CN107928834A - A kind of quick tester of rotating disc type animal phototoxicity - Google Patents
A kind of quick tester of rotating disc type animal phototoxicity Download PDFInfo
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- CN107928834A CN107928834A CN201711350285.1A CN201711350285A CN107928834A CN 107928834 A CN107928834 A CN 107928834A CN 201711350285 A CN201711350285 A CN 201711350285A CN 107928834 A CN107928834 A CN 107928834A
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- 206010034972 Photosensitivity reaction Diseases 0.000 title claims abstract description 48
- 208000007578 phototoxic dermatitis Diseases 0.000 title claims abstract description 48
- 231100000018 phototoxicity Toxicity 0.000 title claims abstract description 48
- 238000005286 illumination Methods 0.000 claims abstract description 85
- 238000002474 experimental method Methods 0.000 claims abstract description 51
- 238000010171 animal model Methods 0.000 claims abstract description 19
- 238000012360 testing method Methods 0.000 claims abstract description 13
- 238000000429 assembly Methods 0.000 claims abstract description 9
- 230000000712 assembly Effects 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims abstract description 4
- 239000000463 material Substances 0.000 claims description 11
- 238000009434 installation Methods 0.000 claims description 8
- 230000033001 locomotion Effects 0.000 claims description 8
- 230000005540 biological transmission Effects 0.000 claims description 6
- 235000004443 Ricinus communis Nutrition 0.000 claims description 4
- 230000004313 glare Effects 0.000 claims description 4
- 230000003287 optical effect Effects 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 230000006641 stabilisation Effects 0.000 claims description 3
- 238000011105 stabilization Methods 0.000 claims description 3
- 230000003670 easy-to-clean Effects 0.000 claims description 2
- 239000013013 elastic material Substances 0.000 claims description 2
- 230000005611 electricity Effects 0.000 claims description 2
- 230000007246 mechanism Effects 0.000 claims description 2
- 239000007769 metal material Substances 0.000 claims description 2
- 238000007789 sealing Methods 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 claims description 2
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 238000007639 printing Methods 0.000 abstract description 2
- 108010066114 cabin-2 Proteins 0.000 description 35
- 238000001514 detection method Methods 0.000 description 10
- 231100000419 toxicity Toxicity 0.000 description 5
- 230000001988 toxicity Effects 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 206010025421 Macule Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 241000233855 Orchidaceae Species 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000003760 hair shine Effects 0.000 description 1
- 239000003845 household chemical Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
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- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Husbandry (AREA)
- Testing Resistance To Weather, Investigating Materials By Mechanical Methods (AREA)
Abstract
The present invention provides a kind of quick tester of rotating disc type animal phototoxicity, the device is included in the illumination cabin installed in the fixed platform equipped with moveable support member and rotating circular disk, there are some spring supports to fix the tested mouse cage equipped with experimental animal on rotating circular disk with step motor control rotating speed, tested mouse cage can push up automatically when being moved to illumination cabin open and close to be entered cabin valve and to go out cabin valve, UV light source assemblies send single wavelength in illumination cabin and the UVA light sources of the 365nm of appropriate intensity carry out experimental animal phototoxicity irradiation experiment, illumination bilge portion surrounding is provided with soft window shade and ensures UVA light sources purity and luminous intensity accuracy during experiment, there is the process of computer control control and the every experiment of record in experiment, etc. as a result parameter or it is output to printer printing laboratory report list.The beneficial effects of the invention are as follows：The fast automatic phototoxicity irradiation experiment for completing toy.The light intensity and irradiation time of such test requirements document can be automatically controlled, interference of stray light is small, improves conventional efficient, makes experimental data accurately and reliably.
Description
Technical field
The present invention relates to a kind of quick tester of rotating disc type animal phototoxicity.
