CN110772358A - Method and device for preparing artificial bone biomaterial - Google Patents
Method and device for preparing artificial bone biomaterial Download PDFInfo
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- CN110772358A CN110772358A CN201910977148.3A CN201910977148A CN110772358A CN 110772358 A CN110772358 A CN 110772358A CN 201910977148 A CN201910977148 A CN 201910977148A CN 110772358 A CN110772358 A CN 110772358A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/30985—Designing or manufacturing processes using three dimensional printing [3DP]
Abstract
The embodiment of the specification provides a method and a device for preparing an artificial bone biomaterial, which are applied to 3D printing and are used for obtaining a first component and the content of the first component; obtaining a second component and the content of the second component; uniformly mixing the first component and the second component to obtain mixed powder; judging whether the mixed powder and the real bone meal have the same first appearance characteristic or not; when the shapes of the mixed powder and the real bone powder have a first shape characteristic, sucking the mixed powder into a printer according to a vacuum conduit of the printer; and obtaining the content of a third component and the third component, mixing the third component and the mixed powder to obtain a first polymer, and obtaining the artificial bone biomaterial according to a spray head of the printer. The needle-shaped appearance of the artificial bone biomaterial is similar to that of real bone powder, the cell attachment growth is facilitated, the rejection is small, and the quality is stable.
Description
Technical Field
The embodiment of the specification relates to the technical field of medical materials, in particular to a method and a device for preparing an artificial bone biomaterial.
Background
In recent years, the preparation of artificial bone scaffolds has been rapidly developed in bone tissue engineering, various new materials are used to prepare bone scaffolds, and complementary mechanisms of various materials are applied to prepare composite scaffolds, so as to improve the mechanical and biological properties of the prepared scaffolds. Meanwhile, the preparation technology of the porous scaffold is continuously updated, and the porous scaffold capable of meeting the requirements of a human body is prepared by different methods. The method for rapidly manufacturing the personalized artificial bone by using the bone tissue engineering material by adopting the 3D printing technology has great academic significance.
The bioceramic material has gradually become a hotspot and a key point in the field of bone graft repair due to good biocompatibility, degradability, osteoinduction and osteoconductivity. The hydroxyapatite has a molecular formula of Ca because of similarity with human skeleton components
10(PO
4)
6(OH)
2Has excellent biocompatibility and bone affinity, is superior to medical titanium, silicon rubber, bone grafting carbon material and other medical implanting materials, and is widely applied to clinic. In addition, hydroxyapatite has excellent osteoconductivity and osseointegration capability, no toxic or side effect and no carcinogenic effect, so that hydroxyapatite is widely applied to physiological scaffolds of bone filling materials and bone repair materials in diseases and accidents. However, the single hydroxyapatite material inevitably has some performance defects, such as low fracture toughness and poor fatigue resistance, is only used for repairing bone defects of non-bearing parts, and is difficult to degrade and absorb by organisms. Therefore, the single material is difficult to meet the requirements of bone repair, and the development of bone repair composite materials is not slow.
The technical problems of great difference between the structure of the artificial bone and the human bone and unstable quality exist in the prior art.
Disclosure of Invention
The embodiment of the specification provides a method and a device for preparing an artificial bone biomaterial, solves the technical problems that the structure of an artificial bone is different from that of a human bone and the quality is unstable in the prior art, achieves the technical effects that the needle-shaped morphology of the artificial bone biomaterial is similar to that of real bone powder, is beneficial to cell attachment growth, has small rejection, stable quality and controllable appearance of the artificial bone, and can print and manufacture a complex artificial bone.
In view of the above problems, embodiments of the present application are provided to provide a method and apparatus for preparing an artificial bone biomaterial.
