CN107982409A

CN107982409A - A kind of Chinese medicine composition for treating syringomyelia, pill and preparation method thereof

Info

Publication number: CN107982409A
Application number: CN201711367634.0A
Authority: CN
Inventors: 郭永昌; 胡建庚; 宋京博; 张其彬; 建展展; 鹿淼; 洪景亚
Original assignee: ZHENGZHOU TRADITIONAL CHINESE HOSPITAL OF ORTHOPAWDICS
Current assignee: ZHENGZHOU TRADITIONAL CHINESE HOSPITAL OF ORTHOPAWDICS
Priority date: 2017-12-18
Filing date: 2017-12-18
Publication date: 2018-05-04
Anticipated expiration: 2037-12-18
Also published as: CN107982409B

Abstract

The invention discloses a kind of Chinese medicine composition for treating syringomyelia, pill and preparation method thereof, which includes the raw material of following parts by weight：78~84 parts of 210~222 parts of saline cistanche, 210~222 parts of rhizoma cibotii, 103~113 parts of psoralea corylifolia, 103~113 parts of radix achyranthis bidentatae, 84~94 parts of the bark of eucommia, 131~139 parts of asparagus fern, 50~58 parts of cicada slough and plantain seed.The Chinese medicine composition of the treatment syringomyelia of the present invention selects natural Chinese traditional medicines raw material, using saline cistanche, rhizoma cibotii as monarch drug in a prescription, using psoralea corylifolia, radix achyranthis bidentatae, the bark of eucommia as ministerial drug, using asparagus fern, cicada slough as adjutant, using plantain seed as medicine is made, the Action advantage and mutually synergistic effect of above-mentioned each Chinese herb are comprehensively utilized, there is the effect of nourishing liver and kidney, life essence-filling, marrow-benefitting, strengthening tendons relaxing muscles and tendons, benefit the moon promoting blood circulation, it is evident in efficacy for the syringomyelia caused by caused by liver and kidney deficiency, it is easy to use.

Description

A kind of Chinese medicine composition for treating syringomyelia, pill and preparation method thereof

Technical field

The present invention relates to Chinese medicine compound prescription technical field, in particular to a kind of Chinese traditional medicine composition for treating syringomyelia Thing, pill and preparation method thereof.

Background technology

Syringomyelia is the chronic progressive degenerative disease of spinal cord, its clinical characters is spinal cord (mainly grey matter) interior shape Into tubular cavity and colloid (non-neuronal cells) hyperplasia, dissociated sensory disturbance occurs in lesion segment, and (pain, athalposis, are touched Feel and exist), muscular atrophy and dystrophia.Lesion in lower neck marrow and upper chest marrow, can also be developed to oblongata upwards more, claim oblongata empty Hole disease, also known as syringobulbia；Also lower breast marrow even waist sacrum marrow can be developed to downwards.This disease belongs to " flaccid paralysis " of the traditional Chinese medical science, " consumptive disease " Deng sick category.Since the course of disease of syringomyelia is touching, recurrent exerbation, many people lose labour capacity.Thus, spinal cord empty Disease brings very big burden to patient and society.

The treatment of syringomyelia at present mainly uses radiotherapy and operative treatment, but radiotherapy to human injury very Greatly, curative effect cannot also be affirmed；And operative treatment is there are certain risk, and postoperative easily recurrence.

The content of the invention

In view of this, a kind of Chinese medicine composition for treating syringomyelia provided by the invention, pill and preparation method thereof, The above-mentioned problems of the prior art and defect preferably are overcome, the Chinese medicine composition of the treatment syringomyelia selects pure day Right Chinese herb, using saline cistanche, rhizoma cibotii as monarch drug in a prescription, using psoralea corylifolia, radix achyranthis bidentatae, the bark of eucommia as ministerial drug, using asparagus fern, cicada slough as assistant Medicine, using plantain seed as medicine is made, comprehensively utilizes the Action advantage of above-mentioned each Chinese herb and mutually acts synergistically, have nourishing liver It is the effect of kidney, life essence-filling, marrow-benefitting, strengthening tendons relaxing muscles and tendons, benefit the moon promoting blood circulation, evident in efficacy for the syringomyelia caused by caused by liver and kidney deficiency, make With conveniently.

A kind of Chinese medicine composition for treating syringomyelia, includes the raw material of following parts by weight：Saline cistanche 210~222 Part, 210~222 parts of rhizoma cibotii, 103~113 parts of psoralea corylifolia, 103~113 parts of radix achyranthis bidentatae, 84~94 parts of the bark of eucommia, asparagus fern 131~139 78~84 parts of part, 50~58 parts of cicada slough and plantain seed.

Further, the saline cistanche is 214~220 parts；The rhizoma cibotii is 214~220 parts.

Further, the psoralea corylifolia is 105~110 parts；The radix achyranthis bidentatae is 105~110 parts；The bark of eucommia for 87~ 92 parts.

Further, the asparagus fern is 133~137 parts；The cicada slough is 52~56 parts；The plantain seed is 80~82 Part.

Further, the saline cistanche is 216 parts；The rhizoma cibotii is 216 parts；The psoralea corylifolia is 108 parts；The bosom ox Knee is 108 parts；The bark of eucommia is 89 parts；The asparagus fern is 135 parts；The cicada slough is 54 parts；The plantain seed is 81 parts.

Present invention also offers a kind of pill for treating syringomyelia, the pill includes above-mentioned treatment spinal cord empty The Chinese medicine composition of disease.

Further, 1~3 part of starch and 10~20 parts of honey have been additionally added in every 100 parts of Chinese medicine compositions.

Present invention also offers a kind of preparation method for the pill for treating syringomyelia, the pill includes above-mentioned control Treat the Chinese medicine composition of syringomyelia；The preparation method includes：Powder is uniformly mixed so as to obtain after the raw material is crushed.

Further, 100 parts of powders, 1~3 part of starch, 10~20 parts of honey and 30~40 parts of pure water are mixed Wet ball is made after stirring.

Further, by the wet ball drying to moisture 5% (weight) below to obtain plain ball, and the plain ball is lived Property charcoal bag charcoal clothing and with talcum powder polishing, wherein, the every 100 parts plain balls using 0.45~0.55 part of activated carbon and 0.45~ 0.55 part of talcum powder.

