CN107970176B - Compound plant extract and application thereof in preparation of sunscreen cream - Google Patents
Compound plant extract and application thereof in preparation of sunscreen cream Download PDFInfo
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- CN107970176B CN107970176B CN201810057730.3A CN201810057730A CN107970176B CN 107970176 B CN107970176 B CN 107970176B CN 201810057730 A CN201810057730 A CN 201810057730A CN 107970176 B CN107970176 B CN 107970176B
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- sunscreen
- olea europaea
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- 239000000419 plant extract Substances 0.000 title claims abstract description 21
- 150000001875 compounds Chemical class 0.000 title claims description 12
- 230000000475 sunscreen effect Effects 0.000 title abstract description 49
- 239000000516 sunscreening agent Substances 0.000 title abstract description 44
- 239000006071 cream Substances 0.000 title abstract description 25
- 238000002360 preparation method Methods 0.000 title description 8
- 239000000284 extract Substances 0.000 claims abstract description 59
- 240000007817 Olea europaea Species 0.000 claims abstract description 56
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 36
- 102100028717 Cytosolic 5'-nucleotidase 3A Human genes 0.000 claims abstract description 22
- 241000219745 Lupinus Species 0.000 claims abstract description 22
- 238000001035 drying Methods 0.000 claims abstract description 20
- 238000000605 extraction Methods 0.000 claims abstract description 6
- 235000002725 Olea europaea Nutrition 0.000 claims description 32
- 240000000894 Lupinus albus Species 0.000 claims description 31
- 235000010649 Lupinus albus Nutrition 0.000 claims description 31
- 239000002904 solvent Substances 0.000 claims description 14
- 238000001914 filtration Methods 0.000 claims description 12
- 238000010992 reflux Methods 0.000 claims description 10
- 238000011084 recovery Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 11
- 239000002131 composite material Substances 0.000 abstract description 10
- 239000002537 cosmetic Substances 0.000 abstract description 10
- 239000000203 mixture Substances 0.000 abstract description 6
- 230000002195 synergetic effect Effects 0.000 abstract description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 13
- 238000012360 testing method Methods 0.000 description 13
- 230000000052 comparative effect Effects 0.000 description 12
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 12
- 238000002835 absorbance Methods 0.000 description 11
- 206010015150 Erythema Diseases 0.000 description 9
- 231100000321 erythema Toxicity 0.000 description 9
- -1 flavonoid compounds Chemical class 0.000 description 9
- 230000008030 elimination Effects 0.000 description 8
- 238000003379 elimination reaction Methods 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 239000002994 raw material Substances 0.000 description 7
- 210000003491 skin Anatomy 0.000 description 7
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 6
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 6
- 241000283973 Oryctolagus cuniculus Species 0.000 description 6
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 6
- 239000004359 castor oil Substances 0.000 description 6
- 235000019438 castor oil Nutrition 0.000 description 6
- DTPCFIHYWYONMD-UHFFFAOYSA-N decaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO DTPCFIHYWYONMD-UHFFFAOYSA-N 0.000 description 6
- 239000008367 deionised water Substances 0.000 description 6
- 229910021641 deionized water Inorganic materials 0.000 description 6
- 239000004205 dimethyl polysiloxane Substances 0.000 description 6
- 235000011187 glycerol Nutrition 0.000 description 6
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 6
- 229940075529 glyceryl stearate Drugs 0.000 description 6
- 229940057995 liquid paraffin Drugs 0.000 description 6
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 6
- 229960005323 phenoxyethanol Drugs 0.000 description 6
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 6
- 229940032094 squalane Drugs 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 230000002745 absorbent Effects 0.000 description 5
- 239000002250 absorbent Substances 0.000 description 5
- 206010040914 Skin reaction Diseases 0.000 description 4
- 239000002390 adhesive tape Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000010453 quartz Substances 0.000 description 4
- 238000012216 screening Methods 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 206010042496 Sunburn Diseases 0.000 description 3
- 239000006096 absorbing agent Substances 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 230000035483 skin reaction Effects 0.000 description 3
- 231100000430 skin reaction Toxicity 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 229940052821 lupinus albus seed extract Drugs 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000037072 sun protection Effects 0.000 description 2
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 244000132436 Myrica rubra Species 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 230000006750 UV protection Effects 0.000 description 1
- 238000011481 absorbance measurement Methods 0.000 description 1
- PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 150000008366 benzophenones Chemical class 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229940114081 cinnamate Drugs 0.000 description 1
- 229930016911 cinnamic acid Natural products 0.000 description 1
- 235000013985 cinnamic acid Nutrition 0.000 description 1
- 239000008408 compound extracted from plant Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 230000004224 protection Effects 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- 239000002884 skin cream Substances 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention discloses a composite plant extract and application thereof in preparing sunscreen cream. The composite plant extract consists of lupin seed extract and olive bark extract, and has excellent sunscreen effect in cosmetics as a sunscreen agent. The lupin seed extract is obtained by conventional extraction and drying with low-concentration ethanol, and the olive bark extract is obtained by conventional extraction and drying with high-concentration ethanol. According to the invention, the lupin seed extract and the olive bark extract are used as sunscreen active components according to a specific mass ratio, so that the sunscreen composition has an obvious synergistic effect in the aspects of absorbing ultraviolet rays and repairing sunburned skin, and an unexpected technical effect is achieved.
