CN107928834B - Carousel formula animal phototoxicity rapid test appearance - Google Patents
Carousel formula animal phototoxicity rapid test appearance Download PDFInfo
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- CN107928834B CN107928834B CN201711350285.1A CN201711350285A CN107928834B CN 107928834 B CN107928834 B CN 107928834B CN 201711350285 A CN201711350285 A CN 201711350285A CN 107928834 B CN107928834 B CN 107928834B
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- 206010034972 Photosensitivity reaction Diseases 0.000 title claims abstract description 47
- 208000007578 phototoxic dermatitis Diseases 0.000 title claims abstract description 47
- 231100000018 phototoxicity Toxicity 0.000 title claims abstract description 47
- 241001465754 Metazoa Species 0.000 title claims abstract description 44
- 238000012360 testing method Methods 0.000 title claims abstract description 15
- 238000005286 illumination Methods 0.000 claims abstract description 88
- 238000002474 experimental method Methods 0.000 claims abstract description 42
- 238000010171 animal model Methods 0.000 claims abstract description 16
- 238000000034 method Methods 0.000 claims abstract description 9
- 241000555745 Sciuridae Species 0.000 claims description 40
- 239000000463 material Substances 0.000 claims description 10
- 230000005540 biological transmission Effects 0.000 claims description 8
- 238000004140 cleaning Methods 0.000 claims description 2
- 239000002131 composite material Substances 0.000 claims description 2
- 239000013013 elastic material Substances 0.000 claims description 2
- 239000007769 metal material Substances 0.000 claims description 2
- 230000003287 optical effect Effects 0.000 claims description 2
- 238000007789 sealing Methods 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 claims description 2
- 238000009827 uniform distribution Methods 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 108010066114 cabin-2 Proteins 0.000 description 45
- 238000001514 detection method Methods 0.000 description 8
- 230000001276 controlling effect Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 101100491335 Caenorhabditis elegans mat-2 gene Proteins 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 206010025421 Macule Diseases 0.000 description 1
- 206010058679 Skin oedema Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000013095 identification testing Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 231100000760 phototoxic Toxicity 0.000 description 1
- 231100000119 phototoxicity / photoirritation testing Toxicity 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
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- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Husbandry (AREA)
- Testing Resistance To Weather, Investigating Materials By Mechanical Methods (AREA)
Abstract
The invention provides a turntable type animal phototoxicity rapid tester, which comprises an illumination cabin and a rotary disc, wherein the illumination cabin and the rotary disc are arranged on a fixed platform provided with a movable supporting component, a plurality of spring brackets are arranged on the rotary disc which controls the rotating speed by using a stepping motor, a tested mouse cage of an experimental animal can be fixedly arranged, when the tested mouse cage moves to the illumination cabin, a cabin inlet valve and a cabin outlet valve can be automatically jacked and closed, a UV light source component in the illumination cabin emits a 365nm UVA light source with single wavelength and proper intensity to carry out phototoxicity irradiation experiments on the experimental animal, soft shades are arranged at the periphery of the bottom of the illumination cabin to ensure the purity and the light intensity accuracy of the UVA light source during the experiments, and a computer controller controls and records parameters such as the process, the result and the like of each experiment or outputs the parameters to a printer to print experiment report. The beneficial effects of the invention are as follows: and the phototoxicity irradiation experiment of the small animals is completed rapidly and automatically. The light intensity and the irradiation time required by the test can be automatically controlled, the stray light interference is small, the experimental efficiency is improved, and the experimental data is accurate and reliable.
Description
Technical Field
The invention relates to a turntable type animal phototoxicity rapid tester.
Background
Various chemical substances, especially daily chemicals or additives in articles of use, are exposed to the human life. These chemicals have the potential to cause injury to the human body under sunlight exposure as evidenced by skin erythema and edema followed by pigmentation peeling within minutes or hours after exposure to sunlight, which requires phototoxicity test detection of such chemicals; observing whether the skin of the tested animal is subjected to adverse reactions such as heavy, red swelling, macula, blisters and the like after the tested animal is irradiated by a certain dose of UVA light, and comparing and determining whether the tested animal has phototoxicity to the animal according to relevant regulated standard, so as to deduce whether phototoxic injury to human is possible; the traditional phototoxicity identification test equipment is simple, only one or a plurality of tested animals can be tested each time, when a large number of phototoxicity tests are needed, the tested squirrel cages of the loaded animals are replaced among batches, the batch replacement is needed, the time is delayed and the test efficiency is low, so that the development of the animal phototoxicity rapid tester capable of automatically and continuously testing the tested squirrel cages at any time can be placed and taken down becomes urgent.
