CN107951468B

CN107951468B - Compound film composition for acquiring skin physiological state and preparation and application thereof

Info

Publication number: CN107951468B
Application number: CN201711154753.8A
Authority: CN
Inventors: 刘建欣; 方兆华; 冯小玲; 孙永; 何海鸥
Original assignee: Zhuhai Easycare Technology Co ltd
Current assignee: Zhuhai Easycare Technology Co ltd
Priority date: 2017-11-20
Filing date: 2017-11-20
Publication date: 2020-08-11
Anticipated expiration: 2037-11-20
Also published as: CN107951468A

Abstract

The invention discloses a laminating composition for acquiring the physiological state of skin, which is characterized by comprising the following components in percentage by weight: 6-35% of film-forming agent, 1-20% of filler, 0.01-4% of grease, 0.1-10% of auxiliary agent and the balance of solvent; the compound film composition is coated on the skin, can obtain information such as skin texture, pores, grease and the like after being dried and solidified, can accurately analyze and obtain the physiological state of the skin, has low cost and convenient use, does not have pain feeling during sampling, and is suitable for developing personalized and customized external skin preparations.

Description

Compound film composition for acquiring skin physiological state and preparation and application thereof

Technical Field

The invention belongs to the technical field of skin external preparations, and particularly relates to a compound film composition for acquiring the physiological state of skin, and a preparation method and application thereof.

Background

Skin texture refers to a pattern of texture appearing on the surface of human skin, also called dermatoglyph, whose human skin is composed of epidermis and dermis. The dermal papilla protrudes into the epidermis to form many aligned, parallel papilla lines, also known as ridge lines. The ridge prints have openings for many sweat glands. The raised ridge lines in turn form recessed channels with each other. These uneven textures constitute the skin texture of the human body. The dermatoglyph of the human body has the advantages of individual heterology and high stability.

With aging, the skin gradually ages, the depth of the skin texture deepens, and wrinkles appear due to aging or excessive exposure to the sun or repeated muscle movements. The skin texture is transcribed through the skin laminating film, so that indexes such as pores, sebum, elasticity and the like of the skin can be observed, and the health condition of the skin can be evaluated.

At present, the skin physiological state collection method on the market generally adopts silica gel composite membrane to prepare a dermatoglyph sample, and adopts a professional skin detector to directly collect a skin image. The silica gel coating is adopted to prepare the dermatoglyph sample, so that the defects of long drying time, few observation indexes (such as observation of texture and depth of a dermatoglyph) and the like exist; adopt the skin detector to gather skin texture data through external image acquisition equipment and transmit to the computer and carry out the analysis to it, the image acquisition equipment size that the specialty is stable is big, inconvenient carrying, and though remove end (smart mobile phone) and shoot conveniently, nevertheless to stability repeatability such as light, photo quality poor.

Therefore, a fast, convenient and low-cost noninvasive detection method for skin physiological status is needed, which obtains a sample containing skin physiological status information, obtains personalized skin physiological status information by directly observing the sample or further quantitatively analyzing the sample by adopting an image analysis instrument, and guides the development of a customized formula, thereby realizing personalized and precise skin care.

Disclosure of Invention

Aiming at the problems in the prior art, the invention aims to provide a compound film composition for acquiring the physiological state of skin, and a preparation method and application thereof. The compound film composition is coated on the skin, and after the compound film composition is solidified into a film, information such as skin texture, sebum, pores and the like is obtained, and then the physiological state of the skin is observed, analyzed and judged.

In order to achieve the purpose, the invention adopts the following technical scheme:

a compound film composition for acquiring skin physiological state comprises the following components in percentage by weight:

6 to 35 percent of film-forming agent,

1 to 20 percent of filler,

0.1 to 10 percent of auxiliary agent,

the balance being solvent.

The laminating composition is prepared by the following steps:

(1) sequentially adding the film forming agent and the filler into a solvent, heating to 70-90 ℃, and uniformly stirring;

(2) cooling to room temperature, adding the auxiliary agent, and uniformly stirring.

Preferably, the adjuvant is selected from at least one of a grease, a thickener, an emulsifier, an anti-sensitivity agent, and a preservative.

