CN107991246A - Dual image acquisition module tissue sample scanner and digital imagery recurrence system - Google Patents
Dual image acquisition module tissue sample scanner and digital imagery recurrence system Download PDFInfo
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- CN107991246A CN107991246A CN201711200457.7A CN201711200457A CN107991246A CN 107991246 A CN107991246 A CN 107991246A CN 201711200457 A CN201711200457 A CN 201711200457A CN 107991246 A CN107991246 A CN 107991246A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B11/00—Measuring arrangements characterised by the use of optical techniques
- G01B11/24—Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
- G02B21/365—Control or image processing arrangements for digital or video microscopes
Abstract
The present invention provides a kind of dual image acquisition module tissue sample scanner and digital imagery recurrence system, including optical microscope system, optical splitter, black white image acquisition module and Color Image Acquisition module, the sampling light path of optical microscope system is divided into two by the optical splitter, black white image acquisition module and Color Image Acquisition module are injected respectively, the black and white and coloured image for the tissue sample that scanner obtains pass through image co-registration, can generate profile and details is apparent and the image of color more saturation.Further, the light source of optical microscope system is line polarisation, black white image acquisition module and the preposition polarizing filter of Color Image Acquisition module, and the polarization direction of the polarizing filter printing opacity is vertical with the polarization direction of light source, to filter out dazzle, further improve imaging effect.
Description
Technical field
It is used to obtain the scanner and digital imagery recurrence system of tissue sample micro-image this application involves a kind of, especially
It is a kind of dual image acquisition module tissue sample scanner and digital imagery recurrence system.
Background technology
Pathologic finding is the Pathomorphology method for the pathological change being used to check in biological organs, tissue or cell.For
Inquire into organ, the lysis that tissue or cell are occurred, the method that can use certain Pathomorphology inspection, checks their institutes
The lesion of generation, inquires into lesion Producing reason, pathogenesis, the occurrence and development process of lesion, finally makes pathological diagnosis.Disease
Morphologic inspection method is managed, looks first at the pathological change of gross specimen, then cuts a certain size pathological tissues, with disease
Pathological section is made in reason Histological method, and lesion is further checked with microscope.
Pathologic finding has been widely used in clinical position and scientific research.The inspection of corpse pathology is substantially carried out in clinicing aspect
Look into and surgery Pathology inspection.The purpose of surgery Pathology inspection, first, in order to clarify a diagnosis and verify preoperative diagnosis, is improved clinical
Diagnostic level；Second, after diagnosis clearly, next step therapeutic scheme and estimating prognosis can be determined, and then improve clinical treatment water
It is flat.By Clinical and Pathological Analysis, a large amount of extremely valuable scientific research datas can be also obtained.
Traditional pathologic finding, using light microscope human eye microscopy, the experience and business water of the single doctor of heavy dependence
Flat, there are certain probability of false detection, detection efficiency is low, and tissue sample preserve and carry it is very inconvenient, to long-range meeting
Examine and cause very big obstacle.The digital slices scanner occurred in recent years, avoids frangible, the preservation cost of traditional histotomy
It is high, not Portable belt the defects of, greatly facilitate the consultation of doctors, and also allow for carrying out pathological tissue by software data processing, calmly
Property analysis, quantitative analysis, this lays a good foundation for the exploitation and the research and development of intelligent diagnostics (auxiliary) system of remote diagnosis platform.
Existing pathological section scanner is color scanner, although color scanner can obtain the colour of tissue sample
Information, but due to color scanner use RGB sensors only filter light just can determine that color should occur where.Cause
This, color scanner can lose some details, and be exactly that these details allow image to become apparent from.In addition, existing big portion absolutely
Divide pathological section image processing software, when carrying out outline identification, feature extraction when operation, it is necessary to the image that scanner is obtained
Black white image is converted into, and cannot directly handle coloured image.Black white image is converted into by coloured image, but can the loss of energy some
Image information.
Therefore, it is necessary to one kind can either obtain tissue sample colour information, and can preferably preserve tissue sample profile
With the scanner and digital imagery recurrence system of details, to overcome the limitation of existing pathological section scanner.
