CN107976795A - Binary channels tissue sample scanner and binary channels tissue sample digital imagery recurrence system - Google Patents
Binary channels tissue sample scanner and binary channels tissue sample digital imagery recurrence system Download PDFInfo
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- CN107976795A CN107976795A CN201711200459.6A CN201711200459A CN107976795A CN 107976795 A CN107976795 A CN 107976795A CN 201711200459 A CN201711200459 A CN 201711200459A CN 107976795 A CN107976795 A CN 107976795A
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Classifications
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/06—Means for illuminating specimens
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/18—Arrangements with more than one light path, e.g. for comparing two specimens
- G02B21/20—Binocular arrangements
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
- G02B21/368—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements details of associated display arrangements, e.g. mounting of LCD monitor
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
- G02B27/01—Head-up displays
- G02B27/017—Head mounted
- G02B27/0172—Head mounted characterised by optical features
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
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- G02B27/017—Head mounted
- G02B2027/0178—Eyeglass type
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Abstract
It is used to obtaining the scanner and digital imagery recurrence system of tissue sample micro-image this application involves a kind of, including the Image Acquisition passage that sets of optical microscope system, two almost symmetries and image output module；The light source of optical microscope system is line polarisation, described two Image Acquisition passages are equipped with light path guidance unit and image acquisition units, the visual angle that people's eyes can be simulated gathers the image of tissue sample from different perspectives, the preposition polarizing filter of two image acquisition units, the polarization direction of the polarizing filter printing opacity is vertical with the polarization direction of light source, so as to filtering out dazzle, make observed tissue sample profile and details is apparent, color is purer, reach more preferable imaging effect.
Description
Technical field
It is used to obtain the scanner and digital imagery recurrence system of tissue sample micro-image this application involves a kind of, especially
It is a kind of binary channels tissue sample scanner and digital imagery recurrence system.
Background technology
Pathologic finding is the Pathomorphology method for the pathological change being used to check in biological organs, tissue or cell.For
Inquire into organ, the lysis that tissue or cell are occurred, the method that can use certain Pathomorphology inspection, checks their institutes
The lesion of generation, inquires into lesion Producing reason, pathogenesis, the occurrence and development process of lesion, finally makes pathological diagnosis.Disease
Morphologic inspection method is managed, looks first at the pathological change of gross specimen, then cuts a certain size pathological tissues, with disease
Pathological section is made in reason Histological method, and lesion is further checked with microscope.
Pathologic finding has been widely used in clinical position and scientific research.The inspection of corpse pathology is substantially carried out in clinicing aspect
Look into and surgery Pathology inspection.The purpose of surgery Pathology inspection, first, in order to clarify a diagnosis and verify preoperative diagnosis, is improved clinical
Diagnostic level；Second, after diagnosis clearly, next step therapeutic scheme and estimating prognosis can be determined, and then improve clinical treatment water
It is flat.By Clinical and Pathological Analysis, a large amount of extremely valuable scientific research datas can be also obtained.
Traditional pathologic finding, using light microscope human eye microscopy, the experience and business water of the single doctor of heavy dependence
Flat, there are certain probability of false detection, detection efficiency is low, and tissue sample preserve and carry it is very inconvenient, to long-range meeting
Examine and cause very big obstacle.The digital slices scanner occurred in recent years, avoids frangible, the preservation cost of traditional histotomy
It is high, not Portable belt the defects of, greatly facilitate the consultation of doctors, and also allow for carrying out pathological tissue by software data processing, calmly
Property analysis, quantitative analysis, this lays a good foundation for the exploitation and the research and development of intelligent diagnostics (auxiliary) system of remote diagnosis platform.