Disclosure of Invention
In order to solve the problems, the invention aims to provide the turntable type animal phototoxicity rapid tester, a tested mouse cage with experimental animals is fixed on a spring bracket of a rotating disc, the rotating disc moves at a uniform speed under the rotation driving of a stepping motor, the rotating disc drives the tested mouse cage to rotate, when the tested mouse cage moves into an illumination cabin to carry out phototoxicity detection, the tested mouse cage automatically moves out of the illumination cabin after the experiment is finished, and the tested mouse cage can be placed and taken down at any time to automatically and continuously carry out phototoxicity detection in a circulating way, so that the detection efficiency is improved.
In order to achieve the above purpose, the technical scheme of the invention is to provide a turntable type animal phototoxicity rapid tester, the device comprises an illumination cabin and a rotating disc which are arranged on a fixed platform provided with a movable supporting component, a plurality of spring brackets are arranged on the rotating disc which is used for controlling the rotating speed by a stepping motor, a tested mouse cage for experimental animals can be fixedly arranged on the rotating disc, when the tested mouse cage moves to the illumination cabin, a cabin inlet valve and a cabin outlet valve can be automatically jacked and closed, a UV light source component in the illumination cabin emits a 365nm UVA light source with single wavelength and proper intensity to carry out phototoxicity irradiation experiments on the experimental animals, soft shades are arranged at the periphery of the bottom of the illumination cabin to ensure the purity and the light intensity accuracy of the UVA light source when the experiments, and a computer controller is used for controlling and recording parameters such as the process, the result and the like of each experiment or outputting the parameters to a printer to print experiment report.
The beneficial effects of the invention are as follows: and the phototoxicity irradiation experiment of the small animals is completed rapidly and automatically. The light intensity and the irradiation time required by the test can be automatically controlled, the stray light interference is small, the experimental efficiency is improved, and the experimental data is accurate and reliable.
Drawings
FIG. 1 is a schematic illustration of the structure of the present invention;
in the figure:
UVA filter 2, light pod 3, pod access door 4, pod support 5, measured squirrel cage 6, computer controller 7, rotating disk 8, stepper motor 9, mounting squirrel cage arm 10, drive gear 11, drive belt 12, lower disk pulley 13, upper foot bar 14, movable support assembly 15, mounting flange 16, center flange 17, drive gear 18, front and rear risers 19, bracket lower plate 20, spring bracket 21, riser jump ring 22, foot flange 23, casters 24, foot brake 25, lower sleeve 26, fastening wheel 27, mounting platform 28, mounting recess 29, removal squirrel cage arm 30, irradiation exposure 31, soft shade 32, pod access door 33, UV light source assembly 34, upper shade 35, UV light source lamp 36, light intensity controller 37, drive shaft.
Description of the embodiments
The invention will be described with reference to fig. 1 and the examples.
