CN107913291A - A kind of compound bee venom oral liquid and preparation method thereof - Google Patents
A kind of compound bee venom oral liquid and preparation method thereof Download PDFInfo
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- CN107913291A CN107913291A CN201610879408.XA CN201610879408A CN107913291A CN 107913291 A CN107913291 A CN 107913291A CN 201610879408 A CN201610879408 A CN 201610879408A CN 107913291 A CN107913291 A CN 107913291A
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- bee venom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Insects & Arthropods (AREA)
- Engineering & Computer Science (AREA)
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- Oil, Petroleum & Natural Gas (AREA)
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a kind of compound bee venom oral liquid, it is made of the raw material of following weight：Bee venom (1.5 2.5) * 10‑3G, 35 45g and 75 ° of 55 65g of white wine of propolis.Its preparation method, comprises the following steps：(1) crushed after freezing after pure natural thick propolis extraction, and with 75 ° of white wine dissolved dilutions, be carried out continuously 72 it is small when uninterruptedly stir, it is every 24 it is small when extract repeatedly, 72 complete dilute filtration when small；(2) the bee venom impurity elimination of extraction refines rear heated-air drying processing, bottling sealing；(3) bee venom extracted addition distilled water is diluted dissolving, then bee venom solution is dissolved in 75 ° of white wine until being completely dissolved；Propolis solution is added in bee venom solution and is diluted dissolving, all dispenses finished product after dilution dissolving mixing.The oral liquid of the present invention have purify the blood, toxin expelling, it is anti-ageing, preserve youthful looks, rheumatism, rheumatoid arthritis, liver protecting, protection kidney, improve sleep, adjust constipation, conditioning stomach trouble, the health-care efficacy such as strengthen immunity.
Description
Technical field
The present invention relates to a kind of health products and preparation method thereof, are specifically a kind of compound bee venom oral liquid and its preparation side
Method.
Background technology
In modern society, getting worse the problems such as environmental pollution, food security, more and more toxin are flooded with us
Life；And most of young men, often because operating pressure is big, life is irregular, lacks the reasons such as movement, it result in skin
The problems such as skin relaxation aging, gastrointestinal disease, rheumatism, rheumatoid arthritis, liver and kidney disease, insomnia, constipation, immunity degradation.
With expanding economy and social progress, modern increasingly payes attention to personal health problem, and recognizes only have
Internal harmful substance is discharged in time, is kept the five internal organs and internal cleaning, could persistently be maintained health.But listing now
While sale have purify the blood, toxin expelling, it is anti-ageing, preserve youthful looks, rheumatism, rheumatoid arthritis, liver protecting, protection kidney, improve sleep
Sleep, to adjust constipation, conditioning stomach trouble, the health products species of strengthen immunity considerably less, but also there is effect not significantly, take effect
The problems such as slow.
The content of the invention
It is an object of the invention to provide a kind of compound bee venom oral liquid and preparation method thereof, to solve above-mentioned background technology
The problem of middle proposition.
To achieve the above object, the present invention provides following technical solution：
A kind of compound bee venom oral liquid, is made of the raw material of following weight：Bee venom (1.5-2.5) * 10-3G, propolis 35-45g
With 75 ° of white wine 55-65g.
As the further scheme of the present invention：It is made of the raw material of following weight：Bee venom 2*10-3G, propolis 40g and 75 ° are white
Wine 60g.
As further scheme of the invention：The preparation method of the compound bee venom oral liquid, comprises the following steps：
(1) will be freezed in refrigerator-freezer after pure natural thick propolis extraction 18-30 it is small when, what will be freezed becomes the thick of lump shape
Propolis takes out and is crushed, the thick propolis crushed with 75 ° of white wine dissolved dilutions, be carried out continuously 72 it is small when and it is continual
Agitation, and it is every 24 it is small when with filter paper or special filtering screen cloth filter residue filtering extract repeatedly, 72 complete dilute filtration when small, filter
Liquid carries out vacuum concentration freezing with the preservation of dark-brown glassware or filtrate；
(2) the bee venom impurity elimination of extraction refines, and impure bee venom is dissolved in 8-12 times of distilled water, by bee venom aqueous solution
Being filtered through middling speed qualitative filter paper, remove water-insoluble, the sediment isolated is bee venom, after being handled using heated-air drying, bottling
Sealing；
(3) bee venom extracted taking-up is added to 8-12 times of distilled water according to the amount to be prepared and is diluted dissolving, and
And solution in distilled water all is dissolved in, then the bee venom solution all diluted is dissolved in 75 ° of white wine until being completely dissolved；Will
Filtered propolis solution adds in the bee venom solution that dilution has been dissolved into completely and is diluted dissolving, and all dilution dissolving is mixed
Finished product is dispensed after conjunction, is no longer sterilized after packing finished product sealing, to prevent the active ingredient inactivation in bee venom.