Background technology
Various chemical substances, especially household chemicals can be touched in people's lives or using in article
Additive.These chemical substances there is a possibility that to damage human body under sunlight condition, it shows as illumination
Erythema and oedema, which occur, for several minutes or a few hours inner skin afterwards followed by pigmentation decortication, this just need to such chemicals into
Row Phototoxicity experiment detects；It is thick and heavy, red whether observation animal subject skin after the UVA light irradiation of doses occurs
The adverse reactions such as swollen, macula, bubble simultaneously determine whether the tested material has light for animal according to the Comparison of standards of pertinent regulations
Toxicity is so as to reason out for whether the mankind may cause phototoxicity to injure；Conventional phototoxicity qualification test equipment is simpler
Single, detection every time can only do one or several animal subjects, when needing to do large quantities of phototoxicity detections, replaced between batch install it is dynamic
The tested mouse cage of thing wants a collection of batch of replacement, wastes time and discontinuously, detection efficiency is low, thus develop one kind can be with
When can place and remove tested mouse cage, the quick tester of animal phototoxicity being automatically continuously detected becomes the task of top priority.
The content of the invention
To solve the above problems, the object of the present invention is to provide a kind of quick tester of rotating disc type animal phototoxicity, will fill
The tested mouse cage for having experimental animal is fixed on the spring support of rotating circular disk, and rotating circular disk is even under stepper motor rotation driving
Fast movement, rotating circular disk drive tested mouse cage to rotate, and carry out phototoxicity detection when tested mouse cage is moved in illumination cabin, have tested
Light extraction is automatically moved into rear tested mouse cage and shines cabin, is moved in circles, can be placed and remove at any time tested mouse cage and automatically continuously carry out
Phototoxicity detects, and improves detection efficiency.
To achieve the above object, the technical scheme is that providing a kind of quick tester of rotating disc type animal phototoxicity,
The device is included in the illumination cabin installed in the fixed platform equipped with moveable support member and rotating circular disk, uses step motor control
There are some spring supports to fix the tested mouse cage equipped with experimental animal on the rotating circular disk of rotating speed, tested mouse cage is moved to illumination
Can be pushed up automatically during cabin it is open and close enter cabin valve and to go out cabin valve, UV light source assemblies send single wavelength and appropriate strong in illumination cabin
The UVA light sources of the 365nm of degree carry out experimental animal phototoxicity irradiation experiment, and illumination bilge portion surrounding is provided with soft window shade and ensures
UVA light sources purity and luminous intensity accuracy during experiment, there is the mistake of computer control control and the every experiment of record in experiment
The parameters such as journey, result are output to printer printing laboratory report list.
The beneficial effects of the invention are as follows：The fast automatic phototoxicity irradiation experiment for completing toy.Such can be automatically controlled
The light intensity and irradiation time of test requirements document, interference of stray light is small, improves conventional efficient, makes experimental data accurately and reliably.
Brief description of the drawings
Attached drawing 1 is the schematic diagram of structure of the present invention；
In figure：
2. illumination cabin 3. of 1.UVA filter discs enters 4. nacelle support plate 5. of cabin valve and is tested 6. computer control of mouse cage
7. 8. stepper motor 9. of rotating circular disk places 11. sliding tooth band of mouse cage 10. drive gear of arm, 12. disk lower sheave
13. before and after 16. core flange of upper support leg bar 14. moveable support member, 15. mounting flange, 17. travelling gear 18.
23. castor of riser 19. stent lower plate, 20. spring support, 21. riser clamp spring, 22. leg flange, 24. foot brake
25. 26. fastening wheel of lower sleeve, 27. fixed platform, 28. fixed groove 29., which takes out mouse cage arm 30., irradiates exposure
31. soft window shades 32. of mouth go out 35. UV illuminators of hood, 36. light on 33. UV light source assemblies 34. of cabin valve
37. transmission shaft of strong controller.
Embodiment
The present invention is illustrated with reference to attached drawing 1 and embodiment.