As shown in fig. 1, the invention provides a rotary table type animal phototoxicity rapid tester, which comprises a fixed platform 27 provided with a movable supporting component 14, wherein the fixed platform 27 is a working table surface made of rigid plate-shaped materials, the movable supporting components 14 are respectively supported and fixed at four corners of the fixed platform to form a stable plane working table which can be adjusted in height and can freely move, a computer controller 6 is arranged at the side edge of the upper surface of the fixed platform 27 and is electrically connected with a stepping motor 8, a UV light source lamp 35 and a light intensity controller 36, an opaque illumination cabin 2 is fixedly arranged at the middle position of the rear edge of the fixed platform 27, the illumination cabin 2 is a sealed box-shaped airtight cabin body with a non-reflective inner surface made of rigid opaque plane sheet materials, a UV light source component 33 is connected with the top of the cabin body in a seamless sealing manner, the bottom edge of the rear part of the cabin body is provided with a cabin body support plate 4 for hanging the whole illumination cabin 2 on a fixed platform 27, a rotary disc 7 is arranged between the illumination cabin 2 and the fixed platform 27, a certain distance is arranged between the illumination cabin 2 and the fixed platform 27, so that the whole illumination cabin 2 is in a hanging state on the fixed platform 27, the rotary disc 7 can be kept to freely pass through the middle of the illumination cabin 2 and the fixed platform 27, the rotary disc 7 is arranged in the center of the fixed platform 27 through an arranged fixed flange 15, a plurality of disc lower pulleys 12 between the lower surface of the rotary disc 7 and the upper surface of the fixed platform 27 ensure that the rotary disc 7 is parallel and stable, the disc lower pulleys 12 are arranged on the upper surface of the fixed platform 27, the rotary disc 7 is freely rotated in a matched manner through a disc center flange 16 arranged in the center and a transmission shaft 37 which passes through the fixed flange 15 arranged in the center of the fixed platform 27, the lower end of the transmission shaft 37 is a transmission gear 17, a driving gear 10 connected to a stepping motor 8 installed below a fixed platform 27 through a driving toothed belt 11, the stepping motor 8 controlling the rotary driving rotary disc 7 to move at a constant speed through a computer controller 6; the rotary disc 7 is a planar thin plate disc which is made of rigid materials and has smooth surface and easy cleaning and disinfection, the rotary disc 7 is provided with a plurality of spring brackets 20 in the same distance from the entrance valve 3 and the exit valve 32 on the illumination cabin 2 to the concentric circle of the rotary disc 7, so that the tested squirrel cage 5 can be conveniently placed and fixed and taken down, and each spring bracket 20 can be matched with the tested squirrel cage 5 to fix the tested squirrel cage 5 firmly; the spring brackets 20 are made of elastic materials, and are firmly fixed on the clamping spring devices on the upper surface of the rotating disc 7, each spring bracket 20 is provided with a rectangular bracket lower plate 19 used for being fixed with the rotating disc 7, two ends of each bracket lower plate 19 are respectively provided with a vertical upward front and rear vertical plate 18, the upper ends of the front and rear vertical plates 18 are respectively provided with a vertical plate clamping spring 21 protruding inwards, and fixing grooves 28 at the two ends of the upper edge of the tested squirrel cage 5 are matched and firmly fixed on the tested squirrel cage 5, the spring brackets 20 are arranged on a concentric circle from the center of the upper surface of the rotating disc 7 to the center distance of the illumination cabin 2 according to the principle of uniform distribution and forward installation, when an operator places the tested squirrel cage 5 filled with animals into the spring brackets 20 and fixes the spring brackets, the rotating disc 7 rotates along the advancing direction, the spring brackets 20 fixed on the upper surface of the rotating disc 7 drive the tested squirrel cage 5 to move along the concentric circle, the tested squirrel cage 3 enter the optical cabin 2, the tested squirrel cage 5 is irradiated by an irradiation exposure port 30 on the upper surface of the tested squirrel cage 5 in sequence, and the tested squirrel cage 5 is irradiated by a shutter 32 from the lower valve 2, and then the tested squirrel cage is conveniently taken out of the valve is carried out by the operator from the test cabin through the valve after the test cage is further; the right middle of the lower parts of the left side and the right side of the illumination cabin are respectively provided with a cabin entering valve 3 and a cabin exiting valve 32 which are provided with springs and can be opened and closed automatically, the right center of the illumination cabin 2 is aligned with the middle points of the cabin entering valve 3 and the cabin exiting valve 32, the right center of the illumination cabin 2 is overlapped with the spring bracket 20 in a concentric circle manner, so that when the tested squirrel cage 5 fixed on the rotating disc 7 moves to the illumination cabin 2, the right aligned cabin entering valve 3 enters the illumination cabin 2, the tested squirrel cage 5 completely enters the illumination cabin 2, the cabin entering valve 3 is closed automatically by the cabin door springs after the tested squirrel cage 