Preferably, the film coating composition for acquiring the physiological state of the skin comprises the following components in percentage by weight:

preferably, the film forming agent is at least one selected from polyvinyl alcohol, polyvinylpyrrolidone, acrylic acid (ester) copolymer, acrylic acid (ester)/ethylhexyl acrylate copolymer, styrene/acrylic acid (ester) copolymer and polyurethane-35.

Preferably, the filler is at least one selected from titanium dioxide, kaolin, zinc oxide, talcum powder, diatomite, mica powder, silica, silicon dioxide, bamboo charcoal powder, quartz powder, attapulgite, bentonite, organic bentonite, volcanic ash, hot spring soil, silt, activated clay, brucite powder, magnesium carbonate and montmorillonite.

Preferably, the thickening agent is selected from at least one of cellulose, magnesium aluminum silicate, xanthan gum, carbomer and carrageenan.

Preferably, the oil and fat is at least one selected from mineral oil, olive oil, jojoba oil, sweet almond oil, caprylic/capric triglyceride, ethylhexyl palmitate, hydrogenated polydecene, isohexadecane, sunflower (helioanthus ANNUUS) seed oil, isopropyl palmitate, C12-15 alcohol benzoate, polydimethylsiloxane and cyclopentadimethylsiloxane.

Preferably, the emulsifier is selected from at least one of polyglyceryl-3 stearate, polyglyceryl-10 oleate, polyglyceryl-4 laurate, monoglyceride, tween-60, coco-glucoside, PEG-100 stearate, ceteareth-6, ceteareth-25, potassium cetyl phosphate.

Preferably, the anti-allergic agent is at least one selected from allantoin, dipotassium glycyrrhizinate and purslane extract.

Preferably, the preservative is selected from at least one of phenoxyethanol, imidazolidinyl urea, DMDM hydantoin.

Preferably, the solvent is at least one selected from water, glycerin, propylene glycol, butylene glycol, glyceryl polyether-26, and alcohol.

The preparation method of the compound membrane composition for acquiring the physiological state of the skin comprises the following steps:

(1) sequentially adding the film forming agent, the thickening agent and the filler into the solvent, heating to 70-90 ℃ within 10-20min, uniformly stirring at the stirring speed of 200-300r/min to obtain a phase A for later use;

(2) mixing, stirring and heating the grease and the emulsifier to 70-80 ℃ to obtain a B phase for later use;

(3) adding phase B into phase A, homogenizing for 2 min, cooling to 40-50 deg.C, adding antiallergic agent and antiseptic, stirring, and dissolving.

The application method of the compound film combination for acquiring the skin physiological state comprises the steps of coating the compound film combination on the skin, preferably coating the compound film combination with the thickness of 0.05-0.5mm, and drying and curing to form the compound film. The laminating composition can not be coated too thickly, which causes difficulty in drying and further can not be transferred to a laminating paste; the laminating composition may not be applied too thinly, resulting in an inability to clearly transcribe the skin texture and an inability to fully reveal the sebum secretion profile.

And amplifying and shooting the obtained outline of the compound film, inputting the obtained outline into a computer, and observing and analyzing information such as skin texture, grease secretion, pore size, pore quantity and the like by a computer image analysis system.

The obtained compound film can also be directly observed by naked eyes to obtain the physiological state information of the skin.

The compositions of the present invention may also be used in conjunction with kits for transcribing skin texture.

The tool kit for transcribing the skin texture comprises a laminating frame and a peritoneal plaster, wherein a hole is formed in the middle of the laminating frame.

Preferably, the film coating kit further comprises a gauge.

Preferably, the length of the laminating frame is 10-30mm, the width of the laminating frame is 10-30mm, and the thickness of the laminating frame is 0.1-0.5 mm.

Preferably, the holes on the laminating frame are square, round, diamond or rectangular.

Further preferably, the size of the hole on the laminating frame is 5-25 mm. For example, when the lamination holes are circular, the diameter is 5-25 mm; when the laminating holes are square, diamond or rectangular, the side length is 5-25 mm.

