CN107890557A - Chinese medicine composition, capsule and preparation method for invigorating Qi and tonifying kidney - Google Patents
Chinese medicine composition, capsule and preparation method for invigorating Qi and tonifying kidney Download PDFInfo
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- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The present invention discloses a kind of Chinese medicine composition, capsule and preparation method for invigorating Qi and tonifying kidney.Chinese medicine composition of the present invention for invigorating Qi and tonifying kidney is made up of barrenwort, fenugreek, Morinda officinalis, psoralea corylifolia, polygala, spina date seed, Poria cocos, Radix Angelicae Sinensis, arillus longan, the Radix Astragali, the bighead atractylodes rhizome, baked ginger, jujube, radix glycyrrhizae, the banksia rose, dog kidney, red ginseng, deer horn glue, colla carapacis et plastri testudinis and Chinese cassia tree plurality of raw materials medicine through water and ethanol extraction.The present invention optimizes the Traditional Chinese medicine composition formula for invigorating Qi and tonifying kidney, selected a variety of Chinese herbal medicines are equipped with suitable method and are prepared, can warming and invigorating kidney Yang, liver and kidney benefiting, replenishing vital essence and blood, strengthening the bones and muscles, there is obvious establishing-Yang, improve the effect of sexuality, antifatigue, anti-aging, immune enhancing, significant curative effect is played to kidney-yang deficiency symptom.
Description
Technical field
The present invention relates to the field of Chinese medicines, more particularly to a kind of Chinese medicine composition, capsule and preparation side for invigorating Qi and tonifying kidney
Method.
Background technology
Theory of traditional Chinese medical science thinks that the kidney being the origin of congenital constitution, internal organs this, 12 through root, hide Kidney-Yin and Yuanyang of residing, be people it
Reproduction, the source of development, kidney essense is sufficient, and negative and positive interpromoting relation in five elements is mutually helped, and the kidney qi of meaning is contained.Kidney qi Sheng person can physically well develop when young,
Life is flourishing, and the young stage is physically strong, energetic, and man has the beauty of strong manliness, and female has youth glamour.The between twenty and fifty phase prolongs relatively
Long, aging is substantially postponed.The light body of body is remained into the senescence phase to be good for, and there is preferable resistance against diseases.The prosperity and decline of kidney qi is for people's
The growing, strengthen of reproductive function and people, old life process plays dominant force effect.Kidney and the same gas of gate of vitality's sheet, are personal negative and positive
The hinge of growth and decline.Kidney yang dominates the yang-energy of the whole body, and the decline card of its then deficiency of yang of fire comes out one after another.
Kidney-yang deficiency, i.e. kidney deficient and weak YANG QI, it is the disease of kidney yang-energy exhaustion performance, more by innate deficiency of YANG in the body, or old kidney
Thanks to, or prolonged illness is impairment of the kidney, or caused by the factor such as excess of sexual intercourse,indulgence in sexual activities." kidney " in " kidney-yang deficiency " concept that traditional medicine is said, not only
Refer to kidney anatomically, and be that a physiological action is quite extensive, with human body reproduction, grow, endocrine metabolism etc.
There is the important organ of direct or indirect relation." kidney-yang deficiency symptom " is a wide in range concept, and it includes urinary system, reproduction
The relevant disease of all multisystems such as system, endocrine metabolism system, neuropsychiatric.
Kidney-yang deficiency clinical symptoms are mainly hypogona dism, in poor health, metal fatigue, lassitude in loin and legs, are had a dizzy spell,
Many nights many urine, forgetful insomnia etc..With the continuous quickening of rhythm of life, social pressures are continuously increased, in sub-health state
Kidney-yang deficiency patient numbers constantly rise, and kidney-yang deficiency illness brings great damage to the body and psychology of many patients, has a strong impact on
Its work and life.However, corresponding medicine, health products etc. are not yet fully up to expectations at present, if Western medicine is more using sex hormone, expansion
Medicine and angiotensin converting enzyme inhibitor of blood vessel etc. are opened, though having certain curative effect, its effect can not be lasting, and west
Medicine is to cure the symptoms, not the disease, and also has side effect to body, can not be long-term use of.
Yangzhou China higher using drug safety made of pure Chinese medicine relative to Western medicine such as sex hormone, such as instantly commercially available
The capsule for invigorating Qi and tonifying kidney of Tian Bao pharmaceutcal corporation, Ltd production, it is with Semen Cuscutae (stir-fry), barrenwort (steaming), teasel root (steaming),
Cynomorium songaricum (steaming), rhizoma cibotii (steaming), spina date seed (stir-fry), prepared fleece flower root, honey-fried licorice root, dried orange peel (steaming), deer horn glue (stir-fry), prepared rhizome of rehmannia, tortoise plastron
Glue (stir-fry), the fruit of Cherokee rose (steaming), the sweet Radix Astragali, Chinese yam (stir-fry), raspberry (steaming) plurality of Chinese are that composition is prepared into capsule, are strengthened the bone,
Replenishing qi and blood, kidney-replenishing.For in poor health caused by kidney-yang deficiency, metal fatigue, lassitude in loin and legs, have a dizzy spell, many nights many urine,
Forgetful insomnia etc..But because its Chinese medicine preparation and preparation technology not enough optimize, effect is not fine.