As further scheme of the invention：24 will be freezed in refrigerator-freezer after pure natural thick propolis extraction in step (1)
Hour.
As further scheme of the invention：Impure bee venom is dissolved in 10 times of distilled water by step in (2).
As further scheme of the invention：Water-insoluble described in step (2) includes dust and wax squama.
As further scheme of the invention：The bee venom extracted is taken out in step (2) and is added according to the amount to be prepared
Enter 10 times of distilled water and be diluted dissolving.
Bee venom：Acrid flavour, it is bitter, it is mild-natured, it is poisonous.Enter liver, lung channel.Major function：Dispelling wind and eliminating dampness, analgesic.Main rheumatism joint
Inflammation, psoas are ached, neuralgia, hypertension, nettle rash, asthma.The tool such as bee venom and its component melittin, the support gentle apamin of peptide
There is obvious neurotropism.Full bee venom and melittin are to the selective retardation of nicotine cholinergic receptor.Apamin can be saturating
Cross blood-brain barrier and directly act on central nervous system.Bee venom has ganglionic blocking effect.Bee venom has obvious analgesia to make
With its inhibitory action for easing pain parathyrine synzyme is about 70 times of indomethacin tablet.Clinic prove, bee venom to neurosis, partially
Headache and trigeminal neuralgia have preferable therapeutic effect.It is generally acknowledged that bee venom has the function that to adjust nervous system tensity, make
Cerebral cortex activity normalization, adjusts metabolism, so as to promote idioneural reparation.Angiocarpy of the bee venom to respiratory system
System has significant impact.The people bitten by bee has the phenomenon of accelerated breathing, it is considered that this be blood pressure reduce cause it is reflexive
Reaction.Substantial amounts of bee venom can make one or animal brain respiratory center benumbs and causes death.Bee venom can cause arterial pressure to reduce
Friendship should, it is related mainly to pull 2 Li with phosphide enzyme A.Melittin is a kind of strong cardiotoxin, and has pressor work
With, heart peptide and apamin in bee venom have the antiarrhythmic effect similar to isoprel, and act on
Duration is grown far beyond isoprel.The haemocylolysis of bee venom is very strong, under extremely low concentration (1/10000), can just produce
Raw haemocylolysis.Its mechanism is melittin in bee venom and what phospholipase A 2 can strengthen erythrocyte wall is impregnated with ability, causes thin
The colloid of intracellular largely oozes out, and intracellular osmotic pressure reduces, and causes cell to split angle；The exudative haemolysis of colloid ".Bee venom in vivo or
There is anticoagulant effect in vitro, be obviously prolonged blood coagulation time.Bee venom has certain radiation resistance, can strengthen body
Stress ability, mitigate the degree of radiation injury, reduce the frequency due to radiating caused Chromosome aberration, improve and move
The survival rate of thing.Bee venom has the latent effect of protection and recovery hematopoietic cell, prevents marrow caused by radiation and spleen
Degradation phenomena.The radiation-resistant primary bioactive components of bee venom are melittin, phospholipase A 2, hyaluronidase, acid phosphorus esterase
And sensibiligen B and C.
Propolis：Mild-natured, bitter, pungent, micro-sweet, there is the effect of moisturizing myogenic, anti-inflammatory analgetic, can treat gastric ulcer, oral cavity is burst
Ulcer, burn and scald, the illness such as skin Tearing Pain, radiation protection.Abundant and unique bioactive substance contained by propolis, makes it have
The multiple functions such as antibacterial, anti-inflammatory, antipruritic, anti-oxidant, immune, the hypoglycemic, reducing blood lipid of enhancing, antitumor, have human body extensively
Medical treatment, health-care effect.
Compared with prior art, the beneficial effects of the invention are as follows：The compound bee venom oral liquid of the present invention, which has, to purify the blood, arranges
It is malicious, anti-ageing, preserve youthful looks, rheumatism, rheumatoid arthritis, liver protecting, protection kidney, improve sleep, adjust constipation, conditioning stomach trouble,
The health-care efficacies such as strengthen immunity.
Embodiment
Below in conjunction with the embodiment of the present invention, the technical solution in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only part of the embodiment of the present invention, instead of all the embodiments.Based in the present invention
Embodiment, those of ordinary skill in the art's all other embodiments obtained without making creative work, all
Belong to the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, a kind of compound bee venom oral liquid, is made of the raw material of following weight：Bee venom 1.5mg, propolis
35g and 75 ° of white wine 65g.