As shown in Figure 1, the present invention provides a kind of quick tester of rotating disc type animal phototoxicity, which includes a dress
There is the fixed platform 27 of moveable support member 14, fixed platform 27 is a work top made by rigid plate-like material,
Fixed platform corner have respectively moveable support member 14 support fix, formed it is stable, can adjust height and can freely move
Dynamic planar working table, computer control 6 is provided with the side of 27 upper surface of fixed platform by being electrically connected to stepping electricity
Machine 8, UV illuminators 35 and light intensity control 36, the back centre position of fixed platform 27 are installed with lighttight illumination cabin
2, illumination cabin 2 is the non-reflective box-like closed bin of sealing of an inner surface being made by the light tight plane sheet material of rigidity
Body, connects a UV light source assembly 33 in warehouse inner top seamless seal, has a nacelle support plate 4 will be whole on the base of warehouse rear portion
A illumination cabin 2 is vacantly installed in fixed platform 27, there is a rotating circular disk 7, illumination cabin between illumination cabin 2 and fixed platform 27
It is at regular intervals so that vacant state is presented in whole illumination cabin 2 in fixed platform 27 between 2 and fixed platform 27, so can
Rotating circular disk 7 is kept freely to be walked among illumination cabin 2 and fixed platform 27, the fixation in fixed platform 27 centrally through installation
Flange 15 loads rotating circular disk 7, several disk lower sheaves 12 between 27 upper surface of 7 lower surface of rotating circular disk and fixed platform are protected
7 parallel stabilization of rotating circular disk is demonstrate,proved, disk lower sheave 12 is installed on the upper surface of fixed platform 27, and rotating circular disk 7 is felt at ease in
The mounting flange 15 of the core flange 16 and transmission shaft 37 of dress through the installation of the center of fixed platform 27, which cooperates, to be rotated freely, and is passed
The lower end of moving axis 37 is a travelling gear 17, the step being connected to by a sliding tooth band 11 below fixed platform 27
Drive gear 10 in stepper motor 8, stepper motor 8 control rotation driving rotating circular disk 7 at the uniform velocity to transport by computer control 6
It is dynamic；Rotating circular disk 7 is the planar sheet disk of the smooth disinfection easy to clean in a surface being made by rigid material, rotation
Disk 7 is first-class according to the concentric circles for entering cabin valve 3 and going out cabin valve 32 to 7 center of circle same distance of rotating circular disk on illumination cabin 2
Distance is forward provided with several spring supports 20, can easily place and fix and remove tested mouse cage 5, each spring branch
Frame 20 can coordinate with tested mouse cage phase 5 by tested 5 fixation of mouse cage；Spring support 20 be by being made with elastic material and
Into, the Circlip apparatus in 7 upper surface of rotating circular disk is fixedly secured, each spring support 20 has a rectangular stent
Lower plate 19 is used for and rotating circular disk 7 is fixed, and respectively there is a front and rear riser 18 vertically upward at 19 both ends of stent lower plate, front and rear vertical
18 upper end of plate respectively have again the fixed groove 28 at an inwardly projecting 5 top both ends of riser clamp spring 21 and tested mouse cage be engaged by
5 fixation of tested mouse cage, the principle that spring support 20 is forward installed according to being uniformly distributed are installed on from 7 upper surface of rotating circular disk
The center of circle on the concentric circles of 2 center distance of illumination cabin, when the tested mouse cage 5 equipped with toy is received in spring by operator
After being fixed in stent 20, rotating circular disk 7 is fixed on the spring branch of 7 upper surface of rotating circular disk when being rotated along direction of advance
Frame 20 drives tested mouse cage 5 to sequentially enter cabin valve 3 in illumination cabin 2 by being tested above mouse cage 5 along concentric circular motion
Irradiation 30 pairs of toys of exposure mouth carry out phototoxicity irradiations, mouse cage 5 is tested after the completion of irradiation and is sent out from cabin valve 32 is gone out, then
Easily the tested mouse cage 5 after test is taken off from spring support 20 by operator in order to continue to complete experiment；Illumination cabin
The right and left lower part middle is respectively provided with that an energy with spring is open-top and what is be automatically closed enters cabin valve 3 and to go out cabin valve 32,
The center in illumination cabin 2 is aligned with entering cabin valve 3 and going out the midpoint of cabin valve 32, and the center in illumination cabin 2 is again and spring support
20 installation concentric circles overlap, and just align when fixed tested mouse cage 5 is moved to illumination cabin 2 on such rotating circular disk 7 and live into cabin
Door 3 is entered in illumination cabin 2, and tested mouse cage 5 is automatically closed completely into will enter cabin valve 3 to rear door spring in illumination cabin 2