Description
Technical Field
The invention relates to the field of daily cosmetics, in particular to a composite plant extract and application thereof in preparing sunscreen cream.
Background
Sunscreen refers to blocking or absorbing ultraviolet rays by some methods for the purpose of preventing skin from being sunburned, etc. General sunscreen method: applying sun-screening products, using sun-screening clothes and other articles, eating sun-screening foods, etc. Sunscreen products are classified as physical, chemical, biological; wherein, the high and low sun protection indexes can reflect the ultraviolet protection capability of the sun protection product.
Sunscreen research is a hot spot in cosmetics and dermatology. The role of sunscreens in cosmetics is an important measure to prevent ultraviolet light from causing damage to the human body. Currently used ultraviolet shielding substances are classified into two types: physical barriers and chemical absorbents. The chemical absorbent is also called ultraviolet absorbent and is divided into chemical synthesis and natural extraction. Chemically synthesized ultraviolet absorbers such as cinnamic acid, cinnamate, salicylate, benzophenone derivatives, and the like; the ultraviolet absorbent of natural extract refers to natural ultraviolet absorbent compounds extracted from plants, such as: flavonoid compounds, anthraquinone compounds, plant polyphenol compounds and derivatives thereof, and the like. Because of the toxic and side effects of chemically synthesized UV absorbers in the cosmetic industry, the research and application of natural and nontoxic UV absorbers has been receiving more and more attention from people.
At present, although there are various sunscreen plant extracts on the market, lupin (LUPINUS ALBUS) seed extract, olive (OLEA EUROPAEA) bark extract also exist in the category of names of cosmetic raw materials used, there is no report on both as sunscreen active ingredients.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a composite plant extract and an application thereof in preparing sunscreen cream. The invention is realized by the following technical scheme:
a compound plant extract comprises Lupinus ALBUS seed extract and Olea EUROPAEA bark extract.
Preferably, the mass ratio of the lupin (LUPINUS ALBUS) seed extract to the olive (OLEA EUROPAEA) bark extract is 1-3: 1-3.
Preferably, the mass ratio of the lupin (LUPINUS ALBUS) seed extract to the olive (OLEA EUROPAEA) bark extract is 3: 1.
preferably, the lupin (LUPINUS ALBUS) seed extract is obtained by conventional extraction and drying with low concentration ethanol, and the olive (OLEA EUROPAEA) bark extract is obtained by conventional extraction and drying with high concentration ethanol.
Preferably, the Lupinus ALBUS (Lupinus ALBUS) seed extract is obtained by refluxing and extracting with 5-10 times by weight of 10-20% ethanol at volume concentration for 2-3 hours, filtering, recovering solvent, and drying, and the Olea EUROPAEA (Olea EUROPAEA) bark extract is obtained by refluxing and extracting with 5-10 times by weight of 80-90% ethanol at volume concentration for 2-3 hours, filtering, recovering solvent, and drying.
The invention also provides application of the composite plant extract in preparation of sunscreen cream.