The content of the invention
The main object of the present invention is to provide a kind of Chinese medicine composition for invigorating Qi and tonifying kidney, it is intended to solves the above problems.
To achieve the above object, the Chinese medicine composition proposed by the present invention for invigorating Qi and tonifying kidney, the Chinese medicine composition are pressed
Parts by weight meter includes：The barrenwort of 80-120 parts, 50-80 part faenum graecums, 50-80 part dog kidneys, 50-80 part psoralea corylifolias, 70-90 parts
Colla carapacis et plastri testudinis, 50-80 part Morinda officinalis, 30-45 part polygalas, 30-45 part spina date seeds, 30-45 part Poria cocos, 30-45 part Radix Angelicae Sinensis, 60-75
Part arillus longan, 30-50 part red ginsengs, 10-25 part Radixs Astragali, 35-45 part bighead atractylodes rhizomes, 35-45 part banksia rose, 35-48 part baked gingers, 58-73 parts
Jujube, 57-71 part radix glycyrrhizaes.
Preferably, each raw material medicines in portions by weight of the Chinese medicine composition is：
100 parts of barrenwort, 67 parts of faenum graecums, 67 parts of dog kidneys, 67 parts of psoralea corylifolias, 83 parts of colla carapacis et plastri testudinises, 67 parts of Morinda officinalis are 67 parts remote
Will, 42 parts of spina date seeds, 42 parts of Poria cocos, 42 parts of Radix Angelicae Sinensis, 67 portions of arillus longans, 42 parts of red ginsengs, 13 parts of Radixs Astragali, 42 parts of bighead atractylodes rhizomes, 42 parts of wood
Perfume (or spice), 42 portions of baked gingers, 67 portions of jujubes, 67 portions of radix glycyrrhizaes.
Preferably, each raw material medicines in portions by weight of the Chinese medicine composition is：
95 parts of barrenwort, 70 parts of faenum graecums, 65 parts of dog kidneys, 65 parts of psoralea corylifolias, 80 parts of colla carapacis et plastri testudinises, 72 parts of Morinda officinalis are 40 parts remote
Will, 35 parts of spina date seeds, 42 parts of Poria cocos, 35 parts of Radix Angelicae Sinensis, 70 portions of arillus longans, 45 parts of red ginsengs, 20 parts of Radixs Astragali, 38 parts of bighead atractylodes rhizomes, 45 parts of wood
Perfume (or spice), 45 portions of baked gingers, 70 portions of jujubes, 70 portions of radix glycyrrhizaes.
In addition, to achieve the above object, the present invention also proposes a kind of capsule for invigorating Qi and tonifying kidney, the capsule includes such as right
It is it is required that upper described for the Chinese medicine composition of invigorating Qi and tonifying kidney, pharmaceutic adjuvant and for wrapping up the Chinese medicine composition and medicinal
The capsule skin of auxiliary material.
Preferably, the pharmaceutic adjuvant is dextrin.
In addition, to achieve the above object, the present invention also proposes a kind of preparation side of the Chinese medicine composition for invigorating Qi and tonifying kidney
Method, the preparation method comprise the following steps：
Step 1, medicinal material processing is handled；
Step 2, crushed after deer horn glue, colla carapacis et plastri testudinis vacuum drying, red ginseng, Chinese cassia tree are cleaned, vacuum drying, crush, standby；
Step 3, dog kidney channel alcohol reflux purifies, ethanol extract filtration, and gained dog Renal extract is standby；
Step 4, by barrenwort, faenum graecum, Morinda officinalis, psoralea corylifolia, polygala, spina date seed, Poria cocos, Radix Angelicae Sinensis, arillus longan, the Radix Astragali, white
Art, baked ginger, jujube, radix glycyrrhizae and the banksia rose are handled through water extracting alcohol, and it is standby to obtain mixed extract；
Step 5, mixed extract merges away ethanol with dog Renal extract, concentration, after drying, and adds deer horn glue, colla carapacis et plastri testudinis, red
Ginseng, Chinese cassia tree mixing, obtain the Chinese medicine composition for invigorating Qi and tonifying kidney.
Preferably, the step 3 specifically includes：
Dog kidney is ground into coarse powder, and with the extraction of 50% alcohol reflux three times, 4 ~ 8 times of amounts, are extracted 3 hours for the first time, 4 ~ 6 times for the second time
Amount, extraction 2 hours, 4 ~ 6 times of amounts of third time, extract 1 hour, merge ethanol extract, filter, filtrate is standby.
Preferably, the step 4 specifically includes：
By barrenwort, faenum graecum, Morinda officinalis, psoralea corylifolia, polygala, spina date seed, Poria cocos, Radix Angelicae Sinensis, arillus longan, the Radix Astragali, the bighead atractylodes rhizome, big gun
Ginger, jujube, radix glycyrrhizae and the banksia rose add water to cook secondary, for the first time plus 4 ~ 8 times of water amount, extract 3 hours, second plus 4 ~ 6 times of amounts of water,
Extraction 2 hours, collecting decoction, filtration, filtrate are concentrated into the clear cream that relative density is 1.14~1.16 at 80 DEG C, add ethanol extremely
Alcohol content is stirred evenly, stood overnight, filter up to 60%.
