CN107927798A - A kind of medicinal and edible plant protein powder composition and preparation method thereof - Google Patents
A kind of medicinal and edible plant protein powder composition and preparation method thereof Download PDFInfo
- Publication number
- CN107927798A CN107927798A CN201711324318.5A CN201711324318A CN107927798A CN 107927798 A CN107927798 A CN 107927798A CN 201711324318 A CN201711324318 A CN 201711324318A CN 107927798 A CN107927798 A CN 107927798A
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Classifications
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A23L33/185—Vegetable proteins
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- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/01—Instant products; Powders; Flakes; Granules
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/10—Products from fruits or vegetables; Preparation or treatment thereof of tuberous or like starch containing root crops
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The present invention relates to a kind of medicinal and edible plant protein powder composition and its preparation method and application, the medicinal and edible plant protein powder composition is made of following component：20 40 parts by weight of medicinal powder composition；60 80 parts by weight of vegetable protein compound powder；0.5 1.0 parts by weight of food additives.Preparation method includes the following steps：S1 prepares medicinal powder composition；S2 prepares medicinal and edible plant protein powder composition：The yam flour prepared in S1 steps, Poria cocos powder, wolfberry fruit powder, jujube powder, vegetable protein compound powder and food additives are added in three-dimensional motion mixer and are mixed, uniformly mixed raw material is added in packing machine hopper, is packaged to be finished product.The present invention has the advantages that high absorptivity, strengthen immunity and alleviates physical fatigue.
Description
Technical field
The present invention relates to technical field of health care food, and in particular to a kind of medicinal and edible plant protein powder composition and its system
Preparation Method.
Background technology
Protein is one of indispensable seven big important nutrient of human body.Protein is by certain suitable by α-amino acid
Sequence combines to form a polypeptide chain, then the macromolecule being combined into by one or more than one polypeptide chains according to its ad hoc fashion
Compound.Protein is exactly the stent and main matter for forming human tissue organ, in human life activity, plays important work
With, it may be said that without protein just without the presence of vital movement.Protein is primarily present in lean meat, egg in daily diet
In class, beans and fish.The protein eaten is hydrolyzed into after amino acid absorbed by digestion in vivo, recombines human body
Required protein, in continuous metabolism and is decomposed, the moment is in dynamic equilibrium again with stylish protein.Therefore, food proteins
The ratio of the quality and quantity of matter, various amino acid, be related to human body protein synthesis amount, especially teen-age growth and development,
The prenatal and postnatal care of pregnant and lying-in women, the good health and a long life of the elderly, all amount with protein in meals have close relationship.Protein is again
It is divided into complete protein and incomplete protein.Rich in essential amino acid, protein best in quality is referred to as complete protein, such as
Milk, egg, fish, meat etc. belong to complete protein, and the soybean in plant also contains complete protein.Lack essential amino acid or
The seldom protein of content claims incomplete protein, the gelatin in Ru Gu, wheat class, protein and animal osteoderm contained by corn
Deng.
Human body absorbs of animal or plant nature albumen by daily animal food and plant food.With people's health
Consciousness is increasingly enhanced and the raising of income level, normal meals approach have been unable to meet the demand to albumen quality, also not
Meet the consumption requirement of people's healthy diet, and the protein-based product sold on the market at present is given birth in digested absorb of human body
Thing availability is all relatively low.
Therefore it can increase what human body protein was digested and assimilated the present invention provides a kind of, while there is strengthen immunity to ease up
The preparation method and applications containing medicinal and edible plant and various plants protein powder composition of physical fatigue.
The content of the invention
It is an object of the invention to overcome the deficiencies of the prior art and provide a kind of medicinal and edible plant protein powder composition and
Its preparation method, solves the problems, such as that protein digestibility is low, absorptivity is low and function of human body change is small.
The purpose of the present invention is what is be achieved through the following technical solutions：
A kind of medicinal and edible plant protein powder composition, the medicinal and edible plant protein powder composition is by following component group
Into：
Medicinal powder composition 20-40 parts by weight；
Vegetable protein compound powder 60-80 parts by weight；
Food additives 0.5-1.0 parts by weight.
The vegetable protein combination of integration of drinking and medicinal herbs is added by medicinal powder composition, vegetable protein compound powder and food
Agent forms, and the content of its traditional Chinese medicinal additive and vegetable protein compound powder is high, and the content of functional components is more, both can reach
Synergistic effect, can promote assimilating for albumen powder and medicinal material functional component, and the immunity that can effectively strengthen human body is eased up disintegration
Power fatigue.