Compared with prior art, a kind of Chinese medicine composition, pill and its preparation side for treating syringomyelia of the invention The beneficial effect of method is：

(1) Chinese medicine composition for the treatment of syringomyelia of the invention selects natural Chinese traditional medicines raw material, with saline cistanche, dog Ridge is monarch drug in a prescription, using psoralea corylifolia, radix achyranthis bidentatae, the bark of eucommia as ministerial drug, using asparagus fern, cicada slough as adjutant, using plantain seed as medicine is made, is comprehensively utilized The Action advantage of above-mentioned each Chinese herb and mutually synergistic effect, have nourishing liver and kidney, life essence-filling, marrow-benefitting, strengthening tendons relaxing muscles and tendons, Yi Yin The effect of promoting blood circulation, ache of the spinal column, the extremity numbness of flaccid paralysis caused by can correcting caused by liver and kidney deficiency are meciless, premature ejaculation of passing out semen, have a dizzy spell, Dry throat tinnitus, menoxenia, and stride give up entirely, the deformation of leg shin, muscular atrophy, pork gradually de-, weak and limp powerless, chilly limb The symptom such as cold；It is evident in efficacy for the syringomyelia caused by caused by liver and kidney deficiency, it is easy to use.In addition, the treatment ridge of the present invention The Chinese medicine composition preparation method of marrow cavity disease is simple, and manufacturing cost is low, and safe to use, no pain, have no toxic side effect.

To enable the above objects, features and advantages of the present invention to become apparent, preferred embodiment cited below particularly, makees detailed It is described as follows.

Embodiment

For the ease of understanding the present invention, elaborate with reference to the mode of embodiment to technical scheme, Many details are elaborated in the following description in order to fully understand the present invention.

But the invention can be embodied in many other ways as described herein, those skilled in the art can be with Similar improvement is done in the case of without prejudice to intension of the present invention, therefore the present invention is not limited to the specific embodiments disclosed below.

A kind of Chinese medicine composition for treating syringomyelia, includes the raw material of following parts by weight：

Such as 210 parts, 212 parts, 215 parts, 216 parts, 218 parts, 220 parts or 222 parts of 210~222 parts of saline cistanche；

Such as 210 parts, 212 parts, 215 parts, 216 parts, 218 parts, 220 parts or 222 parts of 210~222 parts of rhizoma cibotii；

Such as 103 parts, 105 parts, 108 parts, 110 parts or 113 parts of 103~113 parts of psoralea corylifolia；

Such as 103 parts, 105 parts, 108 parts, 110 parts or 113 parts of 103~113 parts of radix achyranthis bidentatae；

Such as 84 parts, 86 parts, 89 parts, 90 parts, 92 parts or 94 parts of 84~94 parts of the bark of eucommia；

Such as 131 parts, 133 parts, 135 parts, 137 parts or 139 parts of 131~139 parts of asparagus fern；

Such as 50 parts, 52 parts, 54 parts, 56 parts or 58 parts of 50~58 parts of cicada slough；

Such as 78 parts, 79 parts, 80 parts, 81 parts, 82 parts, 83 parts or 84 parts of 78~84 parts of plantain seed.

It should be noted that saline cistanche is sweet, salty, temperature, returns kidney, large intestine channel.With kidney-replenishing, the effect of benefiting essence-blood.For The insufficiency of the kidney yang, essence and blood lose Virtual, soreness and weakness of waist and knees, and muscles and bones is powerless.《This warp》：" main general debility ",《Haigoushen》：" beneficial marrow, pleases face Color, macrobiosis ".《Solar corona》：" moisturizing viscera, long muscle, warms up waist and knee ".《Beautiful Chinese catalpa medicine solution》：" warm waist and knee, strong bone meat, nourshing kidney extractum hepatis Blood, ease constipation stomach knot are dry ".《Book on Chinese herbal medicine is just》：" warm waist and knee, hard muscles and bones ".Rhizoma cibotii is bitter, sweet, warm, returns liver and kidney channel.With wind-damp dispelling, mend The effect of liver kidney, strong waist and knee.For arthralgia pain due to rheumatism, soreness and weakness of waist and knees, weakness of the lower extremities.《This warp》：" main back is strong, emergency of shutting down, week Numbness, cold-dampness goinyalgia ".《Do not record》：" treating man's flaccidity of lower limbs pain in the back, hard ridge, sharp pitching ".《Beautiful Chinese catalpa medicine solution》：" impotence analgesic is played, lets out kidney liver Moisture, consciousness restoring, strengthens the bone, and controls pain in the back goinyalgia, and the swollen leg of foot is weak ".《Bencao Jingshu》：" the bitter energy eliminating dampness of rhizoma cibotii, the sweet beneficial blood of energy, Temperature can foster the spirit of nobility, and be the medicine mended and can walked.Then back is strong for kidney deficiency, and there is the disease of emergency in organ.Enriching yin boost qi blood, then back is not strong, Trouble of the organ without emergency ".Two medicine phases 5, filling liver kidney, muscle reinforcing and bone strengthening, strong spinal column, replenishing essence life marrow, is altogether monarch drug in a prescription.

Psoralea corylifolia is pungent, bitter, and temperature, returns kidney, the spleen channel.With warming kidney and enhancing yang, gas of receiving is relievingd asthma, warming spleen and stopping diarrha effect.For kidney YANG deficiency, waist and knee crymodynia, kidney Virtual breathe heavily, Diarrhoea.Radix achyranthis bidentatae is bitter, sweet, sour, puts down, returns liver and kidney channel.With dispelling stasis of blood and stimulating the menstrual flow, mend Liver kidney, strengthening the bones and muscles, the effect of ensurining proper downward flow of the blood.It is powerless for soreness of waist and knee joint, muscles and bones.《Do not record》：" bowl spares continues absolutely, fills out marrow, except brain Middle pain and pain along spinal column ".《The southern regions of the Yunnan Province book on Chinese herbal medicine》：" only muscles and bones pain, strengthening tendons relaxing muscles and tendons, only waist and knee is tingle ".《Book on Chinese herbal medicine is just》：" nourishing marrow and benefitting semen, benefit The moon promoting blood circulation ".Bark of eucommia sweet, warm, returns liver and kidney channel.With filling liver kidney, the effect of strengthening the bones and muscles.For kidney deficiency and liver, soreness of waist and knee joint, muscle Bone is powerless, has a dizzy spell.《This warp》：" main pain along spinal column, bowl spares, strengthening the essence gas, hard muscles and bones, Qiang Zhi, long term usage are made light of one's life by commiting suicide resistance to old ".《Pharmacological property By》：" it is cold to control kidneyPain in the back ".Three medicine phases 5, reinforcement muscles and bones, strong spinal column, filling liver kidney, are altogether ministerial drug with the power of principal drug assistance.

