CN107951936A - There is the wild jujube extract for improving sleep - Google Patents
There is the wild jujube extract for improving sleep Download PDFInfo
- Publication number
- CN107951936A CN107951936A CN201711139557.3A CN201711139557A CN107951936A CN 107951936 A CN107951936 A CN 107951936A CN 201711139557 A CN201711139557 A CN 201711139557A CN 107951936 A CN107951936 A CN 107951936A
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- CN
- China
- Prior art keywords
- wild jujube
- flavones
- jujube extract
- effects
- wild
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
Abstract
The invention discloses a kind of wild jujube extract for having effects that to improve sleep, pretreatment, the hot dipping that method includes wild jujube are carried and isolated and purified.Have the beneficial effect that：Method is simple, and the recovery rate of flavones is high, and extraction time is short, and the flavones purity obtained is big；The movement rate of molecule is big during hot dipping carries, and improves flavones to extracellular stripping quantity, and the not mutability, and the flavones in wild jujube can be fully dissolved out at such a temperature of the flavones with certain reproducibility.
Description
Technical field
The present invention relates to active components of plants extractive technique field, is carried more particularly, to the wild jujube for having effects that to improve sleep
Take thing.
Background technology
Wild jujube, Rhamnaceae jujube, be jujube mutation, also known as spine, spine, wild jujube, mountain jujube, Pueraria lobota pin etc. originate in China
North China, Central-South each province are also distributed.It is more wild, often it is shrub, also some is dungarunga.Tree vigo(u)r is stronger, branch, leaf, the form of flower
It is similar to common jujube, but branch internode is shorter, and care thorn is flourishing, and except growth branch, respectively section is had in addition to care thorn, and fruitful branch stipule is also into point
Thin care thorn；The small and dense life of leaf；Fruit is small, more circles or ellipse, pericarp are thick, smooth, purplish red or puce, interior thin, and taste is mostly very
Acid, core circle or ellipse, core face is more smooth, includes 1 to 2 piece of seed, and benevolence is full to make Chinese medicine.The more common jujube of its adaptability
By force, the florescence is very long, can be nectariferous plant.Pericarp red or aubergine, pulp is relatively thin, loose, sweet and sour.Wherein wild jujube contains rich
Rich flavonoids bioactive ingredients.The method of extraction wild jujube flavones mainly has traditional extraction such as cold soaking, diacolation, but this at present
A little methods are inevitably there are high energy consumption, the shortcomings of time-consuming, and yield is relatively low.
The content of the invention
It is an object of the invention to provide a kind of wild jujube extract for having effects that to improve sleep, which can
Significantly improve sleep quality.
Another object of the present invention is to provide the preparation method of above-mentioned wild jujube extract, method is simple, during wild jujube
The recovery rate of flavones is high, and extraction time is short, and the flavones purity obtained is big.
The present invention is directed to the problem of being mentioned in background technology, and the technical solution taken is：There is the acid for improving sleep
Jujube extract, preparation method comprise the following steps：
The pretreatment of wild jujube：Wild jujube is taken, jujube core is removed, is crushed with medicinal herb grinder, petroleum ether is added, soaks 9- at 25-30 DEG C
11h, filtering, by filter residue in 52-58 DEG C of dry 13-16h, obtains degreasing wild jujube crushed material, carries out ungrease treatment to Poria cocos, avoid
Influence of the lipid to flavones purity, improves the quality of flavones, the bioactivity of product is improved, add technique
Economic value；
Hot dipping carries：Extracting degreasing wild jujube crushed material, adds ethanol water, refluxing extraction, must extract by solid-liquid ratio 2-3g/50mL
Liquid, under the conditions of being somebody's turn to do, the recovery rate of flavones is high, and the quality of the flavones extracted is good；
Isolate and purify：Leaching liquor filters, and gained filtrate is concentrated in vacuo 20-25min at 35-40 DEG C, dry that wild jujube extracts
Thing, under the conditions of being somebody's turn to do, further increases the purity of flavones in extract, effect so that improvement for adding the extract is slept.
Preferably, the mass fraction of ethanol water is 65%-85% during hot dipping carries.Under the conditions of being somebody's turn to do, ethanol water
The polarity of solution is weak, is conducive to the dissolution of the less flavone compound of polarity, and the impurity dissolution such as pigment is few in wild jujube, increase
The recovery rate of flavones.