It is further preferred that the medicinal and edible plant protein powder composition is made of following component：
30 parts by weight of medicinal powder composition；
75 parts by weight of vegetable protein compound powder；
0.8 parts by weight of food additives.
Further, the medicinal powder composition is made of following component：
There are yam flour, Poria cocos powder, wolfberry fruit powder and jujube powder in medicinal powder composition, the cost of four kinds of medicinal materials is low, its
Middle Chinese yam has the function that tonifying spleen nourishing the stomach, engender liquid and benefic lung, kidney tonifying are puckery smart, and Poria cocos has the function that antitoxic heart-soothing and sedative, internal heat anticance, Chinese holly
Qi has the function that qi-restoratives strengthening the essence, heat-clearing improving eyesight, strengthen immunity, and jujube has the function that tonifying middle-Jiao and Qi, nourishing blood and tranquilization, four
Collaboration has effects that nourshing kidney complement and strengthen immunity.
Further, the vegetable protein compound powder is made of following component：
Soybean separation protein white powder 55-60 parts by weight；
Fed Protein Powder of Pea Insteal 5-10 parts by weight；
Gluten powder 5-10 parts by weight.
Vegetable protein compound powder is made of soybean separation protein white powder, Fed Protein Powder of Pea Insteal and gluten powder, protein
Content is high, and absorption easy to digest, can effectively alleviate physical fatigue.
Further, the food additives are made of following component：
Phosphatidase 0 .5-1.0 parts by weight；
Dextrin 0.5-1.0 parts by weight；
Oligofructose 1.0-2.0 parts by weight.
The preparation method of above-mentioned medicinal and edible plant protein powder composition, includes the following steps：
S1 prepares medicinal powder composition：Chinese yam medicine materical crude slice, Poria cocos medicine materical crude slice, matrimony vine and jujube are cleaned, crushed respectively, mistake
Sieve, obtains yam flour, Poria cocos powder, wolfberry fruit powder and jujube powder；
S2 prepares medicinal and edible plant protein powder composition：By the yam flour prepared in S1 steps, Poria cocos powder, wolfberry fruit powder,
Jujube powder, vegetable protein compound powder and food additives are added in three-dimensional motion mixer and mixed, by uniformly mixed raw material
Add in packing machine hopper, be packaged to be finished product.
The preparation method of medicinal and edible plant protein powder composition is simple, and equipment is few, can industrialization degree it is high, be prepared
Medicinal and edible plant protein powder composition meet《Health food is examined and assessment technique specification》Sample has in (2003 editions)
The regulation of strengthen immunity function.
Further, passing-screen size is 100 mesh in the S1 steps.
Further, rotating speed 20-30r/min, incorporation time 30-40min are mixed in the S2 steps.
Application of the medicinal and edible plant protein powder composition in health food.
The beneficial effects of the invention are as follows：
1. the vegetable protein combination of integration of drinking and medicinal herbs is prepared by natural material, by the examination that resisting stress is carried out to mouse
Issue after examination and approval existing, this product has antifatigue, makes the fast quick-recovery physical efficiency of body, improves the effect of resist oxygen lack etc., without any side effects, is adapted to
Move personage, brain worker；
2. the vegetable protein combination of integration of drinking and medicinal herbs is by medicinal powder composition, vegetable protein compound powder and food additive
Agent is added to form, the content of its traditional Chinese medicinal additive and vegetable protein compound powder is high, and the content of functional components is more, both can reach
To synergistic effect, assimilating for albumen powder and medicinal material functional component can be promoted, can effectively strengthen immunity and the alleviation of human body
Physical fatigue；
3. having yam flour, Poria cocos powder, wolfberry fruit powder and jujube powder in medicinal powder composition, the cost of four kinds of medicinal materials is low,
Wherein Chinese yam has the function that tonifying spleen nourishing the stomach, engender liquid and benefic lung, kidney tonifying are puckery smart, and Poria cocos has the function that antitoxic heart-soothing and sedative, internal heat anticance,
Matrimony vine has the function that qi-restoratives strengthening the essence, heat-clearing improving eyesight, strengthen immunity, and jujube has the function that tonifying middle-Jiao and Qi, nourishing blood and tranquilization, four
Person's collaboration has effects that nourshing kidney complement and strengthen immunity；
4. vegetable protein compound powder is made of soybean separation protein white powder, Fed Protein Powder of Pea Insteal and gluten powder, albumen
Matter content is high, and absorption easy to digest, can effectively alleviate physical fatigue；
5. the preparation method of medicinal and edible plant protein powder composition is simple, equipment is few, can industrialization degree it is high, be prepared into
To medicinal and edible plant protein powder composition meet《Health food is examined and assessment technique specification》Sample has in (2003 editions)
There is the regulation of strengthen immunity function.