In a first aspect, the present specification provides a method for preparing an artificial bone biomaterial for 3D printing, the method including: obtaining a first component and a content of the first component; obtaining the content of a second component and the second component, wherein the second component is different from the first component; uniformly mixing the first component and the second component to obtain mixed powder; judging whether the mixed powder and the real bone meal have the same first appearance characteristic or not; when the shapes of the mixed powder and the real bone powder have a first shape characteristic, sucking the mixed powder into a printer according to a vacuum conduit of the printer; and obtaining the content of a third component and the third component, mixing the third component and the mixed powder to obtain a first polymer, and obtaining the artificial bone biomaterial according to a spray head of the printer.
Preferably, the obtaining of the artificial bone biomaterial according to the nozzle of the printer includes: determining process parameters of the showerhead based on the first polymer, wherein the process parameters of the showerhead include: the printing speed, the extrusion pressure, the diameter and the printing temperature of the spray head.
Preferably, the method further comprises: obtaining a first pore size and porosity of the artificial bone biomaterial; determining whether the first pore size and pore size meet a first predetermined threshold; and when the first pore diameter and the pore space meet the first preset threshold value, obtaining the final artificial bone biomaterial.
Preferably, the method further comprises: obtaining a necrotic region of a real bone; determining a first bone model from the necrotic region; judging whether the first bone model is different from the real bone or not; when there is no difference between the first bone model and the real bone, a final artificial bone biomaterial is obtained.
Preferably, the method further comprises: obtaining a second bone model; obtaining a first connection site of a real bone; matching the second bone model with the thread information of the first connection according to the first connection; and obtaining a final artificial bone biomaterial according to the thread information and the second bone model.
In a second aspect, the present specification provides an apparatus for preparing an artificial bone biomaterial for 3D printing, the apparatus including:
a first obtaining unit for obtaining a first component and a content of the first component;
a second obtaining unit for obtaining a second component different from the first component and a content of the second component;
a third obtaining unit for uniformly mixing the first component and the second component to obtain a mixed powder;
the first judging unit is used for judging whether the mixed powder and the real bone powder have the same first appearance characteristic or not;
the first execution unit is used for sucking the mixed powder into a printer according to a vacuum conduit of the printer when the mixed powder and the real bone powder have first appearance characteristics;
and the fourth obtaining unit is used for obtaining the content of a third component and the third component, mixing the third component with the mixed powder to obtain a first polymer, and obtaining the artificial bone biomaterial according to a spray head of the printer.
Preferably, the obtaining of the artificial bone biomaterial according to the nozzle of the printer in the fourth obtaining unit includes:
a first determining unit, configured to determine a process parameter of the showerhead according to the first polymer, wherein the process parameter of the showerhead includes: the printing speed, the extrusion pressure, the diameter and the printing temperature of the spray head.
Preferably, the apparatus further comprises:
a fifth obtaining unit for obtaining a first pore size and pores of the artificial bone biomaterial;
a second judging unit configured to judge whether the first aperture and the pore satisfy a first predetermined threshold;
a sixth obtaining unit, configured to obtain a final artificial bone biomaterial when the first pore size and the pore size satisfy the first predetermined threshold.
Preferably, the apparatus further comprises:
a seventh obtaining unit for obtaining a necrotic region of a real bone;
a second determination unit for determining a first bone model from the necrotic area;
a third judging unit, configured to judge whether the first bone model is different from the real bone;
an eighth obtaining unit, configured to obtain a final artificial bone biomaterial when there is no difference between the first bone model and the real bone.
Preferably, the apparatus further comprises:
a ninth obtaining unit for obtaining a second bone model;
a tenth obtaining unit, configured to obtain a first connection site of a real bone;
a second execution unit for matching the second bone model with the thread information of the first connection according to the first connection;
and the eleventh obtaining unit is used for obtaining the final artificial bone biomaterial according to the thread information and the second bone model.
In a third aspect, the invention provides a computer-readable storage medium having stored thereon a computer program which, when executed by a processor, performs the steps of any of the methods described above.