Preferably, specifically included in the step 5：
The extract solution obtained in the extract solution and step 4 that are obtained in step 3 is merged, ethanol is reclaimed, is concentrated into relative density and exists
It is 1.28~1.30 thick paste at 80 DEG C, is dried under reduced pressure, crushes.
Preferably, each raw material medicines in portions by weight is：
The barrenwort of 80-120 parts, 50-80 part faenum graecums, 50-80 part dog kidneys, 50-80 part psoralea corylifolias, 70-90 part colla carapacis et plastri testudinises,
50-80 part Morinda officinalis, 30-45 part polygalas, 30-45 part spina date seeds, 30-45 part Poria cocos, 30-45 part Radix Angelicae Sinensis, 60-75 part longans
Meat, 30-50 part red ginsengs, 10-25 part Radixs Astragali, 35-45 part bighead atractylodes rhizomes, 35-45 part banksia rose, 35-48 part baked gingers, 58-73 part jujubes,
57-71 part radix glycyrrhizaes.
The mouse test result of Chinese medicine composition of the present invention for invigorating Qi and tonifying kidney shows that it can be significantly improved
The weight of gesture hero mouse preputial gland, seminal fluid and prostate, and YANG asthenia disease model mice body weight can be improved, improved in mouse 5 seconds
Number of activities and Burden-Swimming Ability of KM, as a result better than the capsule and model group of the Chinese medicine composition for being commercially for invigorating Qi and tonifying kidney.
Meanwhile the capsule thing of the present invention for invigorating Qi and tonifying kidney has taken obvious curative effects through clinical kidney-yang deficiency patient, its
Middle to be taken through clinical 96 kidney-yang deficiency patients, the patient feels of 7-15 days 95% are refreshed oneself, energetic, are continuously taken 3 months,
87% patient can carry out normal sexual life, and drug withdrawal does not rebound.Taken through clinical 30 patients, continuously take 30 days, face
Bed total effective rate is 95%, dizziness and tinnitus, spiritlessness and weakness, soreness and weakness of waist and knees, insomnia forgetfulness, and the cold cold grade of limb of shape has improvement.
From above technical scheme, the present invention optimizes the Traditional Chinese medicine composition formula for invigorating Qi and tonifying kidney, it is selected it is a variety of in
Herbal medicine is equipped with suitable method and is prepared, can warming and invigorating kidney Yang, liver and kidney benefiting, replenishing vital essence and blood, strengthening the bones and muscles, have obvious establishing-Yang, improve property
The effect of ability, antifatigue, anti-aging, immune enhancing, significant curative effect is played to kidney-yang deficiency symptom.
Specific embodiment
The embodiment of the invention discloses a kind of Chinese medicine composition for invigorating Qi and tonifying kidney and preparation method thereof.Art technology
Personnel can use for reference content of text, be suitably modified technological parameter realization.In particular, all similar replacements and change
Dynamic apparent to those skilled in the art, they are considered as being included in the present invention.The product of the present invention and side
Method is described by preferred embodiment, and related personnel can substantially not depart from present invention, spirit and scope pair
Product as described herein and method are modified or suitably changed with combining, to realize and using the technology of the present invention.
For a further understanding of the present invention, with reference to embodiment to provided by the invention a kind of in invigorating Qi and tonifying kidney
Drug composition and preparation method thereof.
Embodiment 1：Preparation method of the present invention prepares the Chinese medicine composition for invigorating Qi and tonifying kidney.
Raw material medicine composition：95 parts of barrenwort, 70 parts of faenum graecums, 65 parts of dog kidneys, 65 parts of psoralea corylifolias, 80 parts of colla carapacis et plastri testudinises, 72
Part Morinda officinalis, 40 parts of polygalas, 35 parts of spina date seeds, 42 parts of Poria cocos, 35 parts of Radix Angelicae Sinensis, 70 portions of arillus longans, 45 parts of red ginsengs, 20 parts of Radixs Astragali,
38 parts of bighead atractylodes rhizomes, 45 parts of banksia rose, 45 portions of baked gingers, 70 portions of jujubes, 70 portions of radix glycyrrhizaes.
The taste of the above 20, deer horn glue, colla carapacis et plastri testudinis, red ginseng, Chinese cassia tree are ground into fine powder, standby；Dog kidney is ground into coarse powder, with
50% alcohol reflux extracts three times, for the first time 5 times of amounts, extracts 3 hours, second of 4 times of amount, extracts 2 hours, 4 times of amounts of third time,
Extraction 1 hour, merge ethanol extract, filter, filtrate is standby；The five tastes of remaining barrenwort etc. ten, add water to cook secondary, first time
Add 6 times of amounts of water, extract 3 hours, second plus 4 times of amounts of water, extract 2 hours, collecting decoction, filtration, filtrate is concentrated into relatively close
The clear cream for spending to be 1.15 at 80 DEG C, add ethanol to stir evenly, stand overnight to alcohol content up to 60%, filter, filtrate and above-mentioned dog
Renal extract merges, and reclaims ethanol, is concentrated into relative density as the thick paste for being 1.28 at 80 DEG C, is dried under reduced pressure, crushes, add
Deer horn glue, colla carapacis et plastri testudinis, red ginseng, the fine powder of Chinese cassia tree, mix, obtain mixture.
Embodiment 2：Preparation method of the present invention prepares the Chinese medicine composition for invigorating Qi and tonifying kidney.