Embodiment
Technical scheme is described in further detail with reference to specific embodiment, but protection scope of the present invention is not
It is confined to as described below.
Embodiment 1
A kind of medicinal and edible plant protein powder composition, the medicinal and edible plant protein powder composition is by following component group
Into：
30 parts by weight of medicinal powder composition；
75 parts by weight of vegetable protein compound powder；
0.8 parts by weight of food additives.
Specifically, the medicinal powder composition is made of following component：
Specifically, the vegetable protein compound powder is made of following component：
58 parts by weight of soybean separation protein white powder；
8 parts by weight of Fed Protein Powder of Pea Insteal；
9 parts by weight of gluten powder.
Specifically, the food additives are made of following component：
Phosphatidase 0 .8 parts by weight；
0.8 parts by weight of dextrin；
1.5 parts by weight of oligofructose.
A kind of preparation method of medicinal and edible plant protein powder composition, includes the following steps：
S1 prepares medicinal powder composition：Chinese yam medicine materical crude slice, Poria cocos medicine materical crude slice, matrimony vine and jujube are cleaned, crushed respectively, mistake
Sieve, obtains yam flour, Poria cocos powder, wolfberry fruit powder and jujube powder；
S2 prepares medicinal and edible plant protein powder composition：By the yam flour prepared in S1 steps, Poria cocos powder, wolfberry fruit powder,
Jujube powder, vegetable protein compound powder and food additives are added in three-dimensional motion mixer and mixed, by uniformly mixed raw material
Add in packing machine hopper, be packaged to be finished product.
Specifically, passing-screen size is 100 mesh in the S1 steps.
Specifically, rotating speed 20r/min, incorporation time 40min are mixed in the S2 steps.
Embodiment 2
A kind of medicinal and edible plant protein powder composition, the medicinal and edible plant protein powder composition is by following component group
Into：
20 parts by weight of medicinal powder composition；
60 parts by weight of vegetable protein compound powder；
0.5 parts by weight of food additives.
Specifically, the medicinal powder composition is made of following component：
Specifically, the vegetable protein compound powder is made of following component：
55 parts by weight of soybean separation protein white powder；
5 parts by weight of Fed Protein Powder of Pea Insteal；
5 parts by weight of gluten powder.
Specifically, the food additives are made of following component：
Phosphatidase 0 .5 parts by weight；
0.5 parts by weight of dextrin；
1.0 parts by weight of oligofructose.
The preparation method of the medicinal and edible plant protein powder composition, includes the following steps：
S1 prepares medicinal powder composition：Chinese yam medicine materical crude slice, Poria cocos medicine materical crude slice, matrimony vine and jujube are cleaned, crushed respectively, mistake
Sieve, obtains yam flour, Poria cocos powder, wolfberry fruit powder and jujube powder；
S2 prepares medicinal and edible plant protein powder composition：By the yam flour prepared in S1 steps, Poria cocos powder, wolfberry fruit powder,
Jujube powder, vegetable protein compound powder and food additives are added in three-dimensional motion mixer and mixed, by uniformly mixed raw material
Add in packing machine hopper, be packaged to be finished product.
Specifically, passing-screen size is 100 mesh in the S1 steps.
Specifically, rotating speed 25r/min, incorporation time 35min are mixed in the S2 steps.
Embodiment 3
A kind of medicinal and edible plant protein powder composition, the medicinal and edible plant protein powder composition is by following component group
Into：
40 parts by weight of medicinal powder composition；
80 parts by weight of vegetable protein compound powder；
1.0 parts by weight of food additives.
Specifically, the medicinal powder composition is made of following component：
Specifically, the vegetable protein compound powder is made of following component：
60 parts by weight of soybean separation protein white powder；
10 parts by weight of Fed Protein Powder of Pea Insteal；
10 parts by weight of gluten powder.
Specifically, the food additives are made of following component：
Phosphatidase 1 .0 parts by weight；
1.0 parts by weight of dextrin；
2.0 parts by weight of oligofructose.