Shelter from light, when tested mouse cage 5 will move out illumination cabin 2 it is open-top go out cabin valve 32, mouse cage 5 to be tested is fully removed light
According to cabin 2 it is outer after, hatch door spring, which will go out cabin valve 32 and be automatically closed, shelters from light, and 2 bottom surrounding of illumination cabin is provided with soft window shade
31 shelter from light, single when can not only allow the rotating circular disk 7 to rotate freely but also can prevent ultraviolet light leakage to ensure experiment
The UVA light sources purity of the 365nm of wavelength and luminous intensity accuracy, and then ensure that the condition of experiment is perfect；Top in illumination cabin 2
There is a UV light source assembly 33 that the UVA light sources that single wavelength is 365nm can be sent in the case where computer control 6 controls in portion, and makees
Phototoxicity irradiation experiment is carried out to the experimental animal being fixed in tested mouse cage 5 for test light source, UV light source assemblies 33 are one
The composition element for sending the UVA light sources that single wavelength is 365nm can be controlled, its outer surface is one by the impermeable optical plane of rigidity
The non-reflective upper hood 34 for being sealably coupled to 2 top of illumination cabin of inner surface that light sheet material is made, upper hood 34
Top is the ultraviolet light that a UV illuminator 35 sends UV wave bands, and the upper inside of hood 34 also has one and is connected to UV illuminators 35
Light intensity control 36, the instruction that is sent by computer control 6 realizes that performing control UV illuminators 35 sends appropriate intensity
Wavelength be 365nm UVA ultraviolet lights carry out phototoxicity experiments, a UVA is installed between upper hood 34 and illumination cabin 2
Optical filter 1, can filter out the UVA light that the wavelength that veiling glare ensures that the toy for receiving experiment in experimentation receives is 365nm
Source it is pure and accurate, reduce interference of the veiling glare to experiment, improve and test efficiency；Computer control 6 is by computer
Hardware system and related dedicated software systems two large divisions composition, software systems therein are coordinated by default program to be calculated
Machine hardware system is by being electrically connected to stepper motor 8, UV illuminators 35 and light intensity control 36, to control the open-minded of connecting component
Time, rotary speed, the requirement of experiment of the intensity of light source and parameter, whole Computer controller 6 of testing control every experiment
Process, result and experiment parameter are simultaneously recorded among internal storage, can also be output to printer and be printed experiment report
Accuse single；Moveable support member 14 is the complex mechanical mechanisms being made by firm load-bearing rigid material, has one in its top
The leg flange 22 that a metal material makes, is fixedly installed to an edge of the platen lower surface of fixed platform 27, branch
Footwork 22 intermediate verticals of orchid fix a upper support leg bar 13, and one section of lower sleeve 25, lower sleeve are cased with the lower end of upper support leg bar 13
25 tops are fixed with fastening wheel 26, when unclamping fastening wheel 26, it becomes possible to change upper support leg bar 13 and be inserted between lower sleeve 25
Length, also just changes the height of moveable support member 14, and when tightening fastening wheel 26, the height of moveable support member 14 is consolidated
Fixed motionless, the lower end of each lower sleeve 25 connects a castor 23 for carrying foot brake 24, due to whole rotating disc type animal light
The quick tester of toxicity is fixedly installed in fixed platform 27, and the corner of the table top bottom plate lower surface of fixed platform 27 is solid respectively
It is scheduled on four moveable support members 14, so the moveable support member 14 of adjustment corner, it becomes possible to make rotating disc type animal light malicious
The quick tester of property freely moves in parallel, and can adjust the height water of the whole quick tester of rotating disc type animal phototoxicity
It is flat；The tested mouse cage 5 for being fixed with experimental animal is placed to and will be entered on the spring support 20 in illumination cabin 2 with hand by operator
Afterwards, when rotating circular disk 7 drives tested mouse cage 5 to be moved to illumination cabin 2 it is open-top enter cabin valve 3 enter in illumination cabin 2, when tested mouse
Cage 5 is completely into entering cabin valve 3 to after in illumination cabin 2 and close to shelter from light, the UV light source assemblies of 2 inner top of illumination cabin installation
33 can control the UVA light sources for the 365nm for sending single wavelength and appropriate intensity to carry out spy to the experimental animal being tested in mouse cage 5
Fix time phototoxicity irradiation experiment, after the completion of experiment when tested mouse cage 5 will move out illumination cabin 2 it is open-top go out cabin valve
32, when tested mouse cage 5 be fully removed illumination cabin 2 it is outer after go out cabin valve 32 close shelter from light, operator can be square at this time
Just the tested mouse cage 5 for being fixed with experimental animal is removed with hand.