Existing pathological section scanner is single pass, i.e., is absorbed using single image acquisition module from single angle
The image of section.Even during intake section different parts, the relative position of image capture module and section is changed, but
For any position of section, its shooting angle also only has one determined.Although pathological section is generally made very thin,
Under stereomicroscope, it can be found that still there is convex-concave on histotomy surface to be observed in fact, existing pathological section is swept
Retouch limitation of the instrument due to principle, it is impossible to embody the convex-concave of this tissue surface, cause image (plane) and the doctor obtained
There are larger difference for the image (three-dimensional) that human eye microscopy (referring here to stereomicroscope microscopy) is observed, it is possible to influences
The observation and judgement of doctor.In addition be equally the limitation of principle, observation of the pathological section scanner to on-plane surface tissue samples into
As more aobvious inferior position.For example exfoliative cytology checks common has vaginal fluid plate coating checking cervix cancer, sputum smear examination lung
Cancer, makees plate coating checking the urinary tract after primary or metastatic carcinoma and the urine centrifugation in plate coating checking thoracic cavity or abdominal cavity after chest, ascites centrifugation
Tumour, the fritter tissues for cutting off or winning from live body etc..
Therefore, it is necessary to one kind can obtain tissue sample steric information, group of the output image closer to human eye microscopy effect
Tissue samples scanner and digital imagery recurrence system, to overcome the limitation of existing pathological section scanner.
The content of the invention
The accuracy of pathologic finding, which will be established, to be seen tissue sample in observer truly clear on the basis of this, therefore,
Technical scheme, so that imaging effect is closer to for the purpose of the effect of human eye microscopy.
The present invention provides a kind of twin-channel tissue sample scanner, including optical microphotograph component and two simulation people couple
The Image Acquisition passage of eye visual angle tissues observed sample from different angles.The image observed for human eye microscopy and existing
The difference of the image of high pixel digital pathological section scanner output, it is exactly that human eye microscopy is seen that microscopy doctor, which more intuitively experiences,
To image frame be it is very clean clearly and the image of scanner output is bright flaw or even fuzzy, although scanner
Shooting pixel it is sufficiently high.Existing digital pathological section scanner effectively prevent outside using the structure of encapsulation
The interference of ambient light, but for imaging clearly, the light source illuminated used in sample cannot be excessively dark, by object lens, slide or other
The reflection of intraware, transmission, it is unavoidable to produce dazzle, and the negative role of dazzle --- highlight, weaken color
Saturation degree, can become blurred contour of object, make eye fatigue, the discomfort of observer.Therefore, tissue sample of the invention
Scanner, the light source of its microscopic system using polarized light source (light source sheet as polarization or the ordinary light source combination polarizer),
Black white image acquisition module and the preposition polaroid of Color Image Acquisition module, the polarization direction of the polarizing filter printing opacity with
The polarization direction of light source is vertical；Tissue sample reflected light or transmission light polarization state change the state for becoming approximate natural light again,
It is in partial poolarized light dominant on dazzle polarization direction on the whole and dazzle then maintains original polarization state.Light passes through
When crossing preposition polarizing filter, although a part of luminous intensity can be lost, dazzle can be filtered out, and help to improve artwork master
As profile and the clarity of details, it helps improve the saturation degree of coloured image color, improve visual contrast and euphorosia
Degree, so that observed tissue sample profile and details is apparent, color is purer, reaches more preferable imaging effect.
The two images for the tissue sample that scanner of the present invention obtains pass through image co-registration, and generation can react the depth of field
The image of information, close to the effect of human eye microscopy.Described image fusion process, can there is two kinds of processing modes：First, by image
Software is handled to complete；2nd, independently completed by human brain.
The first processing mode is also there are two kinds of solutions, first, by the image processing module being integrated in inside scanner
Complete, second, scanner directly exports two images to the existing computer of hospital, it is soft by the image procossing on computer
Part carries out fusion treatment.
Second of processing mode, is that the paired image of binary channels tissue sample scanner shooting is conveyed to doctor's phase respectively
The eyes answered, by the automatic blending image of the brain of doctor, had both saved scanner or the step of computer carries out image co-registration, and melt
Effect when closing result more close to human eye microscopy.