Asparagus fern is sweet, slight bitter, is slightly cold, and attaches to the lung and stomach meridians.With clearing heat-fire, promote the production of body fluid to quench thirst, the effect of detumescence and apocenosis.For Pyreticosis polydipsia, lung-heat type cough, Heat Diabetes, sore swollen toxin.《This warp》：" strong marrow, long term usage are made light of one's life by commiting suicide, QI invigorating macrobiosis ".《Detailed outline》： " moisturizing enriching yin, clearing and descending lung-fire ".《Book on Chinese herbal medicine is new again》：" clearing away the heart-fire, kidney-nourishing water, degrading the channel, and regulating blood condition point ".《Changsha medicine solution》：" my god In the winter, clear aurification water, slakes thirst and help produce saliva, and disappear abscess of throat, except cough vomiting of pus and blood.It is aquatic in gold, Jin Qingze is aquatic, kidney water to be given birth to, must be clear Lung gold, clear gold and unboiled water person, the dry withered person of water of soil are very suitable ".Cicada slough is sweet, trembles with fear, return lung, Liver Channel.With dispelling wind and heat from the body, relieving sore-throat, The effect of promoting eruption, removing nebula, spasmolysis.For anemopyretic cold, pharyngalgia hoarse voice, measles without adequate eruption, rubella itch, cataract, shies Wind is twitched, lockjaw.Asparagus fern moistening lung nourshing kidney, makes mutual generation between metal and water, to help the work(of production of sperm mends marrow；The soft muscle dredging collateral of cicada slough, is altogether adjutant.

Plantain seed is sweet, trembles with fear, Return liver, kidney, lung, small intestinl channel.The effect of hot inducing diuresis for treating strangurtia of Ju You Cheongju, eliminating the phlegm, cool blood, removing toxic substances. For puckery pain of heat gonorrhea, oedema oliguria, summer heat damp diarrhea, phlegm-heat cough, hematemesis and epistaxis, carbuncle sore tumefacting virus.《Book on Chinese herbal medicine is newly organized》：" with passing through Among closing, with rushing down within benefit, the energy Li Shui that begins is without gas consumption, and water key is opened and orifice for discharging seminal fluid closes, and natural spirit is healthy and vigorous ".Plantain seed dampness removing And clearind deficient heat, order are mended without stagnant.

The Chinese medicine composition of the treatment syringomyelia of the present invention selects natural Chinese traditional medicines raw material, with saline cistanche, rhizoma cibotii For monarch drug in a prescription, using psoralea corylifolia, radix achyranthis bidentatae, the bark of eucommia as ministerial drug, using asparagus fern, cicada slough as adjutant, using plantain seed to make medicine, in comprehensive utilization State the Action advantage of each Chinese herb and mutually act synergistically, it is cloudy living with nourishing liver and kidney, life essence-filling, marrow-benefitting, strengthening tendons relaxing muscles and tendons, benefit The effect of blood, ache of the spinal column, the extremity numbness of flaccid paralysis caused by can correcting caused by liver and kidney deficiency are meciless, premature ejaculation of passing out semen, have a dizzy spell, swallow Do entirely useless tinnitus, menoxenia, and stride, the deformation of leg shin, muscular atrophy, pork gradually de-, weak and limp powerless, aversion to cold and cold limbs Etc. symptom；It is evident in efficacy for the syringomyelia caused by caused by liver and kidney deficiency, it is easy to use.

Preferably, the saline cistanche is 214~220 parts；The rhizoma cibotii is 214~220 parts.

Preferably, the psoralea corylifolia is 105~110 parts；The radix achyranthis bidentatae is 105~110 parts；The bark of eucommia is 87~92 Part.

Preferably, the asparagus fern is 133~137 parts；The cicada slough is 52~56 parts；The plantain seed is 80~82 parts.

Preferably, the saline cistanche is 216 parts；The rhizoma cibotii is 216 parts；The psoralea corylifolia is 108 parts；The radix achyranthis bidentatae For 108 parts；The bark of eucommia is 89 parts；The asparagus fern is 135 parts；The cicada slough is 54 parts；The plantain seed is 81 parts.

Further, be additionally added in every 100 parts of Chinese medicine compositions 1~3 part such as 1 part, 1.5 parts, 2 parts, 2.5 parts or 3 parts of starch and 10~20 parts such as 10 parts, 12 parts, 15 parts, 18 parts or 20 parts honey.Preferably, every 100 parts of Chinese traditional medicine compositions 1.5 parts of starch and 15 parts of honey have been additionally added in thing.

Preferably, 100 parts of powders, 1~3 part of starch, 10~20 parts of honey and 30~40 parts of pure water are mixed and stirred Wet ball is made after mixing.

Preferably, by the wet ball drying to moisture 5% (weight) below to obtain plain ball, and the plain ball is active Charcoal bag charcoal clothing and with talcum powder polishing, wherein, the every 100 parts plain balls using 0.45~0.55 part as 0.45 part, 0.48 part, Such as 0.45 part, 0.48 part, 0.5 part, 0.52 part or 0.55 of 0.5 part, 0.52 part or 0.55 part activated carbon and 0.45~0.55 part Part talcum powder.

The Chinese medicine composition and its pill of the present invention is safe to use, has no toxic side effect.Because pill makes simple, easy clothes With easy to carry, when preparation can be not added with or less plus auxiliary material, cost is low, and suitable for big production, therefore formulation is preferably pill.Certainly, Other formulations, such as tablet, capsule, granule etc. can be made as needed.

For the ease of understanding the present invention, the technical side of the present invention is further illustrated with reference to embodiment and specific case Case.

Embodiment 1

(1) Chinese medicine material is weighed：210 parts of saline cistanche, 222 parts of rhizoma cibotii, 103 parts of psoralea corylifolia, 113 parts of radix achyranthis bidentatae, the bark of eucommia 84 78 parts of part, 131 parts of asparagus fern, 58 parts of cicada slough and plantain seed.

(2) above-mentioned each Chinese medicine material is ground into carefully with TF300B types Double-grade disintegrating mill (production of Tianjin Chinese traditional medicine machine factory) Powder, it is equal to be subsequently placed in mixing in the efficient three-dimensional motion mixer of GH-200 types (production of Harbin medication chemistry equipment Co., Ltd) It is even, up to powder.

