CN107875139A - 一种壳核α‑生育酚微胶囊及其制备方法 - Google Patents
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Abstract
本发明公开了一种壳核α‑生育酚微胶囊及其制备方法。本发明以α‑生育酚为芯材，加入稀释剂，以海藻酸钠壁材；采用微流控装置制备出O/W/O液滴模板。本发明通过调节内外相流速控制微胶囊所包裹的芯材个数，壳层采用内部与外部凝胶化结合的固化手段可保持很好的球形。恒定Finner和Fmiddle流速，调节Fouter流速来控制壳核微胶囊中芯材的包裹个数，且可以得到粒径均一的壳核结构α‑生育酚微胶囊，并通过内部与外部凝胶化结合使得液滴在固化后可以保持很好的球形。
Description
技术领域
本发明涉及微胶囊技术，具体地说，涉及一种α-生育酚微胶
囊及其制备方法。
背景技术
维生素E属于一组液溶性维生素，其化学术语是α-生育酚。显示具有抗氧化，清除自由基等潜在的健康益处。然而，它在食物，药物和化妆品中的应用在光和氧的存在下迅速降解。目前已经开发了各种封装技术来解决这些问题，因为它们有效地将活性成分与周围环境分离。
近年来，微胶囊技术发展迅速，在实际生产中得到广泛应用的主要是喷雾干燥法和复凝聚。喷雾干燥法制备微胶囊必须经高温热风处理，这样就会导致α-生育酚的氧化，且喷雾干燥法在可控芯材含量和粒径均一方面很难实现，从而影响微胶囊产品的质量；复凝聚法所用的固化剂如甲醛、戊二醛等都是化学物质，不能用于食品行业的生产加工。现有大多微胶囊化的方法很难实现粒径均一且芯材含量可控，从而造成使用过程中的释放不可控，不能达到理想的要求。
微流控技术是通过微通道的特点来制备大小均一的壳核结构微胶囊，可通过调节流体流速控制胶囊的大小及包裹的芯材个数。本发明采用微流控技术制备壳核结构的α-生育酚/海藻酸钙凝胶微球，壳层的交联方式通过内部和外部凝胶化结合，制备了球形度好且芯材个数可控的微胶囊。
发明内容
为了实现上述目的，本发明采用如下技术方案：
一种壳核α-生育酚微胶囊，由如下步骤制得:
（1）取α-生育酚溶于稀释剂中，制成芯材溶液，作为内相流体Finner；
（2）取海藻酸钠溶于水中，加入吐温80和纳米碳酸钙制成壁材溶液，作为中间相流体Fmiddle；
（3）含醋酸的白油溶液作为外相流体Fouter；
（4）取氯化钙溶于水中，制成承接液；
（5）将Finner、Fmiddle与Fouter通过注射泵注入微流控装置中，制备O/W/O液滴，外相流体中的醋酸与碳酸钙反应释放出钙离子，使得壳层进行内部凝胶化，液滴掉入承接液中后进行外部凝胶化，形成壳核结构的α-生育酚微胶囊。
在上述的壳核α-生育酚微胶囊中，步骤（5）中通过恒定Finner和Fmiddle流速，调节Fouter流速来控制壳核微胶囊中芯材的包裹个数。
在上述的壳核α-生育酚微胶囊中，所述稀释剂为苯甲酸苄酯或白油，其用量体积为α-生育酚的2-5倍。
在上述的壳核α-生育酚微胶囊中，步骤（2）中所述壁材溶液的海藻酸钠的质量百分浓度为0.3~1.5％，吐温80的质量百分浓度为0.2~1％，纳米碳酸钙的质量百分浓度为0.1~1％。
在上述的壳核α-生育酚微胶囊中，步骤（3）中所述醋酸的质量百分浓度为0.5~2％。
在上述的壳核α-生育酚微胶囊中，Finner流速为Fmiddle流速的10倍以上。
在上述的壳核α-生育酚微胶囊中，步骤（4）中所述氯化钙的质量百分浓度为2~10％。
在上述的壳核α-生育酚微胶囊中，步骤（2）中所述海藻酸钠为低粘度的，粘度为4-12mpa.s。
与现有技术相比，本发明具有如下有益效果：本发明利用微流控装置，以α-生育酚为内相，加入稀释剂，海藻酸钠和白油分别为中间相和外相；采用微流控装置制备出O/W/O液滴模板，通过调节内外相流速控制微胶囊所包裹的芯材个数，壳层采用内部与外部凝胶化结合的固化手段可保持很好的球形。恒定Finner和Fmiddle流速，调节Fouter流速来控制壳核微胶囊中芯材的包裹个数，且可以得到粒径均一的壳核结构α-生育酚微胶囊，并通过内部与外部凝胶化结合使得液滴在固化后可以保持很好的球形。
