CN107890531A - 一种治疗鸡传染性腺胃炎的中药口服液及其制备方法 - Google Patents

一种治疗鸡传染性腺胃炎的中药口服液及其制备方法 Download PDF

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CN107890531A
CN107890531A CN201711146084.XA CN201711146084A CN107890531A CN 107890531 A CN107890531 A CN 107890531A CN 201711146084 A CN201711146084 A CN 201711146084A CN 107890531 A CN107890531 A CN 107890531A
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穆大勇
王春华
高爽
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Jinzhou Jingliang Animal Pharmaceutical Co Ltd
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Abstract

一种治疗鸡传染性腺胃炎的中药口服液及其制备方法，称取原料药：陈皮50g‑100g，穿心莲100g‑200g，黄连50g‑100g，黄柏100g‑200g，麦芽100g‑200g，颠茄200g‑300g，白芍50g‑100g；将原料药粉碎过100目筛，加水温浸1小时，再加3倍水煎煮两次，每次沸后保持微沸状态，滤过，合并两次煎煮滤液，滤液浓缩，缓慢加入乙醇，充分搅拌，冷藏静置24h‑48h，滤过，滤液回收乙醇，调pH7.0‑7.5，加水稀释，制备成口服剂。优点是：中草药取材方便，生产工艺简单，使用方便，具有无副作用、低毒、无残留、治愈率高的特点。

Description

一种治疗鸡传染性腺胃炎的中药口服液及其制备方法
技术领域
本发明属于兽用中药领域，特别涉及一种治疗鸡传染性腺胃炎的中药口服液及其制备方法。
背景技术
鸡传染性腺胃炎是一种以鸡生长不良、消瘦、整齐度差等临床特征以及腺胃肿大或腺胃乳头扁平甚至消失，腺胃黏膜出血溃疡、脱落、肌胃糜烂为主要特征的传染病。目前，该病已在我国一些地区流行，尤其在山东、辽宁的肉蛋鸡上频繁发生。该病发病非常严重，死亡率很高，给养禽业的发展带来了极大的威胁。
鸡传染性腺胃炎是由多种致病因素共同或者协同作用引起的具有传染性的疾病，发病原因十分复杂，没有有效的对因治疗方法，目前国内外对于鸡传染性腺胃炎的综合防控大多侧重于对症治疗，治愈率不高，效果并不理想，会产生药物残留。
因此，研究一种无毒副作用、低残留的中草药复方制剂，能降低鸡血糖皮质激素的浓度，提高机体的免疫功能，增强机体的免疫力和抗病力的治疗鸡传染性腺胃炎的中药口服液已经成为市场的迫切要求。
发明内容
本发明的目的是提供一种治愈率高，无毒副作用的治疗鸡传染性腺胃炎的中药口服液及其制备方法，可提高机体的免疫功能，增强机体的免疫力和抗病力。
本发明的技术方案是：
一种治疗鸡传染性腺胃炎的中药口服液，原料组成如下：陈皮50g-100g，穿心莲100g-200g，黄连50g-100g，黄柏100g-200g，麦芽100g-200g，颠茄200g-300g，白芍50g-100g。
一种治疗鸡传染性腺胃炎的中药口服液的制备方法，具体步骤如下：
称取原料药：陈皮50g-100g，穿心莲100g-200g，黄连50g-100g，黄柏100g-200g，麦芽100g-200g，颠茄200g-300g，白芍50g-100g；将原料药粉碎过100目筛，加水在70℃-100℃下温浸1小时，再加3倍水煎煮两次，第一次煎煮2小时，第二次煎煮1小时，每次沸后保持微沸状态，滤过，合并两次煎煮滤液，滤液浓缩，缓慢加入乙醇，使含醇量达到65vol％-75vol％，充分搅拌，冷藏静置24h-48h，滤过，滤液回收乙醇，调pH7.0-7.5，加水调至700-1000mL，1mL相当于原生药1g，精滤，灌装，灭菌，制备成口服剂。
本发明中药组方原料组成包括陈皮，穿心莲，黄连，黄柏，麦芽，颠茄，白芍。陈皮具有理气降逆、调中开胃、燥湿化痰的功效；穿心莲具有清热解毒，消炎，消肿止痛的功效；麦芽具有行气消食、健脾开胃的功效；黄连具有清热燥湿、泻火解毒的功效；黄柏具有清热解毒，泻火燥湿的功效；颠茄具有解痉止痛、抑制分泌的作用；白芍具有养血敛阴、柔肝止痛的功效。
本发明的有益效果：
本发明提供的治疗鸡传染性腺胃炎的中药口服液，具有和胃消痞、益气健脾、调中开胃等作用，能降低鸡血糖皮质激素的浓度，消除病毒引起的免疫抑制，改善动物机体的免疫状态，提高机体的非特异性免疫能力，增强机体的免疫力和抗应激能力，从而达到促进生长，防病治病的目的；中草药取材方便，生产工艺简单，使用方便，具有无副作用、低毒、无残留、治愈率高的特点。
具体实施方式
实施例1
1、称取：陈皮100g，穿心莲150g，黄连100g，黄柏150g，麦芽100g，颠茄250g，白芍50g。
2、将上述药粉碎过100目筛，加水在70℃下温浸1小时，再加3倍水煎煮两次，第一次煎煮2小时，第二次煎煮1小时，每次沸后保持微沸状态，滤过，合并两次煎煮滤液，滤液浓缩至相对浓度至1.2。
3、缓慢加入乙醇，使含醇量达到65％，充分搅拌，冷藏静置24h，滤过，滤液回收乙醇，调pH6.5。
4、加水调至900mL，1mL相当于原生药1g，精滤，灌装，灭菌，制备成注射剂。
实施例2
1、称取：陈皮80g，穿心莲100g，黄连50g，黄柏200g，麦芽150g，颠茄200g，白芍100g。
2、将上述药粉碎过100目筛，加水在100℃下温浸1小时，再加3倍水煎煮两次，第一次煎煮2小时，第二次煎煮1小时，每次沸后保持微沸状态，滤过，合并两次煎煮滤液，滤液浓缩至相对浓度至1.3。
3、缓慢加入乙醇，使含醇量达到75％，充分搅拌，冷藏静置248h，滤过，滤液回收乙醇，调pH7.0。
4、加水调至880mL，1mL相当于原生药1g，精滤，灌装，灭菌，制备成注射剂。
实施例3
1、称取：陈皮50g，穿心莲200g，黄连80g，黄柏100g，麦芽200g，颠茄300g，白芍70g。
2、将上述药粉碎过100目筛，加水在80℃下温浸1小时，再加3倍水煎煮两次，第一次煎煮2小时，第二次煎煮1小时，每次沸后保持微沸状态，滤过，合并两次煎煮滤液，滤液浓缩。
3、缓慢加入乙醇，使含醇量达到70％，充分搅拌，冷藏静置36h，滤过，滤液回收乙醇，调pH6.8。
4、加水调至1000mL，1mL相当于原生药1g，精滤，灌装，灭菌，制备成注射剂。
本发明调节pH值时，可以根据pH值情况采用盐酸或氢氧化钠进行调节。
使用效果：
辽宁某鸡养殖场，10000只鸡发生传染性腺胃炎，临床表现为精神沉郁、食欲不振、水样粪便。解剖后腺胃肿大，肌胃糜烂。采用实例1中的雏鸡中药口服添加剂，1mL/L水，一日两次，自由饮水，用量为鸡一次正常饮水量。连续用4天，用药24小时后症状明显减轻，第四天后除个别重症基本治愈，治愈率达92％。不添加本发明的雏鸡中药口服添加剂的水饲喂雏鸡，作为对照组，结果表明，采用本发明雏鸡中药口服添加剂饲喂雏鸡后，成活率达到95％以上；对照组雏鸡成活率为75％，且成活雏鸡多有鸡白痢等病症发生，精神萎靡。有此表明，本发明的雏鸡中药口服添加剂能够增强雏鸡的免疫力，提高成活率。
以上仅为本发明的具体实施例而已，并不用于限制本发明，对于本领域的技术人员来说，本发明可以有各种更改和变化。凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。