5 completely enters the illumination cabin 2, the cabin exiting valve 32 is opened when the tested squirrel cage 5 is about to move out of the illumination cabin 2, the cabin exiting valve 32 is closed automatically by the cabin exiting valve after the tested squirrel cage 5 completely moves out of the illumination cabin 2, the soft shielding curtain 31 is arranged on the periphery of the bottom of the illumination cabin 2 to shield the light, the rotating disc 7 can be rotated freely, the UVA light source with single wavelength at 365nm can be prevented from leaking to ensure the clean experiment accuracy, and the experiment light intensity is guaranteed; the top of the illumination cabin 2 is provided with a UV light source component 33 which can emit a UVA light source with a single wavelength of 365nm under the control of the computer controller 6, the UV light source component 33 is a combined element which can control the emission of the UVA light source with the single wavelength of 365nm and is used for carrying out phototoxicity experiment on experimental animals fixed in the tested mouse cage 5, the outer surface of the UV light source component 33 is provided with an upper light shield 34 which is made of a rigid opaque plane sheet material and is hermetically connected to the upper part of the illumination cabin 2, the top of the upper light shield 34 is provided with a UV light source lamp 35 which emits ultraviolet light with a UV wave band, the inside of the upper light shield 34 is also provided with a light intensity controller 36 which is connected with the UV light source lamp 35, and the instruction emitted by the computer controller 6 is used for realizing the implementation of controlling the ultraviolet light source lamp 35 with a proper intensity to emit the ultraviolet light with the wavelength of 365nm for phototoxicity experiment, a UVA filter 1 is arranged between the upper light shield 34 and the illumination cabin 2, the pure light source with the wavelength of 365nm which is used for filtering and ensuring the acceptance of experimental animals in the experiment process is improved and the stray light interference of the clean test efficiency; the computer controller 6 is composed of two major parts of a computer hardware system and a related special software system, wherein the software system is matched with the computer hardware system through a preset program and is electrically connected to the stepper motor 8, the UV light source lamp 35 and the light intensity controller 36 to control the on time, the rotation speed and the experimental requirement and parameters of the light intensity of the connecting component, the computer controller 6 controls the process, the result and the experimental parameters of each experiment in the whole experiment and records the process, the result and the experimental parameters in an internal memory, and the experimental parameters can also be output to a printer to print out an experimental report; the movable supporting component 14 is a composite mechanical device made of firm bearing rigid materials, the uppermost side of the movable supporting component is provided with a supporting leg flange 22 made of metal materials, the supporting leg flange 22 is fixedly arranged at one corner of the lower surface of a platen of the fixed platform 27, an upper supporting leg rod 13 is vertically fixed in the middle of the supporting leg flange 22, a section of lower sleeve 25 is sleeved at the lower end of the upper supporting leg rod 13, a fastening wheel 26 is fixed at the upper part of the lower sleeve 25, when the fastening wheel 26 is loosened, the length of the upper supporting leg rod 13 inserted between the lower sleeve 25 can be changed, the height of the movable supporting component 14 is also changed, when the fastening wheel 26 is screwed, the height of the movable supporting component 14 is fixed, the lower end of each lower sleeve 25 is connected with a truckle 23 with a foot brake 24, as the whole turntable type animal phototoxicity rapid tester is fixedly arranged on the fixed platform 27, the lower surface of the platen of the fixed platform 27 is respectively fixed on four movable supporting components 14, the movable supporting components 14 at four corners can enable the turntable type animal phototoxicity rapid tester to freely move, and the whole turntable type animal phototoxicity rapid tester can be quickly adjusted in parallel; after the tested squirrel cage 5 fixed with experimental animals is placed on the spring support 20 which is to enter the illumination cabin 2 by hand, the rotating disc 7 drives the tested squirrel cage 5 to move to the illumination cabin 2, the cabin entering valve 3 is opened to enter the illumination cabin 2, after the tested squirrel cage 5 completely enters the illumination cabin 2, the cabin entering valve 3 is closed to shield light, the UV light source assembly 33 arranged at the top in the illumination cabin 2 can control the ultraviolet light source which emits 365nm with single wavelength and proper intensity to carry out phototoxicity irradiation experiments on the experimental animals in the tested squirrel cage 5 for a specific time, after the experiments are completed, the cabin exiting valve 32 is opened when the tested squirrel cage 5 is to move out of the illumination cabin 2, when the tested squirrel cage 5 completely moves out of the illumination cabin 2, the cabin exiting valve 32 is closed to shield light, and at the moment, the tested squirrel cage 5 fixed with the experimental animals can be conveniently taken down by hand by an operator.