Preferably, the material of the laminating frame includes but is not limited to PE and PVC. Further preferably, an adhesive layer is arranged on one side of the laminating frame, so that the laminating frame can be adhered to the skin. The laminating frame is used for coating the laminating composition through the holes on the laminating frame when the laminating composition is coated, so that the effect of preventing the formed laminating film from being too large or too small to influence microscopic observation can be achieved, and the positioning effect can be achieved.

Preferably, the laminating film comprises a transparent film layer, an adhesive layer and a protective layer which are connected in sequence.

The peritoneal plaster is safe and nontoxic, and can directly contact with the skin.

More preferably, the 180-degree peel strength of the adhesive layer is not less than 5.0N/25mm and not more than 10N/25 mm; the adhesive layer has overlarge viscosity, and can cause pain when being torn off and damage the skin; the adhesiveness is too small to stick and transfer the composite film, and even the composite film is damaged during the transfer process. The material of the transparent film layer includes, but is not limited to, polyethylene, polypropylene, cellophane, polyethylene terephthalate, polyolefin, etc.

Further preferably, the protective layer is divided into 2 parts, and the middle part may completely cover the composite film. More preferably, the protective layer is release paper, oil paper or the like.

Preferably, the detection tool is provided with a hole, wherein the hole on the detection tool is larger than or equal to the hole on the laminating frame, so that the skin texture transcribed by the complete laminating can be observed in a microscopic manner.

Further preferably, the gauge is 75-77mm long, 24-26mm wide and 0.5-5mm thick. The hole on the checking fixture is arranged at the middle upper part of the checking fixture. Further preferably, the material of the detection tool is PE, PC or PVC.

More preferably, the tail of the gauge is designed to be rounded (as shown in fig. 8), and can be used for applying the spreading coating on the skin to avoid pollution.

A method of detecting a physiological state of skin comprising the steps of:

(1) after cleaning the skin, wiping the skin dry;

(2) pasting the laminating frame on the skin;

(3) coating the film coating composition on the skin from the holes of the film coating frame, and uniformly coating;

(4) tearing off the laminating frame, and allowing the laminating composition to stay on the skin for 8-15min until the laminating composition is completely dry;

(5) taking a compound membrane patch, tearing off the middle part of the protective layer on the peritoneum patch, aligning the exposed adhesive layer with the compound membrane and sticking the adhesive layer on the compound membrane, and lightly pressing the compound membrane patch to enable the compound membrane to be tightly adhered to the compound membrane patch;

(5) slowly tearing off the compound film sticker stuck with the compound film from top to bottom;

(6) tearing off the residual protective layer of the laminating paste, aligning the laminating paste with the hole on the checking fixture, pasting the laminating paste on the checking fixture, and observing under a microscope with magnification of 10-100 times.

Preferably, the middle position of the left side of the laminating frame is aligned with the intersection point of the horizontal distance of 5mm from the canthus and the nose.

It should be noted that the expression is not changed during the drying and curing process of the composite film, which would affect the analysis result.

Sebum is secreted from sebaceous glands, and combines with lipids produced by keratinocytes and sweat secreted from sweat glands to form a visually undetectable film on the skin surface, called a natural dermal or moisturizing film. The invention cleans the face and then dries the water to immediately coat the compound film composition, sebaceous glands at the coated part still secrete sebum, areas with much sebum secretion generate bulges, and then the positions corresponding to the compound film generate depressions, so that the depressed round holes are observed under a microscope.

Scale-up evaluation criteria:

(1) skin texture was observed at 10 x magnification: the furrows are obvious, and the skin hills are arranged in a regular shape (triangle) and are full and raised, which indicates that the skin texture condition is good, the skin is bright, the surface is moist and has tension and elasticity, and the skin furrows are obvious, and as shown in fig. 5 (a); the condition of shallow, unobvious, uneven, non-raised, flat skin mound arrangement, indicating poor skin texture, darkness, dry surface, lack of tension and elasticity, as shown in fig. 5 (b);

(2) the pores were observed under a 50-fold microscope: the intersection points of the textures are small and not obvious, which shows that pores are small, the number is small, and the skin is smooth and fine, as shown in fig. 6 (a); the intersection points of the textures are large and obvious, which indicates that the pores are large and large in number, so that the skin surface is uneven and has no tension, and makeup is easy to remove, as shown in fig. 6 (b);

(3) when the observation is carried out under the magnification of 100, the concave holes on the composite membrane are more and larger, which indicates that the sebum secretion is vigorous, the pores are large, and the skin is easy to grow pox, as shown in figure 7 (a); the quantity of concave holes on the compound film is moderate, which indicates that sebum secretion is moderate and skin grease is balanced, and is shown in figure 7 (b); the small and small pits in the coated film indicate that the sebum secretion is low, the skin is dry, easy to itch and even painful, as shown in fig. 7 (c).