(3) 100 parts of above-mentioned powders being prepared are taken to be placed in (the Tianshui city China garden pharmacy of CHJ-200 types trough type mixing machine Equipment Science and Technology Ltd. produces) in, first add 1 part of starch and 10 parts of honey are stirred 10min, add 30 parts of pure water and stir About 20min is mixed, obtains softwood.

(4) above-mentioned softwood is placed in YUJ-17B type intelligent and high-efficiencies full automatic machine for producing pills (Tianshui city Hua Yuan pharmaceutical equipments section Skill Co., Ltd produces) in tie rod, rub ball with the hands, obtain the wet ball that rounding is uniform, appearance is consistent, a diameter of 4.0~4.3mm.

(5) the wet ball of above-mentioned preparation is placed in HWL15-1 microwave drying sterilization cases (Tianshui city China garden pharmaceutical equipment science and technology Co., Ltd produces) under the conditions of 50 DEG C of hot winds, 80 DEG C of the temperature inside the box, it is 50~60 minutes dry, solid carbon dioxide point is obtained below 5% Plain ball.

(6) above-mentioned plain ball is placed in TG-1000 coating pans (production of Tianshui city Hua Yuan pharmaceutical equipments Science and Technology Ltd.) Middle bag charcoal clothing, talcum powder polishing, every 100 parts plain balls can add each 0.45 part of activated carbon, talcum powder, obtain pill.

Clinical case：Plum so-and-so, female, 53 years old, people from Huangchuan County of Henan Province.Patient 2015 without obvious inducement occur neck, shoulder, Back pain, symptoms are mild, does not give treatment；Above-mentioned symptom aggravates after patient's fatigue in 2016, through rest and oral drug therapy After have no and be clearly better；On 2 15th, 2017 patients to our hospital's hospitalization, be admitted to hospital symptoms include：Neck, shoulder, back pain, before neck Stretch limitation of activity after bending, god is clear, spirit can, receive dormancy can, stool and urine is normal.Training inspection：Cervical curvature shoals, after anteflexion Stretch limitation of activity, 6 centrum spinous process of neck 3- chests and the equal tenderness in both sides, both shoulders supraspinous muscle tenderness.Auxiliary examination：C spine ap ＆ lat, open Mouth position, t spine ap ＆ lat bit slice：1. cervical vertebra degenerative change；2. thoracic vertebrae degenerative change.Cervical vertebra MRI：1. neck 5-6,6-7 interverbebral disc Prominent 2. neck 4-5 intervertebral disc protrusions；3. 4 horizontal spinal cord abnormality signal of neck 6- chests, considers spinal cord empty；4. cervical vertebra degenerative disease Become.It is diagnosed as：1. cervical spondylosis；2. syringomyelia；3. thoracic vertebrae disordered small joint disease.Give drug therapy of the present invention, warm water Take, a 9g, 3 times a day, patient's neck shoulder back pain relief after 2 weeks, neck anterior flexion and rear stretching limitation of activity improves, without other Discomfort, is left hospital.Continue to take medicine of the present invention after discharge, follow-up neck shoulder back is without obvious pain after 2 months, without obvious Limitation of activity.

Embodiment 2

(1) Chinese medicine material is weighed：212 parts of saline cistanche, 220 parts of rhizoma cibotii, 105 parts of psoralea corylifolia, 110 parts of radix achyranthis bidentatae, the bark of eucommia 86 80 parts of part, 133 parts of asparagus fern, 56 parts of cicada slough and plantain seed.

(3) 100 parts of above-mentioned powders being prepared are taken to be placed in (the Tianshui city China garden pharmacy of CHJ-200 types trough type mixing machine Equipment Science and Technology Ltd. produces) in, first add 1.5 parts of starch and 15 parts of honey are stirred 10min, add 35 parts of pure water Stir about 20min, obtains softwood.

(6) above-mentioned plain ball is placed in TG-1000 coating pans (production of Tianshui city Hua Yuan pharmaceutical equipments Science and Technology Ltd.) Middle bag charcoal clothing, talcum powder polishing, every 100 parts plain balls can add each 0.5 part of activated carbon, talcum powder, obtain pill.

Clinical case：Jiang, female, 46 years old, Gushi County of Henan Province people from county.There is dizziness in 2015 without obvious inducement in patient, Astasia, has foot to step on cotton sense, bows and is aggravated when bending over, neck, back pain, improves after local hospital treatment.2016 Above-mentioned symptom aggravates after year patient's fatigue in July, has no and is clearly better after rest and oral drug therapy, therefore in 2 months 2017 15 days to our hospital's hospitalization, be admitted to hospital symptoms include：Dizziness, astasia, has foot to step on cotton sense, bows and is aggravated when bending over, nape part Pain, god is clear, spirit can, receive dormancy can, stool and urine is normal.Training inspection：Cervical curvature shoals, anterior flexion and rear stretching active receiving Limit, 5 centrum spinous process of neck 3- chests and the equal tenderness in both sides.Auxiliary examination：C spine ap ＆ lat, mouth-open, t spine ap ＆ lat bit slice：1. cervical vertebra Degenerative change；2. thoracic vertebrae degenerative change.Cervical vertebra MRI：1. neck 5-6,6-7 disc herniation 2. neck 6- chests, 4 horizontal spinal cords are different Regular signal, considers spinal cord empty；3. cervical vertebra retrogression pathological changes.It is diagnosed as：1. cervical spondylosis；2. syringomyelia.Give the present invention Drug therapy, warm water delivery service, a 9g, 3 times a day, patient's nape part pain relief after 2 weeks, dizziness mitigate, without it He is uncomfortable, is left hospital.Continuing to take medicine of the present invention after discharge, follow-up nape part is without obvious pain after 2 months, no dizziness, Recover good.

Embodiment 3

(1) Chinese medicine material is weighed：216 parts of saline cistanche, 216 parts of rhizoma cibotii, 108 parts of psoralea corylifolia, 108 parts of radix achyranthis bidentatae, the bark of eucommia 89 81 parts of part, 135 parts of asparagus fern, 54 parts of cicada slough and plantain seed.