Present invention also offers a kind of binary channels tissue sample digital imagery recurrence system, including above-mentioned binary channels tissue sample
Product scanner and image reproduction component, described image reproduction component receive the tissue sample that binary channels tissue sample scanner obtains
Image, be rendered and be respectively delivered to the corresponding eyes of observer.
Binary channels tissue sample scanner provided by the invention and digital imagery recurrence system, overcome existing pathological section to sweep
The limitation of instrument is retouched, can obtain tissue sample steric information, output image is closer to human eye microscopy effect.
Brief description of the drawings
Fig. 1 is the schematic diagram of binary channels tissue sample scanner of the present invention；
Wherein, 1- tissue samples, 2- objective tables, 3- object lens, 4- optical splitters, 5- image capture modules, 6- polarizing filters.
Embodiment
Fig. 1 is a kind of schematic diagram of twin-channel tissue sample scanner of the present invention, and optical microphotograph system is eliminated in figure
Component, the emphasis such as the light source assembly of system, support component, part lens prism show symmetrical light path.As shown in Figure 1, left,
The light of right light path is all divided into two parts by optical splitter, and a part incides eyepiece, and a part incides image capture module.This
Sample observer while digitized sampling can also be observed by eyepiece.It is of course also possible to do not set optical splitter and human eye
Microscopy passage, observer observe sample image indirectly by exterior display device.
Twin-channel tissue sample scanner, including optical microphotograph component and two simulation people's eyes visual angles never with angle
Spend the Image Acquisition passage of tissues observed sample；The light source of optical microphotograph component for polarized light source (light source sheet as polarised light or
Person's ordinary light source combination polarizer), two image capture modules 5 are symmetrical arranged, and keep fixed distance, and are in certain folder
Angle, simulation human eye regard the visual angle of thing, the two collects two images of the tissue sample 1 in synchronization different visual angles at the same time,
The two images pass through image co-registration, you can generation can react the image of depth of view information, close to the effect of human eye microscopy observation
Fruit.The preposition polarizing filter 6 of image capture module of each Image Acquisition passage of the binary channels scanner, polarizing filter
The polarization direction of 6 printing opacity of device is vertical with the polarization direction of microscopic system polarized light source.Light is on dazzle polarization direction on the whole
Dominant partial poolarized light, when by preposition polarizing filter, although a part of luminous intensity can be lost, dazzle can
It is filtered out, helps to improve the clarity of black white image profile and details, it helps the saturation degree of coloured image color is improved,
Visual contrast and visual comfort are improved, so that observed tissue sample profile and details is apparent, color is purer
Only, more preferable imaging effect is reached.
Above-mentioned image co-registration process, can there is two kinds of processing modes：First, completed by image processing software；2nd, by human brain
It is autonomous to complete.
The first processing mode is also there are two kinds of solutions, first, by the image processing module being integrated in inside scanner
Complete, second, scanner directly exports two images to the existing computer of hospital, it is soft by the image procossing on computer
Part carries out fusion treatment.
Second of processing mode, is that the left-and right-eye images of binary channels tissue sample scanner shooting are conveyed to doctor respectively
Raw corresponding eyes, by the automatic blending image of the brain of doctor, had both saved scanner or the step of computer carries out image co-registration,
And fusion results more close to human eye microscopy when effect.
Present invention also offers a kind of binary channels tissue sample digital imagery recurrence system, including above-mentioned binary channels tissue sample
Product scanner and image reproduction component, described image reproduction component receive the tissue sample that binary channels tissue sample scanner obtains
Image, be rendered and be respectively delivered to the corresponding eyes of observer.
Specifically, the first implementation method is that image reproduction component includes image receiver module and reproduction glasses, reproduction
The left and right eyeglass of glasses is identical display screen, shows the left-and right-eye images that binary channels tissue sample scanner obtains respectively.