In a fourth aspect, the present specification provides an apparatus for preparing an artificial bone biomaterial, comprising a memory, a processor and a computer program stored on the memory and executable on the processor, wherein the processor performs the steps of any of the above methods.
One or more technical solutions in the embodiments of the present application have at least one or more of the following technical effects:
the method and the device for preparing the artificial bone biomaterial provided by the embodiment of the specification are used for preparing the artificial bone biomaterial by obtaining a first component and the content of the first component; obtaining the content of a second component and the second component, wherein the second component is different from the first component; uniformly mixing the first component and the second component to obtain mixed powder; judging whether the mixed powder and the real bone meal have the same first appearance characteristic or not; when the shapes of the mixed powder and the real bone powder have a first shape characteristic, sucking the mixed powder into a printer according to a vacuum conduit of the printer; and obtaining the content of a third component and the third component, mixing the third component and the mixed powder to obtain a first polymer, and obtaining the artificial bone biomaterial according to a spray head of the printer. Through choosing for use the composition similar with the appearance of people's bone, and adopt multiple composition to cooperate and prepare out the degradable artificial bone biomaterial extremely similar with the biological nature of people's bone, the structure that has artificial bone among the prior art still has great difference with people's bone, the not yet unstable technical problem of quality has been solved, it is similar with the acicular appearance of true bone meal to have reached artificial bone biomaterial, be favorable to the cell adhesion to grow, the rejection is little, the steady quality, the artificial bone appearance is controllable, can print the technological effect of making complicated artificial bone.
Drawings
FIG. 1 is a flow chart of a method for preparing an artificial bone biomaterial provided in the examples of the present specification;
FIG. 2 is a schematic view of an apparatus for preparing an artificial bone biomaterial provided in an embodiment of the present disclosure;
fig. 3 is a schematic view of another apparatus for preparing an artificial bone biomaterial provided in the embodiments of the present specification.
The reference numbers illustrate: a bus 300, a receiver 301, a processor 302, a transmitter 303, a memory 304, a bus interface 306.
Detailed Description
The embodiment of the invention provides a method and a device for preparing an artificial bone biomaterial, which are used for solving the technical problems that the structure of an artificial bone is greatly different from that of a human bone and the quality is not stable in the prior art, and the technical scheme provided by the invention has the following general ideas:
in the technical scheme of the embodiment of the invention, the content of a first component and the content of the first component are obtained; obtaining the content of a second component and the second component, wherein the second component is different from the first component; uniformly mixing the first component and the second component to obtain mixed powder; judging whether the mixed powder and the real bone meal have the same first appearance characteristic or not; when the shapes of the mixed powder and the real bone powder have a first shape characteristic, sucking the mixed powder into a printer according to a vacuum conduit of the printer; and obtaining the content of a third component and the third component, mixing the third component and the mixed powder to obtain a first polymer, and obtaining the artificial bone biomaterial according to a spray head of the printer. The technical problems that the structure of the artificial bone is different from the human bone and the quality is unstable in the prior art are solved, the needle-shaped appearance of the artificial bone biomaterial is similar to that of real bone powder, cell attachment growth is facilitated, rejection is small, the quality is stable, the appearance of the artificial bone is controllable, and the technical effect of printing and manufacturing the complex artificial bone is achieved.
In order to better understand the technical solutions, the technical solutions of the embodiments of the present specification are described in detail below with reference to the drawings and specific embodiments, and it should be understood that the specific features of the embodiments and embodiments of the present specification are detailed descriptions of the technical solutions of the embodiments of the present specification, and are not limitations of the technical solutions of the present specification, and the technical features of the embodiments and embodiments of the present specification may be combined with each other without conflict.
The terminology used in the description presented herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the disclosure. As used in this disclosure and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. The term "and/or" herein is merely an association describing an associated object, meaning that three relationships may exist, e.g., a and/or B, may mean: a exists alone, A and B exist simultaneously, and B exists alone. In addition, the character "/" herein generally indicates that the former and latter related objects are in an "or" relationship.