Raw material medicine composition：100 parts of barrenwort, 67 parts of faenum graecums, 67 parts of dog kidneys, 67 parts of psoralea corylifolias, 83 parts of colla carapacis et plastri testudinises, 67
Part Morinda officinalis, 67 parts of polygalas, 42 parts of spina date seeds, 42 parts of Poria cocos, 42 parts of Radix Angelicae Sinensis, 67 portions of arillus longans, 42 parts of red ginsengs, 13 parts of Radixs Astragali,
42 parts of bighead atractylodes rhizomes, 42 parts of banksia rose, 42 portions of baked gingers, 67 portions of jujubes, 67 portions of radix glycyrrhizaes.
The taste of the above 20, deer horn glue, colla carapacis et plastri testudinis, red ginseng, Chinese cassia tree are ground into fine powder, standby；Dog kidney is ground into coarse powder, with
50% alcohol reflux extracts three times, for the first time 5 times of amounts, extracts 3 hours, second of 4 times of amount, extracts 2 hours, 4 times of amounts of third time,
Extraction 1 hour, merge ethanol extract, filter, filtrate is standby；The five tastes of remaining barrenwort etc. ten, add water to cook secondary, first time
Add 6 times of amounts of water, extract 3 hours, second plus 4 times of amounts of water, extract 2 hours, collecting decoction, filtration, filtrate is concentrated into relatively close
The clear cream for spending to be 1.15 at 80 DEG C, add ethanol to stir evenly, stand overnight to alcohol content up to 60%, filter, filtrate and above-mentioned dog
Renal extract merges, and reclaims ethanol, is concentrated into relative density as the thick paste for being 1.28 at 80 DEG C, is dried under reduced pressure, crushes, add
Deer horn glue, colla carapacis et plastri testudinis, red ginseng, the fine powder of Chinese cassia tree, mix, obtain mixture.
Embodiment 3：Preparation method of the present invention prepares the Chinese medicine composition for invigorating Qi and tonifying kidney.
Raw material medicine composition：100 parts of barrenwort, 67 parts of faenum graecums, 67 parts of dog kidneys, 67 parts of psoralea corylifolias, 83 parts of colla carapacis et plastri testudinises, 67
Part Morinda officinalis, 67 parts of polygalas, 42 parts of spina date seeds, 42 parts of Poria cocos, 42 parts of Radix Angelicae Sinensis, 67 portions of arillus longans, 42 parts of red ginsengs, 13 parts of Radixs Astragali,
42 parts of bighead atractylodes rhizomes, 42 parts of banksia rose, 42 portions of baked gingers, 67 portions of jujubes, 67 portions of radix glycyrrhizaes.
The taste of the above 20, deer horn glue, colla carapacis et plastri testudinis, red ginseng, Chinese cassia tree are ground into fine powder, standby；Dog kidney is ground into coarse powder, with
50% alcohol reflux extracts three times, for the first time 5 times of amounts, extracts 3 hours, second of 4 times of amount, extracts 2 hours, 4 times of amounts of third time,
Extraction 1 hour, merge ethanol extract, filter, filtrate is standby；The five tastes of remaining barrenwort etc. ten, add water to cook secondary, first time
Add 6 times of amounts of water, extract 3 hours, second plus 4 times of amounts of water, extract 2 hours, collecting decoction, filtration, filtrate is concentrated into relatively close
The clear cream for spending to be 1.15 at 80 DEG C, add ethanol to stir evenly, stand overnight to alcohol content up to 60%, filter, filtrate and above-mentioned dog
Renal extract merges, and reclaims ethanol, is concentrated into relative density as the thick paste for being 1.28 at 80 DEG C, is dried under reduced pressure, crushes, add
Deer horn glue, colla carapacis et plastri testudinis, red ginseng, the fine powder of Chinese cassia tree, mix, obtain mixture.
Embodiment 4：Preparation method of the present invention prepares the Chinese medicine composition for invigorating Qi and tonifying kidney.
Raw material medicine composition：100 parts of barrenwort, 67 parts of faenum graecums, 67 parts of dog kidneys, 67 parts of psoralea corylifolias, 83 parts of colla carapacis et plastri testudinises, 67
Part Morinda officinalis, 67 parts of polygalas, 42 parts of spina date seeds, 42 parts of Poria cocos, 42 parts of Radix Angelicae Sinensis, 67 portions of arillus longans, 42 parts of red ginsengs, 13 parts of Radixs Astragali,
42 parts of bighead atractylodes rhizomes, 42 parts of banksia rose, 42 portions of baked gingers, 67 portions of jujubes, 67 portions of radix glycyrrhizaes.
The taste of the above 20, deer horn glue, colla carapacis et plastri testudinis, red ginseng, Chinese cassia tree are ground into fine powder, standby；Dog kidney is ground into coarse powder, with
50% alcohol reflux extracts three times, for the first time 5 times of amounts, extracts 3 hours, second of 4 times of amount, extracts 2 hours, 4 times of amounts of third time,
Extraction 1 hour, merge ethanol extract, filter, filtrate is standby；The five tastes of remaining barrenwort etc. ten, add water to cook secondary, first time
Add 6 times of amounts of water, extract 3 hours, second plus 4 times of amounts of water, extract 2 hours, collecting decoction, filtration, filtrate is concentrated into relatively close
The clear cream for spending to be 1.15 at 80 DEG C, add ethanol to stir evenly, stand overnight to alcohol content up to 60%, filter, filtrate and above-mentioned dog
Renal extract merges, and reclaims ethanol, is concentrated into relative density as the thick paste for being 1.28 at 80 DEG C, is dried under reduced pressure, crushes, add
Deer horn glue, colla carapacis et plastri testudinis, red ginseng, the fine powder of Chinese cassia tree, mix, obtain mixture.
