CN111973310A

CN111973310A - Mouse fixed station for in vivo experiments

Info

Publication number: CN111973310A
Application number: CN202010826314.2A
Authority: CN
Inventors: 于婧雅
Original assignee: Shandong University
Current assignee: Shandong University
Priority date: 2020-08-17
Filing date: 2020-08-17
Publication date: 2020-11-24

Abstract

The invention is suitable for the technical field of experimental equipment, and particularly relates to a mouse fixing table for a living body experiment, which comprises an operation table and a rotary table, wherein the rotary table is rotatably connected to the upper end of the operation table, a driving assembly is arranged in the operation table and used for driving the rotary table to rotate, four groups of mounting grooves are formed in the rotary table, a first slide seat is fixed in each mounting groove, a guide groove is formed in the upper end of the first slide seat, the first slide seat is slidably connected with a second slide seat through the guide groove, the upper end of the second slide seat is also provided with a guide groove, the second slide seat is slidably connected with a fixing seat through the guide groove, a spring is fixed in an inner cavity of the fixing seat, a four-limb. The mouse fixing table for the in-vivo experiment, provided by the embodiment of the invention, has the advantages of simple structure and reasonable design, can be used for quickly fixing a mouse and can be quickly adjusted according to the body type of the mouse, so that the mouse fixing table can be quickly adapted to mice with different body types, and is convenient to use.

Description

Mouse fixed station for in vivo experiments

Technical Field

The invention belongs to the technical field of experimental equipment, and particularly relates to a mouse fixing table for in-vivo experiments.

Background

Mice (Mus musculus) of the order Rodentia (Rodentia), Muridae (Muridae) and mice (Mus). Experimental mice were derived from wild mice and used for comparative anatomical studies and animal experiments since the 17 th century. More than 500 independent outbred colonies, inbred lines and mutant lines are developed at present, and are the most thoroughly studied experimental mammals in the world at present, and the commonly used animals comprise BALB/c, NIH and Scid mice and the like.

The length of the adult mouse is 9.0-12.5cm, the weight is 20-40g, the adaptation age of day is 65-90 days, 8-15 mice can be born in each fetus, and 6-10 mice can be born in the year. Because the mice are small, the breeding management is convenient, the control is easy, the production and the reproduction are fast, and the quality control standard is clear, so the method is widely applied to the medical research of safety and toxicity experiments, drug screening, oncology, immunology, hereditary diseases and the like.

In existing laboratories, experiments are often performed using mice. However, the existing mouse fixing device is too simple in structure, and the four limbs of the mouse are bound up through the rope-shaped objects, so that the fixing effect is not good, and the mouse fixing device cannot adapt to mice of different body types.

Disclosure of Invention

The embodiment of the invention aims to provide a mouse fixing table for a living body experiment, and aims to solve the problems that the existing mouse fixing device is too simple in structure, poor in fixing effect and incapable of adapting to mice of different body types.

The embodiment of the invention is realized in such a way that the mouse fixing table for the living body experiment comprises an operation table and a rotary table, wherein the rotary table is rotatably connected to the upper end of the operation table, a driving assembly is arranged in the operation table and used for driving the rotary table to rotate, four groups of mounting grooves are formed in the rotary table, a first sliding seat is fixed in each mounting groove, a guide groove is formed in the upper end of the first sliding seat, the first sliding seat is slidably connected with a second sliding seat through the guide groove, the upper end of the second sliding seat is also provided with a guide groove, the second sliding seat is slidably connected with a fixing seat through the guide groove, a spring is fixed in the inner cavity of the fixing seat, a four-limb fixing ring is slidably connected.

Preferably, the upper end of the rotating disc is further provided with a head fixing cover, and the head fixing cover is connected with the rotating disc through a rotating shaft.

Preferably, a sliding groove is formed in the rotary disc, a tail fixing spring is arranged in the sliding groove, a fine hole is formed in the upper end face of the rotary disc, a tail fixing ring penetrates the fine hole, and the tail fixing ring is connected with the tail fixing spring.

Preferably, the driving assembly comprises a motor and a driving gear, gear teeth are arranged on the outer diameter of the rotary table, the motor is fixed in the inner cavity of the operating table, and the driving gear is fixed on the rotating shaft of the motor.

Preferably, the operation panel upper end is provided with curved curb plate, and one side that the curb plate is close to the carousel is provided with the lamp plate, and the lamp plate is the arc.

Preferably, a turntable switch is arranged on the operating platform and electrically connected with the driving assembly.

Preferably, the limb fixing ring is made of rubber.

The mouse fixing table for the in-vivo experiment, provided by the embodiment of the invention, has the advantages of simple structure and reasonable design, can be used for quickly fixing a mouse and can be quickly adjusted according to the body type of the mouse, so that the mouse fixing table can be quickly adapted to mice with different body types, and is convenient to use.