This method needs the display screen of two pieces of ultrahigh resolutions, and since the size of eyeglass limits, the visual field and clarity are difficult
To reach preferable effect at the same time.Therefore, as a further improvement, reappear on glasses and position sensor is housed, its left and right mirror
Piece only shows a part for left-and right-eye images in any position, and eye positions change when observer rotates head, left and right eyeglass
The region of the image of display changes correspondingly and can go through all over entire image.The technical solution is dependent on accurate sensing technology and defeated
Go out algorithm, the requirement to hardware and software is all higher.
Another implementation method is as follows：The binary channels tissue sample digital imagery recurrence system, further include control module,
Display device and liquid crystal glasses, the control module can switch images of left and right eyes according to the control display device of pre-set programs synchronization
The images of left and right eyes eyeglass of image and control liquid crystal switches transparent, completely black pattern so that left eyeglass lens only occur left on the display apparatus
Eye pattern as when it is transparent, and right eye eyeglass only occur on the display apparatus it is transparent during eye image；The pre-set programs can ensure
The refresh rate of display device images is more than 10Hz.
Specifically, control module can control the open and close of liquid crystal lens, opening can control the eyeglass on one side completely black,
To cover the image shown in display device, it is transparent that pass, which can control one side eyeglass, is seen so as to the eyes on the side
Image on to display device.On the other hand, control module output switching signal (such as left eye-＞ right eyes-＞ left eye-＞ right eyes-
Sequentially the continuous diagosis alternate with each other that is repeated up to terminates ＞) display device is arrived, left-and right-eye images is continuously alternately shown in aobvious
On showing device.Control module send out synchronizing signal arrive liquid crystal glasses and display device, make its synchronism switching open and close pattern and a left side,
Eye image, makes left eyeglass lens only occur on the display apparatus transparent during left-eye image, so that only left eye sees left eye this is seen
The image arrived, right eye eyeglass only occur on the display apparatus it is transparent during eye image so that only right eye sees right eye this is seen
Image.Shot although the eyes of observer do not have to receive at the same time in the image of the tissue sample of synchronization, due to
Human eye vision persists the physiological property of (about 0.1~0.4 second), is appropriately arranged with switching frequency (the i.e. display device of left-and right-eye images
Refresh rate) just observer can be made to see real stereo-picture.Since the screen of image reproduction unit can be made than eye
Lens dimension is much larger, therefore during observer's diagosis, is not required to rely on extra position induction device and output algorithm, as long as rotating
As long as head even rotates eyeball, it is possible to it was observed that the various pieces of tissue sample image.
Preferably, the refresh rate of display device images is more than 80Hz.The refresh rate of display device is higher, and image is more steady
Fixed, image display is more natural clear, and the influence to eyes is also smaller.Refreshing frequency is too low, image flicker and shake just very
Severity, eye fatigue obtain also just fast.In general, as can the refresh rate for reaching more than 80Hz be just completely eliminated image flicker and
Shake sense, eyes will not be too easily tired.
The binary channels tissue sample scanner and binary channels tissue sample digital imagery recurrence system of the present invention, both retains existing
Have the advantages that pathological section scanner is automatic, efficient, and overcome existing pathological section scanner can only obtain tissue sample
The limitation of product plane information, its effect being imaged make observer obtain preferably observation body closer to the effect of human eye microscopy
Test.
The foregoing is only a preferred embodiment of the present invention, is not intended to limit the invention, for the skill of this area
For art personnel, the invention may be variously modified and varied.Within the spirit and principles of the invention, that is made any repaiies
Change, equivalent substitution etc., should all be included in the protection scope of the present invention.
Claims (6)
1. a kind of binary channels tissue sample scanner, including the Image Acquisition that optical microscope system, two almost symmetries are set are led to
Road and image output module；The light source of optical microscope system is line polarisation, and described two Image Acquisition passages are equipped with light path and draw
Unit and image acquisition units are led, the visual angle that can simulate people's eyes gathers the image of tissue sample, two figures from different perspectives
As the preposition polarizing filter of collecting unit, the polarization direction of the polarizing filter printing opacity are vertical with the polarization direction of light source.