Embodiment：
Using a kind of rotating disc type animal phototoxicity of the present invention quick tester first move rotating disc type before phototoxicity detection
The quick tester of object light toxicity shifts the place needed using this equipment onto, according to the height of operator and needs adjustment rotating disc type to move
The height and Pingdu of the quick tester of object light toxicity, adjust four edges of the platen lower surface for being fixed on fixed platform 27
Four moveable support members 14, when unclamping the fastening wheel 26 of moveable support member 14, according to suitable Level Change upper support leg bar
Length between 13 insertion lower sleeves 25, so also just changes the height of moveable support member 14, when reaching required height
When fastening wheel 26 is tightened when spending, at this moment the height of moveable support member 14 is fixed, and four moveable support members 14 are divided
Sustained height is not adjusted to, and then the foot brake 24 of the 25 lower end castor 23 of lower sleeve of each moveable support member 14 is stopped
Firmly, height that whole control device maintains like and flatness and immovable are made；Experimental animal is then ready for, according to skin
The relevant standard of skin Phototoxicity experiment provides that carrying out preserved skin to experimental animal prepares, suitable according to the size select of animal subject
Tested mouse cage 5, the experimental animal that will carry out preserved skin preparation loads tested mouse cage 5；Rotating disc type animal phototoxicity is opened quickly to try
The power switch of instrument is tested, while opens the power supply of computer control 6, starts and resets preparation protective program, computer control 6
In preparation state, stepper motor is set by computer control 6 now according to the requirement of experiment of phototoxicity detection
8th, requirement of experiment and the parameter such as the service time of UV illuminators 35 and light intensity control 36, rotary speed, intensity of light source；Set up
Starting to test after, the rotating circular disk 7 between illumination cabin 2 and fixed platform 27 starts with certain speed uniform motion, due to
Vacant state is presented in fixed platform 27 in whole illumination cabin 2, and this makes it possible to keep rotating circular disk 7 in illumination cabin 2 and fix
Freely walked among platform 27, at this moment the tested mouse cage 5 equipped with animal subject is placed to by operator with hand will enter illumination
After being fixed in the spring support 20 in cabin 2, rotating circular disk 7 is fixed on 7 upper table of rotating circular disk when being rotated along direction of advance
The spring support 20 in face just drives tested mouse cage 5 along concentric circular motion, when tested mouse cage 5 is moved to illumination cabin 2 it is open-top enter
Cabin valve 3 is entered in illumination cabin 2, after tested mouse cage 5 completely into entering cabin valve 3 to after in illumination cabin 2 and close to shelter from light
Line, the UV light source assemblies 33 of 2 inner top of illumination cabin installation can control the UVA for the 365nm for sending single wavelength and appropriate intensity
Experimental animal in tested mouse cage 5 of the light source to sequentially entering cabin valve 3 exposes mouth 30 by the irradiation being tested above mouse cage 5
The phototoxicity irradiation experiment of special time is carried out, it is open-top when illumination cabin 2 will be moved out to be tested mouse cage 5 after the completion of irradiation experiment
Go out cabin valve 32, when tested mouse cage 5 be fully removed illumination cabin 2 it is outer after go out cabin valve 32 close shelter from light, then by grasping
Author easily takes off the tested mouse cage 5 after test from spring support 20, and experimental animal is taken out from tested mouse cage 5；
And so on, the tested mouse cage 5 equipped with animal subject can be continuously placed to the bullet that will enter illumination cabin 2 by operator with hand
Fixed in spring bracket 20, with the uniform motion of rotating circular disk 7, rotating circular disk 7 drives tested mouse cage 5 to be moved to illumination cabin 2
Phototoxicity detection is carried out, experiment completes tested mouse cage 5 and removes illumination cabin 2, and operator is continuously taken with hand from spring support 20 again
Under be fixed with the tested mouse cage 5 of experimental animal, what is moved in circles continuous is rapidly performed by Phototoxicity experiment detection；All experimentss are complete
Into the animal subject for completing Phototoxicity experiment detection is sent to and does the scientific experiment and research of next step；Rotating disc type is closed to move
The power supply of the quick tester of object light toxicity and computer control 6, then under the lower sleeve 25 of each moveable support member 14
The foot brake 24 of end feet wheel 23 is opened, and the quick tester of rotating disc type animal phototoxicity is shifted onto to the place for storing this equipment, is checked
The safety storage of foot brake 24.