Example one
FIG. 1 is a schematic flow chart of a method for preparing an artificial bone biomaterial according to an embodiment of the present invention. As shown in fig. 1, the method is applied to an apparatus for preparing an artificial bone biomaterial, the apparatus for preparing an artificial bone biomaterial comprises an input device and an output device, the input device is internally provided with a composition input module, an artificial bone processing module, a memory and a signal input module, the input device can be connected with a device such as a spray head of a printer for generating an output signal, and the output device is connected with the input device and is a device such as a spray head capable of printing the input device such as the spray head of the printer. The method comprises steps S101-S106.
S101: obtaining a first component and a content of the first component;
specifically, in the method for preparing the artificial bone biomaterial in the embodiment of the application, the degradable artificial bone biomaterial which is extremely similar to the biological property of the human bone is prepared by selecting the components which are similar to the shape of the human bone and matching a plurality of components. Firstly, a server side obtains a first component for preparing a degradable artificial bone biomaterial and the content of the first component, at present, the bone injury repair implant materials in international and domestic are mainly three, namely metal materials, polymer materials and ceramic materials, wherein the metal materials are the bone injury repair materials which are used earliest and are also the most widely used materials; the mechanical strength of the non-degradable polymer material is limited, and the degradable polymer often has the defects of inflammatory reaction and the like; ceramic materials mostly have good corrosion resistance, but their brittleness is a not negligible disadvantage. In the embodiment of the present application, it is preferable that the first component is a ceramic material, such as a bioceramic, and the bioceramic is preferably hydroxyapatite. Hydroxyapatite (HA or HAP) HAs a composition similar to that of natural apatite mineral, is the main inorganic component of bones and teeth of vertebrates, HAs a very similar structure, and is in a flaky microcrystalline state. It is used as a bone substitute for bone grafting. HA HAs good biocompatibility, is safe and nontoxic when implanted into a body, and can conduct bone growth. HA enables bone cells to attach to its surface, this junction gradually shrinks as new bone grows and HA becomes part of the bone through the outer layers of the crystal, and new bone can climb from the HA implant to the original bone along the surface of the implant or through the pores inside it. HA bioactive ceramics are typical bioactive ceramics, and can form chemical bond combination with tissues on the interface after being implanted into the body. The mechanism of bonding between HA bioactive ceramics and bone does not require bonding by forming a silicon rich layer on its surface, as with bioglass, and then forming an intermediate bonding zone. After the dense hydroxyapatite ceramic is implanted into bones, osteoblasts are directly differentiated on the surfaces of the osteoblasts to form bone matrixes, an amorphous electron density band with the width of 3-5 mu m is generated, collagen fiber bundles grow between the area and the cells, and bone salt crystallization occurs in the amorphous band. As the mineralization is mature, the amorphous band is reduced to 0.05-0.2 μm, and the bonding of the hydroxyapatite implant and the bone is realized through the narrow bonding band. The content of the bioceramic is controlled to be 14% -36%, wherein the content of the bioceramic is preferably 15% for the age range of 12-20 years old; for the age range of 20-48 years, the bioceramic content is preferably 25%; the content of bioceramic is preferably 35% or 36% for the age range of 48-95 years.
S102: obtaining the content of a second component and the second component, wherein the second component is different from the first component;
s103: uniformly mixing the first component and the second component to obtain mixed powder;
specifically, to avoid brittleness of the bioceramic, it is necessary to add other components to the bioceramic to obtain a second component and a content of the second component, wherein the second component is different from the first component, in the embodiment of the present application, it is preferable that the second component is tricalcium phosphate, tricalcium phosphate (TCP) has good biocompatibility, bioactivity and biodegradability, is an ideal human hard tissue repair and replacement material, and has been receiving close attention in the field of biomedical engineering, a special form of tricalcium phosphate- β -tricalcium phosphate is commonly used in medicine, β -tricalcium phosphate is mainly composed of calcium and phosphorus, and has a composition similar to inorganic components of bone matrix and is well combined with bone, β -tricalcium phosphate can be widely applied to joint and spinal fusion, limb trauma, oromaxillofacial surgery, cardiovascular surgery, and filling up cavities of stomata, etc. the content is selected within a range of 14% -30%, wherein, for 12-20 years old, the content of tricalcium phosphate is preferably 15%, for 20-48 years old, and for a second age old age, the content of tricalcium phosphate is preferably 95-30%, and the first component is mixed with the second component to obtain a uniform pulverized powder.
