CN107890584A - Medical adhesive composition - Google Patents
Medical adhesive composition Download PDFInfo
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- CN107890584A CN107890584A CN201711229921.5A CN201711229921A CN107890584A CN 107890584 A CN107890584 A CN 107890584A CN 201711229921 A CN201711229921 A CN 201711229921A CN 107890584 A CN107890584 A CN 107890584A
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- CN
- China
- Prior art keywords
- parts
- adhesive composition
- phoenix
- camellia
- extraction concentrat
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention discloses a kind of medical adhesive composition, belongs to medical macromolecular materials technical field.The present invention is made by the raw material of following parts by weight:10 parts~15 parts of 50 parts~80 parts of polyisobutene, 15 parts~20 parts of glycerin monostearate, 15 parts~20 parts of camellia, 10 parts~20 parts of phoenix-tail fern, 6 parts~10 parts of cacumen biotae, 0.1 part~0.2 part of lignosulfonate, 15 parts~25 parts of ethanol, 1 part~5 parts of sodium alginate, 1 part~5 parts of agar and deionized water.The present invention is by adding camellia extraction concentrat, phoenix-tail fern extraction concentrat and cacumen biotae extraction concentrat, utilize caused potent antibacterial effect after its mutual compatibility so that the medical adhesive composition of product with the quick closure surface of a wound while acting on also with potent anti-infectious effect.
Description
Technical field
The invention belongs to medical macromolecular materials technical field, more particularly to a kind of medical adhesive composition.
Background technology
In the various operations of the surgeries such as traumatic wounds, cosmetic surgery, family planning, wound and the most common method of the surface of a wound are handled
It is that the position of tear or breakage is sutured using suture to fix, assists the healing of wound to reach healing purpose.But this method
With certain limitation, such as some operative sites are difficult to fix using suture, sewing effect again with doctor's operation skill
Qualification is relevant；And operation is relatively time consuming, and larger, obvious spot may be left after wound healing, applies art and took out stitches
Patient can not feel well in journey.Therefore medical field makes treatment faster, easy in searching one kind for a long time, and patient is in the treatment
Sense of discomfort it is less, treat more preferable wound processing method, to improve quality of medical care, reduce sufferer pain.And with adhesive come
Bonding wound is one of approach for solving this problem.
However, although medical adhesive composition has the advantages of as described above, but as scope of its application constantly expands,
Substantial amounts of clinical practice is found that some problems, such as：When open wound is applied, because substantial amounts of bacterium dirt be present in wound
Dye, the risk of infection is larger, although the application of adhesive enormously simplify operation technique, the energy quick closure surface of a wound, another aspect
The incidence of infection is still very high.Therefore, how to be provided simultaneously with the case where making the surface of a wound of adhesive quick closure anti-infective
Effect be one of research direction of current adhesive of medical.
The content of the invention
The present invention provides a kind of medical adhesive composition, so as to solve the only quick envelope of existing medical adhesive composition
The problem of effect of the surface of a wound closed is without anti-infectious effect.
In order to solve the above-mentioned technical problem, the technical solution adopted in the present invention is：
It is made by the raw material of following parts by weight：
50 parts~80 parts of polyisobutene, 15 parts~20 parts of glycerin monostearate, 15 parts~20 parts of camellia, 10 parts of phoenix-tail fern~
20 parts, 6 parts~10 parts of cacumen biotae, 0.1 part~0.2 part of lignosulfonate, 15 parts~25 parts of ethanol, 1 part~5 parts of sodium alginate,
10 parts~15 parts of 1 part~5 parts of agar and deionized water.
In above-mentioned technical proposal, more specifically technical scheme can also be：It, which is adopted, is prepared by the following steps：
A. based on above-mentioned parts by weight, first the camellia in raw material, phoenix-tail fern, cacumen biotae is extracted with water respectively, concentrated, is obtained
It is standby to camellia extraction concentrat, phoenix-tail fern extraction concentrat and cacumen biotae extraction concentrat；
B. first polyisobutene, glycerin monostearate and deionized water are uniformly mixed, are added followed by made from step A
Camellia extraction concentrat, phoenix-tail fern extraction concentrat and cacumen biotae extraction concentrat are uniformly mixed, and finally add sulphur
Change lignin, ethanol, sodium alginate, agar, stir.
Further, the electrical conductivity of the deionized water is less than 5 μ S/cm.