The content of the invention
The tissue sample scanner of the present invention includes optical microscope system, optical splitter, black white image acquisition module and colour
The reflected light of tissue sample or transmitted light are divided into two by image capture module, the optical splitter, inject black white image respectively and adopt
Collect module and Color Image Acquisition module.How much interested injection light of the black white image acquisition module only to any set point is,
What kind of the color that it does not have to consideration light is, therefore can obtain the profile and detailed information of tissue sample exactly, it is adopted
The image of collection can be directly used for image processing software and carry out the operation such as outline identification, feature extraction.
The image that the image and existing high pixel digital pathological section scanner observed for human eye microscopy export
Difference, microscopy doctor more intuitively experience be exactly image frame that human eye microscopy is seen be very it is clean clearly, and scanner
The image of output is bright to be had flaw or even obscures, although the shooting pixel of scanner is sufficiently high.Existing numeral disease
Structure of the slice scanner using encapsulation is managed, effectively prevent the interference of external ambient light, but for imaging clearly, illuminate sample
Light source used in product cannot be excessively dark, by the reflection of object lens, slide or other intrawares, transmission, it is unavoidable to produce it is dizzy
Light, and the negative role of dazzle --- highlight, weaken color saturation, contour of object can be become blurred, make sight
Eye fatigue, the discomfort for the person of examining.Therefore, as a further improvement, dual image acquisition module tissue sample of the invention scanning
Instrument, using polarized light source, (light source sheet is combined and is polarized light source used in its optical microphotograph component as polarised light or ordinary light source
Device), black and white and the preposition polarizing filter of Color Image Acquisition module, the polarization direction of the polarizing filter printing opacity with partially
Shake light source polarization direction it is vertical.The light (i.e. information light) for reflecting or transmiting by tissue sample, its polarization state changes to be become again
Into the state of approximate natural light, and dazzle then maintains original polarization state, therefore when light passes through polarizing filter, although meeting
Lose a part of information luminous intensity, but the polarization direction dazzle vertical with the direction that polarizing filter printing opacity polarizes can be filtered
Remove, it is possible to increase the clarity of image outline and details, saturation degree, visual contrast and the visual comfort of color, reach more preferable
Imaging effect.
Simplify as one kind, it is convenient to omit the optical splitter in dual image acquisition module tissue sample scanner, passes through switching
The position of two image capture modules, makes black white image acquisition module and Color Image Acquisition module alternately receive optical microphotograph system
The sampling light path of system.Correspondingly, preposition polarizing filter has two, before being respectively arranged at two image capture modules；Can also
An only polarizing filter, is fixed on the sampling light path of optical microscope system between the image capture module that is sampling.
Another improved mode is dual image acquisition module tissue sample scanner of the invention, its optical microphotograph group
Light source used in part uses polarized light source (light source sheet is as polarised light or the ordinary light source combination polarizer), using polarization parallel point
Beam device replaces optical splitter.Polarization parallel beam splitter device (Wollaston prism as made of YVO4, a-BBO, Iceland spar) will can enter
The information light penetrated is divided into the polarised light of two beam polarization states orthogonal (i.e. light polarization direction is vertical), the propagation of the polarised light of two beams outgoing
Direction is parallel to each other with incident light, i.e., while light splitting, also achieves the separation of polarization state.By rationally setting polarization flat
The position of row beam splitter, makes the polarization direction of its two-way light being emitted, light and polarized light source polarization direction are identical and another all the way
Road is vertical with polarized light source polarization direction.So that vertical with polarized light source polarization direction light all the way, by polarizing parallel point
During beam device, the dazzle for keeping former polarization state has been fallen in natural filtration (dazzle is identical with the polarization direction of polarized light source).So use
This technical solution of polarized light source and polarization parallel beam splitter device, can ensure black and white and Color Image Acquisition mould in the block one
The image of a collection from dazzle influence.
Further, the position of black and white and Color Image Acquisition module can be switched, make its alternately receiving and polarized light source
Vertical that in polarization direction emergent light all the way, you can ensure the image of the two collection from the influence of dazzle.Alternatively, it is also possible to
The plane of polarization (such as 90 degree of rotation light source polarizers) of 90 degree of rotatory polarization light sources, and the position of black and white and Color Image Acquisition module
Put constant, can also realize that two image capture modules alternately receive that vertical with polarized light source polarization direction emergent light all the way.