The preparation method of the medicinal and edible plant protein powder composition, includes the following steps：
S1 prepares medicinal powder composition：Chinese yam medicine materical crude slice, Poria cocos medicine materical crude slice, matrimony vine and jujube are cleaned, crushed respectively, mistake
Sieve, obtains yam flour, Poria cocos powder, wolfberry fruit powder and jujube powder；
S2 prepares medicinal and edible plant protein powder composition：By the yam flour prepared in S1 steps, Poria cocos powder, wolfberry fruit powder,
Jujube powder, vegetable protein compound powder and food additives are added in three-dimensional motion mixer and mixed, by uniformly mixed raw material
Add in packing machine hopper, be packaged to be finished product.
Specifically, passing-screen size is 100 mesh in the S1 steps.
Specifically, rotating speed 30r/min, incorporation time 30min are mixed in the S2 steps.
The effect of medicinal and edible plant protein powder composition component protein matter, the assay of polysaccharides (1.8%)
1 instrument and material
1.1 instrument
Electric-heated thermostatic water bath (Zhengzhou Great Wall), ultraviolet specrophotometer (Shimadzu UV-2600), electronic balance (Sai Duoli
This CPA225D), apparatus,Soxhlet's, electric heater (Zhengzhou Great Wall DRT-SX), ultrasonic cleaner (Kunshan Shu Mei KQ-300),
Full-automatic Kjeldahl determination device (Fox ZRQF-F305)
1.2 medicines and reagent
Glucose control product (Nat'l Pharmaceutical ＆ Biological Products Control Institute, lot number 20051126), medicinal and edible plant albumen
Compound powder (embodiment 1, embodiment 2, embodiment 3), sulfuric acid, vanillic aldehyde, glacial acetic acid, perchloric acid, ethyl acetate, hydroxide
Sodium, methyl red, bromocresol green are that analysis is pure.
2 protein content determinations
Accurately weighed 0.2~0.3g of sample, after adding 10g catalyst, adds the 12mL concentrated sulfuric acids, is put into digesting,
When digestion 2 is small at 420 DEG C, it is put into after sample cooling in full-automatic Kjeldahl determination device, option program is dilute for addition 40mL's
Release liquid (water), 60mL lye (40% sodium hydroxide), 30mL reception liquids (1L1% boric acid solution+10mL bromocresol greens indicator solution+
7mL methyl reds indicator solution), and detected according to the operational procedure of full-automatic Kjeldahl determination device, with sulfuric acid titrating solution (0.05mol/L)
Titration, as reaction end when the color of question response liquid is changed into light red from green.With method operating space.
3rd, the assay of polysaccharides
2.1.1 the preparation of reference substance solution：Take glucose control product appropriate, it is accurately weighed, add water that every 1ml is made and contain
The solution of 0.1mg, to obtain the final product.
2.1.2 the preparation of sulfuric acid anthrone solution：Precision weighs anthrone 0.1g, adds 80% sulfuric acid solution 100ml to make dissolving,
Shake up, to obtain the final product.
The preparation of 2.2 standard curves：Respectively it is accurate measure reference substance solution 0.2ml, 0.4m1,0.6ml, 0.8ml,
1.0ml, 1.2ml, put in 10ml tool plug test tubes, add water to 2.0ml, and precision adds sulfuric acid anthrone solution 6ml, shakes up, put water-bath
Middle heating 15min, takes out, is put into ice bath and cools down 15min, and using corresponding reagent as blank, extinction is measured at 625nm wavelength
Degree, using absorbance as ordinate, concentration is abscissa, draws standard curve.
2.3 the preparation of test solution：Take sample about 2g, it is accurately weighed, put in apparatus,Soxhlet's, add water 90ml, electricity plus
To extracting liquid colourless, extracting solution is transferred in 100ml measuring bottles hot device heating and refluxing extraction, adds water to scale, is shaken up.Precision measures
10ml, adds ethanol 150ml, shakes up, and when 4 DEG C of placements 12 are small, takes out, and centrifugation, incline supernatant, and precipitation is dissolved in water, transfer
Into 50ml measuring bottles, add water to scale, shake up, to obtain the final product.
2.4 determination method：Precision measures test solution 2ml, puts in 10ml tool plug test tubes, and precision adds sulfuric acid anthrone solution
6ml, shakes up, and puts in water-bath and heats 15 minutes, takes out, puts in people's ice bath and cool down 15 minutes, using corresponding reagent as blank,
Absorbance is measured at 625nm wavelength, the weight (mg) containing glucose in test solution is read from standard curve, is calculated, i.e.,
.This product is calculated by dry product, containing polysaccharides with DEXTROSE ANHYDROUS (C6H12O6) meter.Test result is as shown in table 1：
Table 1
It can be seen that the active ingredient of protein is very high from the data of table 1, the active ingredient of polysaccharides is also very
Stablize.