Due to being had the advantages that using above-mentioned technical proposal, the present invention：
The present invention is utilized by adding camellia extraction concentrat, phoenix-tail fern extraction concentrat and cacumen biotae extraction concentrat
Caused potent antibacterial effect after its mutual compatibility so that the medical adhesive composition of product is acting on the quick closure surface of a wound
Also there is potent anti-infectious effect simultaneously.
Embodiment
Below in conjunction with instantiation, the invention will be further described：
Embodiment 1 --- medical adhesive composition
It uses following raw material：
Polyisobutene 50kg, glycerin monostearate 15kg, camellia 15kg, phoenix-tail fern 10kg, cacumen biotae 6kg, sulfonation are wooden
Plain 0.1kg, ethanol 15kg, sodium alginate 1kg, agar 1kg and the ionized water 10kg for going electrical conductivity to be less than 5 μ S/cm；
Its preparation method comprises the following steps：
A. according to the above ratio, first the camellia in raw material, phoenix-tail fern, cacumen biotae are extracted with water respectively, concentrated, obtain mountain
Camellia extraction concentrat, phoenix-tail fern extraction concentrat and cacumen biotae extraction concentrat, it is standby；
B. first polyisobutene, glycerin monostearate and deionized water are uniformly mixed, are added followed by made from step A
Camellia extraction concentrat, phoenix-tail fern extraction concentrat and cacumen biotae extraction concentrat are uniformly mixed, and finally add sulphur
Change lignin, ethanol, sodium alginate, agar, stir.
Find that medical adhesive composition Wound healing rate made from the present embodiment reaches 100% ± 0.0, and can have through experiment
Suppression hospital bacteria yellow staphylococcus pyogenes, MRSE, Escherichia coli, Pseudomonas aeruginosa and the proteus mirabilis of effect
In the degree of solid culture basal growth, its inhibiting rate is followed successively by 90%, 91%, 88%, 88.9%, 90%.
Embodiment 2 --- medical adhesive composition
It uses following raw material：
Polyisobutene 70kg, glycerin monostearate 18kg, camellia 17kg, phoenix-tail fern 16kg, cacumen biotae 9kg, sulfonation are wooden
Plain 0.16kg, ethanol 20kg, sodium alginate 3kg, agar 4kg and the ionized water 14kg for going electrical conductivity to be less than 5 μ S/cm；
Its preparation method comprises the following steps：
A. according to the above ratio, first the camellia in raw material, phoenix-tail fern, cacumen biotae are extracted with water respectively, concentrated, obtain mountain
Camellia extraction concentrat, phoenix-tail fern extraction concentrat and cacumen biotae extraction concentrat, it is standby；
B. first polyisobutene, glycerin monostearate and deionized water are uniformly mixed, are added followed by made from step A
Camellia extraction concentrat, phoenix-tail fern extraction concentrat and cacumen biotae extraction concentrat are uniformly mixed, and finally add sulphur
Change lignin, ethanol, sodium alginate, agar, stir.
Find that medical adhesive composition Wound healing rate made from the present embodiment reaches 100% ± 0.0, and can have through experiment
Suppression hospital bacteria yellow staphylococcus pyogenes, MRSE, Escherichia coli, Pseudomonas aeruginosa and the proteus mirabilis of effect
In the degree of solid culture basal growth, its inhibiting rate is followed successively by 90.5%, 91.1%, 88.8%, 88.7%, 90.8%.
Embodiment 3 --- medical adhesive composition
It uses following raw material：
Polyisobutene 80kg, glycerin monostearate 20kg, camellia 20kg, phoenix-tail fern 20kg, cacumen biotae 10kg, sulfonation are wooden
Plain 0.2kg, ethanol 25kg, sodium alginate 5kg, agar 5kg and the ionized water 15kg for going electrical conductivity to be less than 5 μ S/cm；
Its preparation method comprises the following steps：
A. according to the above ratio, first the camellia in raw material, phoenix-tail fern, cacumen biotae are extracted with water respectively, concentrated, obtain mountain
Camellia extraction concentrat, phoenix-tail fern extraction concentrat and cacumen biotae extraction concentrat, it is standby；
B. first polyisobutene, glycerin monostearate and deionized water are uniformly mixed, are added followed by made from step A
Camellia extraction concentrat, phoenix-tail fern extraction concentrat and cacumen biotae extraction concentrat are uniformly mixed, and finally add sulphur
Change lignin, ethanol, sodium alginate, agar, stir.