Examples
Before the phototoxicity test is carried out by using the turntable type animal phototoxicity quick tester, the turntable type animal phototoxicity quick tester is firstly pushed to a place where the equipment is required to be used, the height and the flatness of the turntable type animal phototoxicity quick tester are adjusted according to the height and the requirement of an operator, four movable supporting components 14 fixed at four corners of the lower surface of a platen of a fixed platform 27 are adjusted, when a fastening wheel 26 of the movable supporting components 14 is loosened, the length of an upper supporting leg rod 13 inserted between lower sleeves 25 is changed according to the proper height, so that the height of the movable supporting components 14 is changed, when the fastening wheel 26 is screwed when the required height is reached, the height of the movable supporting components 14 is fixed, the four movable supporting components 14 are respectively adjusted to the same height, and then foot brakes 24 of foot casters 23 at the lower ends of the lower sleeves 25 of the movable supporting components 14 are braked, so that the whole control device keeps the same height and flatness and cannot move; preparing an experimental animal, preparing skin for the experimental animal according to the standard related to skin phototoxicity test, selecting a proper tested squirrel cage 5 according to the size of the tested animal, and loading the experimental animal prepared with skin into the tested squirrel cage 5; turning on a power switch of the turntable type animal phototoxicity rapid tester, turning on a power supply of the computer controller 6, starting a reset preparation protection program, and setting experimental requirements and parameters such as the turn-on time, the rotation speed, the light source intensity and the like of the stepper motor 8, the UV light source lamp 35 and the light intensity controller 36 through the computer controller 6 according to the experimental requirements of phototoxicity detection, wherein the computer controller 6 is in a preparation working state; after the experiment is finished, the rotating disc 7 between the illumination cabin 2 and the fixed platform 27 starts to move at a constant speed, as the whole illumination cabin 2 is in a suspended state on the fixed platform 27, the rotating disc 7 can be kept to freely pass through the middle of the illumination cabin 2 and the fixed platform 27, at the moment, an operator places the tested mouse cage 5 filled with tested animals into the spring bracket 20 which is about to enter the illumination cabin 2 by hand, when the rotating disc 7 rotates along the forward direction, the spring bracket 20 fixed on the upper surface of the rotating disc 7 drives the tested mouse cage 5 to move along a concentric circle, when the tested mouse cage 5 moves to the illumination cabin 2, the top opening cabin valve 3 enters the illumination cabin 2, the to-be-tested mouse cage 5 completely enters the illumination cabin 2, the shutter 3 is closed to block light, the UV light source component 33 arranged at the top of the illumination cabin 2 can control the tested mouse cage 5 which is about to enter the illumination cabin 3 by hand, the UVA light source which is provided with single wavelength and proper intensity, the tested mouse cage 5 sequentially passes through the special bracket 30, the top opening cabin 365 is arranged on the illumination cabin 2, the tested mouse cage is completely removed from the illumination cabin 2, the top of the experiment cabin is completely removed from the experiment cabin 2, and the light is completely removed from the experiment cabin 32 when the top of the tested mouse cage is completely removed from the illumination cabin 2, and the experiment cabin is completely removed from the illumination cabin 2; by analogy, an operator can continuously place the tested squirrel cage 5 filled with tested animals into the spring support 20 which is about to enter the illumination cabin 2 by hand and fix the tested squirrel cage 5, the rotating disk 7 drives the tested squirrel cage 5 to move to the illumination cabin 2 for phototoxicity detection along with uniform motion of the rotating disk 7, the tested squirrel cage 5 is moved out of the illumination cabin 2 after the experiment is completed, the operator continuously removes the tested squirrel cage 5 with the tested animals from the spring support 20 by hand, and the phototoxicity test detection is continuously and rapidly carried out in a circulating way; all experiments are completed, and the tested animals subjected to phototoxicity test detection are sent to be subjected to the next scientific experiment and study; the power supply of the turntable type animal phototoxicity rapid tester and the computer controller 6 is turned off, then the foot brake 24 of the caster wheel 23 at the lower end of the lower sleeve 25 of each movable supporting component 14 is turned on, the turntable type animal phototoxicity rapid tester is pushed to a place for storing the equipment, and the foot brake 24 is braked for safe storage.