Drawings

FIG. 1 is a top view of a mouse fixing table for in vivo experiments according to an embodiment of the present invention;

FIG. 2 is a schematic structural diagram of a mouse fixing table for in vivo experiments according to an embodiment of the present invention;

FIG. 3 is a schematic partial structural view of a mouse fixing table for in vivo experiments according to an embodiment of the present invention;

fig. 4 is a schematic structural diagram of a turntable according to an embodiment of the present invention.

In the drawings: 1. an operation table; 2. a side plate; 3. a lamp panel; 4. a turntable; 5. a tail fixing ring; 6. mounting grooves; 7. a first slider; 8. a second slide carriage; 9. a guide groove; 10. fixing rings for four limbs; 11. a head fixing cover; 12. a rotating shaft; 13. a motor; 14. a drive gear; 15. a fixed seat; 16. a spring.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

Specific implementations of the present invention are described in detail below with reference to specific embodiments.

As shown in fig. 1, 2, 3, and 4, a top view of a mouse fixing table for in vivo experiments provided by an embodiment of the present invention includes an operation table 1 and a turntable 4, the turntable 4 is rotatably connected to an upper end of the operation table 1, a driving assembly is disposed in the operation table 1, the driving assembly is configured to drive the turntable 4 to rotate, four sets of mounting grooves 6 are disposed on the turntable 4, a first slide seat 7 is fixed in the mounting grooves 6, a guide groove 9 is disposed at an upper end of the first slide seat 7, the first slide seat 7 is slidably connected to a second slide seat 8 through the guide groove 9, the upper end of the second slide seat 8 is also provided with the guide groove 9, the second slide seat 8 is slidably connected to a fixing seat 15 through the guide groove 9, a spring 16 is fixed in an inner cavity of the fixing seat 15, a limb fixing ring 10 is slidably connected to the fixing seat 15, and.

In one example of the invention, when in use, according to the body type of a mouse, the mouse is flatly laid on the upper end of the rotating disc 4, then the four-limb fixing ring 10 is pulled upwards, so that the distance between the four-limb fixing ring 10 and the rotating disc 4 is increased until the distance between the four-limb fixing ring 10 and the rotating disc 4 exceeds the diameter of the four limbs of the mouse, then the four limbs of the mouse are inserted into a gap between the four-limb fixing ring 10 and the rotating disc 4, finally the four-limb fixing ring 10 is loosened, the spring 16 is fixed in the inner cavity of the fixing seat 15, and the four-limb fixing ring 10 is fixedly connected with the spring 16, so that the four-limb fixing ring 10 presses the four limbs of the mouse on the upper end surface of the rotating disc 4 under the driving of; for mice of different body types, the distances between the four limbs are different, and if the fixed distance is adopted to fix the mice, the fixing effect is not good, because the first slide seat 7 is fixed in the mounting groove 6, the upper end of the first slide seat 7 is provided with the guide groove 9, the first slide seat 7 is connected with the second slide seat 8 in a sliding way through the guide groove 9, the upper end of the second slide seat 8 is also provided with the guide groove 9, the second slide seat 8 is connected with the fixed seat 15 in a sliding way through the guide groove 9, therefore, the user can actively adjust the distance between the four limb fixing rings 10 according to the size of the mouse, during adjustment, the second sliding seat 8 is firstly slid, so that the second sliding seat 8 slides unidirectionally relative to the first sliding seat 7, thereby adjusting the distance between the forelimbs or the hind limbs, then the fixed seat 15 is slid to enable the fixed seat 15 to slide relative to the second sliding seat 8, so that the distance between the front limb and the rear limb on the same side is adjusted; certainly, in the test process, the position of each limb fixing ring 10 can be adjusted according to actual needs, so that the posture of the mouse can be flexibly adjusted, and an operator can conveniently perform the test. The mouse fixing table for the in-vivo experiment, provided by the embodiment of the invention, has the advantages of simple structure and reasonable design, can be used for quickly fixing a mouse and can be quickly adjusted according to the body type of the mouse, so that the mouse fixing table can be quickly adapted to mice with different body types, and is convenient to use.

As shown in fig. 1, 2 and 3, as a preferred embodiment of the present invention, a head fixing cover 11 is further disposed at an upper end of the turntable 4, and the head fixing cover 11 is connected to the turntable 4 through a rotating shaft 12.

In one example of the invention, mice, while temperate in nature, also perform aggressive actions when stimulated. In order to protect the safety of operators, the upper end of the rotary table 4 is provided with the head fixing cover 11, when a mouse is fixed, the mouse is fixed on the rotary table 4 through the head fixing cover 11, the head fixing cover is also provided with an air hole, the air hole is used for facilitating the breathing of the mouse, and the mouse is prevented from dying due to oxygen deficiency.