Clinical case：Feng so-and-so, man, 49 years old, Henan Province people from Wuzhi.Occurs the cold pain of waist acid after patient's fatigue in 2016 Bitterly, rest no alleviation, it is impossible to which long row is found in sitting long, in local commune hospital's drug administration (specifically unknown) less effective afterwards, is not given Further treatment.Patient pain aggravates within 2 months 2017, is treated then in 2017.2.15 Ru our hospital.Be admitted to hospital symptoms include：Flank pain, Lumbar vertebrae limitation of activity, god is clear, spirit can, receive the difference that can sleep, stool and urine is normal, pale tongue with white fur, small and wiry pulse.Physical examination：Waist is stiff, raw Reason bending shoals, lumbar vertebrae lateral bending to the left, waist 3-4, tenderness between 1 spinous process of waist 5- sacrums and by vertebra.Auxiliary examination：L spine ap ＆ lat, bone Basin P-A Cephalomatrics：1. regression that lumbar vertebrae is slight；2. lumbar lateral curvature.Pelvic position can, all bony structures of pelvis, density and joint space are not See obvious exception.Lumbar vertebrae CT：1. degenerative lumbar；2.L3/4, L4/5 intervertebral disc protrusion, the left back protrusion of L5/S1 interverbebral discs；3. consider Syringomyelia.It is diagnosed as：1. syringomyelia；2. lumbar disc herniation；3. scoliosis.Give medicine of the present invention to control Treat, a 9g, 3 times a day, warm water delivery service.Patient's flank pain is uncomfortable after January mitigates, lumbar vertebrae mobility can, do not tell remaining Discomfort, stable disease, gives discharge.Continue to take medicine of the present invention after discharge, 2017.11.22 follow-ups lumbosacral region without obvious pain, Without lumbar vertebrae limitation of activity.

Embodiment 4

(1) Chinese medicine material is weighed：218 parts of saline cistanche, 215 parts of rhizoma cibotii, 110 parts of psoralea corylifolia, 105 parts of radix achyranthis bidentatae, the bark of eucommia 92 83 parts of part, 137 parts of asparagus fern, 52 parts of cicada slough and plantain seed.

Clinical case：So-and-so is defended, man, 52 years old, people from Tongling Anhui.There is double lower limb in 2015 without obvious inducement in patient Powerless, right lower extremity is attached most importance to, difficulty in walking, dizzy, astasia, is treated in local hospital with " cervical spondylosis ", less effective, then in On December 16th, 2015 is to our hospital.Be admitted to hospital symptoms include：Double lower limb is powerless, and right lower extremity is attached most importance to, and walks lamely, and difficulty in walking is dizzy, stands Vertical shakiness, receive food can, sleep is poor, and stool and urine is normal, pale tongue with white fur, deep,thready and forceless pulse.Training inspection：Cervical vertebrate active degree is anteflexion 35 °, after stretch 30 °, 35 ° of left and right lateroflexion, 40 ° of left rotation and right rotation, rotation neck experiment is positive, and bilateral Hoffmann sign is stealthy, bilateral Babin this Base sign is negative, IV grade of double lower limb muscular strength.Auxiliary examination：Cervical vertebra MRI:Neck 4/5,5/6,6/7,7/ chest of neck, 1 interverbebral disc exit, neck 2- 5 centrum horizontal centre enlargement of pipe of chest, incorporated by reference to clinic.It is diagnosed as：1. cervical spondylosis；2. syringomyelia.Give medicine of the present invention Treatment, a 9g, 3 times a day, warm water delivery service.After 1 month patient's symptom improve, dizziness alleviate, can normal stand, double lower limb IV grade of muscular strength, does not tell that remaining is uncomfortable, stable disease, it is desirable to leave hospital.Continue to take medicine of the present invention, follow-up after 3 months after discharge Without dizziness, energy normal stand, double lower limb is strong earlier above, and walking is normal.

Embodiment 5

(1) Chinese medicine material is weighed：222 parts of saline cistanche, 210 parts of rhizoma cibotii, 113 parts of psoralea corylifolia, 103 parts of radix achyranthis bidentatae, the bark of eucommia 84 84 parts of part, 139 parts of asparagus fern, 50 parts of cicada slough and plantain seed.

(3) 100 parts of above-mentioned powders being prepared are taken to be placed in (the Tianshui city China garden pharmacy of CHJ-200 types trough type mixing machine Equipment Science and Technology Ltd. produces) in, first add 3 parts of starch and 20 parts of honey are stirred 10min, add 40 parts of pure water and stir About 20min is mixed, obtains softwood.

(6) above-mentioned plain ball is placed in TG-1000 coating pans (production of Tianshui city Hua Yuan pharmaceutical equipments Science and Technology Ltd.) Middle bag charcoal clothing, talcum powder polishing, every 100 parts plain balls can add each 0.55 part of activated carbon, talcum powder, obtain pill.

Clinical case：Mr. Lin, female, 62 years old, Shanxi Province Changzhi City people.There is right lower extremity after patient's fatigue in January, 2016 Powerless, right knee pain, does not give treatment, after because pain aggravate, it is to our hospital on 2 26th, 2016.Be admitted to hospital symptoms include：Right lower extremity Powerless, right knee pain, flank pain, squats down limited, and walking is unstable, receive food can, sleep is poor, and stool and urine is normal, pale tongue with white fur, arteries and veins It is heavy thin.Training inspection：Scoliosis, bow-backed deformity, squats down limited, the equal tenderness III of lower edge, external lower margin, ligamentum patellae in right knee kneecap Level, right II grade of condylus medialis femoris tenderness, there is knee articulation degree：100 ° of flexing, 0 ° of hyperextension.Right knee kneecap grinding test is positive. There are tenderness, percussion pain in 2,3,4,5 spinous process of waist and spinous process both sides.Auxiliary examination：Right knee MRI：1. right knee joint degeneration bone closes Section is scorching；2. right knee joint cavity level suprapatellar bursa hydrops；3. right knee joint surface edge sub-dermal soft tissue oedema.Lumbar vertebrae CT：1. degenerative lumbar； 2.L3/4, L4/5 intervertebral disc protrusion；3. syringomyelia.It is diagnosed as：1. right knee osteoarthritis and synovitis；2. spinal cord empty Disease；3. scoliosis, give drug therapy of the present invention, a 9g, 3 times a day, warm water delivery service.Patient's symptom after January Improve, flank pain mitigates, and right knee pain relief, right lower extremity is strong earlier above, does not tell that remaining is uncomfortable, stable disease, it is desirable to leave hospital. Continue to take medicine of the present invention after discharge, follow-up waist is substantially painless after 3 months, and energy normal stand, right lower extremity is strong earlier above, OK Walk normal.