Control module or outer computer in scanner, position or 90 degree of rotations according to pre-set programs switching image capture module
The polarization direction of polarized light source, makes two image capture modules alternately receive and gathers that vertical with polarized light source polarization direction
Emergent light all the way.
Certainly, under this thinking, those of ordinary skill in the art, it should can also find other polarization state separation assemblies
Instead of polarizing parallel beam splitter device, incident light (including information light and dazzle) is separated and dazzle polarization direction (i.e. polarized light source
Polarization direction) vertical polarised light all the way, so as to eliminate influence of the dazzle to the road photoimaging.
The black and white and coloured image for the tissue sample that scanner of the present invention obtains pass through image co-registration, can generate wheel
The wide and image of color more saturation apparent with details.Described image fusion process, can there is two kinds of processing modes：First, by collecting
Completed into the image processing module inside scanner, second, directly exporting two images by scanner to the existing calculating of hospital
Machine, fusion treatment is carried out by the image processing software on computer.
Present invention also offers a kind of dual image acquisition module tissue sample digital imagery recurrence system, including above-mentioned digraph
As acquisition module tissue sample scanner, image processing module, display device, described image processing module receives tissue sample
Black and white and coloured image carry out image co-registration, generate profile and details is apparent and the image of color more saturation, and be transported to aobvious
Showing device is shown.
Dual image harvester tissue sample scanner provided by the invention and digital imagery recurrence system, overcome existing
The limitation of pathological section scanner, can either obtain tissue sample colour information, and can preferably preserve tissue sample wheel
Wide and details.
Brief description of the drawings
Fig. 1 is the schematic diagram of the first embodiment of the invention；
Fig. 2 is the schematic diagram of second of embodiment of the invention；
Fig. 3,4 for 4th kind of embodiment of the invention schematic diagram.
Wherein, 1- tissue samples, 2- objective tables, 3- object lens, 4- optical splitters, 5- black white image acquisition modules, 6- cromograms
As acquisition module, 7- polarizing filters, 8- polarization parallel beam splitter devices.
Embodiment
As shown in Figure 1, the dual image acquisition module tissue sample scanner of the present invention includes optical microscope system, optical splitter
4th, black white image acquisition module 5 and Color Image Acquisition module 6, the optical splitter is by the reflected light of tissue sample or transmitted light one
It is divided into two, injects black white image acquisition module and Color Image Acquisition module respectively.Black white image acquisition module is only given to any
How much interested the injection light of fixed point is, what kind of the color that it does not have to consideration light is, therefore can obtain tissue exactly
The profile and detailed information of sample, its image gathered can be directly used for image processing software progress outline identification, feature carries
The operation such as take.
The image that the image and existing high pixel digital pathological section scanner observed for human eye microscopy export
Difference, microscopy doctor more intuitively experience be exactly image frame that human eye microscopy is seen be very it is clean clearly, and scanner
The image of output is bright to be had flaw or even obscures, although the shooting pixel of scanner is sufficiently high.Existing numeral disease
Structure of the slice scanner using encapsulation is managed, effectively prevent the interference of external ambient light, but for imaging clearly, illuminate sample
Light source used in product cannot be excessively dark, by the reflection of object lens, slide or other intrawares, transmission, it is unavoidable to produce it is dizzy
Light, and the negative role of dazzle --- highlight, weaken color saturation, contour of object can be become blurred, make sight
Eye fatigue, the discomfort for the person of examining.Therefore, as a further improvement, dual image acquisition module tissue sample of the invention scanning
Instrument, as shown in Fig. 2, light source used in its optical microphotograph component is using polarized light source, (light source sheet is as polarised light or ordinary light source
With reference to the polarizer), black and white and the preposition polarizing filter of Color Image Acquisition module, the polarization side of the polarizing filter printing opacity
It is vertical to the polarization direction with polarized light source.The light (i.e. information light) for reflecting or transmiting by tissue sample, its polarization state
Change the state for becoming approximate natural light again, and dazzle then maintains original polarization state, is seen as polarizing in dazzle on the whole
Dominant partial poolarized light on direction.When light passes through polarizing filter, although a part of information luminous intensity can be lost, polarization
The direction dazzle vertical with the direction that polarizing filter printing opacity polarizes can be filtered out, it is possible to increase image outline and details it is clear
Clear degree, the saturation degree of color, visual contrast and visual comfort, reach more preferable imaging effect.