The preparation method of the compound bee venom oral liquid, comprises the following steps：
(1) the thick bee as lump shape that when freezing 18 is small in refrigerator-freezer after pure natural thick propolis extraction, will will be freezed
Glue takes out and is crushed, the thick propolis crushed with 75 ° of white wine dissolved dilutions, be carried out continuously 72 it is small when and continual stir
It is dynamic, and it is every 24 it is small when extracted repeatedly with filter paper or the filtering of special filtering screen cloth filter residue, 72 complete dilute filtration, filtrate when small
Vacuum concentration freezing is carried out with the preservation of dark-brown glassware or filtrate；
(2) the bee venom impurity elimination of extraction refines, and impure bee venom is dissolved in 8 times of distilled water, bee venom aqueous solution is passed through
Middling speed qualitative filter paper filters, and removes the water-insoluble such as dust and wax squama, the sediment isolated is bee venom, at heated-air drying
After reason, bottling sealing；
(3) bee venom extracted taking-up is added to 8 times of distilled water according to the amount to be prepared and is diluted dissolving, and entirely
Portion is dissolved in solution in distilled water, and then the bee venom solution all diluted is dissolved in 75 ° of white wine until being completely dissolved；Will filtering
Good propolis solution adds in the bee venom solution that dilution has been dissolved into completely and is diluted dissolving, all after dilution dissolving mixing
Finished product is dispensed, is no longer sterilized after packing finished product sealing, to prevent the active ingredient inactivation in bee venom.
Embodiment 2
In the embodiment of the present invention, a kind of compound bee venom oral liquid, is made of the raw material of following weight：Bee venom 2mg, propolis
40g and 75 ° of white wine 60g.
The preparation method of the compound bee venom oral liquid, comprises the following steps：
(1) the thick bee as lump shape that when freezing 24 is small in refrigerator-freezer after pure natural thick propolis extraction, will will be freezed
Glue takes out and is crushed, the thick propolis crushed with 75 ° of white wine dissolved dilutions, be carried out continuously 72 it is small when and continual stir
It is dynamic, and it is every 24 it is small when extracted repeatedly with filter paper or the filtering of special filtering screen cloth filter residue, 72 complete dilute filtration, filtrate when small
Vacuum concentration freezing is carried out with the preservation of dark-brown glassware or filtrate；
(2) the bee venom impurity elimination of extraction refines, and impure bee venom is dissolved in 10 times of distilled water, bee venom aqueous solution is passed through
Middling speed qualitative filter paper filters, and removes the water-insoluble such as dust and wax squama, the sediment isolated is bee venom, at heated-air drying
After reason, bottling sealing；
(3) bee venom extracted taking-up is added to 10 times of distilled water according to the amount to be prepared and is diluted dissolving, and
Solution in distilled water all is dissolved in, then the bee venom solution all diluted is dissolved in 75 ° of white wine until being completely dissolved；Incited somebody to action
The propolis solution filtered adds in the bee venom solution that dilution has been dissolved into completely and is diluted dissolving, all dilution dissolving mixing
After dispense finished product, no longer sterilized after packing finished product sealing, to prevent the active ingredient inactivation in bee venom.
Embodiment 3
In the embodiment of the present invention, a kind of compound bee venom oral liquid, is made of the raw material of following weight：Bee venom 2.5mg, propolis
45g and 75 ° of white wine 55g.
The preparation method of the compound bee venom oral liquid, comprises the following steps：
(1) the thick bee as lump shape that when freezing 30 is small in refrigerator-freezer after pure natural thick propolis extraction, will will be freezed
Glue takes out and is crushed, the thick propolis crushed with 75 ° of white wine dissolved dilutions, be carried out continuously 72 it is small when and continual stir
It is dynamic, and it is every 24 it is small when extracted repeatedly with filter paper or the filtering of special filtering screen cloth filter residue, 72 complete dilute filtration, filtrate when small
Vacuum concentration freezing is carried out with the preservation of dark-brown glassware or filtrate；
(2) the bee venom impurity elimination of extraction refines, and impure bee venom is dissolved in 12 times of distilled water, bee venom aqueous solution is passed through
Middling speed qualitative filter paper filters, and removes the water-insoluble such as dust and wax squama, the sediment isolated is bee venom, at heated-air drying
After reason, bottling sealing；
(3) bee venom extracted taking-up is added to 12 times of distilled water according to the amount to be prepared and is diluted dissolving, and
Solution in distilled water all is dissolved in, then the bee venom solution all diluted is dissolved in 75 ° of white wine until being completely dissolved；Incited somebody to action
The propolis solution filtered adds in the bee venom solution that dilution has been dissolved into completely and is diluted dissolving, all dilution dissolving mixing
After dispense finished product, no longer sterilized after packing finished product sealing, to prevent the active ingredient inactivation in bee venom.
The purposes of the present invention：Purify the blood, toxin expelling, it is anti-ageing, preserve youthful looks, rheumatism, rheumatoid arthritis, liver protecting, protection kidney,
Improve sleep, adjust the health-care efficacies such as constipation, stomach trouble, strengthen immunity.
