CN107898862A - A kind of Chinese medicine composition for treating chronic cheilitis and preparation method thereof - Google Patents
A kind of Chinese medicine composition for treating chronic cheilitis and preparation method thereof Download PDFInfo
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- CN107898862A CN107898862A CN201711274841.1A CN201711274841A CN107898862A CN 107898862 A CN107898862 A CN 107898862A CN 201711274841 A CN201711274841 A CN 201711274841A CN 107898862 A CN107898862 A CN 107898862A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/58—Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
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Abstract
The present invention relates to a kind of Chinese medicine composition for treating chronic cheilitis and preparation method thereof.The Chinese medicine is prepared by Chinese medicine materials such as passion plant, Veronica, greyhair cipadessa root or leafs.Present invention also offers the preparation method of this Chinese medicine composition.Chinese medicine composition provided by the invention is mainly used for treating chronic cheilitis.
Description
Technical field
The present invention relates to the field of Chinese medicines, and in particular to a kind of Chinese medicine composition for treating chronic cheilitis and preparation method thereof.
Background technology
Chronic cheilitis is also known as exfoliative cheilitis, chronic actinic cheilitis.Using lip mucous membrane redness, rotten to the corn, chap, furfur as spy
Sign, when it is light when weight, be not with the passing of time cured.This disease is equivalent to " exfoliative inflammation of lips " that TCM Document is recorded, " tight lip ".The cause of disease may be with day illumination
Penetrate, external used medicine and some bad habits (such as lick lip, sting lip) it is related.
Chronic cheilitis can be divided into " stomach wind fire " and " the spleen channel blood is dry " two kinds of disease types, can be respectively cooperating with clearing heat-fire, cool
Blood dispelling wind, or cool blood is moisturized, the conditioning of the product of expelling wind and clearing away heat.
" stomach wind fire " card, belongs to outside the heresy of wind-heat and attacks, influence lip.Clinical manifestations are onset is anxious, just starts mouth
Lip is itched, color is red, swelling and pain, may then rupture flowing water afterwards, and with halitosis is seen, easy thirsty, cool drink, constipation, tongue fur is yellow, slippery
Number.Principle of reatment is with clearing heat-fire, based on cool blood dispelling wind.
" the spleen channel blood is dry " is demonstrate,proved, and majority morbidity is slow, shows as lip swelling, dry as burnt, and ruptures furfur.Or dry and cracked stream
Water, dark urine, tongue lack Tianjin, rapid pulse.It is more hot because feeding, caused by retention of damp-heat in the interiorization fire, dryness-transformation.Control suitable cool blood to moisturize, wind-dispelling
Heat-clearing.
The content of the invention
The object of the present invention is to provide a kind of Chinese medicine composition for treating chronic cheilitis；
It is a further object of the present invention to provide a kind of preparation method for the Chinese medicine composition for treating chronic cheilitis.
The purpose of the present invention is what is realized by following technical solution：
The Chinese medicine composition for the treatment of chronic cheilitis of the present invention, is prepared by the Chinese medicine material of following parts by weight：
15-35 parts of passion plant, 25-45 parts of Veronica, 15-35 parts of greyhair cipadessa root or leaf.
Preferably, it is to be prepared by the Chinese medicine material of following parts by weight：
20-30 parts of passion plant, 30-40 parts of Veronica, 20-30 parts of greyhair cipadessa root or leaf.
It is the crude drug source of Chinese medicine preparation of the present invention below：
Passion plant, Passifloraceae passion plant Passiflora foetida L., with all herbal medicine.【Nature and flavor】It is sweet, sour, put down.Gas
It is fragrant.【Major function】Clearing heat and cooling blood, moistening dryness and resolving phlegm.Cure mainly traumatic cornea or conjunctivitis, lymphnoditis.
Veronica, Scrophulariaceae brooklime Veronica Veronica didyma Tenore [V. agrestis
Sensu Miq. non L.], with all herbal medicine.【Nature and flavor】It is light, it is cool.【Major function】Cooling blood and hemostasis, regulating qi-flowing for relieving pain.For spitting
Blood, hernia, orchitis, leukorrhea.
Greyhair cipadessa root or leaf, is the root or leaf of Meliaceae plant gray wool Cipadessa baecifera Miq.【Nature and flavor】It is arduous, tepor.【Major function】Wind-dispelling
It is wet, promoting qi circulation and relieving pain.
Another aspect of the present invention there is provided the preparation method of the active ingredient of Chinese medicine composition of the present invention, and this method is
Carried using water or the extraction of the ethanol of 40-80% concentration expressed in percentage by volumes is prepared.Specific preparation method is as follows：
Scheme one：Take whole medicinal materials, extracting in water 2-3 times after mixing, each amount of water equivalent to 6-12 times of medicinal material gross weight,
When each extraction time is 1-3 small, merge extracting solution, filtration, relative density is 1.15-1.20 when filtrate is concentrated into 70-80 DEG C
Clear cream, up to active ingredient.