It is as follows to the pill progress compliance test result of the treatment marrow cavity disease of the present invention：

By the patient of 500 syringomyelias, the age is 40~65 years old, is randomly divided into 5 groups, by above-mentioned application method originally The Chinese medicine composition of inventive embodiments 1~5 is treated.

Curative effect judges：

Cure：Symptom and sign disappears substantially.

Effectively：Symptom and sign is alleviated.

It is invalid：Symptom and sign is preceding without improvement with treatment.

Application method：It is oral, a 9g, 3 times a day；10 days as a treatment course, are used continuously in 3 course for the treatment of present invention After drug composition, statistical result is as follows：

Group	Total number of persons	Cure	Effectively	It is invalid	Total effective rate
						Embodiment 1	100	82	12	6	94%
Embodiment 2	100	82	13	5	95%
						Embodiment 3	100	88	10	2	98%
Embodiment 4	100	81	13	6	94%
						Embodiment 5	100	80	13	7	93%

As seen from the above table, after traditional Chinese medicine composition for treating of the present invention, work well, effective percentage is more than 93%, cure rate Up to more than 80%, it can be seen that, the treatment of pill of the invention to syringomyelia has preferable effect.In addition, from cure rate With effective percentage in general, the therapeutic effect of embodiment 3 is best.

It is to be directed to using the pill (hereinafter referred to as mends marrow ball) of the treatment syringomyelia of the preparation of the embodiment of the present invention 3 below Muscular atrophy experiment, acute toxicity testing and the long term toxicity test of animal.

First, mends marrow ball is amyotrophic on rat denervation influences experiment

1 experiment material

1.1 test medicine：Mends marrow ball, face the used time with 0.1%CMC-Na be configured to debita spissitudo for examination.

1.2 positive drug：Jewellery ball, 1g/10, lot number 060921, Chinese medicines quasi-word Z21020292, Fuxin anaesthetic is limited Responsible company produces, and when experiment is made into the suspension of 0.06g/ml with 0.1%CMC-Na.

1.3 instrument：DS-671 type electronic scales, Shanghai Teraoka Electronic Co., Ltd.'s production；BS223S type electronic balances, Beijing Sai Duolisi instrument systems Co., Ltd produces.

Experimental subjects：Wistar rats 60,200~220g of weight, half male and half female, is carried by experimental animal center of henan province For.

2 experimental methods：

2.1 experiment packet：Above-mentioned Wistar rats are randomly divided into 6 groups, every group 10, half male and half female.

2.1.1 model control group：0.1%CMC-Na, 10ml/kg；

2.1.2 Normal group：0.1%CMC-Na, 10ml/kg；

2.1.3 positive drug control group：Jewellery ball 0.6g/kg；

2.1.4 mends marrow ball 3.1g patent medicine/kg (31%, 8 times of quite clinical daily dose)；

2.1.5 mends marrow ball 1.55g patent medicine/kg (15.5%, 4 times of quite clinical daily dose)；

2.1.6 mends marrow ball 0.775g patent medicine/kg (7.75%, 2 times of quite clinical daily dose).

2.2 experimental procedure

2.2.1 anaesthetized with the intraperitoneal injection of 30mg/kg yellow Jackets, outer middle side part aseptic operation appears after right lateral thigh Sciatic nerve, in pyriformis lower edge to cut off sciatic nerve at remote 5mm, is sutured, notch is closed in layering with microsutures.

2.2.2 postoperative animal sub-cage rearing；It is administered 8 weeks, is administered once a day, 10ml/kg weight to each group rat oral gavage (model control group, Normal group 10ml 0.1%CMC-Na/kg weight).

2.2.3 after the last administration 24 it is small when, with lethal dose yellow Jackets be injected intraperitoneally put to death animal, separation cut sura Flesh, weighs on assay balance immediately.

2.3 statistical method：Comparison among groups t is examined.

3 experimental results

The gastrocnemius of the heavy dose of group of mends marrow ball it is full it is flexible, appearance is glossy；And the obvious atrophy of control group gastrocnemius becomes Small, appearance is dim；Wet weight of gastrocnemius muscle is higher than model control group, and difference has significant；The mends marrow ball is to denervated muscle The influence of atrophy is as shown in table 1 below.

The influence weak to experimental rat muscular atrophy muscles and bones impotence of 1 mends marrow ball of table

Note：Compared with model control group, * P ＜ 0.05, * * P ＜ 0.01.

4 conclusions

It can be drawn by upper table 1, mends marrow ball has the function that denervated muscle atrophy rat to improve denervated muscle atrophy.

2nd, influence experiment of the mends marrow ball to myasthenia mouse muscular strength

1 experiment material

1.3 acetylcholinergic receptors (AChR), U.S.'s sigma Products；Split completely (FCA), U.S. sigma are public Take charge of product.

Experimental subjects：10~12 week old Kunming rats 60,25~30g of weight, half male and half female, by Henan Province experimental animal Center provides.

2 experimental methods：

2.1 experiment packet：Above-mentioned experimental rat is randomly divided into 6 groups, every group 10, half male and half female.

2.1.1 model control group：0.1%CMC-Na, 10ml/kg；

2.1.2 Normal group：0.1%CMC-Na, 10ml/kg；

2.1.3 positive drug control group：Jewellery ball 0.6g/kg；

2.2 experimental procedure

2.2.1 1 is pressed with AChR and freund adjuvant：2 mix after mouse is immunized, first sensitization takes AChR that 75 μ g/ml are made to resist Former emulsion, in back, limbs, many places intradermal vaccination of tail base portion.

2.2.2 used after 4 weeks and contain 150 μ g/ml antigens emulsions sensitization again.Vehicle control group is immunized with equivalent freund adjuvant.

2.2.3 model was determined in 7~14 days after final immunization, criterion：There is hair and dry up, is grand in EAMG mouse The different degrees of myasthenia performance such as the back of the body, appetite decline, activity reduction and cyllopodia；Swimming test shows that EAMG model mices are swum The swimming time is significantly shorter than vehicle control group and Normal group.

2.2.4 after model foundation, 4 weeks, 1 time a day, 20mL/kg weight (model comparisons are administered in each group rat continuous gavage Group, Normal group, freund adjuvant control group 20ml 0.1%CMC-Na/kg weight).