Embodiment 5：Preparation method of the present invention prepares the Chinese medicine composition for invigorating Qi and tonifying kidney.
Raw material medicine composition：100 parts of barrenwort, 67 parts of faenum graecums, 67 parts of dog kidneys, 67 parts of psoralea corylifolias, 83 parts of colla carapacis et plastri testudinises, 67
Part Morinda officinalis, 67 parts of polygalas, 42 parts of spina date seeds, 42 parts of Poria cocos, 42 parts of Radix Angelicae Sinensis, 67 portions of arillus longans, 42 parts of red ginsengs, 13 parts of Radixs Astragali,
42 parts of bighead atractylodes rhizomes, 42 parts of banksia rose, 42 portions of baked gingers, 67 portions of jujubes, 67 portions of radix glycyrrhizaes.
The taste of the above 20, deer horn glue, colla carapacis et plastri testudinis, red ginseng, Chinese cassia tree are ground into fine powder, standby；Dog kidney is ground into coarse powder, with
50% alcohol reflux extracts three times, for the first time 5 times of amounts, extracts 3 hours, second of 4 times of amount, extracts 2 hours, 4 times of amounts of third time,
Extraction 1 hour, merge ethanol extract, filter, filtrate is standby；The five tastes of remaining barrenwort etc. ten, add water to cook secondary, first time
Add 6 times of amounts of water, extract 3 hours, second plus 4 times of amounts of water, extract 2 hours, collecting decoction, filtration, filtrate is concentrated into relatively close
The clear cream for spending to be 1.15 at 80 DEG C, add ethanol to stir evenly, stand overnight to alcohol content up to 60%, filter, filtrate and above-mentioned dog
Renal extract merges, and reclaims ethanol, is concentrated into relative density as the thick paste for being 1.28 at 80 DEG C, is dried under reduced pressure, crushes, add
Deer horn glue, colla carapacis et plastri testudinis, red ginseng, the fine powder of Chinese cassia tree, mix, obtain mixture.
Embodiment 6：To hydrocortisone type YANG asthenia disease mouse body weight, body temperature, freely activity and the influence of swimming time：
Male white mouse 60 is cleaned, 30 ± 1.0g of body weight, 6 groups is randomly divided into, is grouped as follows：
Blank group（1 group）, physiological saline, injection volume 20mg/kg, 1 times/day, continuous 15 days；
Model group（2 groups）, physiological saline, injection volume 20mg/kg, 1 times/day, continuous 15 days, from the 11st day, increase note
Penetrate hydrocortisone 25mg/kg/ days；
The Chinese medicine composition for invigorating Qi and tonifying kidney of 30% concentration（3 groups）, with 20mg/kg be used for invigorating Qi and tonifying kidney Chinese medicine composition,
Physiological saline is configured to 30% concentration, from injecting 1 times/day, continuous 15 days, the 11st day, increase injection hydrocortisone 25mg/kg/
My god, using the capsule of embodiment 12；
The Chinese medicine composition for invigorating Qi and tonifying kidney of 60% concentration（4 groups）, with 20mg/kg be used for invigorating Qi and tonifying kidney Chinese medicine composition,
Physiological saline is configured to 60% concentration, from injecting 1 times/day, continuous 15 days, the 11st day, increase injection hydrocortisone 25mg/kg/
My god, using the capsule of embodiment 8；
The Chinese medicine composition for invigorating Qi and tonifying kidney of 80% concentration（5 groups）, with 20mg/kg be used for invigorating Qi and tonifying kidney Chinese medicine composition,
Physiological saline is configured to 60% concentration, from injecting 1 times/day, continuous 15 days, the 11st day, increase injection hydrocortisone 25mg/kg/
My god, using company A product；
Positive controls（6 groups）, testosterone propionate is injected without processing, from the 7th day 13mg/kg/ days within the 1-6 days, 1 times/day, the
Increase injection oxidation cortisone 25mg/kg/ days at 11 days, until the 15th day.
Free number of activities and low temperature in 30 minutes side mouse weights, body temperature, 5m after last dose（4℃）During swimming
Between, it is shown in Table 1 through statistical disposition；
Table 1 be used for invigorating Qi and tonifying kidney Chinese medicine composition to hydrogen can type mouse weight, body temperature, the influence of autonomic activities and swimming time
（N=10, X ± S）
| Group | Body weight | Body temperature | Number of activities in 5s（It is secondary） | Swimming time（min） |
| Before administration（g）Growth rate % | ||||
| 1 | 30.0±2 7.3±6.9 | 37.4±1.0 | 55±24.7 | 17±14 |
| 2 | 30.4±2.5 -0.5±4.0△△ | 36.6±0.4△△ | 33±15△△ | 4±4△△ |
| 3 | 30.8±2.8 7.3±5* | 37.6±1.0 | 48±9* | 8±7.4* |
| 4 | 30.5±3.1 13±4** | 37.1±0.3** | 54±25** | 8.7±5** |
| 5 | 30.3±2.3 7.9±5.8* | 36.8±0.7 | 45±15* | 6±3 |
| 6 | 30.9±2.7 14±6** | 37.4±0.1** | 82±19** | 8±2** |
Note：△ △ signs the p ＜ 0.01 compared with blank group, * are expressed as model group than p ＜ 0.05, and * * are represented with being mended for QI invigorating
The Chinese medicinal composition capsules control group of kidney p ＜ 0.01 compared with model group.