As shown in fig. 1, 2 and 3, as a preferred embodiment of the present invention, a sliding groove is provided in the rotary plate 4, a tail fixing spring is provided in the sliding groove, a fine hole is provided on the upper end surface of the rotary plate 4, a tail fixing ring 5 penetrates through the fine hole, and the tail fixing ring 5 is connected to the tail fixing spring.

In one embodiment of the present invention, the present invention further provides a tail fixing structure, wherein in the experiment, the tail of the mouse is inserted into the tail fixing ring 5, and then the tail fixing ring 5 is driven to slide along the fine hole by the elasticity of the tail fixing spring, so that the tail of the mouse is fixed on the upper end surface of the turntable 4, and the swing of the tail of the mouse is prevented from affecting the experiment of the operator.

As shown in fig. 1, 2 and 3, as a preferred embodiment of the present invention, the driving assembly includes a motor 13 and a driving gear 14, the outer diameter of the rotating disk 4 is provided with gear teeth, the motor 13 is fixed in the inner cavity of the operating table 1, and the driving gear 14 is fixed on the rotating shaft of the motor 13.

In an example of the invention, during experiments, the operation angle often needs to be adjusted, at this time, the motor 13 can drive the driving gear 14 to rotate, and then the driving gear 14 rotates with the disc 4, so that the angle of the mouse is adjusted, therefore, an operator does not need to move, and the use experience of the operator is improved.

As shown in fig. 1, 2 and 3, as a preferred embodiment of the present invention, an arc-shaped side plate 2 is disposed at an upper end of the operating platform 1, a lamp panel 3 is disposed on a side of the side plate 2 close to the turntable 4, and the lamp panel 3 is arc-shaped.

In one embodiment of the invention, the laboratory is illuminated by light, the light at the top is easily shielded by an operator and is difficult to see clearly, the side plate 2 and the lamp panel 3 are arranged for auxiliary illumination, and the lamp panel 3 is arc-shaped, so that the illumination effect can be ensured to be consistent.

As shown in fig. 1, 2 and 3, as a preferred embodiment of the present invention, a turntable switch is disposed on the operation table 1, and the turntable switch is electrically connected to the driving assembly.

As shown in fig. 1, 2 and 3, the limb fixation ring 10 is made of rubber as a preferred embodiment of the present invention.

In one embodiment of the present invention, the limb securing ring 10 made of rubber is used to avoid injuring the limbs of the mouse.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.

Claims

1. The utility model provides a mouse fixed station for the live body experiment, a serial communication port, mouse fixed station for the live body experiment includes operation panel (1) and carousel (4), carousel (4) rotate to be connected in the upper end of operation panel (1), be provided with drive assembly in operation panel (1), drive assembly is used for driving carousel (4) rotatory, be provided with four groups mounting groove (6) on carousel (4), mounting groove (6) internal fixation has first slide (7), first slide (7) upper end is provided with guide slot (9), first slide (7) have second slide (8) through guide slot (9) sliding connection, second slide (8) upper end also is provided with guide slot (9), second slide (8) have fixing base (15) through guide slot (9) sliding connection, fixing base (15) inner chamber is fixed with spring (16), sliding connection has four limbs solid fixed ring (10) on fixing base (15), the four-limb fixing ring (10) is fixedly connected with the spring (16).

2. The mouse fixing table for the in-vivo experiment according to claim 1, wherein a head fixing cover (11) is further arranged at the upper end of the rotating disc (4), and the head fixing cover (11) is connected with the rotating disc (4) through a rotating shaft (12).

3. The mouse fixing table for the in-vivo experiment according to claim 1, wherein a sliding groove is formed in the rotary plate (4), a tail fixing spring is arranged in the sliding groove, a fine hole is formed in the upper end surface of the rotary plate (4), a tail fixing ring (5) penetrates through the fine hole, and the tail fixing ring (5) is connected with the tail fixing spring.

4. The mouse fixing table for the in-vivo experiment as claimed in any one of claims 1 to 3, wherein the driving component comprises a motor (13) and a driving gear (14), gear teeth are arranged on the outer diameter of the rotary table (4), the motor (13) is fixed in the inner cavity of the operating table (1), and the driving gear (14) is fixed on the rotating shaft of the motor (13).

5. The mouse fixed station for the in-vivo experiment according to claim 4, wherein an arc-shaped side plate (2) is arranged at the upper end of the operating platform (1), a lamp panel (3) is arranged on one side of the side plate (2) close to the turntable (4), and the lamp panel (3) is arc-shaped.

6. The mouse fixing table for the in-vivo experiment as claimed in claim 1, wherein a rotary switch is arranged on the operation table (1), and the rotary switch is electrically connected with the driving assembly.

7. The mouse fixing table for in vivo experiments according to claim 1, wherein the limb fixing ring (10) is made of rubber.