2.2.5 after the last administration 24 it is small when, mouse hind leg is hanging, make its fore paw grasp a diameter 0.5cm metal it is thin Bar 20 times, records the number that each animal successfully holds steady metal thin bar；Then, by mouse be put into sink 2 minutes (depth of water 20cm, 25 DEG C of water temperature), observe and record the number of animals that can normally swim 2 minutes.

2.3 statistical method：Comparison among groups t is examined.

3 experimental results

The normal necton number and successfully grasping number is higher than model control group that mends marrow ball heavy dose is organized, difference has Significant；The mends marrow ball grasps myasthenia mouse and the influence of Burden-Swimming Ability of KM is as shown in table 2 below.

Myasthenia mouse is grasped 2 mends marrow ball of table and the influence of Burden-Swimming Ability of KM

Note：Compared with model control group, * P ＜ 0.05, * * P ＜ 0.01.

4 conclusions

It can be drawn by upper table 2, mends marrow ball has the function that myasthenia mouse to improve muscular strength.

3rd, acute toxicity testing

Experiment material：Mends marrow ball；47.2% suspension is made into 0.1%CMC-Na during experiment.

Experimental subjects：Kunming mouse 20,18~22g of weight, half male and half female, is carried by experimental animal center of henan province For licensing：SCXK (Henan) 2005-0001.

Experimental method：

Kunming mouse 20 is used in experiment, half male and half female, and after fasting 12h, by 47.2% gavage of Cmax, volume is 0.4ml/10g, gavage 3 times (at intervals of 8h) in one day, total dosage reach 56.64g patent medicine/kg, conventinal breeding after administration, observation Two weeks.

Experimental result：

As shown in table 3, after administration, mouse activity is normal；Its hair, the state of mind and diet etc. are showed no exception；Weight Change is normal；Mouse is without death in two weeks；LD is not measured₅₀, the mouse maximum dosage-feeding for measuring mends marrow ball gastric infusion is 56.64g patent medicine/kgd, equivalent to 146.74 times of clinical application amount.

Before and after 3 mends marrow ball gavage of table mouse weight change (g)

4th, long term toxicity test

Experiment material：

1 test medicine：Mends marrow ball, when experiment, are made into 40.77% suspension with 0.1%CMC-Na.

2 kits

Alanine aminotransferase (lactic dehydrogenase enzyme process), Shanghai Kehua Bio-engineering Co., Ltd provide, lot number 071220；

Aspartate amino transferase (malate dehydrogenase enzyme process), Shanghai Kehua Bio-engineering Co., Ltd carries For lot number 071220；

Alkaline phosphatase (AMP buffer methods), Shanghai Kehua Bio-engineering Co., Ltd provide, lot number 071202；

R- glutamyl transpeptidases：East China water chestnut diagnostic products corporation of Shanghai section provides, lot number 071202；

Total protein (biuret method), Shanghai Kehua Bio-engineering Co., Ltd provide, lot number 071116；

Albumin (Bromocresol green), Shanghai Kehua Bio-engineering Co., Ltd provide, lot number 071116；

T-CHOL (enzymatic measurement), Shanghai Kehua Bio-engineering Co., Ltd provide, lot number 071218；

Triglycerides：East China water chestnut diagnostic products corporation of Shanghai section provides, lot number 071208；

Blood glucose：East China water chestnut diagnostic products corporation of Shanghai section provides, lot number 071202；

Urea nitrogen (glutamate dehydrogenase enzyme process), Shanghai Kehua Bio-engineering Co., Ltd provide, lot number 071208；

Creatinine (enzymic creatinine assay method), Shanghai Kehua Bio-engineering Co., Ltd provide, lot number 071222；

Total bilirubin (Vanadic acid oxidation), Shanghai Kehua Bio-engineering Co., Ltd provide, lot number 071226；

3 instruments

DS-671 type electronic scales, Shanghai Teraoka Electronic Co., Ltd.；

BS223S type electronic balances, Beijing Sai Duolisi instrument systems Co., Ltd；

MS9-5 cellanalyzers, France；

Au-400 automatic clinical chemistry analyzers, Japan.

Experimental subjects：Wistar rats, half male and half female, 80~100g of weight, is provided by experimental animal center of henan province, is permitted It can demonstrate,prove：SCXK (Henan) 2005-0001.

Experimental method：

1 animal packet and administration：Wistar rats 80 are used in experiment, and half male and half female, is randomly divided into 4 groups, every group 20.Raise Material is provided by experimental animal center of henan province, 23 ± 2 DEG C of room temperature, humidity 50~70%, natural lighting, and daily timing ventilation changes Gas, group rearing, male and female are separated, per 5 rats of cage, observation three days before testing.Gastric infusion, 2 times a day, each 20ml/kg, continuously Three months.

1. blank control group：0.1%CMC-Na, 20ml/kg.d；

2. mends marrow ball high dose group：18.88g patent medicine/kg.d, equivalent to 48.95 times of clinical application amount；

3. mends marrow ball middle dose group：17.59g patent medicine/kg.d, equivalent to 45.60 times of clinical application amount；

4. mends marrow ball low dose group：16.31g patent medicine/kg.d, equivalent to 42.29 times of clinical application amount.

2 observation index

2.1 ordinary circumstances and weight：The behavioral activity of observation animal, amount of drinking water, excrement excretion and animal dead etc. daily Situation, measures appetite daily, claims a weight weekly, and adjust dosage according to changes of weight.

2.2 blood cell analysis：It is administered the 90th day and is discontinued after raising 14 days (fasting 12h, can't help water), every group of each work every time 10 animals, half male and half female are killed, broken end takes blood to carry out blood cell analysis, including red blood cell number (RBC), content of hemoglobin (Hb), leukocyte count (WBC) and leukocyte differential count (LY, MO, GR), platelet count (BPC).

2.3 blood biochemicals measure：Including alanine aminotransferase (ALT), Aspartate amino converting Enzyme (AST), It is alkaline phosphatase (ALP), r- glutamyl transpeptidases (GGT), total protein (TP), albumin (ALB), total bilirubin (TBI), total Cholesterol (CHO), triglycerides (TG), blood glucose (GLU), flesh liver (CR), urea nitrogen (BUN).

2.4 organ indexs and histopathologic examination：After taking blood, weigh each main organs (brain, the heart, liver, spleen, lung, kidney, Adrenal gland, thymus gland, Testes And Epididymides, ovary and uterus), visually observed and calculate organ index；10% formalin fixes, Specimens paraffin embedding slices, H.E. dyeing carry out histopathologic examination.