S104: judging whether the mixed powder and the real bone meal have the same first appearance characteristic or not;
s105: when the shapes of the mixed powder and the real bone powder have a first shape characteristic, sucking the mixed powder into a printer according to a vacuum conduit of the printer;
specifically, judging whether the mixed powder and the real bone powder have the same first morphological feature, for example, mixing the bioceramic with tricalcium phosphate to synthesize the calcium phosphate bioceramic, wherein the calcium phosphate bioceramic is a nano-crystalline grain, has a needle-like shape, is similar to the needle-like shape of the real bone powder, and is beneficial to cell attachment growth. And when the shapes of the mixed powder and the real bone powder have a first shape characteristic, namely the needle-shaped shapes of the calcium phosphate bioceramic and the real bone powder are similar, sucking the mixed powder into a printer according to a vacuum conduit of the printer.
S106: and obtaining the content of a third component and the third component, mixing the third component and the mixed powder to obtain a first polymer, and obtaining the artificial bone biomaterial according to a spray head of the printer.
Further, the obtaining of the artificial bone biomaterial according to the nozzle of the printer includes: determining process parameters of the showerhead based on the first polymer, wherein the process parameters of the showerhead include: the printing speed, the extrusion pressure, the diameter and the printing temperature of the spray head.
Specifically, by obtaining the content of the third component and the third component, wherein the third component is a liquid mixture contained in a liquid tank, it is preferable in the present embodiment that the third component is an osteogenesis inducing factor and polylactic acid, wherein the osteogenesis inducing factor is preferably a Bone Morphogenetic Protein (BMP), which plays an important role in cell differentiation and bone formation as a secretory protein. Polylactic acid (PLA) is a new biodegradable material made using starch feedstocks proposed by renewable plant resources such as corn. It has good biodegradability, and can be completely degraded by microorganisms in nature after use to finally generate carbon dioxide and water. Wherein, the content of the osteogenesis inducing factor is selected to be 5 percent, the content of the polylactic acid is selected to be in the range of 30 to 65 percent, and the content of the polylactic acid is preferably 65 percent for the age group of 12 to 20 years old; for the age range of 20-48 years, the content of polylactic acid is preferably 50%; the content of polylactic acid is preferably 30% for the age range of 48-95 years. Mixing the third component with the mixed powder to obtain a first polymer, and determining the process parameters of the sprayer according to the first polymer, wherein the process parameters of the sprayer comprise: the printing speed, the extrusion pressure, the diameter and the printing temperature of the spray head. Obtaining the artificial bone biomaterial through the filament-free printing by selecting the parameters of the nozzle of the printer.
Further, the method further comprises: obtaining a first pore size and porosity of the artificial bone biomaterial; determining whether the first pore size and pore size meet a first predetermined threshold; and when the first pore diameter and the pore space meet the first preset threshold value, obtaining the final artificial bone biomaterial.
Specifically, in order to verify the performance of the artificial bone biomaterial, a first pore diameter and a pore diameter of the artificial bone biomaterial are obtained, the artificial bone biomaterial has a gradient pore diameter with relatively dense outer part and loose and porous inner part, and whether the first pore diameter and the pore diameter meet a first preset threshold value is judged, wherein the first preset threshold value is a set standard value range of the first pore diameter and the pore diameter of the human bone. When the first aperture and the pore meet the first preset threshold, the final artificial bone biomaterial is obtained, namely the artificial bone prepared by adopting the components and the content meets the performance requirement of human bone, and the aperture is adjustable and has wide applicability.