The promotion digestion of medicinal and edible plant protein powder composition
It is described in further detail by promotion digestion of the zoopery to the present composition：
1st, promote bowel movement, intragastric administration on mice is administered with the protein powder composition of 0.375g/kg.The result shows that the present invention
Protein powder composition can promote gastrointestinal smooth muscle to promote sexuality, compared with physiological saline group, difference highly significant.
2nd, the secretion of peptic digest liquid is promoted：Stomach total acidity and total acid output titration experiments, with the albumen powder group of 0.375g/kg
Intragastric administration on mice is administered in compound.The result shows that gastric juice amount, total acidity and total acid output have increase, especially with total acid output
The most obvious, dosage group is compared with physiological saline group, the equal highly significant of difference.
3rd, pepsin activity is increased：Blood capillary tube method shows that the protein powder composition of 0.375/kg can be obviously promoted
The secretion of mouse pepsin.
The strengthen immunity effect of medicinal and edible plant protein powder composition
The experiment includes weight, internal organs/weight ratio, vola pedis thickness (cellular immune function experiment), lymphocyte
Competence for added value (cellular immune function experiment), antibody-producting cell number (humoral immune function experiment), half hemolytic value (HC50)
(humoral immune function experiment), carbonic clearance index (monocytes/macrophages function test), the phagocytic rate of phagocyte and phagocytosis refer to
Number (monocytes/macrophages function), NK cytoactives (NK cell activity assays).
The strengthen immunity function foundation of protein powder composition of the present invention is studied below《Health food is examined and assessment technique
Specification (2003 editions)》Content is tested.
Wherein, test specimen, animal, medicine and reagent, instrument, dosage setting, experimental animal and administration etc. are as follows：
1st, sample human oral recommended intake is three times a day, every time three/piece, and (weight presses 60kg to every/piece 0.5g
Meter), 4.5g/60kgBW, takes capsules/tablets agent content to be tested.
2nd, animal Kunming mouses, cleaning grade, complete female, weight 18-22g
3rd, medicine and reagent
The mouse lymphocyte conversion test (mtt assay) of ConA inductions：RPMIl640 nutrient solutions, calf serum, 2-ME, green grass or young crops
Mycin, streptomysin, concanavalin A (ConA), hydrochloric acid, isopropanol, MTT, Hank ' s liquid (pH7.2-7.4)
Delayed allergy (sheep red blood cell (SRBC) SRBC inducing mouses DTH：Toes thicken method)：Sheep red blood cell (SRBC) (SRBC)
Antibody-producting cell detection (Jerne improves slide methods)：Hank ' s liquid, sheep red blood cell (SRBC) (SRBC), complement (guinea pig serum), SA
Buffer solution, agarose, RPMIl640 nutrient solutions.
The measure (the measure HC50 methods of half hemolytic value) of serum hemolysin：Sheep red blood cell (SRBC) (SRBC), SA buffer solutions, all
Family name's reagent (sodium acid carbonate 1.0g, high-potassium ferricyanide 0.2g, potassium cyanide 0.05g, adds distilled water to 1000mL)
Carbonic clearance index (monocytes/macrophages function test)：India ink, 0.1%Na2CO3
Turnover of Mouse Peritoneal Macrophages phagocytosis chicken red blood cell experiment：Methanol, acetone, chicken red blood cell, physiological saline, Giemsa dyes
Liquid NK cytoactive detections：RPMIl640 nutrient solutions, YAC-1 cells, lithium lactate, nitro tetrazolium chloride, azophenlyene dimethyl ester sulphur
Hydrochlorate, oxidized coenzyme I, Tris-HCl buffer solutions (pH 8.2), the 1%NP40 of 0.2mol/L
4th, instrument
ES-2100A electronic balances, BS223S electronic balances, 755 spectrophotometers, microplate reader, CO2gas incubator,
Low speed centrifuge, water bath with thermostatic control, microscope, inverted microscope, spiral micrometer.It is clean bench, sterile surgical instrument, micro
Syringe (25 μ L), cell counter, the flat Tissue Culture Plate in 24 holes and 96 holes, the U-shaped Tissue Culture Plate in 96 holes, glass dish,
Gauze, test tube, glass frame, 200 mesh sieve nets, timer, hemoglobin pipet, glass slide etc..