Body weight, body temperature and sportive efforts endurance are to react a whether vigorous important indicator of body energy, and kidney
The middle energy of the deficiency of yang is not good, fatiguability, direct performance slow in reacting etc. because improving exercise tolerance and muscle power and kidney-yang deficiency
Improvedd direct embodiment.As shown in Table 1, the Chinese medicine composition of the present invention for invigorating Qi and tonifying kidney dramatically increases mouse trip
Swim number of activities in time and 5s, not only better than existing product control group, be also advantageous over existing product control group, while maintain body
For gentle normal group without marked difference, showing the kidney-yang deficiency symptom such as its, fatiguability not good to energy, slow in reacting has significant curative effect.
Embodiment 7：
Influence during Chinese medicinal composition capsules for invigorating Qi and tonifying kidney are wet to castration male mice accessory sex organ（N=10, × ± S）
| Group | Preputial gland | Seminal fluid+prostate |
| Mg/10g body weight | Mg/10g body weight | |
| 1 | 25±4.2 | 93±12.5 |
| 2 | 8±5.2△ | 6.6±2.3△ |
| 3 | 10±4* | 12±6.7* |
| 4 | 9.6±5.4* | 11.5±4.3* |
| 5 | 7.5±3.3 | 8.8±2.8 |
| 6 | 27±7* | 130±33* |
Note：△ is represented and blank group（Non- castration group）The p ＜ 0.01. compared with control group are represented compared to p ＜ 0.01, *
As shown in Table 2, castration mouse bag can be increased using the Chinese medicinal composition capsules of the present invention for invigorating Qi and tonifying kidney
Cutaneous gland and seminal fluid, the weight of prostate, the development for promoting sexual organ are the means of enhancing ability, and it is exactly to change that sexuality, which improves,
One reaction of kind male's kidney-yang deficiency.Show that the Chinese medicinal composition capsules of the present invention for invigorating Qi and tonifying kidney can promote sexual organ
Development, there is curative effect to kidney-yang deficiency symptom.
Embodiment 8：The Chinese medicinal composition capsules of the present invention stated for invigorating Qi and tonifying kidney
Chinese medicine composition for invigorating Qi and tonifying kidney prepared by Example 1, the parts by weight of dextrin 60 are added, be well mixed, wet method system
Grain, capsule leather jacket fill and present into capsule.
Embodiment 9：The Chinese medicinal composition capsules of the present invention stated for invigorating Qi and tonifying kidney
Chinese medicine composition for invigorating Qi and tonifying kidney prepared by Example 1, the parts by weight of dextrin 65 are added, be well mixed, wet method system
Grain, capsule leather jacket fill and present into capsule.
Embodiment 10：The Chinese medicinal composition capsules of the present invention stated for invigorating Qi and tonifying kidney
Chinese medicine composition for invigorating Qi and tonifying kidney prepared by Example 1, the parts by weight of dextrin 70 are added, be well mixed, wet method system
Grain, capsule leather jacket fill and present into capsule.
Embodiment 11：The Chinese medicinal composition capsules of the present invention stated for invigorating Qi and tonifying kidney
Chinese medicine composition for invigorating Qi and tonifying kidney prepared by Example 1, the parts by weight of dextrin 75 are added, be well mixed, wet method system
Grain, capsule leather jacket fill and present into capsule.
Embodiment 12：The Chinese medicinal composition capsules of the present invention stated for invigorating Qi and tonifying kidney
Chinese medicine composition for invigorating Qi and tonifying kidney prepared by Example 1, the parts by weight of dextrin 80 are added, be well mixed, wet method system
Grain, capsule leather jacket fill and present into capsule.
Embodiment 13,：Clinical test
Clinical efficacy investigation is carried out using the Chinese medicine composition for invigorating Qi and tonifying kidney prepared by 8-12 of the embodiment of the present invention, it is clinical
Case row are as follows：
1st, poplar, man, 30 years old, usually feel and be short of physical strength, impotence is lifted, shortness of breath, manual labor lethargy.It is kidney through tcm diagnosis
Void, quote capsule of the present invention and raised and treated, 4 tablets each time, three times a day.Continuously to drink one month, muscle power is restored,
Energetic, impotence symptom disappears, and supports and hard.Think after pulse wave spectrum, its renal function reaches as normal person.Confirm
Its symptom obtains medical treatment, and muscle power is restored with energy, it was demonstrated that capsule of the invention is effective to kidney deficiency.