Further, the method further comprises: obtaining a necrotic region of a real bone; determining a first bone model from the necrotic region; judging whether the first bone model is different from the real bone or not; when there is no difference between the first bone model and the real bone, a final artificial bone biomaterial is obtained.
Specifically, a necrotic region of a real bone, namely a diseased region of a human bone, a part of an artificial bone which needs to be replaced is obtained, a first bone model is determined according to the necrotic region, the first bone model is a three-dimensional solid figure and comprises functional parameters of the bone of the necrotic region and the like, whether the first bone model and the real bone are different or not is judged, namely whether the first bone model and the real bone are different in shape, bone density, bone pore size, pore space and the like is judged, and when the first bone model and the real bone are not different, namely the difference is within an error range, a final artificial bone biomaterial is obtained.
Further, the method further comprises: obtaining a second bone model; obtaining a first connection site of a real bone; matching the second bone model with the thread information of the first connection according to the first connection; and obtaining a final artificial bone biomaterial according to the thread information and the second bone model.
Particularly, this application embodiment still is applied to the large-scale bone, through obtaining second skeleton model, obtains the first junction of real skeleton, matches according to the thread printing technique second skeleton model with the screw thread information of first junction, according to the screw thread information with second skeleton model obtains final artificial bone biomaterial, realizes artificial bone from connecting assembly structure combination manufacturing, realizes the large-scale bone from connecting simultaneously, guarantees joint strength, can satisfy the quick manufacturing of complicated artificial bone customization.
Example two
Based on the same inventive concept as the method for preparing the artificial bone biomaterial in the previous embodiment, the present invention also provides an apparatus for preparing the artificial bone biomaterial, as shown in fig. 2, the apparatus being applied to 3D printing, comprising:
a first obtaining unit 11 for obtaining a first component and a content of the first component;
a second obtaining unit 12 for obtaining a second component different from the first component and a content of the second component;
a third obtaining unit 13 for uniformly mixing the first component and the second component to obtain a mixed powder;
the first judging unit 14 is used for judging whether the mixed powder and the real bone powder have the same first appearance characteristic or not;
the first execution unit 15 is used for sucking the mixed powder into a printer according to a vacuum conduit of the printer when the shapes of the mixed powder and the real bone powder have a first shape characteristic;
a fourth obtaining unit 16, configured to obtain contents of a third component and the third component, mix the third component with the mixed powder to obtain a first polymer, and obtain an artificial bone biomaterial according to a nozzle of the printer.
Further, the obtaining of the artificial bone biomaterial according to the nozzle of the printer in the fourth obtaining unit includes:
a first determining unit, configured to determine a process parameter of the showerhead according to the first polymer, wherein the process parameter of the showerhead includes: the printing speed, the extrusion pressure, the diameter and the printing temperature of the spray head.
Further, the apparatus further comprises:
a fifth obtaining unit for obtaining a first pore size and pores of the artificial bone biomaterial;
a second judging unit configured to judge whether the first aperture and the pore satisfy a first predetermined threshold;
a sixth obtaining unit, configured to obtain a final artificial bone biomaterial when the first pore size and the pore size satisfy the first predetermined threshold.
Further, the apparatus further comprises:
a seventh obtaining unit for obtaining a necrotic region of a real bone;
a second determination unit for determining a first bone model from the necrotic area;
a third judging unit, configured to judge whether the first bone model is different from the real bone;
an eighth obtaining unit, configured to obtain a final artificial bone biomaterial when there is no difference between the first bone model and the real bone.
Further, the apparatus further comprises:
a ninth obtaining unit for obtaining a second bone model;
a tenth obtaining unit, configured to obtain a first connection site of a real bone;
a second execution unit for matching the second bone model with the thread information of the first connection according to the first connection;
and the eleventh obtaining unit is used for obtaining the final artificial bone biomaterial according to the thread information and the second bone model.