Simplify as one kind, it is convenient to omit the optical splitter in dual image acquisition module tissue sample scanner, passes through switching
The position of two image capture modules, makes black white image acquisition module and Color Image Acquisition module alternately receive optical microphotograph system
The sampling light path of system.Correspondingly, preposition polarizing filter has two, before being respectively arranged at two image capture modules；Can also
An only polarizing filter, is fixed on the sampling light path of optical microscope system between the image capture module that is sampling.
Another improved mode as shown in Figure 3 and Figure 4, dual image acquisition module tissue sample scanner of the invention,
Light source used in its optical microphotograph component uses polarized light source (light source sheet is as polarised light or the ordinary light source combination polarizer), adopts
Optical splitter is replaced with polarization parallel beam splitter device.Polarize (as made of YVO4, a-BBO, the Iceland spar Wollaston of parallel beam splitter device 8
Prism) incident information light can be divided into the polarised light of two beam polarization states orthogonal (i.e. light polarization direction is vertical), the outgoing of two beams
The direction of propagation of polarised light be parallel to each other with incident light, i.e., while light splitting, also achieve the separation of polarization state.Pass through
The position of polarization parallel beam splitter device is rationally set, makes the polarization direction of its two-way light being emitted, light is polarized with polarized light source all the way
Direction is identical and another way is vertical with polarized light source polarization direction.So that vertical with polarized light source polarization direction light all the way,
During by polarizing parallel beam splitter device, the dazzle (polarization direction of dazzle and polarized light source for keeping former polarization state has been fallen in natural filtration
It is identical).So employing polarized light source and polarizing this technical solution of parallel beam splitter device, it can ensure black and white and cromogram
As one in acquisition module collection image from dazzle influence.
Further, the position of black and white and Color Image Acquisition module can be switched, make its alternately receiving and polarized light source
Vertical that in polarization direction emergent light all the way, you can ensure the image of the two collection from the influence of dazzle.Alternatively, it is also possible to
The plane of polarization (such as 90 degree of rotation light source polarizers) of 90 degree of rotatory polarization light sources, and the position of black and white and Color Image Acquisition module
Put constant, can also realize that two image capture modules alternately receive that vertical with polarized light source polarization direction emergent light all the way.
Control module or outer computer in scanner, position or 90 degree of rotations according to pre-set programs switching image capture module
The polarization direction of polarized light source, makes two image capture modules alternately receive and gathers that vertical with polarized light source polarization direction
Emergent light all the way.
Certainly, under this thinking, those of ordinary skill in the art, it should can also find other polarization state separation assemblies
Instead of polarizing parallel beam splitter device, incident light (including information light and dazzle) is separated and dazzle polarization direction (i.e. polarized light source
Polarization direction) vertical polarised light all the way, so as to eliminate influence of the dazzle to the road photoimaging.
Black white image acquisition module and Color Image Acquisition module in Fig. 1-4 are served only for illustrating, both positions can be mutual
Change.
The black and white and coloured image for the tissue sample that scanner of the present invention obtains pass through image co-registration, can generate wheel
The wide and image of color more saturation apparent with details.Described image fusion process, can there is two kinds of processing modes：First, by collecting
Completed into the image processing module inside scanner, second, directly exporting two images by scanner to the existing calculating of hospital
Machine, fusion treatment is carried out by the image processing software on computer.
Present invention also offers a kind of dual image acquisition module tissue sample digital imagery recurrence system, including above-mentioned digraph
As acquisition module tissue sample scanner, image processing module, display device, described image processing module receives tissue sample
Black and white and coloured image carry out image co-registration, generate profile and details is apparent and the image of color more saturation, and be transported to aobvious
Showing device is shown.
