the dimension data after structural motif adjustment, which exceedes, pre-sets dimension data, after being adjusted according to the structural motif Dimension data build corresponding STL models；When the dimension data after structural motif adjustment, which is no more than, pre-sets dimension data, then the structural motif is not built The corresponding STL models.
- 5. the method as described in claim 1, it is characterised in that according to CT images data and obtain the branch to be built previously generated The outline data of frame, obtains the bone density distribution of the stent to be built corresponding each pixel in the CT images data The step of include：The outline data of the stent to be built previously generated according to CT images data and acquisition, obtains the stent to be built in institute State the CT values of corresponding each pixel in CT images data；According to the CT values of corresponding each pixel, using interpolation method, the bone for calculating corresponding each pixel is close Degree distribution.
- 6. method as claimed in claim 5, it is characterised in that according to CT images data and obtain the branch to be built previously generated The outline data of frame, the acquisition stent to be built is in the CT images data the step of CT values of corresponding each pixel Including：When the stent to be built, corresponding region is lesion region in the CT images data, then extracts the lesion region In each pixel the CT values；When the stent to be built, corresponding region is defect area in the CT images data, then from gathering in advance and institute State the CT that each pixel is extracted in the corresponding region in the CT images data of the opposite side normal bone of defect area Value.
- 7. the method as described in claim 1, it is characterised in that the method further includes：Organizational boundary's profile of lesion region or defect area is extracted from the CT images data；The outline data of the stent to be built is generated according to organizational boundary's profile.
- 8. a kind of 3D porous supports model foundation device, it is characterised in that described device includes：Acquisition module, for the outline data according to CT images data and the stent to be built being obtained ahead of time, structure is treated described in acquisition Build the bone density distribution of stent corresponding each pixel in the CT images data；Module is built, for the structural motif based on the topological classification chosen in advance and outline data generation initial support mould Type；Module is adjusted, for being adjusted using the bone density distribution of corresponding each pixel to the initial support model It is whole, to generate the 3D porous support models of the corresponding class cancellous bone of the stent to be built.
- 9. device as claimed in claim 8, it is characterised in that adjustment module includes：Determination sub-module, for determining the corresponding bone density distribution of each structural motif；Calculating sub module, for the dimension data according to each structural motif and the corresponding bone density distribution, calculates Each corresponding bone density value of the structural motif；Submodule is adjusted, for being adjusted according to the bone density value to the structural motif, to obtain the structural motif Dimension data after adjustment；Submodule is built, for according to the dimensional parameters after the adjustment, building the 3D porous supports model.
- 10. a kind of 3D porous supports model preparation system, it is characterised in that the preparation system includes 3D printer and modeling eventually End, the 3D printer are electrically connected with the modeling terminal, the system comprises：The modeling terminal, for the outline data according to CT images data and the stent to be built being obtained ahead of time, described in acquisition The bone density distribution of stent to be built corresponding each pixel in the CT images data；The modeling terminal, is additionally operable to the structural motif based on the topological classification chosen in advance and the outline data generates initially Stent model；The modeling terminal, is additionally operable to be distributed to the initial support model using the bone density of corresponding each pixel It is adjusted, generates the 3D porous supports model of the corresponding class cancellous bone of the stent to be built and send to the 3D printing Machine；The 3D printer, for printing generation 3D porous supports according to the 3D porous supports model.
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