The invention has the beneficial effects that:

(1) the compound film composition is coated on the skin, and can transcribe information including skin texture, pores, grease and the like after being dried and solidified, so that the physiological state of the skin is analyzed and judged;

(2) the laminating composition has low cost and convenient use; no pain is caused during sampling;

(3) with the use of the film-coating composition of the present invention, it is possible to provide a technique for judging the physiological state of the skin, which enables a high-precision and rapid judgment of the state of the skin;

(4) the film coating composition of the present invention is an external skin preparation suitable for providing individuality customization.

Drawings

FIG. 1 is a top view of a laminating frame;

FIG. 2 is a schematic view of the structure of a peritoneal patch with a membrane adhered thereto;

FIG. 3 is a schematic view of a protective layer;

FIG. 4 is a schematic view of a gauge;

FIGS. 5a-5b are micrographs of skin texture;

FIGS. 6a-6b are micrographs of skin pores;

FIGS. 7a-7c are micrographs of sebum secretion from the skin;

FIG. 8 is a side view of the gauge;

FIGS. 9a-9B are photomicrographs of the cover film before volunteer A and volunteer B use the personalized product, respectively;

FIGS. 10a-10B are photomicrographs of the coated films of volunteer A and volunteer B, respectively, after use of the personalized product.

Detailed Description

The following detailed description of specific embodiments of the present invention is made with reference to the accompanying drawings and examples. It should be understood that the detailed description and specific examples, while indicating the present invention, are given by way of illustration and explanation only, not limitation.

Example 1

A compound film composition for acquiring skin physiological state comprises the following raw materials in percentage by weight:

8% of polyvinyl alcohol, 15% of acrylic acid (ester) copolymer, 13% of kaolin, 2% of mineral oil, 0.02% of cellulose, 2% of polyglycerol-3 stearate, 2% of anti-allergic agent, 0.3% of preservative and the balance of water.

The preparation method comprises the following steps: sequentially adding polyvinyl alcohol, acrylic acid (ester) copolymer, cellulose and kaolin into water, stirring and heating to 78 ℃, homogenizing for 2 minutes, cooling to 45 ℃, adding mineral oil, polyglycerol-3 stearate, an anti-sensitivity agent and a preservative, and stirring and dissolving uniformly.

Example 2

5% of polyvinyl alcohol, 20% of styrene/acrylic acid (ester) copolymer, 20% of titanium dioxide, 4% of olive oil, 1% of magnesium aluminum silicate, 0.01% of polyglycerol-4 laurate, 4% of anti-allergy agent, 0.5% of preservative and the balance of water.

The preparation method comprises the following steps: sequentially adding polyvinyl alcohol, styrene/acrylic acid (ester) copolymer, magnesium aluminum silicate and titanium dioxide into water, stirring, heating to 80 ℃, homogenizing for 2 minutes, cooling to 45 ℃, adding olive oil, polyglycerol-4 laurate, an anti-allergy agent and a preservative, and stirring and dissolving uniformly.

Example 3

15% of acrylic acid (ester)/ethylhexyl acrylate copolymer, 1% of acrylic acid (ester) copolymer, 1% of zinc oxide, 0.01% of ethylhexyl palmitate, 0.05% of xanthan gum, 4% of polyglycerol-4 laurate, 0.1% of anti-sensitivity agent, 0.5% of preservative and the balance of glycerol.

The preparation method comprises the following steps: sequentially adding acrylic acid (ester)/ethylhexyl acrylate copolymer, acrylic acid (ester) copolymer, xanthan gum and zinc oxide into glycerol, stirring and heating to 75 ℃, homogenizing for 2 minutes, cooling to 45 ℃, adding ethylhexyl palmitate, polyglycerol-4 laurate, anti-sensitivity agent and preservative, and stirring and dissolving uniformly to obtain the product.