Find that medical adhesive composition Wound healing rate made from the present embodiment reaches 100% ± 0.0, and can have through experiment
Suppression hospital bacteria yellow staphylococcus pyogenes, MRSE, Escherichia coli, Pseudomonas aeruginosa and the proteus mirabilis of effect
In the degree of solid culture basal growth, its inhibiting rate is followed successively by 91%, 90.9%, 89.0%, 88.7%, 90.5%.
Comparative example 1 --- medical adhesive composition
It uses following raw material：
Polyisobutene 50kg, glycerin monostearate 15kg, lignosulfonate 0.1kg, ethanol 15kg, sodium alginate 1kg, agar
The 1kg and ionized water 10kg for going electrical conductivity to be less than 5 μ S/cm；
Its preparation method comprises the following steps：
First polyisobutene, glycerin monostearate and deionized water are uniformly mixed, are added followed by lignosulfonate, second
Alcohol, sodium alginate, agar, stir.
Find that its Wound healing rate of medical adhesive composition is only 91% ± 0.0 made from this comparative example, and right through experiment
Hospital bacteria yellow staphylococcus pyogenes, MRSE, Escherichia coli, Pseudomonas aeruginosa and proteus mirabilis are trained in solid
The inhibiting rate for supporting basal growth degree is only 50%, 51%, 48%, 48.9%, 50% successively.
Comparative example 2 --- medical adhesive composition
It uses following raw material：
Polyisobutene 70kg, glycerin monostearate 18kg, lignosulfonate 0.16kg, ethanol 20kg, sodium alginate 3kg, fine jade
The fat 4kg and ionized water 14kg for going electrical conductivity to be less than 5 μ S/cm；
Its preparation method comprises the following steps：
First polyisobutene, glycerin monostearate and deionized water are uniformly mixed, are added followed by lignosulfonate, second
Alcohol, sodium alginate, agar, stir.
Find that its Wound healing rate of medical adhesive composition is only 91% ± 0.0 made from this comparative example, and right through experiment
Hospital bacteria yellow staphylococcus pyogenes, MRSE, Escherichia coli, Pseudomonas aeruginosa and proteus mirabilis are trained in solid
The inhibiting rate for supporting basal growth degree is only 50.5%, 51.1%, 48.8%, 48.7%, 50.8% successively.
Comparative example 3 --- medical adhesive composition
It uses following raw material：
Polyisobutene 80kg, glycerin monostearate 20kg, lignosulfonate 0.2kg, ethanol 25kg, sodium alginate 5kg, agar
The 5kg and ionized water 15kg for going electrical conductivity to be less than 5 μ S/cm；
Its preparation method comprises the following steps：
First polyisobutene, glycerin monostearate and deionized water are uniformly mixed, are added followed by lignosulfonate, second
Alcohol, sodium alginate, agar, stir.
Find that its Wound healing rate of medical adhesive composition is only 91% ± 0.0 made from this comparative example, and right through experiment
Hospital bacteria yellow staphylococcus pyogenes, MRSE, Escherichia coli, Pseudomonas aeruginosa and proteus mirabilis are trained in solid
The inhibiting rate for supporting basal growth degree is only 51%, 50.9%, 49.0%, 48.7%, 50.5% successively.
Claims (3)
1. a kind of medical adhesive composition, it is characterised in that be made by the raw material of following parts by weight：
50 parts~80 parts of polyisobutene, 15 parts~20 parts of glycerin monostearate, 15 parts~20 parts of camellia, 10 parts of phoenix-tail fern~
20 parts, 6 parts~10 parts of cacumen biotae, 0.1 part~0.2 part of lignosulfonate, 15 parts~25 parts of ethanol, 1 part~5 parts of sodium alginate,
10 parts~15 parts of 1 part~5 parts of agar and deionized water.
2. medical adhesive composition according to claim 1, it is characterised in that adopt and be prepared by the following steps：
A. based on above-mentioned parts by weight, first the camellia in raw material, phoenix-tail fern, cacumen biotae is extracted with water respectively, concentrated, is obtained
It is standby to camellia extraction concentrat, phoenix-tail fern extraction concentrat and cacumen biotae extraction concentrat；
B. first polyisobutene, glycerin monostearate and deionized water are uniformly mixed, are added followed by made from step A
Camellia extraction concentrat, phoenix-tail fern extraction concentrat and cacumen biotae extraction concentrat are uniformly mixed, and finally add sulphur
Change lignin, ethanol, sodium alginate, agar, stir.
