CN103432160A - Broad spectrum contact type medical surgical lavage fluid and preparation method thereof - Google Patents
Broad spectrum contact type medical surgical lavage fluid and preparation method thereof Download PDFInfo
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- CN103432160A CN103432160A CN2013103584274A CN201310358427A CN103432160A CN 103432160 A CN103432160 A CN 103432160A CN 2013103584274 A CN2013103584274 A CN 2013103584274A CN 201310358427 A CN201310358427 A CN 201310358427A CN 103432160 A CN103432160 A CN 103432160A
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- lavage fluid
- purified water
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- rustless steel
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- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 239000012530 fluid Substances 0.000 title abstract 5
- 239000008213 purified water Substances 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229920001661 Chitosan Polymers 0.000 claims abstract description 9
- 239000008363 phosphate buffer Substances 0.000 claims abstract description 9
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 9
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229920000153 Povidone-iodine Polymers 0.000 claims abstract description 6
- 229960001621 povidone-iodine Drugs 0.000 claims abstract description 6
- 230000001954 sterilising effect Effects 0.000 claims abstract description 6
- 239000013010 irrigating solution Substances 0.000 claims description 16
- 229910000831 Steel Inorganic materials 0.000 claims description 12
- 239000010959 steel Substances 0.000 claims description 12
- 239000000839 emulsion Substances 0.000 claims description 9
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims description 8
- 229940070384 ventolin Drugs 0.000 claims description 8
- 229940099259 vaseline Drugs 0.000 claims description 6
- 239000000243 solution Substances 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 3
- 238000012423 maintenance Methods 0.000 claims description 3
- 239000011259 mixed solution Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 4
- 230000012010 growth Effects 0.000 abstract description 3
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 3
- 230000029663 wound healing Effects 0.000 abstract description 3
- 230000008901 benefit Effects 0.000 abstract description 2
- 210000002950 fibroblast Anatomy 0.000 abstract description 2
- 230000001737 promoting effect Effects 0.000 abstract 2
- KUXGUCNZFCVULO-UHFFFAOYSA-N 2-(4-nonylphenoxy)ethanol Chemical compound CCCCCCCCCC1=CC=C(OCCO)C=C1 KUXGUCNZFCVULO-UHFFFAOYSA-N 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 229920002385 Sodium hyaluronate Polymers 0.000 abstract 1
- 244000052616 bacterial pathogen Species 0.000 abstract 1
- 230000000740 bleeding effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 229950003169 nonoxinol Drugs 0.000 abstract 1
- 235000019271 petrolatum Nutrition 0.000 abstract 1
- 229940010747 sodium hyaluronate Drugs 0.000 abstract 1
- 208000031737 Tissue Adhesions Diseases 0.000 description 4
- 230000002980 postoperative effect Effects 0.000 description 2
- 206010058046 Post procedural complication Diseases 0.000 description 1
- 208000035965 Postoperative Complications Diseases 0.000 description 1
- 230000002547 anomalous effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to broad spectrum contact type medical surgical lavage fluid which comprises the following components in percent by weight: 2-15 percent of sodium hyaluronate, 10-15 percent of phosphate buffer, 5-15 percent of povidone-iodine, 5-15 percent of chitosan, 5-15 percent of petroleum jelly for medical purposes, 2-7 percent of nonoxinol and the balance of purified water. According to the broad spectrum contact type medical surgical lavage fluid and the preparation method thereof, the lavage fluid with the design can have an effect of killing germs, the advantage that the sterilization product is always rapid, high-efficiency and long-term in duration is ensured, and the lavage fluid has the functions of stopping bleeding, killing bacteria, promoting epidermal growth and inhibiting fibroblast growth and has the effects of repairing a protection box and promoting wound healing.
Description
Technical field
The present invention relates to the field of medical care articles for use, especially a kind of broad-spectrum touch-out medical operation irrigating solution and preparation method thereof.
Background technology
At present, in medical treatment clinical course, irrigating solution is in therapeutic process, can prevent postoperative tissue adhesion, adhesion is that connective fiber band and adjacent tissue or organ combine and the anomalous structure that forms, and postoperative tissue adhesion is one of the most serious post-operative complication of causing of operation process.Tissue adhesion's idealized model after the proposition iatrotechnics: can effectively prevent tissue adhesion's form, but can not affect wound healing; Can effectively stop blooding; Can suppress micro-organisms, this irrigating solution is of paramount importance on current clinical medicine, but the irrigating solution used does not at present possess the purpose of sterilization, and its function is relatively single.
Summary of the invention
The technical problem to be solved in the present invention is: in order to overcome the problem of above-mentioned middle existence, provide a kind of broad-spectrum touch-out medical operation irrigating solution and preparation method thereof.
The technical solution adopted for the present invention to solve the technical problems is: a kind of broad-spectrum touch-out medical operation irrigating solution comprises that the weight percentage by each component is: hyaluronate sodium 2～15%, phosphate buffer 10～15%, povidone iodine 5～15%, chitosan 5～15%, medical ventolin 5～15%, nonoxynolum 2～7%, all the other are purified water.
Weight percentage by each component is: hyaluronate sodium 10%, phosphate buffer 12%, povidone iodine 12%, chitosan 12%, medical ventolin 12%, nonoxynolum 5%, all the other are purified water
Concrete steps are as follows:
A. purchased the each component raw material according to the total amount percentage composition of each component;
B. according to matched proportion density, medical ventolin is put into to reactor in first rustless steel container and boiled maintenance 30 minutes, until vaseline is all melted, then nonoxynolum is added in the rustless steel container with vaseline and forms emulsion, emulsion is lowered the temperature 30 minutes, added chitosan and purified water in the emulsion after cooling;
C. inject purified water after according to matched proportion density, hyaluronate sodium, phosphate buffer being mixed in the second rustless steel container, carry out autoclaving; Sterilizing 30 minutes;
D. b and the mixed solution of c are added in the 3rd rustless steel container and mixed, after stirring 10 minutes, solution left standstill, after 6 hours, is to the irrigating solution finished product.