Example 4

2g of the laminating composition prepared in example 2 was applied to the skin at the desired location to form a layer of about 0.05-0.5mm thick on the skin. Keeping the skin state for 15 minutes, asking the user to change the posture of the using part as little as possible, otherwise influencing the analysis result, and forming a laminating sample after the laminating composition is dried and cured and then tearing off.

Amplifying and shooting the outline of the compound film, inputting the amplified and shot outline into a computer, observing the height of the bulges on the surface of the compound film close to the skin side by a computer image analysis system, and measuring the depths of the textures and the wrinkles; observing the quantity of the grease on the surface of the compound film close to the skin to obtain the grease secretion condition of the skin; and counting the size and the number of pores on the near-skin side.

Example 5

The film coating composition of the invention is used together with a tool kit for transcribing skin texture

Referring to fig. 1-3, a laminating kit for transcribing skin texture comprises a laminating frame 1, a laminating film 2, a peritoneum patch 3 and a detection tool 4, wherein a hole 11 is formed in the middle of the laminating frame. The length of the laminating frame 1 is 15mm, the width is 15mm, and the thickness is 0.5 mm; the side length of the hole on the laminating frame is 11 mm; the material of the laminating frame is PVC; and one side of the laminating frame is provided with an adhesive layer. The composite membrane 2 is formed by coating the composite membrane composition of the embodiment 2 on the skin, drying and curing after 15min, and is arranged in a hose; the thickness of the peritoneum is 0.1 mm. The peritoneal plaster 3 comprises a transparent film layer 31, an adhesive layer 32 and a protective layer 33 which are connected in sequence; the protective layer 33 is divided into 2 portions, and one portion is an intermediate portion which can completely cover the composite film. The 180-degree peel strength of the adhesive layer is 6N/25 mm. The checking fixture 4 is provided with a hole 41, wherein the hole on the checking fixture is slightly larger than the hole 11 on the laminating frame. The length of the checking fixture 4 is 76mm, the width is 25mm, and the thickness is 1.5 mm.

The use method of the film coating kit for transcribing the skin texture comprises the following steps:

(1) after cleaning the skin, wiping the skin dry;

(2) adhering one side of the laminating frame, which is provided with the adhesive layer, to the skin, so that the middle position of the left side of the laminating frame is aligned to the intersection point of the horizontal part 5mm away from the canthus and the nose;

(3) extruding the compound film agent into the holes on the compound film frame and uniformly coating the compound film agent, or taking a proper amount of the compound film agent from the tail part of the detection tool and uniformly coating the compound film agent on the skin along the holes in the compound film frame;

(4) after tearing off the laminating frame, keeping the laminating agent on the skin for 15min until the laminating agent is completely dried to form a laminating film;

(5) taking a compound membrane sticker 3, tearing the middle part of the protective layer 33, aligning the exposed adhesive layer with the compound membrane 2, and sticking the adhesive layer and the compound membrane on the compound membrane to enable the compound membrane to be completely transferred to the peritoneal sticker after the compound membrane and the compound membrane are tightly stuck;

(6) slowly tearing off the compound film sticker stuck with the compound film from top to bottom;

(7) and tearing off the residual protective layer on the laminating film, aligning the laminating film with the hole on the checking fixture, adhering the laminating film on the checking fixture, and magnifying by 10-100 times for observation.

Example 6

20 volunteers between the ages of 16 and 50 were selected, sampled by the method of example 5, and observed at 100-fold magnification. The micrographs of the multiple membranes of 2 of the volunteers, volunteer a and volunteer B are respectively shown in fig. 9a and fig. 9B:

as can be seen from the test chart of fig. 9a and 9B, the oil secretion of volunteer a is less, and the oil of volunteer B is too vigorous; the personalized and customized external skin preparation for the volunteer A is mainly characterized in that jojoba oil and sodium hyaluronate are added to enhance the moisture and oil content of the skin; in addition, the ceramide can improve the skin lipid membrane, balance the water and oil of the skin and enhance the self-protection function of the skin.