3. medical adhesive composition according to claim 1 or 2, it is characterised in that：The electrical conductivity of the deionized water is small
In 5 μ S/cm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711229921.5A CN107890584A (en) | 2017-11-29 | 2017-11-29 | Medical adhesive composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711229921.5A CN107890584A (en) | 2017-11-29 | 2017-11-29 | Medical adhesive composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107890584A true CN107890584A (en) | 2018-04-10 |
Family
ID=61806721
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711229921.5A Withdrawn CN107890584A (en) | 2017-11-29 | 2017-11-29 | Medical adhesive composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107890584A (en) |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1225022A (en) * | 1996-07-10 | 1999-08-04 | 科洛普拉斯特公司 | Adhesive agent and use of such agent |
| CN101530437A (en) * | 2008-03-12 | 2009-09-16 | 北京星昊嘉宇医药科技有限公司 | Method for extracting flavonoid compound from bracken |
| CN102224212A (en) * | 2008-12-18 | 2011-10-19 | 科洛普拉斯特公司 | A permeable pressure sensitive adhesive |
| CN102961600A (en) * | 2012-11-02 | 2013-03-13 | 常杰 | Hemostatic medicine |
| CN104548194A (en) * | 2014-12-18 | 2015-04-29 | 方萌 | Medical high-performance binding agent |
| CN106267326A (en) * | 2016-11-01 | 2017-01-04 | 金福兴 | A kind of clinical medical binding agent of low irritant and preparation method thereof |
| CN106362199A (en) * | 2016-11-01 | 2017-02-01 | 金福兴 | Medical adhesive with good antibacterial property and preparation method of medical adhesive |
| CN106362197A (en) * | 2016-11-01 | 2017-02-01 | 金福兴 | Adhesive for surgical operation and preparation method thereof |
| CN106390183A (en) * | 2016-11-01 | 2017-02-15 | 金福兴 | Adhesive used for human body soft tissues, and preparation method thereof |
| CN106943537A (en) * | 2017-02-28 | 2017-07-14 | 上海清轩生物科技有限公司 | Bactericidal composition and the moisturizing remediation composition containing camellia seed oil |
| CN107530471A (en) * | 2015-04-30 | 2018-01-02 | 科洛普拉斯特公司 | Adhesive composition |
-
2017
- 2017-11-29 CN CN201711229921.5A patent/CN107890584A/en not_active Withdrawn
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1225022A (en) * | 1996-07-10 | 1999-08-04 | 科洛普拉斯特公司 | Adhesive agent and use of such agent |
| CN101530437A (en) * | 2008-03-12 | 2009-09-16 | 北京星昊嘉宇医药科技有限公司 | Method for extracting flavonoid compound from bracken |
| CN102224212A (en) * | 2008-12-18 | 2011-10-19 | 科洛普拉斯特公司 | A permeable pressure sensitive adhesive |
| CN102961600A (en) * | 2012-11-02 | 2013-03-13 | 常杰 | Hemostatic medicine |
| CN104548194A (en) * | 2014-12-18 | 2015-04-29 | 方萌 | Medical high-performance binding agent |
| CN107530471A (en) * | 2015-04-30 | 2018-01-02 | 科洛普拉斯特公司 | Adhesive composition |
| CN106267326A (en) * | 2016-11-01 | 2017-01-04 | 金福兴 | A kind of clinical medical binding agent of low irritant and preparation method thereof |
| CN106362199A (en) * | 2016-11-01 | 2017-02-01 | 金福兴 | Medical adhesive with good antibacterial property and preparation method of medical adhesive |
| CN106362197A (en) * | 2016-11-01 | 2017-02-01 | 金福兴 | Adhesive for surgical operation and preparation method thereof |
| CN106390183A (en) * | 2016-11-01 | 2017-02-15 | 金福兴 | Adhesive used for human body soft tissues, and preparation method thereof |
| CN106943537A (en) * | 2017-02-28 | 2017-07-14 | 上海清轩生物科技有限公司 | Bactericidal composition and the moisturizing remediation composition containing camellia seed oil |
Non-Patent Citations (2)
| Title |
|---|
| 傅瑞春等: "20 种中草药提取物的体外抗菌作用研究", 《时珍国医国药》 * |
| 邹家丽等: "山茶花中多酚提取的方法及其抗氧化活性测定研究", 《北方园艺》 * |
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Application publication date: 20180410 |
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