Scheme two：Whole medicinal materials are taken, are extracted 2-3 times with 40-80% alcohol refluxs after mixing, each ethanol consumption is medicinal material total amount
4-10 times, extraction time for 1-4 it is small when, merge extracting solution, filtering, relative density is when filtrate is concentrated into 70-80 DEG C
The clear cream of 1.15-1.20, up to active ingredient.
Scheme three：Whole medicinal materials are taken, extracting in water 2-3 times after mixing, 6- of each amount of water equivalent to medicinal material gross weight
12 times, when each extraction time is 1-3 small, merge extracting solution, filtration, relative density is when filtrate is concentrated into 70-80 DEG C
The clear cream of 1.15-1.20, adds ethanol, and it is 40-70% to make alcohol content, and when standing 12-24 is small, filtration, filtrate is concentrated into 70-80
DEG C when relative density be 1.10-1.25 medicinal extract, up to active ingredient.
The Chinese medicine composition for the treatment of chronic cheilitis of the present invention, can also match somebody with somebody with pharmaceutically acceptable carrier
Close, various oral formulations, such as pill, tablet, capsule, oral liquid, syrup, mixture are made.
The pharmaceutically acceptable carrier of the present invention includes but not limited to following：
Oral formulations：
Diluent：Starch, Icing Sugar, lactose, dextrin, microcrystalline cellulose, inorganic salts, glycitols etc..
Wetting agent and adhesive：Purified water, ethanol, gelatin, polyethylene glycol, cellulose derivative etc..
Disintegrant：Starch, sodium carboxymethyl starch, cellulose derivative, crospovidone etc..
Lubricant：Magnesium stearate, superfine silica gel powder, talcum powder, polyethylene glycol etc..
Cosolvent：Water, ethanol, glycerine, propane diols, liquid paraffin, vegetable oil etc..
Flavouring：Sucrose, monose, aromatic etc..
Preservative：Benzoic acid, sorbic acid, methyl esters, ethyl ester, propyl ester etc..
Method 1：Tablet
Scheme one is taken to add tablet and often use auxiliary material one of to three gained active ingredient of scheme, routinely production method is prepared into
Invention tablet.
Above-mentioned tablet often includes one of diluent, wetting agent, adhesive, disintegrant, lubricant or whole with auxiliary material.
Method 2：Capsule
Scheme one is taken to add capsule and often use auxiliary material, routinely production method is prepared into one of to three gained active ingredient of scheme
Capsule of the present invention.
Above-mentioned capsule often includes one of diluent, wetting agent, adhesive, disintegrant, lubricant or whole with auxiliary material.
Method 3：Syrup
Scheme one is taken to add syrup and often use auxiliary material, routinely production method is prepared into one of to three gained active ingredient of scheme
Syrup of the present invention.
Above-mentioned syrup often includes one of flavouring, preservative, cosolvent or whole with auxiliary material.
Method 4：Mixture
Scheme one is taken to add mixture and often use auxiliary material one of to three gained active ingredient of scheme, routinely production method is prepared into
Invention mixture.
Above-mentioned mixture often includes one of flavouring, preservative or whole with auxiliary material.
Method 5：Oral liquid
Taking scheme one, dissolving after-purification, concentration, add oral liquid and often use auxiliary material, by normal one of to three gained active ingredient of scheme
Rule production method is prepared into oral liquid of the present invention.
A kind of Chinese medicine composition for treating chronic cheilitis provided by the invention has the following advantages：
1st, composite preparation provided by the invention is safe and effective, be applicant for many years clinical experience combination theory of traditional Chinese medical science side and
Into：In side passion plant clearing heat and cooling blood moisturize, the qi-regulating of Veronica cool blood, greyhair cipadessa root or leaf wind-dispelling dampness elimination, clearing heat and cooling blood, dispelling wind are played altogether by full side
The effect of moisturizing, the treatment for chronic cheilitis.
2nd, clinical tests prove that, after being treated with the present invention to chronic cheilitis patient, effective percentage shows this hair up to 97.7%
It is bright effectively to treat chronic cheilitis.
3rd, Chinese medicinal composition preparation provided by the invention, scientific formulation is reasonable, and technique is simple, in good taste, and cost is low.
Embodiment
The present invention is further illustrated below by embodiment.It should be understood that the embodiment of the present invention is to be used to illustrate
The present invention rather than limitation of the present invention.The simple modifications that essence carries out the present invention according to the present invention belong to the present invention
Claimed scope.Unless otherwise indicated, the percentage of the amount of alcohol in the present invention is percentage by volume, and v/v represents solution
Volume ratio.