The personalized and customized external skin preparation for the volunteer B is mainly prepared by adding the PCA zinc oil control component, regulating sebum secretion amount, reducing activity of lipase and having effect in a short time. In addition, the product also has strong moisturizing effect and antibacterial property.

The following products are individually customized for the volunteer A and the volunteer B respectively:

volunteer a the formulation of personalized custom product a is shown in table 1:

TABLE 1 formulation of product A

The formulation of volunteer B personalized custom product B is shown in table 2:

TABLE 2 formulation of product B

After the volunteers A and B cleaned their faces in the morning and evening, 5g of the corresponding personalized products were applied to the faces. Samples were taken 28 days later using the method of example 5 and observed at 100 x magnification. The micrographs of the coated films of volunteers A and B, respectively, are shown in FIGS. 10a and 10B.

As can be seen from the test results of the filmed skin oil test charts of fig. 10a and 10b, the skin oil content of volunteer a was increased to be close to normal by using the personalized skin external preparation; the skin oil secretion of volunteer B was reduced and was near normal.

Therefore, the laminating composition disclosed by the invention can be used for accurately analyzing and acquiring the physiological state of the skin, is suitable for developing a personalized external skin preparation, and can effectively perform personalized skin care on an individual by using the personalized external skin preparation so as to achieve the optimal skin care effect.

The above is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, many variations and modifications can be made without departing from the inventive concept of the present invention, which falls into the protection scope of the present invention.

Claims

1. A film coating composition for transcribing skin texture through skin coating is characterized by comprising the following components in percentage by weight:

the balance being solvent;

the preparation method comprises the following steps:

(1) sequentially adding the film forming agent and the filler into a solvent, and uniformly stirring at the temperature of 20-90 ℃;

2. The composition for skin filming transcription of skin texture of claim 1, wherein said film forming agent is selected from at least one of polyvinyl alcohol, polyvinyl pyrrolidone, acrylic acid (ester) copolymer, acrylic acid (ester)/ethylhexyl acrylate copolymer, styrene/acrylic acid (ester) copolymer, and polyurethane-35.

3. The composition for skin coating transcription of skin texture according to claim 1, wherein the filler is at least one selected from titanium dioxide, kaolin, zinc oxide, talc, diatomaceous earth, mica powder, silica, silicon dioxide, bamboo charcoal powder, quartz powder, attapulgite, bentonite, organic bentonite, volcanic ash, thermal spring soil, sludge, activated clay, brucite powder, magnesium carbonate, and montmorillonite.

4. The composition for transcription of skin texture by skin coating according to claim 1, wherein the thickener is at least one selected from the group consisting of cellulose, magnesium aluminum silicate, xanthan gum, carbomer, and carrageenan.

5. The composition for skin lamination transcription of skin texture according to claim 1, wherein the oil is at least one selected from mineral oil, olive oil, jojoba oil, sweet almond oil, caprylic/capric triglyceride, ethylhexyl palmitate, hydrogenated polydecene, isohexadecane, sunflower seed oil, isopropyl palmitate, C12-15 alcohol benzoate, polydimethylsiloxane, and cyclopentadimethylsiloxane.

6. The composition for skin-filming transcription of skin texture according to claim 1, wherein said emulsifier is selected from at least one of polyglyceryl-3 stearate, polyglyceryl-10 oleate, polyglyceryl-4 laurate, monoglyceride, tween-60, coco glucoside, PEG-100 stearate, ceteareth-6, ceteareth-25, potassium cetyl phosphate.

7. The film-coating composition for transcribing skin texture through skin coating according to claim 1, wherein the anti-sensitivity agent is at least one selected from the group consisting of allantoin, dipotassium glycyrrhizinate, and purslane extract; the preservative is at least one selected from phenoxyethanol, imidazolidinyl urea and hydantoin; the solvent is at least one selected from water, glycerol, propylene glycol, butanediol, glyceryl polyether-26 and alcohol.

8. Use of a coating composition for transcribing skin texture through skin coating according to any one of claims 1 to 7, characterized in that it is suitable for providing a personalized, customized skin preparation for external use.