2nd, Chen, man, 35 years old, dizziness and tinnitus after serious disease, face complexion without lustreness.Think through tcm diagnosis, speen-kidney dificiency.Use this
Invention capsule is nursed one's health, 3 times a day, 4 tablets each time.Through taking 20 days, not in dizziness and tinnitus, complexion numbering, feel and feel
It is full of physical strength.Prove that capsule of the present invention generates the effect for the treatment of and regulation.
3rd, Chen, man is 40 years old, conscious absent minded, weak, has no appetite.Think through tcm diagnosis, spleen kidney two
It is empty, it is proposed that to be raised with the capsule of the present invention.Four every time, three times a day.After the taking of two weeks, from head to foot effectively,
Shortness of breath phenomenon disappears, and night sweat stops.Prove, capsule of the present invention generates the effect of conditioning.
4th, Luo, man, 45 years old, pain of often turning sour, can not mitigate after rest, sinciput pushes up equal baldness with after.It is through tcm diagnosis
Kidney deficiency, after taking capsule of the present invention, the diseases such as kidney deficiency and sex dysfunction are not only cured, and it is radiant, and hair starts
Growth.
5th, Lee, man, 42 years old, suffer from insomnia, the not normal illness of sexual function influences work, when it is good when it is bad, take this capsule one
It is clearly better after month, is returned to one's perfect health after three months.Do not having a sleepless night, sexual function recovers normal.
6th, Mr. Wang, male, 56 years old, kidney deficiency and liver, waist and knee weakness, blockage of main and collateral channels symptom are suffered from.It is in poor health, lassitude, warp
Multi-treatment curative effect is little.To present, this capsule is taken three months, health recovers good.
7th, Zhao, man, 53 years old, patient suffer from pain in the back throughout the year, insomnia, repeatedly treat, when it is good when it is bad.Chilly is cold, and waist is stranded
Weak, insomnia and dreamful sleep, impotence is not lifted.Take this capsule after 7 days pain in the back substantially mitigate, after continuously taking three months later, pain in the back
It is wholly absent, sleep is good and dream is few, and trick is warmed up, and body is strengthened, energetic.
The preferred embodiments of the present invention are the foregoing is only, are not intended to limit the scope of the invention, it is every at this
Under the inventive concept of invention, the equivalent structure transformation made using present specification, or directly/it is used in indirectly
He is included in the scope of patent protection of the present invention related technical field.
Claims (10)
1. a kind of Chinese medicine composition for invigorating Qi and tonifying kidney, it is characterised in that the Chinese medicine composition includes by weight：
The barrenwort of 80-120 parts, 50-80 part faenum graecums, 50-80 part dog kidneys, 50-80 part psoralea corylifolias, 70-90 part colla carapacis et plastri testudinises,
50-80 part Morinda officinalis, 30-45 part polygalas, 30-45 part spina date seeds, 30-45 part Poria cocos, 30-45 part Radix Angelicae Sinensis, 60-75 part longans
Meat, 30-50 part red ginsengs, 10-25 part Radixs Astragali, 35-45 part bighead atractylodes rhizomes, 35-45 part banksia rose, 35-48 part baked gingers, 58-73 part jujubes,
57-71 part radix glycyrrhizaes.
2. the Chinese medicine composition according to claim 1 for invigorating Qi and tonifying kidney, it is characterised in that the Chinese medicine composition
Each raw material medicines in portions by weight is：
100 parts of barrenwort, 67 parts of faenum graecums, 67 parts of dog kidneys, 67 parts of psoralea corylifolias, 83 parts of colla carapacis et plastri testudinises, 67 parts of Morinda officinalis are 67 parts remote
Will, 42 parts of spina date seeds, 42 parts of Poria cocos, 42 parts of Radix Angelicae Sinensis, 67 portions of arillus longans, 42 parts of red ginsengs, 13 parts of Radixs Astragali, 42 parts of bighead atractylodes rhizomes, 42 parts of wood
Perfume (or spice), 42 portions of baked gingers, 67 portions of jujubes, 67 portions of radix glycyrrhizaes.
3. the Chinese medicine composition according to claim 1 for invigorating Qi and tonifying kidney, it is characterised in that the Chinese medicine composition
Each raw material medicines in portions by weight is：
95 parts of barrenwort, 70 parts of faenum graecums, 65 parts of dog kidneys, 65 parts of psoralea corylifolias, 80 parts of colla carapacis et plastri testudinises, 72 parts of Morinda officinalis are 40 parts remote
Will, 35 parts of spina date seeds, 42 parts of Poria cocos, 35 parts of Radix Angelicae Sinensis, 70 portions of arillus longans, 45 parts of red ginsengs, 20 parts of Radixs Astragali, 38 parts of bighead atractylodes rhizomes, 45 parts of wood
Perfume (or spice), 45 portions of baked gingers, 70 portions of jujubes, 70 portions of radix glycyrrhizaes.
4. a kind of capsule for invigorating Qi and tonifying kidney, it is characterised in that the capsule is included as described in any one of claim 1 ~ 3
For the Chinese medicine composition of invigorating Qi and tonifying kidney, pharmaceutic adjuvant and capsule for wrapping up the Chinese medicine composition and pharmaceutic adjuvant
Skin.
5. the capsule according to claim 4 for invigorating Qi and tonifying kidney, it is characterised in that the pharmaceutic adjuvant is dextrin.