1 granule of embodiment
Weigh passion plant 15g, Veronica 25g, greyhair cipadessa root or leaf 15g.Extracting in water 3 times, amount of water is respectively medicinal material gross weight three times
12 times, 8 times, 6 times, when extraction time is respectively 3 small three times, 2 it is small when, 1 it is small when, merge extracting solution, filtration, filtrate is concentrated into
Relative density is 1.25 clear cream at 70 DEG C, adds starch, dextrin, granulation, dry, whole grain to obtain the final product.
2 tablet of embodiment
Weigh passion plant 35g, Veronica 45g, greyhair cipadessa root or leaf 35g.Extracted 2 times with alcohol reflux, each concentration of alcohol is respectively
80%th, 60%, each ethanol consumption is respectively 10 times of medicinal material total amount, 8 times, when extraction time is respectively 4 small, 3 it is small when, merging carries
Liquid is taken, is filtered, relative density is 1.10 medicinal extract when filtrate is concentrated into 80 DEG C, adds supplementary product starch, ethanol, talcum powder, is made
Tablet.
3 tablet of embodiment
Weigh passion plant 20g, Veronica 30g, greyhair cipadessa root or leaf 20g.Extracting in water 3 times, it is total to be respectively equivalent to medicinal material for amount of water three times
12 times, 8 times, 6 times of weight, when each extraction time difference 3 is small, 2 it is small when, 1 it is small when, merge extracting solution, filtration, filtrate concentration
To the clear cream that relative density at 70 DEG C is 1.20, ethanol is added, it is 40% to make alcohol content, when standing 24 is small, filtration, filtrate concentration
Relative density is 1.10 medicinal extract when being concentrated into 70 DEG C to filtrate, adds supplementary product starch, ethanol, talcum powder, and tablet is made.
4 capsule of embodiment
Weigh passion plant 30g, Veronica 40g, greyhair cipadessa root or leaf 30g.Extracted 3 times with 40% alcohol reflux, each ethanol consumption is respectively
10 times, 8 times, 4 times of medicinal material total amount, extraction time difference 3 it is small when, 2 it is small when, 1 it is small when, merge extracting solution, filtering, filtrate concentration
Relative density is 1.25 medicinal extract at 60 DEG C, supplementary product starch, ethanol, dextrin, magnesium stearate is added in medicinal extract, according to a conventional method
Capsule is made.
5 granule of embodiment
Weigh passion plant 25g, Veronica 35g, greyhair cipadessa root or leaf 25g.Extracting in water 2 times, it is total that each amount of water is respectively equivalent to medicinal material
12 times, 10 times of weight, when each extraction time is respectively 3 small, 2 it is small when, merge extracting solution, filtration, filtrate is concentrated into 80 DEG C
Lower relative density is 1.05 clear cream, adds ethanol, and it is 70% to make alcohol content, and when standing 12 is small, filtration, filtrate is concentrated into 70 DEG C
When relative density be 1.25 medicinal extract, add starch, dextrin, granulation, dry, whole grain to obtain the final product.
6 syrup of embodiment
Weigh passion plant 18g, Veronica 28g, greyhair cipadessa root or leaf 18g.Extracting in water 2 times, amount of water is respectively medicinal material gross weight twice
10 times, 8 times, when extraction time is respectively 2 small twice, 1 it is small when, merge extracting solution, filtration, filtrate is concentrated into opposite at 80 DEG C
Density is 1.10 medicinal extract.Syrup auxiliary material sucrose, sorbic acid, water are added in medicinal extract to stir evenly, and syrup is made.
7 oral liquid of embodiment
Weigh passion plant 23g, Veronica 32g, greyhair cipadessa root or leaf 23g.Extracting in water 2 times, amount of water is respectively medicinal material gross weight twice
10 times, 8 times, when extraction time is respectively 2 small twice, 1 it is small when, merge extracting solution, filtration, filtrate is concentrated into opposite at 80 DEG C
Density is 1.10 medicinal extract, and auxiliary material mannitol, sorbic acid, water are added in medicinal extract and is stirred evenly, is dispensed, oral liquid is made.
8 mixture of embodiment
Weigh passion plant 28g, Veronica 38g, greyhair cipadessa root or leaf 28g.Extracting in water 3 times, it is total to be respectively equivalent to medicinal material for amount of water three times
12 times, 8 times, 6 times of weight, when each extraction time difference 3 is small, 2 it is small when, 1 it is small when, merge extracting solution, filtration, filtrate concentration
Ad pond om is 3 times of medicinal material gross weight, filling, adds mixture auxiliary material sucrose, ethyl ester, water, sorbic acid and stirs evenly, is made and closes
Agent.