Claims (8)
1. a kind of quick tester of rotating disc type animal phototoxicity, it is characterized in that：The device is equipped with moveable support member including one
（14）Fixed platform（27）, fixed platform（27）On lighttight illumination cabin is installed（2）, illumination cabin（2）With fixed platform
（27）Between have a rotating circular disk（7）, rotating circular disk（7）And fixed platform（27）Between disk lower sheave is installed（12）Ensure
Rotating circular disk（7）Stablize rotation, rotating circular disk（7）Transmission shaft（37）Through fixed platform（27）Mounting flange（15）Gu
Determine flange（15）The travelling gear of lower end（17）With sliding tooth band（11）It is connected to stepper motor（8）On drive gear（10）,
Pass through computer control（6）Control stepper motor（8）Rotation driving rotating circular disk（7）Rotating speed uniform motion as required,
Rotating circular disk（7）According to illumination cabin（2）On enter cabin valve（3）With go out cabin valve（32）To rotating circular disk（7）The center of circle it is identical away from
From concentric circles on equidistant several spring supports are forward installed（20）, each spring support（20）Can be with tested mouse
Cage phase（5）Coordinate tested mouse cage（5）Fixation, illumination cabin（2）Inner top have one can be in computer control（6）Control
Under send single wavelength be 365nm UVA light sources UV light source assemblies（33）, as test light source to being fixed on tested mouse cage
（5）Interior experimental animal carries out phototoxicity irradiation experiment, and operator will be fixed with the tested mouse cage of experimental animal（5）Placed with hand
To illumination cabin will be entered（2）Spring support（20）After upper, rotating circular disk（7）Drive tested mouse cage（5）It is moved to illumination cabin
（2）Shi Dingkai enters cabin valve（3）Enter illumination cabin（2）It is interior, when tested mouse cage（5）Completely into illumination cabin（2）Enter after interior
Cabin valve（3）Closing shelters from light, illumination cabin（2）The UV light source assemblies of inner top installation（33）It can control and send single ripple
The UVA light sources of long and appropriate intensity 365nm are to being tested mouse cage（5）Interior experimental animal carries out the phototoxicity irradiation of special time
Experiment, when tested mouse cage after the completion of experiment（5）Illumination cabin will be moved out（2）Shi Dingkai goes out cabin valve（32）, when tested mouse cage
（5）It is fully removed illumination cabin（2）Go out cabin valve after outer（32）Closing shelters from light, and operator can be conveniently with hand at this time
Remove the tested mouse cage for being fixed with experimental animal（5）, illumination cabin（2）Bottom surrounding is provided with soft window shade（31）Light can be sheltered from
Line, can not only prevent that ultraviolet light from revealing but also can ensure the UVA light sources purity and luminous intensity of the 365nm of single wavelength during experiment
Accuracy, and then ensure that the condition of experiment is perfect, there is computer control in whole experiment（6）Control and the every experiment of record
Process, result and experiment parameter can also be output to printer and print laboratory report list.
