CN1079662A - Method for producing " glossy ganoderma-gynostemma pentaphyllum " oral liquid - Google Patents
Method for producing " glossy ganoderma-gynostemma pentaphyllum " oral liquid Download PDFInfo
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- CN1079662A CN1079662A CN 93103433 CN93103433A CN1079662A CN 1079662 A CN1079662 A CN 1079662A CN 93103433 CN93103433 CN 93103433 CN 93103433 A CN93103433 A CN 93103433A CN 1079662 A CN1079662 A CN 1079662A
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- liquid
- lucidum
- resin
- saponin
- clear water
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Abstract
A kind of method for producing " glossy ganoderma-gynostemma pentaphyllum " oral liquid has been filled up blank of the prior art.It is characterized in that extraction, trisodium glycyrrhizinate preparation, and this three is merged, add sucrose, cyclamate, Mentholum, sorbic acid at last and make through lucidum liquid preparation, Herb Gynostemmae Pentaphylli total glycosides.Can give full play to health-care effect with the " glossy ganoderma-gynostemma pentaphyllum " oral liquid that the present invention produces, have tranquilizing by nourishing the heart, strengthening by means of tonics, invigorating the spleen and regulating the stomach, Fructus Alpiniae Oxyphyllae skin care, enhancing human body immunity function, the effect of strengthening the body resistance.Be mainly used in neurasthenia, inappetence, body void, fatigue and weak after being ill, but clothes life prolonging for a long time.
Description
The present invention is the production method of a kind of production method of health care medicine, particularly a kind of lucidum herba gynostemae liquid.
The production method of various oral liquids is more in the prior art, but still finds no the production method of this health care medicine of lucidum herba gynostemae liquid.
The objective of the invention is to fill up above-mentioned blank part of the prior art, and a kind of production method of health care medicine-lucidum herba gynostemae liquid is provided.
Technical solution of the present invention is: the preparation lucidum liquid, extract total gypenoside, the preparation trisodium glycyrrhizinate, then with it with sucrose, cyclamate, Mentholum, sorbic acid, feeding intake by a certain percentage made.
The present invention has the following advantages compared to existing technology:
1, Ganoderma is a strengthening by means of tonics, the treasure of strengthening the body resistance.The successive dynasties book on Chinese herbal medicine is recorded and narrated: " but tonifying five ZANG-organs, beneficial six gas.Clothes can be made light of one's life by commiting suicide life prolonging for a long time." modern study proves: it contains various active composition and trace element, the many functions of body is all had strengthen and protective effect; Herb Gynostemmae Pentaphylli has the laudatory title of " southern Radix Ginseng ", " second Radix Ginseng ", and the similar Radix Ginseng of its active ingredient and pharmacological action has the enhancing human body immunity function, SOD activity improving, many-sided physiologically active such as slow down aging.The present invention uses both compatibilities, can strengthen the effect of strengthening by means of tonics, strengthening the body resistance, gives full play to health-care effect.
2, the lucidum herba gynostemae liquid of producing with the present invention has tranquilizing by nourishing the heart, invigorating the spleen and regulating the stomach, Fructus Alpiniae Oxyphyllae skin care, suppresses paracytic growth, the enhancing human body immunity function.Be mainly used in neurasthenia, inappetence, body void, fatigue and weak after being ill, for a long time clothes can make light of one's life by commiting suicide, life prolonging.
The present invention is described in further detail below in conjunction with embodiment:
One, lucidum liquid preparation
The clear water that the Ganoderma dry product is ground into 8 times of 1-2 centimetre of fragment addings boils 2-2.5 hour after-filtration; In its medicinal residues, add clear water, be advisable and boil 1-1.5 hour after-filtration to flood medicinal residues; In its medicinal residues, add clear water again, boil 1 hour, filter to flood to be advisable.Volume when being concentrated into 8 times of clear water of approximate adding the merging of gained filtrate with three times.By the ethanol of 2.8 times of this volume addings, make it contain the alcohol amount and reach 70%, leave standstill more than 8 hours, filter.To filter back gained filtrate and be distilled to and contain the alcohol amount and reach at 50% o'clock, and stop distillation, and open container door, residual ethanol is fully volatilized must not have pure lucidum liquid after clean.Distilled water diluting with no pure lucidum liquid adding equivalent filters and promptly gets lucidum liquid.