5th, dosage is set
Dosage setting principle：This health food recommended dose is adult's (pressing 60kg batheroom scales), and it is 4.5g/ that people, which intends with dosage,
60kgBW days.Experiment sets 5 times, 10 times, 30 times of human body recommended amounts, i.e., daily 0.375g/kgBW, 0.75g/kg
BW, 2.25g/kgBW, basic, normal, high 3 dosage formulation concentration is respectively 0.375,0.75,2.25mg/mL, separately set distilled water
For negative control group.
6th, experimental animal and administration
160 Kunming mouses are divided into 4 batches, every batch of is randomly divided into 4 groups, every group 10.
(1) I group of carry out delayed allergy experiment, the measure and antibody-producting cell of half hemolytic value (HC50) is immunized
Several measure；
(2) II group of carry out carbonic clearance experiment is immunized；
(3) III group of carry out Turnover of Mouse Peritoneal Macrophages phagocytosis chicken red blood cell experiment is immunized；
(4) the mouse lymphocyte transformation experiment and NK cytoactive detections of IV group of carry out ConA induction is immunized.Per Nikkei
Oral drink gives each experimental group health food once, and blank group gives distilled water, continuous feeding 30 days.
7th, criterion
《Health food is examined and assessment technique specification》(2003 editions) regulations：Cellular immune function, humoral immune function,
Monocytes/macrophages function, any two aspect results of four aspects of NK cytoactives are positive, can determine that the given the test agent has and increase
Strong immunity function effect.Two experiments wherein in cellular immune function assay project, i.e. mouse spleen lymphocyte conversion are real
Test, delayed allergy experiment, result is the positive, or two dosage group results of any experiment are positive, can determine that cell
Test on immune function result is positive.Two experiments in humoral immune function measure project, i.e. antibody-producting cell detection, serum
Hemolysin test, result are the positive, or two dosage group results of any experiment are positive, can determine that humoral immune function measures
As a result it is positive.Two experiments in monocytes/macrophages functional examination project, the i.e. experiment of mouse carbonic clearance, mouse peritoneal macrophage
Cell phagocytosis chicken red blood cell experiment, result is the positive, or two dosage group results of any experiment are positive, can determine that monokaryon-
Macrophage function result is positive.More than one dosage group result of NK cytoactive detections experiment is positive, can determine that NK cells
Activity Results are positive.
8th, data processing
Variance analysis generally is used, but need to first carry out homogeneity test of variance by the program of variance analysis, variance is neat, calculates F
Value, F value ＜ F0.05, conclusion：No significant difference between each group mean, F values >=F0.05, P≤0.05, with multiple experimental groups and one
The comparative approach two-by-two of mean is counted between a control group；Appropriate variable turn is carried out to the data of abnormal or heterogeneity of variance
Change, after normal state or the neat requirement of variance is met, counted with transformed data；If variable conversion after still be not up to normal state or
The neat purpose of variance, uses rank sum test instead and is counted.
9th, specific experiment data are as follows
Influence to immune I group of mouse weight is as shown in table 2：
Influence of the table 2 to II group mouse weights are immunized is as shown in table 3：
Influence of the table 3 to III group mouse weights are immunized is as shown in table 4：
Influence of the table 4 to IV group mouse weights are immunized is as shown in table 5：
Table 5
By table 2-5 as it can be seen that each dosage group tests initial stage, experiment mid-term, experiment latter stage mouse weight and during the experiment mouse
Body weight increase is compared with blank control group, and there are no significant for difference (P ＞ 0.05), i.e., health food of the present invention to mouse weight without
Harmful effect, it is safe.
Influence to mouse immune organ internal organs/weight ratio is as shown in table 6：
Table 6
By table 6 as it can be seen that this health food of orally administration mouse various dose 30 days, to mouse spleen/weight ratio and
Thymus gland/weight ratio does not make significant difference (P ＞ 0.05).
Mouse lymphocyte conversion capability result of the test is as shown in table 7：
Table 7
As can be seen from Table 7, this health food of orally administration mouse various dose 30 days, each dosage group mouse lymph
Cell transformation capacity compared with the control group, does not make significant difference (P ＞ 0.05).
Mouse delayed allergy (DTH) result of the test is as shown in table 8：
Table 8
As shown in Table 8, this health food of orally administration mouse various dose 30 days, middle and high dosage group swelling degree of the paw
Apparently higher than control group (P ＜ 0.05 or P ＜ 0.01).