Claims (8)
1. A rotary disk type animal phototoxicity rapid tester is characterized in that: the device comprises a fixed platform (27) provided with a movable supporting component (14), wherein an opaque illumination cabin (2) is arranged on the fixed platform (27), a rotary disc (7) is arranged between the illumination cabin (2) and the fixed platform (27), a pulley (12) under the disc is arranged between the rotary disc (7) and the fixed platform (27) to ensure the stable rotation of the rotary disc (7), a cabin support plate (4) is arranged on the bottom edge of the rear part of the cabin body of the illumination cabin (2) to suspend the whole illumination cabin (2) on the fixed platform (27), a certain interval is arranged between the illumination cabin (2) and the fixed platform (27) to enable the whole illumination cabin (2) to present a suspending state on the fixed platform (27), so that a transmission shaft (37) of the rotary disc (7) can freely pass through the middle of the illumination cabin (2) and the fixed platform (27), a transmission gear (17) at the lower end of the fixed flange (15) passes through a fixed flange (15) of the fixed platform (27), a driving gear (8) and a driving gear (11) at the lower end of the fixed flange (15) are connected to a driving gear (8) to a stepping motor (8) to control the rotation speed of the rotary disc (8) according to a constant speed of the calculation, the rotary disc (7) is provided with a plurality of spring brackets (20) in the same distance from a cabin inlet valve (3) and a cabin outlet valve (32) on the illumination cabin (2) to the concentric circle of the rotary disc (7) in the same distance, each spring bracket (20) can be matched with the tested mouse cage (5) to fix the tested mouse cage (5) firmly, the top in the illumination cabin (2) is provided with a UV light source component (33) capable of emitting a UVA light source with a single wavelength of 365nm under the control of a computer controller (6), the ultraviolet light source component is used as a test light source to carry out an illumination experiment on experimental animals fixed in the tested mouse cage (5), after the tested mouse cage (5) fixed with the experimental animals is manually placed on the spring brackets (20) which are about to enter the illumination cabin (2), the rotary disc (7) drives the tested mouse cage (5) to move to the illumination cabin (2), the top of the cabin inlet valve (3) enters the illumination cabin (2), when the tested mouse cage (5) completely enters the illumination cabin (2), the ultraviolet light source component is used for carrying out the experiment with a specific illumination intensity of the ultraviolet light source (365 nm, and the light source is controlled to emit the ultraviolet light with a specific wavelength in the top of the experiment light source (365 nm, after the experiment is finished, when the detected mouse cage (5) is about to move out of the illumination cabin (2), the cabin outlet valve (32) is jacked up, when the detected mouse cage (5) is completely moved out of the illumination cabin (2), the cabin outlet valve (32) is closed to shield light, at the moment, an operator can conveniently take down the detected mouse cage (5) fixed with experimental animals by hand, soft shielding curtains (31) are arranged on the periphery of the bottom of the illumination cabin (2) to shield light, ultraviolet light leakage can be prevented, purity and light intensity accuracy of a 365nm UVA light source with single wavelength in the experiment can be guaranteed, further, the experimental condition is perfect, the process, the result and the experimental parameters of each experiment are controlled and recorded by a computer controller (6) in the whole experiment, and an experiment report can be printed out by a printer.
2. A rotary disc type animal phototoxicity rapid tester according to claim 1, characterized in that: the illumination cabin (2) is a sealed box-shaped closed cabin body with the inner surface not reflecting light and made of rigid light-tight plane sheet materials, the top of the cabin body is in seamless sealing connection with a UV light source assembly (33), a cabin support plate (4) is arranged on the bottom edge of the rear part of the cabin body, a cabin entering valve (3) and a cabin exiting valve (32) which are provided with springs and can be opened and closed automatically are respectively arranged in the middle of the right and left lower parts of the illumination cabin, the center of the illumination cabin (2) is aligned with the middle points of the cabin entering valve (3) and the cabin exiting valve (32), the center of the illumination cabin (2) is aligned with a concentric circle arranged on a spring support (20), so that a detected mouse cage (5) fixed on a rotary disc (7) just right aligns the cabin entering valve (3) into the illumination cabin (2), the rear spring of the detected mouse cage (5) completely enters the illumination cabin (2) to automatically close the cabin entering valve (3), and when the detected mouse cage (5) moves out of the illumination cabin, the door (32) is completely moved out of the illumination cabin, and the light shielding valve (32) is completely moved out of the cabin after the detected mouse cage (5) is completely moved out.