2. a kind of quick tester of rotating disc type animal phototoxicity according to claim 1, it is characterized in that：Illumination cabin（2）It is
The non-reflective box-like closed bin body of sealing of one inner surface being made by the light tight plane sheet material of rigidity, in warehouse
Top seamless seal connects a UV light source assembly（33）, have a nacelle support plate on the base of warehouse rear portion（4）By whole illumination
Cabin（2）Vacantly it is installed on fixed platform（27）On, illumination cabin（2）With fixed platform（27）Between it is at regular intervals so that whole light
According to cabin（2）In fixed platform（27）Upper presentation vacant state, can so keep rotating circular disk（7）In illumination cabin（2）And fixation
Platform（27）Centre is freely walked, and illumination cabin the right and left lower part middle is respectively provided with the open-top and automatic pass of an energy with spring
That closes enters cabin valve（3）With go out cabin valve（32）, illumination cabin（2）Center and enter cabin valve（3）With go out cabin valve（32）'s
Midpoint aligns, illumination cabin（2）Center again and spring support（20）Concentric circles is installed to overlap, such rotating circular disk（7）It is upper solid
Fixed tested mouse cage（5）It is moved to illumination cabin（2）When just align into cabin valve（3）Enter illumination cabin（2）It is interior, it is tested mouse cage
（5）Completely into illumination cabin（2）Interior rear door spring will enter cabin valve（3）It is automatically closed and shelters from light, when tested mouse cage
（5）Illumination cabin will be moved out（2）Shi Dingkai goes out cabin valve（32）, mouse cage to be tested（5）It is fully removed illumination cabin（2）After outer,
Hatch door spring will go out cabin valve（32）It is automatically closed and shelters from light, illumination cabin（2）Bottom surrounding is provided with soft window shade（31）Come
Light is sheltered from, can both allow rotating circular disk（7）Single ripple when rotating freely and can prevent ultraviolet light leakage to ensure experiment
The UVA light sources purity of long 365nm and luminous intensity accuracy, and then ensure that the condition of experiment is perfect.
3. a kind of quick tester of rotating disc type animal phototoxicity according to claim 1, it is characterized in that：UV light source assemblies
（33）The composition element for sending the UVA light sources that single wavelength is 365nm can be controlled by being one, its outer surface is one by rigidity
Inner surface that light tight plane sheet material is made it is non-reflective be sealably coupled to illumination cabin（2）The upper hood on top
（34）, upper hood（34）Top is a UV illuminator（35）Send the ultraviolet light of UV wave bands, upper hood（34）Inside is also
There is one to be connected to UV illuminators（35）Light intensity control（36）, pass through computer control（6）The instruction sent is realized and held
Row control UV illuminators（35）The UVA ultraviolet lights that the wavelength for sending appropriate intensity is 365nm carry out phototoxicity experiments, in upper shading
Cover（34）With illumination cabin（2）Between a UVA optical filter is installed（1）, veiling glare can be filtered out and ensure to receive in experimentation
The wavelength that the toy of experiment receives is the pure and accurate of the UVA light sources of 365nm, reduces interference of the veiling glare to experiment,
Improve and test efficiency.
4. a kind of quick tester of rotating disc type animal phototoxicity according to claim 1, it is characterized in that：Rotating circular disk（7）
It is the planar sheet disk of the smooth disinfection easy to clean in a surface being made by rigid material, in rotating circular disk（7）On
Surface is from the center of circle to illumination cabin（2）It is uniformly distributed on the concentric circles of center distance and several spring supports is forward installed
（20）, can easily place and fix and remove tested mouse cage（5）, rotating circular disk（7）The core installed by lower surface center
Flange（16）And transmission shaft（37）Through fixed platform（27）The mounting flange of center installation（15）Cooperation rotates freely, rotational circle
Disk（7）Fixed platform is contacted by lower surface（27）Several disk lower sheaves of upper equidistant installation（12）Ensure rotating circular disk
（7）Parallel stabilization.
5. a kind of quick tester of rotating disc type animal phototoxicity according to claim 1, it is characterized in that：Fixed platform（27）
It is a work top made by rigid plate-like material, has moveable support member respectively in fixed platform corner（14）Support is solid
It is fixed, planar working table stable, that height can be adjusted and can be moved freely is formed, in fixed platform（27）The side of upper surface
While computer control is installed（6）By being electrically connected to stepper motor（8）, UV illuminators（35）And light intensity control（36）,
Fixed platform（27）Back centre position be installed with illumination cabin（2）, illumination cabin（2）With fixed platform（27）Between have one
Determining deviation causes whole illumination cabin（2）In fixed platform（27）Upper presentation vacant state, in fixed platform（27）Centrally through peace
The mounting flange of dress（15）Load rotating circular disk（7）, rotating circular disk（7）Lower surface and fixed platform（27）If between upper surface
Dry disk lower sheave（12）Ensure rotating circular disk（7）Parallel stabilization, disk lower sheave（12）Installed in fixed platform（27）Upper table
On face, rotating circular disk（7）The core flange installed by center（16）And transmission shaft（37）Through fixed platform（27）Center peace
The mounting flange of dress（15）Mutual cooperation rotates freely, transmission shaft（37）Lower end be a travelling gear（17）, pass through one
Sliding tooth band（11）It is connected to and is installed on fixed platform（27）Following stepper motor（8）On drive gear（10）, stepping electricity
Machine（8）Pass through computer control（6）Control rotation driving rotating circular disk（7）Uniform motion.