Preferably, the weight percentage of the composite plant extract in the sunscreen cream is 2-5%.
Compared with the prior art, the cosmetic has the beneficial effects that: the composite plant extract of the invention is composed of lupin (LUPINUS ALBUS) seed extract and olive (OLEA EUROPAEA) bark extract, and has excellent sunscreen effect in cosmetics as a sunscreen agent. The Lupinus ALBUS (Lupinus ALBUS) seed extract is obtained by extracting with low concentration ethanol and drying, and the Olea EUROPAEA (Olea EUROPAEA) bark extract is obtained by extracting with high concentration ethanol and drying. The invention adopts lupin (LUPINUS ALBUS) seed extract and olive (OLEA EUROPAEA) bark extract as sunscreen active components according to specific mass ratio, has obvious synergistic effect in the aspects of absorbing ultraviolet rays and repairing sunburn skin, and obtains unexpected technical effect.
Detailed Description
The present invention will be further specifically described with reference to the following examples.
Example 1:
a sunscreen cream is prepared from the following raw materials in percentage by mass:
the compound plant extract is 3%
Glyceryl stearate 5%
PEG-60 hydrogenated Castor oil 4%
PEG-10 polydimethylsiloxane 3%
Liquid paraffin 5%
1 percent of squalane
5 percent of glycerin
0.5 percent of triethanolamine
0.1 percent of phenoxyethanol
0.05 percent of essence
The balance of deionized water.
The compound plant extract is prepared from lupin (LUPINUS ALBUS) seed extract, olive (OLEA EUROPAEA) bark extract according to the mass ratio of 3: 1, the white lupin (LUPINUS ALBUS) seed extract is obtained by refluxing and extracting for 3 hours by 8 times of ethanol with volume concentration of 20% by weight, filtering, recovering the solvent and drying, and the olive (OLEA EUROPAEA) bark extract is obtained by refluxing and extracting for 2 hours by 10 times of ethanol with volume concentration of 90% by weight, filtering, recovering the solvent and drying.
The preparation method of the sunscreen cream specifically comprises the following process steps:
(1) the raw materials are divided into the following three groups:
group one: glyceryl stearate, PEG-60 hydrogenated castor oil, PEG-10 polydimethylsiloxane, liquid paraffin, and squalane;
and a second group: glycerol, triethanolamine and deionized water;
and (3) group III: composite plant extract, phenoxyethanol and essence;
(2) mixing all the components of the first component, adding the mixture into an oil phase pot, heating to 85 ℃, rotating speed: 2500 rpm, stirring evenly for 20 minutes;
(3) mixing all the components of the second group, adding the mixture into a water phase pot, heating to 85 ℃, rotating speed: 2500 rpm, stirring evenly for 20 minutes;
(4) mixing the liquids obtained in the steps (1) and (2) with each other, homogenizing and emulsifying at the temperature of 80 ℃ and the rotating speed: 2000 rpm, duration 20 minutes;
(5) cooling to 45 ℃ after emulsification, adding all the components of the group III, stirring uniformly, and rotating speed: 2500 rpm, lasting for 10 minutes, finally cooling to room temperature and discharging.
Example 2:
a sunscreen cream is prepared from the following raw materials in percentage by mass:
the compound plant extract is 3%
Glyceryl stearate 5%
PEG-60 hydrogenated Castor oil 4%
PEG-10 polydimethylsiloxane 3%
Liquid paraffin 5%
1 percent of squalane
5 percent of glycerin
0.5 percent of triethanolamine
0.1 percent of phenoxyethanol
0.05 percent of essence
The balance of deionized water.
The compound plant extract is prepared from lupin (LUPINUS ALBUS) seed extract, olive (OLEA EUROPAEA) bark extract according to the mass ratio of 1: 1, the white lupin (LUPINUS ALBUS) seed extract is obtained by refluxing and extracting for 3 hours by 8 times of ethanol with volume concentration of 20% by weight, filtering, recovering the solvent and drying, and the olive (OLEA EUROPAEA) bark extract is obtained by refluxing and extracting for 2 hours by 10 times of ethanol with volume concentration of 90% by weight, filtering, recovering the solvent and drying.