3. A rotary disc type animal phototoxicity rapid tester according to claim 1, characterized in that: the ultraviolet light source assembly (33) is a combined element capable of controlling and emitting ultraviolet light with single wavelength of 365nm, the outer surface of the combined element is an upper light shield (34) which is made of rigid light-proof plane sheet materials and the inner surface of which is light-proof, the upper light shield is hermetically connected to the upper part of the illumination cabin (2), the top of the upper light shield (34) is provided with ultraviolet light of ultraviolet light wavelength of 365nm emitted by an ultraviolet light source lamp (35), an optical intensity controller (36) connected with the ultraviolet light source lamp (35) is arranged in the upper light shield (34), and the instruction emitted by the computer controller (6) is used for realizing and executing ultraviolet light with proper intensity of 365nm emitted by the ultraviolet light source lamp (35) to carry out phototoxicity experiments, and a UVA filter (1) is arranged between the upper light shield (34) and the illumination cabin (2) and can filter stray light to ensure that the ultraviolet light with the wavelength of 365nm received by small animals in the experimental process is clean and accurate, the interference of stray light on the experimental experiment is reduced, and the experimental efficiency is improved.
4. A rotary disc type animal phototoxicity rapid tester according to claim 1, characterized in that: the rotary disc (7) is a planar thin plate disc which is made of rigid materials and has smooth surface and easy cleaning and disinfection, a plurality of spring brackets (20) are uniformly distributed on the concentric circle of the upper surface of the rotary disc (7) from the center of the circle to the center distance of the illumination cabin (2), the tested mouse cage (5) can be conveniently placed and fixed and taken down, the rotary disc (7) is matched with the fixed flange (15) which is installed through the center of the fixed platform (27) through a disc center flange (16) which is installed on the center of the lower surface and a transmission shaft (37) to freely rotate, and the rotary disc (7) is ensured to be parallel and stable through a plurality of disc lower pulleys (12) which are installed on the lower surface contact fixed platform (27) at equal distance.
5. A rotary disc type animal phototoxicity rapid tester according to claim 1, characterized in that: the fixed platform (27) is a working table surface made of rigid plate-shaped materials, movable supporting components (14) are respectively arranged at four corners of the fixed platform to support and fix the fixed platform to form a stable plane working table which can be adjusted in height and can move freely, a computer controller (6) is arranged on the side edge of the upper surface of the fixed platform (27) and is electrically connected to a stepping motor (8), a UV light source lamp (35) and a light intensity controller (36), an illumination cabin (2) is fixedly arranged at the middle position of the rear side of the fixed platform (27), a certain interval is reserved between the illumination cabin (2) and the fixed platform (27) so that the whole illumination cabin (2) presents a suspension state on the fixed platform (27), the center of the fixed platform (27) is arranged into a rotary disc (7) through a fixed flange (15) arranged, a plurality of disc lower pulleys (12) between the lower surface of the rotary disc (7) and the upper surface of the fixed platform (27) ensure that the rotary disc (7) is parallel and stable, the rotary disc lower pulleys (12) are arranged on the upper surface of the fixed platform (27), the rotary disc (7) passes through a transmission shaft (37) arranged at the center of the rotary disc (7) and penetrates through a transmission shaft (37) arranged at the middle end of the fixed flange (37), the stepping motor (8) is controlled by a computer controller (6) to rotate and drive the rotary disc (7) to move at a uniform speed through a driving gear (10) connected with a stepping motor (8) arranged below the fixed platform (27) through a driving toothed belt (11).
6. A rotary disc type animal phototoxicity rapid tester according to claim 1, characterized in that: the computer controller (6) is composed of a computer hardware system and a software system, wherein the software system is matched with the computer hardware system through a preset program and is electrically connected to the stepping motor (8), the UV light source lamp (35) and the light intensity controller (36) to control the on time, the rotation speed and the experimental requirements and parameters of the light intensity of the connecting component, and the computer controller (6) controls the process, the result and the experimental parameters of each experiment in the whole experiment and records the process, the result and the experimental parameters in the internal memory and can be output to the printer to print an experiment report.