The dose of the compound bee venom oral liquid of the present invention：Dose is daily：30ml, is each taking dosage：10ml, point
Take, taken again after the oral preceding warm water dilution for adding 2 times every time three times in the morning, afternoon and evening.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Profit requires rather than described above limits, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although the present specification is described in terms of embodiments, not each embodiment is only wrapped
Containing an independent technical solution, this narrating mode of specification is only that those skilled in the art should for clarity
Using specification as an entirety, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
It is appreciated that other embodiment.
Claims (7)
1. a kind of compound bee venom oral liquid, it is characterised in that be made of the raw material of following weight：Bee venom (1.5-2.5) * 10-3g、
Propolis 35-45g and 75 ° of white wine 55-65g.
2. compound bee venom oral liquid according to claim 1, it is characterised in that be made of the raw material of following weight：Bee venom
2*10-3G, propolis 40g and 75 ° of white wine 60g.
3. the preparation method of a kind of compound bee venom oral liquid as described in claim 1-2 is any, it is characterised in that including following
Step：
(1) will be freezed in refrigerator-freezer after pure natural thick propolis extraction 18-30 it is small when, the thick propolis as lump shape that will freeze
Taking-up is crushed, the thick propolis crushed with 75 ° of white wine dissolved dilutions, be carried out continuously 72 it is small when and continual stir
It is dynamic, and it is every 24 it is small when extracted repeatedly with filter paper or the filtering of special filtering screen cloth filter residue, 72 complete dilute filtration, filtrate when small
Vacuum concentration freezing is carried out with the preservation of dark-brown glassware or filtrate；
(2) the bee venom impurity elimination of extraction refines, and impure bee venom is dissolved in 8-12 times of distilled water, during bee venom aqueous solution is passed through
Fast qualitative filter paper filtering, removes water-insoluble, and the sediment isolated is bee venom, after being handled using heated-air drying, bottling sealing；
(3) bee venom extracted taking-up is added to 8-12 times of distilled water according to the amount to be prepared and is diluted dissolving, and entirely
Portion is dissolved in solution in distilled water, and then the bee venom solution all diluted is dissolved in 75 ° of white wine until being completely dissolved；Will filtering
Good propolis solution adds in the bee venom solution that dilution has been dissolved into completely and is diluted dissolving, all after dilution dissolving mixing
Finished product is dispensed, is no longer sterilized after packing finished product sealing, to prevent the active ingredient inactivation in bee venom.
4. the preparation method of compound bee venom oral liquid according to claim 3, it is characterised in that by pure day in step (1)
When so freezing 24 is small in refrigerator-freezer after thick propolis extraction.
5. the preparation method of compound bee venom oral liquid according to claim 3, it is characterised in that will contain in step (2) miscellaneous
The bee venom of matter is dissolved in 10 times of distilled water.
6. the preparation method of compound bee venom oral liquid according to claim 3, it is characterised in that described in step (2)
Water-insoluble includes dust and wax squama.
7. the preparation method of compound bee venom oral liquid according to claim 3, it is characterised in that will extraction in step (2)
The distilled water that good bee venom taking-up adds 10 times according to the amount to be prepared is diluted dissolving.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610879408.XA CN107913291A (en) | 2016-10-09 | 2016-10-09 | A kind of compound bee venom oral liquid and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610879408.XA CN107913291A (en) | 2016-10-09 | 2016-10-09 | A kind of compound bee venom oral liquid and preparation method thereof |
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| CN107913291A true CN107913291A (en) | 2018-04-17 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112641072A (en) * | 2021-01-13 | 2021-04-13 | 飞天蜂(天津)健康科技有限公司 | Royal jelly concentration and purification process and royal jelly concentration and purification production line |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103736033A (en) * | 2014-01-28 | 2014-04-23 | 林军庭 | Infantile convulsions tincture for dredging channels and expelling wind-damp |
| CN104958322A (en) * | 2015-06-04 | 2015-10-07 | 刘国灿 | Mist spray reagent for treating sphagitis and preparing method of mist spray reagent |
-
2016
- 2016-10-09 CN CN201610879408.XA patent/CN107913291A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103736033A (en) * | 2014-01-28 | 2014-04-23 | 林军庭 | Infantile convulsions tincture for dredging channels and expelling wind-damp |
| CN104958322A (en) * | 2015-06-04 | 2015-10-07 | 刘国灿 | Mist spray reagent for treating sphagitis and preparing method of mist spray reagent |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112641072A (en) * | 2021-01-13 | 2021-04-13 | 飞天蜂(天津)健康科技有限公司 | Royal jelly concentration and purification process and royal jelly concentration and purification production line |
| CN112641072B (en) * | 2021-01-13 | 2021-07-27 | 飞天蜂(天津)健康科技有限公司 | Royal jelly concentration and purification process and royal jelly concentration and purification production line |
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Application publication date: 20180417 |