Various modifications and embodiments of the method for preparing an artificial bone biomaterial according to the first embodiment of fig. 1 are also applicable to the apparatus for preparing an artificial bone biomaterial of the present embodiment, and the method for preparing an artificial bone biomaterial according to the present embodiment is clearly known to those skilled in the art from the foregoing detailed description of the method for preparing an artificial bone biomaterial, and therefore, for the brevity of the description, will not be described in detail herein.
EXAMPLE III
Based on the same inventive concept as the method of preparing the artificial bone biomaterial in the first embodiment, the present invention also provides a computer-readable storage medium having stored thereon a computer program that, when being executed by a processor, implements the steps of any one of the methods of preparing the artificial bone biomaterial described above.
Where in fig. 3 a bus architecture (represented by bus 300), bus 300 may include any number of interconnected buses and bridges, bus 300 linking together various circuits including one or more processors, represented by processor 302, and memory, represented by memory 304. The bus 300 may also link together various other circuits such as peripherals, voltage regulators, power management circuits, and the like, which are well known in the art, and therefore, will not be described any further herein. A bus interface 306 provides an interface between the bus 300 and the receiver 301 and transmitter 303. The receiver 301 and the transmitter 303 may be the same element, i.e., a transceiver, providing a means for communicating with various other apparatus over a transmission medium. The processor 302 is responsible for managing the bus 300 and general processing, and the memory 304 may be used for storing data used by the processor 302 in performing operations.
One or more technical solutions in the embodiments of the present application have at least one or more of the following technical effects:
the method and the device for preparing the artificial bone biomaterial provided by the embodiment of the specification are used for preparing the artificial bone biomaterial by obtaining a first component and the content of the first component; obtaining the content of a second component and the second component, wherein the second component is different from the first component; uniformly mixing the first component and the second component to obtain mixed powder; judging whether the mixed powder and the real bone meal have the same first appearance characteristic or not; when the shapes of the mixed powder and the real bone powder have a first shape characteristic, sucking the mixed powder into a printer according to a vacuum conduit of the printer; and obtaining the content of a third component and the third component, mixing the third component and the mixed powder to obtain a first polymer, and obtaining the artificial bone biomaterial according to a spray head of the printer. Through choosing for use the composition similar with the appearance of people's bone, and adopt multiple composition to cooperate and prepare out the degradable artificial bone biomaterial extremely similar with the biological nature of people's bone, the structure that has artificial bone among the prior art still has great difference with people's bone, the not yet unstable technical problem of quality has been solved, it is similar with the acicular appearance of true bone meal to have reached artificial bone biomaterial, be favorable to the cell adhesion to grow, the rejection is little, the steady quality, the artificial bone appearance is controllable, can print the technological effect of making complicated artificial bone.
As will be appreciated by one skilled in the art, embodiments of the present invention may be provided as a method, system, or computer program product. Accordingly, the present invention may take the form of an entirely hardware embodiment, an entirely software embodiment or an embodiment combining software and hardware aspects. Furthermore, the present invention may take the form of a computer program product embodied on one or more computer-usable storage media (including, but not limited to, disk storage, CD-ROM, optical storage, and the like) having computer-usable program code embodied therein.
The description has been presented with reference to flowchart illustrations and/or block diagrams of methods, apparatus (systems), and computer program products according to embodiments of the description. It will be understood that each flow and/or block of the flow diagrams and/or block diagrams, and combinations of flows and/or blocks in the flow diagrams and/or block diagrams, can be implemented by computer program instructions. These computer program instructions may be provided to a processor of a general purpose computer, special purpose computer, embedded processor, or other programmable data processing apparatus to produce a machine, such that the instructions, which execute via the processor of the computer or other programmable data processing apparatus, create means for implementing the functions specified in the flowchart flow or flows and/or block diagram block or blocks.