Preferably, reflux temperature is 70-90 DEG C during hot dipping carries.Under the conditions of being somebody's turn to do, the movement rate of molecule is big, improves
Flavones is to extracellular stripping quantity, and the not mutability at such a temperature of the flavones with certain reproducibility.
Preferably, return time is 1.5-2.3h during hot dipping carries.Under the conditions of being somebody's turn to do, the flavones in wild jujube can be abundant
Dissolution, while the molecular structure of flavones is not influenced.
Compared with prior art, the advantage of the invention is that：The present invention has effects that the wild jujube extract energy for improving sleep
Sleep quality is enough significantly improved, pretreatment, the hot dipping that its preparation method includes wild jujube are carried and isolated and purified, and method is simple, yellow
The recovery rate of ketone is high, and extraction time is short, and the flavones purity obtained is big；The movement rate of molecule is big during hot dipping carries, and improves
Flavones is to extracellular stripping quantity, and the not mutability, and Huang in wild jujube at such a temperature of the flavones with certain reproducibility
Ketone can be fully dissolved out.
Embodiment
Below by embodiment, the present invention will be further described：
Embodiment 1：
There is the wild jujube extract for improving sleep, preparation method comprises the following steps：
1) pretreatment of wild jujube：Wild jujube is taken, jujube core is removed, is crushed with medicinal herb grinder, petroleum ether is added, soaks 9h, mistake at 25 DEG C
Filter, by filter residue in 52 DEG C of dry 13h, obtains degreasing wild jujube crushed material, carries out ungrease treatment to Poria cocos, it is pure to flavones to avoid lipid
The influence of degree, improves the quality of flavones, the bioactivity of product is improved, and adds the economic value of technique；
2) hot dipping carries：Extracting degreasing wild jujube crushed material, the ethanol water that mass fraction is 65% is added by solid-liquid ratio 2g/50mL,
In 70 DEG C of refluxing extraction 1.5h, leaching liquor is obtained, under the conditions of being somebody's turn to do, the recovery rate of flavones is high, and the quality of the flavones extracted is good；
3) isolate and purify：Leaching liquor filters, and gained filtrate is concentrated in vacuo 20min at 35 DEG C, dry wild jujube extract, should
Under the conditions of, the purity of flavones in extract is further increased, effect so that improvement for adding the extract is slept.
Embodiment 2：
There is the wild jujube extract for improving sleep, preparation method comprises the following steps：It is the pretreatment of wild jujube first：Take acid
Jujube, removes jujube core, is crushed with medicinal herb grinder, adds petroleum ether, soaks 11h at 30 DEG C, filters, by filter residue in 58 DEG C of dry 16h,
Obtain degreasing wild jujube crushed material；Carried followed by hot dipping：Extracting degreasing wild jujube crushed material, adding mass fraction by solid-liquid ratio 3g/50mL is
85% ethanol water, in 90 DEG C of refluxing extraction 2.3h；Finally isolate and purify：Leaching liquor is filtered, gained filtrate is existed
It is concentrated in vacuo 25min at 40 DEG C, dry wild jujube extract.
Embodiment 3：
There is the wild jujube extract for improving sleep, preparation method comprises the following steps：
1) pretreatment of wild jujube：Wild jujube is taken, jujube core is removed, is crushed with medicinal herb grinder, petroleum ether is added, soaks 10h, mistake at 26 DEG C
Filter, by filter residue in 54 DEG C of dry 15h, obtains degreasing wild jujube crushed material, carries out ungrease treatment to Poria cocos, it is pure to flavones to avoid lipid
The influence of degree, improves the quality of flavones, the bioactivity of product is improved, and adds the economic value of technique；
2) hot dipping carries：Extracting degreasing wild jujube crushed material, it is water-soluble to add the ethanol that mass fraction is 67% by solid-liquid ratio 2.5g/50mL
Liquid, adds 3, the 5- dichlorobenzoic acids for accounting for degreasing wild jujube crushed material quality 0.1% and accounts for degreasing wild jujube crushed material quality
0.14% 2- iodo-benzoic acids, in 75 DEG C of refluxing extraction 1.7h, obtain leaching liquor, and under the conditions of being somebody's turn to do, the recovery rate of flavones is high, is extracted
Flavones quality it is good, 3,5- dichlorobenzoic acids, 2- iodo-benzoic acids and the ethanol added has synergistic effect, changes thin
The molecule arranging structure of after birth, makes selectivity add the transmission speed of flavones through being changed into whole-permeable, shorten extraction when
Between, improve the recovery rate of flavones；
3) isolate and purify：Leaching liquor filters, and gained filtrate is concentrated in vacuo 22min at 36 DEG C, dry wild jujube extract, should
Under the conditions of, the purity of flavones in extract is further increased, effect so that improvement for adding the extract is slept.