Mouse antibodies cellulation testing result is as shown in table 9：
Table 9
As shown in Table 9, this health food of orally administration mouse various dose 30 days, middle and high dosage group mouse antibodies life
There is conspicuousness (P ＜ 0.05 or P ＜ 0.01) into cell number apparently higher than blank group, difference.
Mouse half hemolytic value (HC50) result of the test is as shown in table 10：
Table 10
By table 10 as it can be seen that this health food of orally administration mouse various dose 30 days, each dosage mouse half blood value with
Control group compares, no significant difference (P>0.05).
Mouse monokaryon-macrophage carbonic clearance ability test result is as shown in table 11：
Table 11
By table 11 as it can be seen that this health food of orally administration mouse various dose 30 days, high dose group mouse phagocytic index
It is significantly higher than blank group, difference has conspicuousness (P ＜ 0.05).
Mouse macrophage phagocytosis chicken red blood cell phagocytic index result of the test is as shown in table 12：
Table 12
By table 12 as it can be seen that this health food of orally administration mouse various dose 30 days, each dosage group compared with blank group,
There was no significant difference (P ＞ 0.05).I.e. each dosage group has no significant effect mouse macrophage phagocytosis chicken red blood cell ability.
NK cells in mice activity test result is as shown in table 13：
Table 13
By table 13 as it can be seen that this health food of orally administration mouse various dose 30 days, high dose group is to NK cells in mice
Activity has significant difference (P compared with blank group<0.05).
In conclusion in cellular immune function, humoral immune function, monocytes/macrophages function, NK cytoactives four
Two aspect results of cellular immunity and humoral immunity are the positive in aspect, can determine that it has the function of strengthen immunity.
Conclusion：Take orally the present invention protein powder composition have the function of strengthen immunity and conveniently, safely the advantages that.
The alleviation physical fatigue effect of medicinal and edible plant protein powder composition
This experiment is tested according to common resisting stress, the fatigue starvation to having taken pharmaceutical composition of the present invention
Mouse is observed.Major experimental is：Resist oxygen lack is tested, antifatigue experiment, high temperature resistant experiment.
The research of mouse anti-stress effect
1. reagent and material
1.1 experimental subjects：Kunming kind aged mouse (10 monthly age), 50~60g of weight, female.
1.2 packets and administration
4 groups are randomly divided into, every group 10, it is respectively blank control group (normal group) and embodiment 1, embodiment 2 and reality
Apply 3 sample sets of example.Above-mentioned is respectively that mouse dosage adds suitable quantity of water dissolving gavage to use with dose lonvestion by people.Each group animal exists
0.1%BSA acidifying waters are freely drunk in experimentation, blank group gavages physiological saline daily, and other 3 groups gavage test sample respectively
Product 0.375g/kg, one time a day, continuous 4 weeks.
2 methods and result
Starvation 16h before the influence last dose of 2.1 pairs of mouse oxygen deficit tolerance endurance, 1h, mouse is put after the last administration
In the 250ml wide-mouth bottles for entering to fill 10g soda limes, capping vaseline sealing, records the mouse survival time.The result is shown in table 14 below.
Mouse is put into 27 ± 1 DEG C of insulating boxs the experiment of 2.2 high temperature resistants by 1h after the last administration, records life span.As a result
It see the table below 14.
Influence (x ± s) of 14 present composition of table to mouse oxygen deficit tolerance ability
| Group | Dosage (g/kg) | Number of animals (only) | Time-to-live (min) |
| Blank control group | - | 10 | 15.23±3.01 |
| Embodiment 1 | 0.375 | 10 | 18.50±2.31* |
| Embodiment 2 | 0.375 | 10 | 20.18±4.56* |
| Embodiment 3 | 0.375 | 10 | 22.88±6.12* |
Compared with control group, * P ＜ 0.05
The result shows that the present composition can be obviously prolonged the time-to-live of mouse.
Starvation 24h before the influence last dose of 2.3 pairs of mouse anti-reflecting fatigues effect, after the last administration 1h mouse is put into 27 ±
In 2 DEG C of ponds, record mouse life span in water (record mouse enters water to mouth and nose and sinks under the water up to more than the 10s times).It is anti-
Stress test result (n=10) is as shown in Table 15：
Note：Blank control group is compared with each group, * P ＜ 0.05.
The result shows that in three indexs such as anti anoxia, antifatigue, high temperature resistance, have between blank control group and each group significantly
Sex differernce, illustrates that said composition can increase mouse resist oxygen lack, endurance, heat safe time-to-live.