The invention has the beneficial effects as follows: described a kind of broad-spectrum touch-out medical operation irrigating solution and preparation method thereof; the irrigating solution of this kind of design; can possess the effect of disinfection; and guaranteed sterilising prods all the time in rapidly and efficiently, permanent advantage of persistent period; and possessed simultaneously hemostasis, antibacterial, promote epithelial cell growth, be suppressed to the function of fibroblast growth, the effect that there is good protection box repair and promote wound healing.
The specific embodiment
A kind of broad-spectrum touch-out medical operation of the present invention irrigating solution and preparation method thereof, concrete steps are as follows:
A. purchased the each component raw material according to the total amount percentage composition of each component, wherein hyaluronate sodium 10%, phosphate buffer 12%, povidone iodine 12%, chitosan 12%, medical ventolin 12%, nonoxynolum 5%, all the other are purified water;
B. according to matched proportion density, medical ventolin is put into to reactor in first rustless steel container and boiled maintenance 30 minutes, until vaseline is all melted, then 5% nonoxynolum is added in the rustless steel container with vaseline and forms emulsion, emulsion is lowered the temperature 30 minutes, added 12% chitosan and purified water in the emulsion after cooling;
C. inject purified water after according to matched proportion density, 10% hyaluronate sodium, 12% phosphate buffer being mixed in the second rustless steel container, carry out autoclaving; Sterilizing 30 minutes;
D. b and the mixed solution of c are added in the 3rd rustless steel container and mixed, after stirring 10 minutes, solution left standstill, after 6 hours, is to the irrigating solution finished product.
The above-mentioned foundation desirable embodiment of the present invention of take is enlightenment, and by above-mentioned description, the relevant staff can, in the scope that does not depart from this invention technological thought, carry out various change and modification fully.The technical scope of this invention is not limited to the content on description, must determine its technical scope according to the claim scope.
Claims (3)
1. broad-spectrum touch-out medical operation irrigating solution is characterized in that: comprise that the weight percentage by each component is: hyaluronate sodium 2～15%, phosphate buffer 10～15%, povidone iodine 5～15%, chitosan 5～15%, medical ventolin 5～15%, nonoxynolum 2～7%, all the other are purified water.
2. a kind of broad-spectrum touch-out medical operation irrigating solution according to claim 1, it is characterized in that: the weight percentage by each component is: hyaluronate sodium 10%, phosphate buffer 12%, povidone iodine 12%, chitosan 12%, medical ventolin 12%, nonoxynolum 5%, all the other are purified water.
3. the preparation method of broad-spectrum touch-out medical operation irrigating solution, it is characterized in that: concrete steps are as follows:
A. purchased the each component raw material according to the total amount percentage composition of each component;
B. according to matched proportion density, medical ventolin is put into to reactor in first rustless steel container and boiled maintenance 30 minutes, until vaseline is all melted, then nonoxynolum is added in the rustless steel container with vaseline and forms emulsion, emulsion is lowered the temperature 30 minutes, added chitosan and purified water in the emulsion after cooling;
C. inject purified water after according to matched proportion density, hyaluronate sodium, phosphate buffer being mixed in the second rustless steel container, carry out autoclaving; Sterilizing 30 minutes;
D. b and the mixed solution of c are added in the 3rd rustless steel container and mixed, after stirring 10 minutes, solution left standstill, after 6 hours, is to the irrigating solution finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013103584274A CN103432160A (en) | 2013-08-16 | 2013-08-16 | Broad spectrum contact type medical surgical lavage fluid and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013103584274A CN103432160A (en) | 2013-08-16 | 2013-08-16 | Broad spectrum contact type medical surgical lavage fluid and preparation method thereof |
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| Publication Number | Publication Date |
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| CN103432160A true CN103432160A (en) | 2013-12-11 |
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| CN2013103584274A Pending CN103432160A (en) | 2013-08-16 | 2013-08-16 | Broad spectrum contact type medical surgical lavage fluid and preparation method thereof |
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| Country | Link |
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| CN (1) | CN103432160A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019119668A1 (en) * | 2017-12-21 | 2019-06-27 | 惠觅宙 | Composition with strong anti-inflammatory activity and application thereof |
| CN113144281A (en) * | 2021-04-19 | 2021-07-23 | 深圳市安多福消毒高科技股份有限公司 | Wound surface disinfection gel and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101028280A (en) * | 2006-03-01 | 2007-09-05 | 上海其胜生物制剂有限公司 | Lavage liquor preparation for operation and its production |
| CN101816678A (en) * | 2010-04-19 | 2010-09-01 | 江苏省健尔康医用敷料有限公司 | Broad-spectrum contact type hemostatic medical fungicide and preparation method thereof |
-
2013
- 2013-08-16 CN CN2013103584274A patent/CN103432160A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101028280A (en) * | 2006-03-01 | 2007-09-05 | 上海其胜生物制剂有限公司 | Lavage liquor preparation for operation and its production |
| CN101816678A (en) * | 2010-04-19 | 2010-09-01 | 江苏省健尔康医用敷料有限公司 | Broad-spectrum contact type hemostatic medical fungicide and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019119668A1 (en) * | 2017-12-21 | 2019-06-27 | 惠觅宙 | Composition with strong anti-inflammatory activity and application thereof |
| CN113144281A (en) * | 2021-04-19 | 2021-07-23 | 深圳市安多福消毒高科技股份有限公司 | Wound surface disinfection gel and preparation method thereof |
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Application publication date: 20131211 |