Dual image harvester tissue sample scanner provided by the invention and digital imagery recurrence system, overcome existing
The limitation of pathological section scanner, can either obtain tissue sample colour information, and can preferably preserve tissue sample wheel
Wide and details.The foregoing is only a preferred embodiment of the present invention, is not intended to limit the invention, for the skill of this area
For art personnel, the invention may be variously modified and varied.Within the spirit and principles of the invention, that is made any repaiies
Change, equivalent substitution etc., should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of dual image acquisition module tissue sample scanner, it is characterised in that including optical microscope system, optical splitter, black
The sampling light path of optical microscope system is divided into two by white image capture module and Color Image Acquisition module, the optical splitter,
Black white image acquisition module and Color Image Acquisition module are injected respectively.
2. dual image acquisition module tissue sample scanner according to claim 1, it is characterised in that optical microscope system
Light source be line polarisation, black white image acquisition module and the preposition polarizing filter of Color Image Acquisition module, the polarization filter
The polarization direction of light device printing opacity is vertical with the polarization direction of light source.
A kind of 3. dual image acquisition module tissue sample digital imagery recurrence system, it is characterised in that including：
Dual image acquisition module tissue sample scanner, including optical microscope system, optical splitter, black white image acquisition module and coloured silk
The sampling light path of optical microscope system is divided into two by color image acquisition module, the optical splitter, injects black white image respectively and adopts
Collect module and Color Image Acquisition module；
Image processing module, described image processing module receive tissue sample black and white and coloured image carry out image procossing and/
Or image co-registration, and it is transported to display device；
Display device, receives the handling result of image processing module output and shows.
4. a kind of dual image acquisition module tissue sample scanner, it is characterised in that adopted including optical microscope system, black white image
Collect module and Color Image Acquisition module, the black white image acquisition module and Color Image Acquisition module alternately receive optics and show
The sampling light path of micro-system.
5. dual image acquisition module tissue sample scanner according to claim 4, it is characterised in that optical microscope system
Light source be line polarisation, black white image acquisition module and the preposition polarizing filter of Color Image Acquisition module, the polarizing filter
The polarization direction of device printing opacity is vertical with the polarization direction of light source.
A kind of 6. dual image acquisition module tissue sample digital imagery recurrence system, it is characterised in that including：
Dual image acquisition module tissue sample scanner, including optical microscope system, black white image acquisition module and coloured image
Acquisition module, the black white image acquisition module and Color Image Acquisition module alternately receive the sampled light of optical microscope system
Road；
Image processing module, described image processing module receives the black and white of tissue sample and coloured image carries out image procossing, and
It is transported to display device；
Display device, receives the handling result of image processing module output and shows.
7. a kind of dual image acquisition module tissue sample scanner, it is characterised in that including optical microscope system, polarization state point
From component, black white image acquisition module and Color Image Acquisition module, the light source of the optical microscope system is line polarisation, described
Light splitting polarization state separation assembly isolates all the way line polarisation vertical with the polarization direction of light source by light path is sampled, and black white image is adopted
Collect module and Color Image Acquisition module interleaved acquisition it is vertical with the polarization direction of light source line polarisation imaging.
8. dual image acquisition module tissue sample scanner according to claim 7, it is characterised in that the polarization state
Separation assembly polarizes parallel beam splitter device for polarization parallel beam splitter device.
A kind of 9. dual image acquisition module tissue sample digital imagery recurrence system, it is characterised in that including：
Dual image acquisition module tissue sample scanner, including optical microscope system, polarization state separation assembly, black white image are adopted
Collect module and Color Image Acquisition module, the light source of the optical microscope system is line polarisation, the light splitting polarization state separation group
Part will sample light path and isolate all the way line polarisation vertical with the polarization direction of light source, black and white and Color Image Acquisition module alternating
The collection line polarisation imaging vertical with the polarization direction of light source；
Image processing module, described image processing module receive tissue sample black and white and coloured image carry out image procossing and/
Or image co-registration, and it is transported to display device；
Display device, receives the handling result of image processing module output and shows.
10. dual image acquisition module tissue sample digital imagery recurrence system according to claim 9, it is characterised in that
The polarization state separation assembly is polarization parallel beam splitter device.
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