Two, total gypenoside extracts
Getting does not have the Herb Gynostemmae Pentaphylli scapus leaf that goes rotten, and adds clear water, boils 3 times to flood to be advisable.2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, three times filtrates are merged, residue discards.Hydro-oxidation sodium in filtrate, stirring, adjustment pH value are 10-10.5, staticly settle the clear liquid that the upper strata is drawn in the back, incorporate in the clear liquid behind the dope elimination sediment of lower floor.Reuse hydrochloric acid transfers pH value to neutral, obtains flaxen crude extract.The effect of this technology mainly is to remove impurity such as tannin, protein.Crude extract is passed through DA type macroporous resin with the flow velocity that 200ml/ divides, and Saponin and partial pigment are adsorbed on the resin, and inorganic salts and some other impurity then discard by resin with water.Reuse clear water drip washing resin, leacheate discards.Slowly pass through resin with ethanol with the flow velocity that 100ml/ divides, the Saponin on it is collected stripping liquid promptly by desorbing.The stripping liquid of collecting is slowly passed through DB type resin with the flow velocity that 100ml/ divides, and pigment promptly is adsorbed on the resin, and is the Saponin refining liquid by the solution of resin, and its color is little yellow.Saponin refining liquid concentrating under reduced pressure that will be in vacuum concentration pot reclaims ethanol.In the Saponin refining liquid after reclaiming ethanol in 1: the ratio of 1-1.5 adds butanols and extracts, and decompression is heated to 80-100 ℃, the recovery butanols, again with Saponin refining liquid concentrate drying, its drying means can be with spray drying method or vacuum forced air drying method.At last dry thing is pulverized the gypenoside that gets product.Because gypenoside has certain moisture, so packing is tight, reliable.
Three, the preparation of trisodium glycyrrhizinate
Add clear water Radix Glycyrrhizae is flooded 1/5 after-filtration of infusion to the clear water original volume, add sulphuric acid in the gained filtrate and extremely no longer produce till the precipitation, refilter, wash precipitate with water, in 60-80 ℃ constant temperature, wear into powder after the oven dry, be the trisodium glycyrrhizinate crude product.This crude product is with acetone three after-filtration that reflux, and residue discards, and acetone extract cools and adds 20% sodium hydroxide ethanol liquid to alkalescence (pH value is 8-9) in stirring, separates out crystallization after the placement.This crystallization is trisodium glycyrrhizinate.
Four, the preparation of lucidum herba gynostemae liquid
With lucidum liquid, total gypenoside, trisodium glycyrrhizinate, sucrose, cyclamate, Mentholum and sorbic acid successively in 300: 20: 15: 350: 5: 25: 1 ratio dropped in proper order, through dissolving, be diluted to 1000 units (all the other are distilled water), filtration, packing, sterilization promptly get lucidum herba gynostemae liquid.The present invention is used to produce lucidum herba gynostemae liquid.
Claims (1)
1, the production method of a kind of production method of health care medicine, particularly a kind of lucidum herba gynostemae liquid comprises pulverizing, infusion, filters, leaves standstill, concentrates, stirs, and it is characterized in that:
One, lucidum liquid preparation
The Ganoderma dry product is ground into 1-2 centimetre of fragment, the clear water that adds 8 times boils 2-2.5 hour after-filtration, in its medicinal residues, add clear water, be advisable and boil 1-1.5 hour after-filtration to flood medicinal residues, in its medicinal residues, add clear water again, boil 1 hour to flood to be advisable, filter, three gained filtrate is merged and be concentrated into approximate volume when adding 8 times of clear water, add 2.8 times ethanol by this volume, make it contain the alcohol amount and reach 70%, leave standstill more than 8 hours, filter, will filter back gained filtrate and be distilled to and contain alcohol and measure and reach at 50% o'clock, stop distillation, open container door, residual ethanol is fully volatilized must not have pure lucidum liquid after clean, with the distilled water diluting of no pure lucidum liquid adding equivalent, filter and promptly get lucidum liquid
Two, total gypenoside extracts