7. A rotary disc type animal phototoxicity rapid tester according to claim 1, characterized in that: the spring brackets (20) are made of elastic materials and firmly fixed on the upper surface of the rotary disc (7), each spring bracket (20) is provided with a rectangular bracket lower plate (19) for being fixed with the rotary disc (7), two ends of the bracket lower plate (19) are respectively provided with a vertical upward front vertical plate and a vertical upward rear vertical plate (18), the upper ends of the front vertical plate and the rear vertical plate (18) are respectively provided with a vertical plate snap spring (21) protruding inwards and fixing grooves (28) at the two ends of the upper edge of the tested squirrel cage (5) which are matched with each other to firmly fix the tested squirrel cage (5), the spring brackets (20) are arranged on concentric circles from the center of the upper surface of the rotary disc (7) to the center distance of the lighting cabin (2) according to the principle of uniform distribution, after an operator places the tested squirrel cage (5) with small animals into the spring brackets (20) and fixes the spring brackets, the rotary disc (7) rotates along the forward direction, the spring brackets (20) fixed on the upper surface of the rotary disc (7) drive the upper surface of the rotary disc and the tested squirrel cage (5) to move along the forward direction, the lighting cabin (2) to irradiate the lighting cabin (30) from the center of the upper surface of the rotary disc (7) to the lighting cabin (2), and then the tested mouse cage (5) is conveniently taken off from the spring bracket (20) by an operator so as to conveniently continue to complete the experiment.
8. A rotary disc type animal phototoxicity rapid tester according to claim 1, characterized in that: the movable supporting component (14) is a composite mechanical device made of firm bearing rigid materials, the uppermost side of the movable supporting component is provided with a supporting foot flange (22) made of metal materials, the supporting foot flange (22) is fixedly arranged at one corner of the lower surface of a platen of the fixed platform (27), an upper supporting foot rod (13) is vertically fixed in the middle of the supporting foot flange (22), a section of lower sleeve (25) is sleeved at the lower end of the upper supporting foot rod (13), a fastening wheel (26) is fixed on the upper part of the lower sleeve (25), when the fastening wheel (26) is loosened, the length of the upper supporting foot rod (13) inserted between the lower sleeve (25) is changed, the height of the movable supporting component (14) is changed, when the fastening wheel (26) is screwed, the height of each movable supporting component (14) is fixed, the lower end of each lower sleeve (25) is connected with a trundle (23) with a foot brake (24), and as the whole turntable animal phototoxicity tester is fixedly arranged on the fixed platform (27), four movable supporting components are respectively arranged on the four corners of the lower surface of the bottom plate of the fixed platform (27), the turntable animal phototoxicity tester can be quickly adjusted, and the animal phototoxicity tester can be quickly moved in parallel.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006136348A (en) * | 2004-11-10 | 2006-06-01 | Daicel Chem Ind Ltd | Endotracheal sample administration aid for small animal |
| CN101554340A (en) * | 2008-04-07 | 2009-10-14 | 范维林 | Phototoxicity experiment detection device |
| CN103275871A (en) * | 2013-06-13 | 2013-09-04 | 天津开发区合普工贸有限公司 | Detecting device used in phototoxicity experiment of cells in perforated plates |
| CN203378384U (en) * | 2013-07-29 | 2014-01-08 | 延边大学 | Automatic-revolving multifunctional laboratory animal cage |
| CN105342721A (en) * | 2015-12-08 | 2016-02-24 | 天津开发区合普工贸有限公司 | Phototoxicity exposure experimental animal fixing and protecting device |
| CN105769374A (en) * | 2016-05-10 | 2016-07-20 | 广西壮族自治区疾病预防控制中心 | Small animal high-voltage electric shock narcotizing device |
-
2017
- 2017-12-15 CN CN201711350285.1A patent/CN107928834B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006136348A (en) * | 2004-11-10 | 2006-06-01 | Daicel Chem Ind Ltd | Endotracheal sample administration aid for small animal |
| CN101554340A (en) * | 2008-04-07 | 2009-10-14 | 范维林 | Phototoxicity experiment detection device |
| CN103275871A (en) * | 2013-06-13 | 2013-09-04 | 天津开发区合普工贸有限公司 | Detecting device used in phototoxicity experiment of cells in perforated plates |
| CN203378384U (en) * | 2013-07-29 | 2014-01-08 | 延边大学 | Automatic-revolving multifunctional laboratory animal cage |
| CN105342721A (en) * | 2015-12-08 | 2016-02-24 | 天津开发区合普工贸有限公司 | Phototoxicity exposure experimental animal fixing and protecting device |
| CN105769374A (en) * | 2016-05-10 | 2016-07-20 | 广西壮族自治区疾病预防控制中心 | Small animal high-voltage electric shock narcotizing device |
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