These computer program instructions may also be stored in a computer-readable memory that can direct a computer or other programmable data processing apparatus to function in a particular manner, such that the instructions stored in the computer-readable memory produce an article of manufacture including instruction means which implement the function specified in the flowchart flow or flows and/or block diagram block or blocks.
These computer program instructions may also be loaded onto a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer implemented process such that the instructions which execute on the computer or other programmable apparatus provide steps for implementing the functions specified in the flowchart flow or flows and/or block diagram block or blocks.
While preferred embodiments of the present specification have been described, additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. Therefore, it is intended that the appended claims be interpreted as including preferred embodiments and all changes and modifications that fall within the scope of the specification.
It will be apparent to those skilled in the art that various changes and modifications may be made in the present specification without departing from the spirit and scope of the specification. Thus, if such modifications and variations of the present specification fall within the scope of the claims of the present specification and their equivalents, the specification is intended to include such modifications and variations.
Claims (8)
1. A method for preparing an artificial bone biomaterial for 3D printing, the method comprising:
obtaining a first component and a content of the first component;
obtaining the content of a second component and the second component, wherein the second component is different from the first component;
uniformly mixing the first component and the second component to obtain mixed powder;
judging whether the mixed powder and the real bone meal have the same first appearance characteristic or not;
when the shapes of the mixed powder and the real bone powder have a first shape characteristic, sucking the mixed powder into a printer according to a vacuum conduit of the printer;
and obtaining the content of a third component and the third component, mixing the third component and the mixed powder to obtain a first polymer, and obtaining the artificial bone biomaterial according to a spray head of the printer.
2. The method of claim 1, wherein obtaining the artificial bone biomaterial from a jet of the printer comprises:
determining process parameters of the showerhead based on the first polymer, wherein the process parameters of the showerhead include: the printing speed, the extrusion pressure, the diameter and the printing temperature of the spray head.
3. The method of claim 1, wherein the method further comprises:
obtaining a first pore size and porosity of the artificial bone biomaterial;
determining whether the first pore size and pore size meet a first predetermined threshold;
and when the first pore diameter and the pore space meet the first preset threshold value, obtaining the final artificial bone biomaterial.
4. The method of claim 1, wherein the method further comprises:
obtaining a necrotic region of a real bone;
determining a first bone model from the necrotic region;
judging whether the first bone model is different from the real bone or not;
when there is no difference between the first bone model and the real bone, a final artificial bone biomaterial is obtained.
5. The method of claim 1, wherein the method further comprises:
obtaining a second bone model;
obtaining a first connection site of a real bone;
matching the second bone model with the thread information of the first connection according to the first connection;
and obtaining a final artificial bone biomaterial according to the thread information and the second bone model.
6. An apparatus for preparing artificial bone biomaterial for 3D printing, the apparatus comprising:
a first obtaining unit for obtaining a first component and a content of the first component;
a second obtaining unit for obtaining a second component different from the first component and a content of the second component;
a third obtaining unit for uniformly mixing the first component and the second component to obtain a mixed powder;
the first judging unit is used for judging whether the mixed powder and the real bone powder have the same first appearance characteristic or not;
the first execution unit is used for sucking the mixed powder into a printer according to a vacuum conduit of the printer when the mixed powder and the real bone powder have first appearance characteristics;
and the fourth obtaining unit is used for obtaining the content of a third component and the third component, mixing the third component with the mixed powder to obtain a first polymer, and obtaining the artificial bone biomaterial according to a spray head of the printer.
7. A computer-readable storage medium, on which a computer program is stored which, when being executed by a processor, carries out the steps of the method according to any one of claims 1 to 5.
8. An apparatus for preparing an artificial bone biomaterial comprising a memory, a processor and a computer program stored on the memory and executable on the processor, wherein the processor implements the steps of the method of any one of claims 1-5 when executing the program.
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