The acute toxicological experiment of medicinal and edible plant protein powder composition
Preliminary experiment：By acute toxicological experiment method, kunming mice 40 is selected, fasting, can't help water 12h.Albumen powder group
Compound (Example 1, embodiment 2 and embodiment 3 respectively) is configured to the suspension of Cmax.The each gavage of every mouse is about
For 0.8mL/20g (weight), gavage 3 times in 24h, is spaced 4h.Then routinely raise, and observe the toxic reaction situation of mouse
(appearance, activity, breathing, secretion, defecation, death etc.), and continuous weighting 7 days.Because being held with maximum administration concentration, maximum administration
Amount, does not measure median lethal dose (LD50), therefore do maximum dosage-feeding experiment.
1. general performance：After administration in 14 days, the equal diet of experimental mice is normal, and fur is smooth, activity freely, stool and urine
Normally, secretion without exception, its respiratory system, cardiovascular system, nervous system, digestive system and urinary system are showed no different
Often, mouse all survives.Its daily maximum dosage-feeding is that per kilogram is 180g, equivalent to 202 times of clinical adult's dosage.
2. changes of weight situation：After administration in 14 days, weight change without exception.
3. main organs are observed：2 groups of mouse are through gross anatomy and observe by the naked eye, and have no internal organs enlargement, atrophy, necrosis
Etc. abnormal phenomenon, main organs are close with blank control group without any bad lesion.In conclusion prompt this medicine nontoxic, its
Clinical application amount is the dosage of a safety, and clinical application is safe.
The above is only the preferred embodiment of the present invention, it should be understood that the present invention is not limited to described herein
Form, is not to be taken as the exclusion to other embodiment, and can be used for various other combinations, modification and environment, and can be at this
In the text contemplated scope, it is modified by the technology or knowledge of above-mentioned teaching or association area.And those skilled in the art institute into
Capable modifications and changes do not depart from the spirit and scope of the present invention, then all should be in the protection domain of appended claims of the present invention
It is interior.
Claims (9)
- A kind of 1. medicinal and edible plant protein powder composition, it is characterised in that the medicinal and edible plant protein powder composition by Following component composition：Medicinal powder composition 20-40 parts by weight；Vegetable protein compound powder 60-80 parts by weight；Food additives 0.5-1.0 parts by weight.
- A kind of 2. medicinal and edible plant protein powder composition according to claim 1, it is characterised in that the integration of drinking and medicinal herbs Vegetable protein compound powder is made of following component：30 parts by weight of medicinal powder composition；75 parts by weight of vegetable protein compound powder；0.8 parts by weight of food additives.
- A kind of 3. medicinal and edible plant protein powder composition according to claim 1 or 2, it is characterised in that the medicinal material Powder composition is made of following component：
- A kind of 4. medicinal and edible plant protein powder composition according to claim 1 or 2, it is characterised in that the plant Protein powder composition is made of following component：Soybean separation protein white powder 55-60 parts by weight；Fed Protein Powder of Pea Insteal 5-10 parts by weight；Gluten powder 5-10 parts by weight.
- A kind of 5. medicinal and edible plant protein powder composition according to claim 1 or 2, it is characterised in that the food Additive is made of following component：Phosphatidase 0 .5-1.0 parts by weight；Dextrin 0.5-1.0 parts by weight；Oligofructose 1.0-2.0 parts by weight.
- 6. a kind of preparation method of medicinal and edible plant protein powder composition of claim 1-5 any one of them, its feature exist In including the following steps：S1 prepares medicinal powder composition：Chinese yam medicine materical crude slice, Poria cocos medicine materical crude slice, matrimony vine and jujube are cleaned, crushed respectively, is sieved, Obtain yam flour, Poria cocos powder, wolfberry fruit powder and jujube powder；S2 prepares medicinal and edible plant protein powder composition：Yam flour, Poria cocos powder, wolfberry fruit powder, the jujube that will be prepared in S1 steps Powder, vegetable protein compound powder and food additives are added in three-dimensional motion mixer and mixed, and uniformly mixed raw material is added In packing machine hopper, finished product is packaged to be.
- A kind of 7. preparation method of medicinal and edible plant protein powder composition according to claim 6, it is characterised in that institute It is 100 mesh to state passing-screen size in S1 steps.
- A kind of 8. preparation method of medicinal and edible plant protein powder composition according to claim 6, it is characterised in that institute State mixing rotating speed 20-30r/min, incorporation time 30-40min in S2 steps.
- 9. application of any one of the claim 1-5 medicinal and edible plant protein powder compositions in health food.
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Application publication date: 20180420 |