3 statistical methods：As a result comparison among groups t inspections are carried out.

Experimental result：

Influence (unit of the 4 mends marrow ball of table to male rat weight：G,)

Influence (unit of the 5 mends marrow ball of table to female rats weight：G,)

Influence of the 6 mends marrow ball of table (administration 3 months) to rat blood index

Influence of the 7 mends marrow ball of table (administration 3 months, is discontinued 14 days) to rat blood index

Influence of the 8 mends marrow ball of table (administration 3 months) to rat blood biochemistry

Influence of the 9 mends marrow ball of table (administration 3 months) to rat blood biochemistry

Influence of the 10 mends marrow ball of table (administration 3 months, is discontinued 14 days) to rat blood biochemistry

Influence of the 11 mends marrow ball of table (administration 3 months, is discontinued 14 days) to rat blood biochemistry

12 mends marrow ball of table (administration 3 months) to Rats Organs and Tissues index influence (Unit:%)

13 mends marrow ball of table (administration 3 months, be discontinued 14 days) to Rats Organs and Tissues index influence (Unit:%)

It can be drawn by above-mentioned table 4~13：

1 general status：During mends marrow ball is administered and after drug withdrawal, the feelings such as behavioral activity, amount of drinking water and excrement excretion of animal Condition is showed no exception.

2 weight and food-intake：During mends marrow ball is administered and after drug withdrawal, the weight of animals increases compared with the control group, without significantly Sex differernce, is shown in Table 4 and table 5.

4 haemocyte inspections：Mends marrow ball be administered three months and be discontinued 2 weeks, haemocyte is had no significant effect, indices with it is right Compare according to group, there was no significant difference, is shown in Table 6 and table 7.

5 blood biochemistry checkings：Mends marrow ball is administered three months and is discontinued 2 weeks, though indivedual biochemical indicators have compared with the control group Significant difference, but in normal range (NR), abiology meaning, is shown in Table 8 to table 11.

6 organ coefficients：Mends marrow ball is administered three months and is discontinued 2 weeks, and main organs index is had no significant effect, is shown in Table 12 Hes Table 13.

7 histopathologic examinations：The visible major organs regular shape of each group animal naked eyes, flexible, envelope is smooth complete, Soft texture, section have no tissue protrusion and shrinkage depression.The lesions such as cell degeneration, muddiness, liquefaction and necrosis, cell membrane are had no under mirror And nuclear structures are clear, institutional framework is close, and cell arrangement is neat, well arranged.

To sum up, mends marrow ball is with 18.88g patent medicine/kg weight, 17.59g patent medicine/kg weight and 16.31g patent medicine/kg weight (48.95 times, 45.60 times and 42.29 times that are respectively equivalent to clinical application amount) three dosage are administered 3 to rat continuous gavage Month and be discontinued 2 weeks, to rat body weight growth, haemocyte, blood biochemical, main organs index and histopathological examination without bright Development is rung, and there was no significant difference compared with blank control group.Therefore, it can be deduced that：The mends marrow ball is to rat without obvious accumulative Toxicity and retardance toxic reaction.

It should be noted that the pill for the treatment of syringomyelia prepared by the embodiment of the present invention 3 is replaced with of the invention real The medicine pill for the treatment of syringomyelia prepared by example 1~2 and embodiment 4~5 is applied, can reach above-mentioned same experiment effect.

The preferred embodiment of the present invention is above are only, is not intended to limit the invention, for those skilled in the art For member, inventive formulation and preparation process can have various modifications and variations.Within the spirit and principles of the invention, institute Any modification, equivalent substitution, improvement and etc. of work, should all be included in the protection scope of the present invention.

Claims

A kind of 1. Chinese medicine composition for treating syringomyelia, it is characterised in that：Include the raw material of following parts by weight：Saline cistanche 210~222 parts, 210~222 parts of rhizoma cibotii, 103~113 parts of psoralea corylifolia, 103~113 parts of radix achyranthis bidentatae, 84~94 parts of the bark of eucommia, asparagus fern 78~84 parts of 131~139 parts, 50~58 parts of cicada slough and plantain seed.
2. the Chinese medicine composition for the treatment of syringomyelia according to claim 1, it is characterised in that：The saline cistanche is 214~220 parts；The rhizoma cibotii is 214~220 parts.
3. the Chinese medicine composition for the treatment of syringomyelia according to claim 1, it is characterised in that：The psoralea corylifolia is 105~110 parts；The radix achyranthis bidentatae is 105~110 parts；The bark of eucommia is 87~92 parts.
4. the Chinese medicine composition for the treatment of syringomyelia according to claim 1, it is characterised in that：The asparagus fern is 133 ~137 parts；The cicada slough is 52~56 parts；The plantain seed is 80~82 parts.
5. the Chinese medicine composition for the treatment of syringomyelia according to claim 1, it is characterised in that：The saline cistanche is 216 parts；The rhizoma cibotii is 216 parts；The psoralea corylifolia is 108 parts；The radix achyranthis bidentatae is 108 parts；The bark of eucommia is 89 parts；It is described Asparagus fern is 135 parts；The cicada slough is 54 parts；The plantain seed is 81 parts.
A kind of 6. pill for treating syringomyelia, it is characterised in that：The pill includes any one of Claims 1 to 5 institute The Chinese medicine composition for the treatment syringomyelia stated.
7. the pill for the treatment of syringomyelia according to claim 6, it is characterised in that：Every 100 parts of Chinese traditional medicine compositions 1~3 part of starch and 10~20 parts of honey have been additionally added in thing.
A kind of 8. preparation method for the pill for treating syringomyelia：It is characterized in that：The pill includes Claims 1 to 5 Any one for the treatment of syringomyelia Chinese medicine composition；The preparation method includes：Mixed after the raw material is crushed It is even to obtain powder.
9. the preparation method of the pill for the treatment of syringomyelia according to claim 8, it is characterised in that：By 100 parts of institutes State after powder, 1~3 part of starch, 10~20 parts of honey and 30~40 parts of pure water are mixed and wet ball is made.
10. the preparation method of the pill for the treatment of syringomyelia according to claim 9, it is characterised in that：Will be described wet Ball drying to moisture 5% (weight) below to obtain plain ball, and by the plain ball with active charcoal bag charcoal clothing and with talcum powder polishing, Wherein, the every 100 parts plain balls use 0.45~0.55 part of activated carbon and 0.45~0.55 part of talcum powder.