The preparation method of the sunscreen cream is the same as that of example 1.
Example 3:
a sunscreen cream is prepared from the following raw materials in percentage by mass:
the compound plant extract is 3%
Glyceryl stearate 5%
PEG-60 hydrogenated Castor oil 4%
PEG-10 polydimethylsiloxane 3%
Liquid paraffin 5%
1 percent of squalane
5 percent of glycerin
0.5 percent of triethanolamine
0.1 percent of phenoxyethanol
0.05 percent of essence
The balance of deionized water.
The compound plant extract is prepared from lupin (LUPINUS ALBUS) seed extract, olive (OLEA EUROPAEA) bark extract according to the mass ratio of 1: 3, the lupin (LUPINUS ALBUS) seed extract is obtained by refluxing and extracting with 8 times of ethanol with volume concentration of 20% for 3 hours, filtering, recovering solvent, and drying, and the olive (OLEA EUROPAEA) bark extract is obtained by refluxing and extracting with 10 times of ethanol with volume concentration of 90% for 2 hours, filtering, recovering solvent, and drying.
The preparation method of the sunscreen cream is the same as that of example 1.
Comparative example 1:
a sunscreen cream is prepared from the following raw materials in percentage by mass:
lupinus ALBUS (LUPINUS ALBUS) seed extract 3%
Glyceryl stearate 5%
PEG-60 hydrogenated Castor oil 4%
PEG-10 polydimethylsiloxane 3%
Liquid paraffin 5%
1 percent of squalane
5 percent of glycerin
0.5 percent of triethanolamine
0.1 percent of phenoxyethanol
0.05 percent of essence
The balance of deionized water.
The Lupinus ALBUS seed extract is obtained by extracting with 8 times of 20% ethanol by volume for 3 hr, filtering, recovering solvent, and drying.
The preparation method of the sunscreen cream is the same as that of example 1.
Comparative example 2:
a sunscreen cream is prepared from the following raw materials in percentage by mass:
olive (Olea EUROPAEA) bark extract 3%
Glyceryl stearate 5%
PEG-60 hydrogenated Castor oil 4%
PEG-10 polydimethylsiloxane 3%
Liquid paraffin 5%
1 percent of squalane
5 percent of glycerin
0.5 percent of triethanolamine
0.1 percent of phenoxyethanol
0.05 percent of essence
The balance of deionized water.
The extract of the bark of Olea EUROPAEA (Olea EUROPAEA) is obtained by extracting under reflux with 10 times of 90% ethanol by volume for 2 hours, filtering, recovering solvent, and drying.
The preparation method of the sunscreen cream is the same as that of example 1.
First, evaluation of sunscreen effect of sunscreen cream of the present invention
The test was carried out by ultraviolet spectrophotometry, and the samples to be tested were the sunscreen creams prepared in examples 1 to 3 and comparative examples 1 to 2. The test method refers to the content recorded in "evaluation of cosmetic safety and effectiveness" (red bayberry, plum loyd army, foucault, chemical industry press, 2016, 3 month, 1 st edition), and specifically includes the following steps:
(1) the 3M medical permeable adhesive tape is cut into a size of 1cm multiplied by 4cm and is stuck on the light-transmitting side surface of the quartz cuvette.
(2) And (3) switching on a power supply, preheating an ultraviolet spectrophotometer, and setting the detection wavelengths of the UVB region to be 285nm, 290nm, 295nm, 300nm, 305nm, 310nm, 315nm and 320 nm.
(3) And placing the quartz cuvette pasted with the adhesive tape in a sample light path and a reference light path, and adjusting the zero point of the instrument.
(4) 8mg of a sample to be measured is accurately weighed, and the sample is uniformly coated on a quartz cuvette 3M adhesive tape. Five replicates were prepared in the same way.
(5) And (3) placing the prepared sample cuvette in a drying oven at 35 ℃ and drying for 30 minutes.
(6) And placing the sample cuvette to be measured in a sample light path, placing the other quartz cuvette attached with the adhesive tape in a reference light path, respectively measuring the ultraviolet absorbance values of the set wavelengths in the UVB region, and then taking the arithmetic mean of the measured values.