6. a kind of quick tester of rotating disc type animal phototoxicity according to claim 1, it is characterized in that：Computer control
（6）It is made of computer hardware system and related dedicated software systems two large divisions, software systems therein pass through default
Program coupled computer hardware system by being electrically connected to stepper motor（8）, UV illuminators（35）And light intensity control（36）,
It is whole to test Computer control to control the service time of connecting component, rotary speed, the requirement of experiment of the intensity of light source and parameter
Device processed（6）Process, result and the experiment parameter of the every experiment of control are simultaneously recorded among internal storage, can also be exported
Laboratory report list is printed to printer.
7. a kind of quick tester of rotating disc type animal phototoxicity according to claim 1, it is characterized in that：Spring support（20）
By being made with elastic material, it is fixedly secured in rotating circular disk（7）The Circlip apparatus of upper surface, each spring branch
Frame（20）There is a rectangular stent lower plate（19）It is used for and rotating circular disk（7）It is fixed, stent lower plate（19）Both ends respectively have
One front and rear riser vertically upward（18）, in front and rear riser（18）Respectively there is an inwardly projecting riser clamp spring in upper end again（21）
With tested mouse cage（5）The fixed groove at top both ends（28）It is engaged tested mouse cage（5）Fixation, spring support（20）Press
It is installed on according to the principle forward installed is uniformly distributed from rotating circular disk（7）The center of circle of upper surface to illumination cabin（2）Center distance
Concentric circles on, when operator is by the tested mouse cage equipped with toy（5）It is received in spring support（20）After inside fixing, rotation
Disk（7）Rotating circular disk is fixed on when being rotated along direction of advance（7）The spring support of upper surface（20）Drive tested mouse
Cage（5）Along concentric circular motion, sequentially enter into cabin valve（3）In illumination cabin（2）It is interior to pass through tested mouse cage（5）Irradiation above
Exposure mouth（30）Phototoxicity irradiation is carried out to toy, mouse cage is tested after the completion of irradiation（5）From going out cabin valve（32）Send out, then
By operator easily by the tested mouse cage after test（5）From spring support（20）Take off in order to continue to complete experiment.
8. a kind of quick tester of rotating disc type animal phototoxicity according to claim 1, it is characterized in that：Moveable support member
（14）It is the complex mechanical mechanisms being made by firm load-bearing rigid material, there is what a metal material made in its top
Leg flange（22）, it is fixedly installed to fixed platform（27）Platen lower surface an edge, leg flange（22）In
Between vertically fix a upper support leg bar（13）, in upper support leg bar（13）Lower end be cased with one section of lower sleeve（25）, lower sleeve（25）
Top is fixed with fastening wheel（26）, when release fastening wheel（26）When, it becomes possible to change upper support leg bar（13）It is inserted into lower sleeve（25）
Between length, also just change moveable support member（14）Height, when tightening fastening wheel（26）When, moveable support member
（14）Height it is fixed, each lower sleeve（25）Lower end connect one carry foot brake（24）Castor（23）,
Since the whole quick tester of rotating disc type animal phototoxicity is fixedly installed to fixed platform（27）On, fixed platform（27）Platform
The corner of face bottom plate lower surface is separately fixed at four moveable support members（14）On, so the moveable support member of adjustment corner
（14）, it becomes possible to the quick tester of rotating disc type animal phototoxicity is freely moved in parallel, and whole rotating disc type can be adjusted
The quick tester of animal phototoxicity it is uneven.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111973310A (en) * | 2020-08-17 | 2020-11-24 | 山东大学 | Mouse fixed station for in vivo experiments |
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| CN107928834B (en) | 2023-08-01 |
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