Routine operation in the operating procedure of the present invention is well known to those skilled in the art, herein without repeating.
Technical scheme is described in detail in embodiment described above, it should be understood that the above is only
For the specific embodiment of the present invention, it is not intended to limit the invention, all any modifications made in the spirit of the present invention,
Supplement or similar fashion replacement etc., should all be included in the protection scope of the present invention.
Claims (6)
1. there is the wild jujube extract for improving sleep, it is characterised in that：The preparation method of the wild jujube extract include with
Lower step：
1) pretreatment of wild jujube：Wild jujube is taken, jujube core is removed, is crushed with medicinal herb grinder, petroleum ether is added, soaks 9- at 25-30 DEG C
11h, filtering, by filter residue in 52-58 DEG C of dry 13-16h, obtains degreasing wild jujube crushed material；
2) hot dipping carries：Extracting degreasing wild jujube crushed material, adds ethanol water, refluxing extraction, obtains leaching liquor；
3) isolate and purify：Leaching liquor filters, and gained filter vacuum is concentrated, dry wild jujube extract.
2. the wild jujube extract according to claim 1 for having effects that to improve sleep, it is characterised in that：In the step 2)
The solid-liquid ratio of degreasing wild jujube crushed material and ethanol water is 2-3g/50mL.
3. the wild jujube extract according to claim 1 for having effects that to improve sleep, it is characterised in that：In the step 2)
The mass fraction of ethanol water is 65%-85%.
4. the wild jujube extract according to claim 1 for having effects that to improve sleep, it is characterised in that：In the step 2)
Reflux temperature is 70-90 DEG C.
5. the wild jujube extract according to claim 1 for having effects that to improve sleep, it is characterised in that：In the step 2)
Return time is 1.5-2.3h.
6. the wild jujube extract according to claim 1 for having effects that to improve sleep, it is characterised in that：In the step 3)
The temperature of vacuum concentration is 35-40 DEG C, time 20-25min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711139557.3A CN107951936A (en) | 2017-11-16 | 2017-11-16 | There is the wild jujube extract for improving sleep |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711139557.3A CN107951936A (en) | 2017-11-16 | 2017-11-16 | There is the wild jujube extract for improving sleep |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107951936A true CN107951936A (en) | 2018-04-24 |
Family
ID=61964687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711139557.3A Pending CN107951936A (en) | 2017-11-16 | 2017-11-16 | There is the wild jujube extract for improving sleep |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114081177A (en) * | 2021-11-12 | 2022-02-25 | 滨州医学院 | Preparation method of winter jujube kernel extract |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101926452A (en) * | 2009-12-25 | 2010-12-29 | 河北农业大学 | Wild jujube leaf total flavonoids extract and preparation method thereof |
| CN104073390A (en) * | 2014-06-10 | 2014-10-01 | 南京泽朗农业发展有限公司 | Wild jujube beer and preparation method thereof |
-
2017
- 2017-11-16 CN CN201711139557.3A patent/CN107951936A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101926452A (en) * | 2009-12-25 | 2010-12-29 | 河北农业大学 | Wild jujube leaf total flavonoids extract and preparation method thereof |
| CN104073390A (en) * | 2014-06-10 | 2014-10-01 | 南京泽朗农业发展有限公司 | Wild jujube beer and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 何桂霞主编: "《中药化学实用技术》", 31 August 2015, 中国中医药出版社 * |
| 田秀红等: ""河北酸枣总黄酮提取工艺研究"", 《食品研究与开发》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114081177A (en) * | 2021-11-12 | 2022-02-25 | 滨州医学院 | Preparation method of winter jujube kernel extract |
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Application publication date: 20180424 |