(7) The five parallel samples are measured in sequence, the mean value of the five samples is obtained by the method, and the arithmetic mean of the mean values of the five samples is calculated, so that the absorbance of the test sample is obtained.
Evaluation criteria: the absorbance value is less than 1.0 +/-0.1, which indicates that the sample has no sun-proof effect; the absorbance value =1.0 ± 0.1, which indicates that the sample has low-grade sun-screening effect and is suitable for winter, spring, autumn, morning and evening and rainy days; an absorbance value of >1.0 and <2.0 ± 0.2, indicating that the sample has a medium sunscreen effect, suitable for medium intensity solar irradiation; the absorbance value is more than 2.0, which shows that the sample has high sunscreen effect and is suitable for summer illumination or outdoor activities, travels and the like. Therefore, the larger the absorbance value is, the better the protection effect on UVB is.
The test results are shown in Table 1.
TABLE 1 Absorbance measurement results
| Group of | Absorbance value |
| Example 1 | 2.55 |
| Example 2 | 2.14 |
| Example 3 | 2.07 |
| Comparative example 1 | 1.32 |
| Comparative example 2 | 1.15 |
As can be seen from table 1, the sunscreen creams of examples 1 to 3 of the present invention have excellent UVB ultraviolet absorbance, good sunscreen effect, and are suitable for summer illumination or outdoor activities, traveling, etc., wherein the sunscreen cream of example 1 has the best sunscreen effect, and it can be seen that when the composite plant extract is prepared from lupin (LUPINUS ALBUS) seed extract, olive (OLEA EUROPAEA) bark extract in a mass ratio of 3: 1, the highest ability to absorb ultraviolet rays.
Meanwhile, as can be seen from the absorbance values of example 1 and comparative examples 1 to 2, example 1, which contains the lupin (LUPINUS ALBUS) seed extract and the olive (OLEA EUROPAEA) bark extract as sunscreen active ingredients at the same concentrations, has a significantly higher UVB ultraviolet absorbance than comparative examples 1 to 2, which contain the lupin (LUPINUS ALBUS) seed extract and the olive (OLEA EUROPAEA) bark extract alone. Therefore, the compound sunscreen composition adopts the compound of the lupin (LUPINUS ALBUS) seed extract and the olive (OLEA EUROPAEA) bark extract as sunscreen active components, has obvious synergistic effect in the aspect of absorbing ultraviolet rays, and obtains unexpected technical effect.
II, comparing and testing the erythema elimination rate:
50 healthy rabbits are selected, the weight of the rabbits is 2-2.5 kg, the rabbits are averagely divided into 5 groups, namely test groups 1-5, and each group comprises 10 rabbits. The sunscreen cream test was conducted for examples 1 to 3 and comparative examples 1 to 2, respectively.
24h before the test, the two sides of the bilateral symmetry of the back of each rabbit are cut off, the epidermis cannot be damaged, and the hair removing range is about 3cm multiplied by 3cm on the left side and the right side respectively. During the test, ultraviolet irradiation is firstly carried out, the irradiation dose is 2MED, 0.5g of sunscreen cream is uniformly smeared on one side of the tested skin after half hour of irradiation, and the other side of the tested skin is a blank control. The composition is applied in the morning and evening for 1 time and 2 days. The remaining test substance was removed with water or a non-irritating solvent before each application, while the other side of the blank was wiped with the same solvent. The skin reaction was observed 24h after the application was stopped, and the erythema elimination rate was calculated according to the integral standard of skin irritation reaction specified in the "cosmetic hygiene code" of the ministry of health (2007 edition), and the average of 10 rabbits per test group was taken.
Erythema elimination = (skin reaction integral on blank control side after 72 hours-skin reaction integral on test side after 72 hours)/skin reaction integral on blank control side after 72 hours = 100%
The test results are shown in Table 2.
TABLE 2 erythema elimination test results
| Group of | Erythema elimination rate |
| Example 1 | 92% |
| Example 2 | 75% |
| Example 3 | 70% |
| Comparative example 1 | 25% |
| Comparative example 2 | 15% |
As can be seen from table 2, the sunscreen creams of examples 1 to 3 of the present invention have a good effect of removing erythema on skin caused by uv rays, and especially the sunscreen cream of example 1 has the highest erythema elimination rate, and it can be seen that when the composite plant extract is prepared from lupin (LUPINUS ALBUS) seed extract and olive (OLEA EUROPAEA) bark extract in a mass ratio of 3: 1, the capacity of repairing sunburn skin is strongest.