具体实施方式：
下面结合实施例对本发明做进一步的说明，但本发明的保护范围并不局限于实施例表示的范围。
实施例1：
采用微流控方式制备壳核α-生育酚微胶囊：取10g α-生育酚溶于30 g稀释剂（苯甲酸苄酯：白油=2：1)中，用注射器吸取作为Finner，用注射器吸取海藻酸钠和白油溶液分别作为Fmiddle和Fouter。调节Finner和Fmiddle流量分别为4和40μL/min，Fouter流量为2000μL/min，形成单核微胶囊，掉入CaCL2溶液中，形成壳核结构的凝胶微球，1-2小时后用去离子水清洗后自然干燥。
实施例2：
采用微流控方式制备壳核α-生育酚微胶囊：取10g α-生育酚溶于30 g稀释剂（苯甲酸苄酯：白油=2：1)中，用注射器吸取作为Finner，用注射器吸取海藻酸钠和白油溶液分别作为Fmiddle和Fouter。调节Finner和Fmiddle流量分别为4和40μL/min，Fouter流量为1500μL/min，形成双核微胶囊，掉入CaCL2溶液中，形成壳核结构的凝胶微球，1-2小时后用去离子水清洗后自然干燥。
实施例3：
采用微流控方式制备壳核α-生育酚微胶囊：取10g α-生育酚溶于30 g稀释剂（苯甲酸苄酯：白油=2：1)中，用注射器吸取作为Finner，用注射器吸取海藻酸钠和白油溶液分别作为Fmiddle和Fouter。调节Finner和Fmiddle流量分别为4和40μL/min，Fouter流量为800μL/min，形成三核微胶囊，掉入CaCL2溶液中，形成壳核结构的凝胶微球，1-2小时后用去离子水清洗后自然干燥。
实施例4：
采用微流控方式制备壳核α-生育酚微胶囊：取10g α-生育酚溶于30 g稀释剂（苯甲酸苄酯：白油=2：1)中，用注射器吸取作为Finner，用注射器吸取海藻酸钠和白油溶液分别作为Fmiddle和Fouter。调节Finner和Fmiddle流量分别为4和40μL/min，Fouter流量为600μL/min，形成四核微胶囊，掉入CaCL2溶液中，形成壳核结构的凝胶微球，1-2小时后用去离子水清洗后自然干燥。
Claims (8)
1.一种壳核α-生育酚微胶囊，其特征在于由如下步骤制得:
（1）取α-生育酚溶于稀释剂中，制成芯材溶液，作为内相流体Finner；
（2）取海藻酸钠溶于水中，加入吐温80和纳米碳酸钙制成壁材溶液，作为中间相流体Fmiddle；
（3）含醋酸的白油溶液作为外相流体Fouter；
（4）取氯化钙溶于水中，制成承接液；
（5）将Finner、Fmiddle与Fouter通过注射泵注入微流控装置中，制备O/W/O液滴，外相流体中的醋酸与碳酸钙反应释放出钙离子，使得壳层进行内部凝胶化，液滴掉入承接液中后进行外部凝胶化，形成壳核结构的α-生育酚微胶囊。
2.如权利要求1所述的壳核α-生育酚微胶囊，其特征在于，步骤（5）中通过恒定Finner和Fmiddle流速，调节Fouter流速来控制壳核微胶囊中芯材的包裹个数。
3.如权利要求1所述的壳核α-生育酚微胶囊，其特征在于，所述稀释剂为苯甲酸苄酯或白油，其用量体积为α-生育酚的2-5倍。
4.如权利要求1所述的壳核α-生育酚微胶囊，其特征在于，步骤（2）中所述壁材溶液的海藻酸钠的质量百分浓度为0.3~1.5％，吐温80的质量百分浓度为0.2~1％，纳米碳酸钙的质量百分浓度为0.1~1％。
5.如权利要求1所述的壳核α-生育酚微胶囊，其特征在于，步骤（3）中所述醋酸的质量百分浓度为0.5~2％。
6.如权利要求1所述的壳核α-生育酚微胶囊，其特征在于，Finner流速为Fmiddle流速的10倍以上。
7.如权利要求1所述的壳核α-生育酚微胶囊，其特征在于，步骤（4）中所述氯化钙的质量百分浓度为2~10％。
8.如权利要求1所述的壳核α-生育酚微胶囊，其特征在于，步骤（2）中所述海藻酸钠为低粘度的，粘度为4-12mpa.s。
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