9 pulvis of embodiment
Weigh passion plant 32g, Veronica 42g, greyhair cipadessa root or leaf 32g.Crush, sieving, to obtain the final product.
Embodiment 10
Capsule prepared by the embodiment of the present invention 4, gives chronic cheilitis patient and takes orally, 2 every time, 3 times a day, clinical data
It is as follows：
| Disorder class | Illness number of cases | The course of disease | Treatment time | Efficiently individual quantity | Total effective rate |
| Chronic cheilitis | 44 | 2-7 | 7 days-January | 43 people | 97.7% |
Embodiment 11
History XX, female, 27 years old, from before 2 years lip occurred itched, and peeled, and swelling, flowing water, is not relieved in hospitalize, and nearly half
Still there is breaking-out after year external application hormone drug, and occur double upper limbs in the recent period and itch, face is also itched, with scurf.Dehisce pain.Give
Give the embodiment of the present invention 8 to treat, after a week further consultation, be clearly better earlier above, feel that face still slightly has swelling, dehisce to increase earlier above.
Continual cure two weeks, it is almost recovered.
Claims (7)
- A kind of 1. Chinese medicine composition for treating chronic cheilitis, it is characterised in that it be by following parts by weight Chinese medicine material prepare and Into：15-35 parts of passion plant, 25-45 parts of Veronica, 15-35 parts of greyhair cipadessa root or leaf.
- 2. the Chinese medicine composition for the treatment of chronic cheilitis as claimed in claim 1, it is characterised in that it is by including following weight What the Chinese medicine material of part was prepared：20-30 parts of passion plant, 30-40 parts of Veronica, 20-30 parts of greyhair cipadessa root or leaf.
- 3. the Chinese medicine composition for the treatment of chronic cheilitis as claimed in claim 1 or 2, it is characterised in that its active ingredient is to adopt Carried with water or the extraction of the ethanol of 40-80% concentration expressed in percentage by volumes is prepared.
- 4. the Chinese medicine composition for the treatment of chronic cheilitis as claimed in claim 3, it is characterised in that its active ingredient is to pass through What following methods were prepared：Whole medicinal materials are taken, extracting in water 2-3 times after mixing, each amount of water is equivalent to medicinal material gross weight 6-12 times, each extraction time for 1-3 it is small when, merge extracting solution, filtration, relative density is when filtrate is concentrated into 70-80 DEG C The clear cream of 1.15-1.20, up to active ingredient.
- 5. the Chinese medicine composition for the treatment of chronic cheilitis as claimed in claim 3, it is characterised in that its active ingredient is to pass through What following methods were prepared：Whole medicinal materials are taken, are extracted 2-3 times with 40-80% alcohol refluxs after mixing, each ethanol consumption is 4-10 times of medicinal material total amount, when extraction time is 1-4 small, merges extracting solution, filtering, filtrate is concentrated into relatively close at 70-80 DEG C The clear cream for 1.15-1.20 is spent, up to active ingredient.
- 6. the Chinese medicine composition for the treatment of chronic cheilitis as claimed in claim 3, it is characterised in that its active ingredient is to pass through What following methods were prepared：Whole medicinal materials are taken, extracting in water 2-3 times after mixing, each amount of water is equivalent to medicinal material gross weight 6-12 times, each extraction time for 1-3 it is small when, merge extracting solution, filtration, relative density is when filtrate is concentrated into 70-80 DEG C The clear cream of 1.15-1.20, adds ethanol, and it is 40-70% to make alcohol content, and when standing 12-24 is small, filtration, filtrate is concentrated into 70-80 DEG C when relative density be 1.10-1.25 medicinal extract, up to active ingredient.
- 7. a kind of preparation for treating chronic cheilitis, Chinese medicine composition and doctor as the treatment chronic cheilitis described in claim 1-6 Pharmaceutically acceptable carrier, which prepares, to be formed.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011063580A (en) * | 2009-06-30 | 2011-03-31 | Kowa Co | Composition |
| CN106389594A (en) * | 2016-11-02 | 2017-02-15 | 杨均初 | Traditional Chinese medicine composition for curing nyctalopia and preparation method thereof |
-
2017
- 2017-12-06 CN CN201711274841.1A patent/CN107898862A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011063580A (en) * | 2009-06-30 | 2011-03-31 | Kowa Co | Composition |
| CN106389594A (en) * | 2016-11-02 | 2017-02-15 | 杨均初 | Traditional Chinese medicine composition for curing nyctalopia and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 王德鉴: "《中医耳鼻咽喉口腔科学》", 31 January 1994, 人民卫生出版社 * |
| 蒋红钢: "唇炎病案", 《HTTPS://MIP.HAODF.COM/ZHUANJIAGUANDIAN/4473153271.HTM》 * |
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Application publication date: 20180413 |