Meanwhile, as can be seen from the erythema elimination rates of the sunscreen skin cream of examples 1 and comparative examples 1 to 2, in example 1 containing the lupin (LUPINUS ALBUS) seed extract and the olive (OLEA EUROPAEA) bark extract as sunscreen active ingredients at the same concentrations, the erythema elimination rate was significantly higher than that of comparative examples 1 to 2 containing the lupin (LUPINUS ALBUS) seed extract and the olive (OLEA EUROPAEA) bark extract alone. Therefore, the lupin (LUPINUS ALBUS) seed extract and the olive (OLEA EUROPAEA) bark extract are compounded to be used as sunscreen active components, so that the sunscreen composition has an obvious synergistic effect on repairing sunburn skin, and an unexpected technical effect is achieved.
The above-mentioned embodiments are merely preferred embodiments of the present invention, and the scope of the present invention should not be limited thereby, and those skilled in the art should not make any insubstantial changes and substitutions based on the present invention.
Claims (1)
1. A compound plant extract is prepared from Lupinus ALBUS (Lupinus ALBUS) seed extract, and Olea EUROPAEA (Olea EUROPAEA) bark extract at a mass ratio of 1-3: 1-3, characterized in that the lupin (LUPINUS ALBUS) seed extract is obtained by reflux extraction with 5-10 times by weight of 10-20% ethanol with volume concentration for 2-3 hours, filtration, solvent recovery and drying; the extract of the bark of Olea EUROPAEA (Olea EUROPAEA) is obtained by reflux-extracting with 5-10 times by weight of 80-90% ethanol for 2-3 hr, filtering, recovering solvent, and drying.
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| CN201810057730.3A CN107970176B (en) | 2018-01-22 | 2018-01-22 | Compound plant extract and application thereof in preparation of sunscreen cream |
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| CN201810057730.3A CN107970176B (en) | 2018-01-22 | 2018-01-22 | Compound plant extract and application thereof in preparation of sunscreen cream |
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| CN1409637A (en) * | 1999-10-14 | 2003-04-09 | 日清制油株式会社 | Skin-care agent, skin antiaging agent, whitening agent and external skin preparations |
| CN101336871A (en) * | 2007-07-06 | 2009-01-07 | 莱雅公司 | Sun-protection composition containing the association of a semi-crystalline polymer and hollow latex particles |
| CN102755265A (en) * | 2012-08-10 | 2012-10-31 | 南通永源服饰有限公司 | Multiple-effect renovating sun cream |
| JP2017014202A (en) * | 2015-06-30 | 2017-01-19 | 株式会社コーセー | Cosmetic |
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| EP1370272A1 (en) * | 2001-03-02 | 2003-12-17 | Biopharmacopae Design International Inc. | Inhibitors of extracellular proteases |
| BRPI1104880A2 (en) * | 2011-10-27 | 2013-11-05 | Botica Com Farmaceutica Ltda | NUTRITIVE COMPOSITION AND COSMETIC AND / OR DERMATOLOGICAL FORMULATION CONTAINING THE SAME |
| ES2710719T3 (en) * | 2015-02-16 | 2019-04-26 | Frezyderm S A | Composition of anhydrous solar protection complete with underwater technology |
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|---|---|---|---|---|
| CN1409637A (en) * | 1999-10-14 | 2003-04-09 | 日清制油株式会社 | Skin-care agent, skin antiaging agent, whitening agent and external skin preparations |
| CN101336871A (en) * | 2007-07-06 | 2009-01-07 | 莱雅公司 | Sun-protection composition containing the association of a semi-crystalline polymer and hollow latex particles |
| CN102755265A (en) * | 2012-08-10 | 2012-10-31 | 南通永源服饰有限公司 | Multiple-effect renovating sun cream |
| JP2017014202A (en) * | 2015-06-30 | 2017-01-19 | 株式会社コーセー | Cosmetic |
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