2. a kind of binary channels tissue sample digital imagery recurrence system, including following device：
Binary channels tissue sample scanner, including the Image Acquisition passage and figure that optical microscope system, two almost symmetries are set
As output module；The light source of optical microscope system is line polarisation, and described two Image Acquisition passages are equipped with light path guidance unit
And image acquisition units, the visual angle that can simulate people's eyes gather the image of tissue sample, two Image Acquisition from different perspectives
The preposition polaroid of unit, the polarization direction of the polarizing filter printing opacity are vertical with the polarization direction of light source；
Image reproduction component, receives the image for the tissue sample that binary channels tissue sample scanner obtains, and is rendered and distinguishes
It is transported to the corresponding eyes of observer.
3. binary channels tissue sample digital imagery recurrence system according to claim 2, it is characterised in that described image is multiple
Existing component includes image receiver module and reproduction glasses, and the left and right eyeglass of the glasses is identical display screen, and display is double respectively
The left-and right-eye images that channel organization Sample Scan instrument obtains.
4. binary channels tissue sample digital imagery recurrence system according to claim 3, it is characterised in that on reproduction glasses
Equipped with position sensor, its left and right eyeglass only shows a part for left-and right-eye images in any position, when eye positions change,
The region for the image that left and right eyeglass is shown changes correspondingly and can go through all over entire image.
5. binary channels tissue sample digital imagery recurrence system according to claim 2, it is characterised in that including controlling mould
Block, display device and liquid crystal glasses, the control module can switch left and right according to the control display device of pre-set programs synchronization
The images of left and right eyes eyeglass of eye pattern picture and control liquid crystal switches transparent, completely black pattern so that left eyeglass lens only occur on the display apparatus
It is transparent during left-eye image, and right eye eyeglass only occur on the display apparatus it is transparent during eye image；The pre-set programs can protect
The refresh rate of card display device images is more than 10Hz.
6. binary channels tissue sample digital imagery recurrence system according to claim 5, it is characterised in that the display dress
The refresh rate put is more than 80Hz.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111103679A (en) * | 2019-12-03 | 2020-05-05 | 苏州福尼亚医疗科技有限公司 | External double-path synchronous parallel light 3D image real-time acquisition device and system of microscope |
| US11006093B1 (en) | 2020-01-22 | 2021-05-11 | Photonic Medical Inc. | Open view, multi-modal, calibrated digital loupe with depth sensing |
| CN113885300A (en) * | 2021-09-14 | 2022-01-04 | 拾斛科技(南京)有限公司 | Wafer alignment microscope, photoetching machine, bonding machine and stamping machine |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111103679A (en) * | 2019-12-03 | 2020-05-05 | 苏州福尼亚医疗科技有限公司 | External double-path synchronous parallel light 3D image real-time acquisition device and system of microscope |
| US11006093B1 (en) | 2020-01-22 | 2021-05-11 | Photonic Medical Inc. | Open view, multi-modal, calibrated digital loupe with depth sensing |
| US11166006B2 (en) | 2020-01-22 | 2021-11-02 | Photonic Medical Inc. | Open view, multi-modal, calibrated digital loupe with depth sensing |
| US11412202B2 (en) | 2020-01-22 | 2022-08-09 | Photonic Medical Inc. | Open view, multi-modal, calibrated digital loupe with depth sensing |
| US11611735B2 (en) | 2020-01-22 | 2023-03-21 | Photonic Medical Inc. | Open view, multi-modal, calibrated digital loupe with depth sensing |
| CN113885300A (en) * | 2021-09-14 | 2022-01-04 | 拾斛科技(南京)有限公司 | Wafer alignment microscope, photoetching machine, bonding machine and stamping machine |
| CN113885300B (en) * | 2021-09-14 | 2024-05-31 | 拾斛科技(南京)有限公司 | Wafer alignment microscope, photoetching machine, bonding machine and stamping machine |
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Application publication date: 20180501 |