6. the preparation method of a kind of Chinese medicine composition for invigorating Qi and tonifying kidney, it is characterised in that the preparation method includes as follows
Step：
Step 1, medicinal material processing is handled；
Step 2, crushed after deer horn glue, colla carapacis et plastri testudinis vacuum drying, red ginseng, Chinese cassia tree are cleaned, vacuum drying, crush, standby；
Step 3, dog kidney channel alcohol reflux purifies, ethanol extract filtration, and gained dog Renal extract is standby；
Step 4, by barrenwort, faenum graecum, Morinda officinalis, psoralea corylifolia, polygala, spina date seed, Poria cocos, Radix Angelicae Sinensis, arillus longan, the Radix Astragali, white
Art, baked ginger, jujube, radix glycyrrhizae and the banksia rose are handled through water extracting alcohol, and it is standby to obtain mixed extract；
Step 5, mixed extract merges away ethanol with dog Renal extract, concentration, after drying, and adds deer horn glue, colla carapacis et plastri testudinis, red
Ginseng, Chinese cassia tree mixing, obtain the Chinese medicine composition for invigorating Qi and tonifying kidney.
7. the preparation method of the Chinese medicine composition according to claim 6 for invigorating Qi and tonifying kidney, it is characterised in that the step
Rapid 3 specifically include：
Dog kidney is ground into coarse powder, and with the extraction of 50% alcohol reflux three times, 4 ~ 8 times of amounts, are extracted 3 hours for the first time, 4 ~ 6 times for the second time
Amount, extraction 2 hours, 4 ~ 6 times of amounts of third time, extract 1 hour, merge ethanol extract, filter, filtrate is standby.
8. the preparation method of the Chinese medicine composition according to claim 7 for invigorating Qi and tonifying kidney, it is characterised in that the step
Rapid 4 specifically include：
By barrenwort, faenum graecum, Morinda officinalis, psoralea corylifolia, polygala, spina date seed, Poria cocos, Radix Angelicae Sinensis, arillus longan, the Radix Astragali, the bighead atractylodes rhizome, big gun
Ginger, jujube, radix glycyrrhizae and the banksia rose add water to cook secondary, for the first time plus 4 ~ 8 times of water amount, extract 3 hours, second plus 4 ~ 6 times of amounts of water,
Extraction 2 hours, collecting decoction, filtration, filtrate are concentrated into the clear cream that relative density is 1.14~1.16 at 80 DEG C, add ethanol extremely
Alcohol content is stirred evenly, stood overnight, filter up to 60%.
9. the preparation method of the Chinese medicine composition according to claim 8 for invigorating Qi and tonifying kidney, it is characterised in that the step
Specifically included in rapid 5：
The extract solution obtained in the extract solution and step 4 that are obtained in step 3 is merged, ethanol is reclaimed, is concentrated into relative density and exists
It is 1.28~1.30 thick paste at 80 DEG C, is dried under reduced pressure, crushes.
10. the preparation method of the Chinese medicine composition for invigorating Qi and tonifying kidney according to any one of claim 6 ~ 9, its feature exist
In each raw material medicines in portions by weight is：
The barrenwort of 80-120 parts, 50-80 part faenum graecums, 50-80 part dog kidneys, 50-80 part psoralea corylifolias, 70-90 part colla carapacis et plastri testudinises,
50-80 part Morinda officinalis, 30-45 part polygalas, 30-45 part spina date seeds, 30-45 part Poria cocos, 30-45 part Radix Angelicae Sinensis, 60-75 part longans
Meat, 30-50 part red ginsengs, 10-25 part Radixs Astragali, 35-45 part bighead atractylodes rhizomes, 35-45 part banksia rose, 35-48 part baked gingers, 58-73 part jujubes,
57-71 part radix glycyrrhizaes.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108524625A (en) * | 2018-05-31 | 2018-09-14 | 广州聚澜健康产业研究院有限公司 | Cloudy capsule of a kind of kidney tonifying benefit and preparation method thereof |
| CN110420283A (en) * | 2019-09-02 | 2019-11-08 | 徐州生物工程职业技术学院 | A kind of strengthen immunity, the health care product for alleviating physical strength and preparation method thereof |
| CN111228414A (en) * | 2020-02-02 | 2020-06-05 | 江苏大学 | Health food or Chinese herbal compound for improving male sexual function and ultrasonic preparation method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105456972A (en) * | 2014-09-05 | 2016-04-06 | 湖南康寿制药有限公司 | Turtle and deer kidney nourishing traditional Chinese medicine composition and preparing method thereof |
-
2017
- 2017-12-08 CN CN201711297060.4A patent/CN107890557A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105456972A (en) * | 2014-09-05 | 2016-04-06 | 湖南康寿制药有限公司 | Turtle and deer kidney nourishing traditional Chinese medicine composition and preparing method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108524625A (en) * | 2018-05-31 | 2018-09-14 | 广州聚澜健康产业研究院有限公司 | Cloudy capsule of a kind of kidney tonifying benefit and preparation method thereof |
| CN110420283A (en) * | 2019-09-02 | 2019-11-08 | 徐州生物工程职业技术学院 | A kind of strengthen immunity, the health care product for alleviating physical strength and preparation method thereof |
| CN111228414A (en) * | 2020-02-02 | 2020-06-05 | 江苏大学 | Health food or Chinese herbal compound for improving male sexual function and ultrasonic preparation method |
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