Claims (2)

1.一种治疗鸡传染性腺胃炎的中药口服液，其特征是：
原料组成如下：陈皮50g-100g，穿心莲100g-200g，黄连50g-100g，黄柏100g-200g，麦芽100g-200g，颠茄200g-300g，白芍50g-100g。
2.一种治疗鸡传染性腺胃炎的中药口服液的制备方法，其特征是：
具体步骤如下：
称取原料药：陈皮50g-100g，穿心莲100g-200g，黄连50g-100g，黄柏100g-200g，麦芽100g-200g，颠茄200g-300g，白芍50g-100g；将原料药粉碎过100目筛，加水在70℃-100℃下温浸1小时，再加3倍水煎煮两次，第一次煎煮2小时，第二次煎煮1小时，每次沸后保持微沸状态，滤过，合并两次煎煮滤液，滤液浓缩，缓慢加入乙醇，使含醇量达到65vol％-75vol％，充分搅拌，冷藏静置24h-48h，滤过，滤液回收乙醇，调pH7.0-7.5，加水调至700mL-1000mL，1mL相当于原生药1g，精滤，灌装，灭菌，制备成口服剂。
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Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN108853241A (zh) * 2018-07-03 2018-11-23 淄博维希尔生物技术有限公司 一种兽用治疗腺肌胃炎中药浓缩液和口服液及其制备方法

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Publication number Priority date Publication date Assignee Title
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