Getting does not have the Herb Gynostemmae Pentaphylli scapus leaf that goes rotten, and adds clear water, boils 3 times to flood to be advisable, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, three times filtrates are merged, residue discards, hydro-oxidation sodium in filtrate, and stirring, adjustment pH value are 10-10.5, staticly settle the back and draw the clear liquid on upper strata, incorporate in the clear liquid behind the dope elimination sediment of lower floor, reuse hydrochloric acid transfers pH value to neutral, obtains flaxen crude extract.Crude extract is passed through DA type macroporous resin with the flow velocity that 200ml/ divides, Saponin and partial pigment are adsorbed on the resin, inorganic salts and some other impurity then discard by resin with water, reuse clear water drip washing resin, leacheate discards, slowly pass through resin with ethanol with the flow velocity that 100ml/ divides, Saponin on it is promptly by desorbing, collect stripping liquid, the stripping liquid of collecting is slowly passed through DB type resin with the flow velocity that 100ml/ divides, pigment promptly is adsorbed on the resin, and be the Saponin refining liquid by the solution of resin, its color is little yellow, and Saponin refining liquid concentrating under reduced pressure that will be in vacuum concentration pot reclaims ethanol, in the Saponin refining liquid after reclaiming ethanol in 1: the ratio adding butanols of 1-1.5 extracts, decompression is heated to 80-100 ℃, reclaims butanols, again with Saponin refining liquid concentrate drying.At last dry thing is pulverized the gypenoside that gets product,
Three, the preparation of trisodium glycyrrhizinate
Add clear water Radix Glycyrrhizae is flooded 1/5 after-filtration of infusion to the clear water original volume, adding sulphuric acid in the gained filtrate extremely no longer produces till the precipitation, refilter, wash precipitate with water, in 60-80 ℃ constant temperature, wear into powder after the oven dry, be the trisodium glycyrrhizinate crude product, this crude product is with acetone three after-filtration that reflux, residue discards, and acetone extract cools and adds 20% sodium hydroxide ethanol liquid to alkalescence (pH value is 8-9) in stirring, separates out crystallization after the placement.This crystallization is trisodium glycyrrhizinate,
Four, the preparation of lucidum herba gynostemae liquid
With lucidum liquid, the total blue Saponin of strand, trisodium glycyrrhizinate, sucrose, cyclamate, Mentholum and sorbic acid successively in 300: 20: 15: 350: 5: 25: 1 ratio dropped in proper order, dissolved, is diluted to 1000 units (all the other for distilled water), filtered.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93103433 CN1079662A (en) | 1993-03-26 | 1993-03-26 | Method for producing " glossy ganoderma-gynostemma pentaphyllum " oral liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93103433 CN1079662A (en) | 1993-03-26 | 1993-03-26 | Method for producing " glossy ganoderma-gynostemma pentaphyllum " oral liquid |
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| Publication Number | Publication Date |
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| CN1079662A true CN1079662A (en) | 1993-12-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93103433 Pending CN1079662A (en) | 1993-03-26 | 1993-03-26 | Method for producing " glossy ganoderma-gynostemma pentaphyllum " oral liquid |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007065539A1 (en) * | 2005-12-06 | 2007-06-14 | Unilever Plc | Extracts of gynostemma and compositions for reducing blood lipid levels |
| CN101011450B (en) * | 2007-02-07 | 2011-11-16 | 贵州顺健制药有限公司 | Quality control method for lucid ganoderma gynostemma pentaphylla oral liquid |
| CN106889028A (en) * | 2017-02-25 | 2017-06-27 | 寻乌县华丰蛋鸡场 | A kind of technique with ganoderma lucidum water raising chicken class |
| CN108452122A (en) * | 2018-07-08 | 2018-08-28 | 高戈 | A kind of compound Chinese medicinal preparation and preparation method thereof of tranquilizing the mind, brain tonic of having one's ideas straightened out |
| CN109200205A (en) * | 2017-06-30 | 2019-01-15 | 湖北悟芝堂生物科技有限公司 | Ganoderma lucidum traditional Chinese medicine oral liquid |
-
1993
- 1993-03-26 CN CN 93103433 patent/CN1079662A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007065539A1 (en) * | 2005-12-06 | 2007-06-14 | Unilever Plc | Extracts of gynostemma and compositions for reducing blood lipid levels |
| CN101011450B (en) * | 2007-02-07 | 2011-11-16 | 贵州顺健制药有限公司 | Quality control method for lucid ganoderma gynostemma pentaphylla oral liquid |
| CN106889028A (en) * | 2017-02-25 | 2017-06-27 | 寻乌县华丰蛋鸡场 | A kind of technique with ganoderma lucidum water raising chicken class |
| CN109200205A (en) * | 2017-06-30 | 2019-01-15 | 湖北悟芝堂生物科技有限公司 | Ganoderma lucidum traditional Chinese medicine oral liquid |
| CN108452122A (en) * | 2018-07-08 | 2018-08-28 | 高戈 | A kind of compound Chinese medicinal preparation and preparation method thereof of tranquilizing the mind, brain tonic of having one's ideas straightened out |
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| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
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