CN107873030B - 5-ht2c受体激动剂和组合物及使用方法 - Google Patents

5-ht2c受体激动剂和组合物及使用方法 Download PDF

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CN107873030B
CN107873030B CN201680037275.XA CN201680037275A CN107873030B CN 107873030 B CN107873030 B CN 107873030B CN 201680037275 A CN201680037275 A CN 201680037275A CN 107873030 B CN107873030 B CN 107873030B
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individual
compound
smoking
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pharmaceutically acceptable
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CN107873030A (zh
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A·S·任
G·森普尔
X·朱
C·R·塞志
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Arena Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Child & Adolescent Psychology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201680037275.XA 2015-04-27 2016-04-26 5-ht2c受体激动剂和组合物及使用方法 Active CN107873030B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562153082P 2015-04-27 2015-04-27
US62/153,082 2015-04-27
PCT/US2016/029308 WO2016176177A1 (en) 2015-04-27 2016-04-26 5-ht2c receptor agonists and compositions and methods of use

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CN107873030A CN107873030A (zh) 2018-04-03
CN107873030B true CN107873030B (zh) 2021-03-19

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US (1) US10392390B2 (https=)
EP (1) EP3288946B1 (https=)
JP (1) JP6675688B2 (https=)
KR (1) KR102275505B1 (https=)
CN (1) CN107873030B (https=)
AU (1) AU2016255009B2 (https=)
BR (1) BR112017023088B1 (https=)
CA (1) CA3002544C (https=)
DK (1) DK3288946T3 (https=)
EA (1) EA034446B1 (https=)
ES (1) ES2757922T3 (https=)
HK (1) HK1244005B (https=)
HR (1) HRP20192044T1 (https=)
HU (1) HUE047169T2 (https=)
IL (1) IL255171A0 (https=)
MX (2) MX373319B (https=)
PT (1) PT3288946T (https=)
WO (1) WO2016176177A1 (https=)

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US12459965B2 (en) 2017-10-09 2025-11-04 Compass Pathfinder Limited Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
EP3733204A4 (en) 2017-12-27 2021-09-15 Takeda Pharmaceutical Company Limited THERAPEUTIC AGENT FOR URINARY INCONTINENCE OF STRESS AND FECAL INCONTINENCE
EP3746126B1 (en) 2018-01-30 2024-07-31 Apnimed, Inc. (Delaware) Methods and compositions for treating sleep apnea or simple snoring
US20210393621A1 (en) 2018-10-26 2021-12-23 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
EP4635514A3 (en) * 2019-02-08 2025-12-24 The Brigham & Women's Hospital, Inc. Methods and compositions for treating sleep apnea
KR20220009954A (ko) 2019-04-17 2022-01-25 컴퍼스 패쓰파인더 리미티드 신경인지 장애, 만성 통증을 치료하고 염증을 감소시키는 방법
US12205686B2 (en) * 2020-02-27 2025-01-21 The Cleveland Clinic Foundation Identifying patients for intensive hyperglycemia management
US20250073206A1 (en) * 2021-10-29 2025-03-06 Sensorium Therapeutics, Inc. Solid forms of mesembrine and therapeutic uses thereof
JP2024546484A (ja) * 2021-12-10 2024-12-24 ジーエーティーシー ヘルス コーポレーション 中毒および神経障害を治療する方法
CA3254932A1 (en) * 2022-03-10 2023-09-14 Arena Pharmaceuticals, Inc. TREATMENT METHODS
CN114965250B (zh) * 2022-05-19 2025-02-14 道生天合材料科技(上海)股份有限公司 胶粘剂储存期的预测方法
WO2023225773A1 (en) * 2022-05-23 2023-11-30 Sensorium Therapeutics, Inc. Solid forms of mesembrine and therapeutic uses thereof
EP4626437A1 (en) 2022-12-02 2025-10-08 Arena Pharmaceuticals, Inc. Methods of treatment
WO2024173626A1 (en) * 2023-02-17 2024-08-22 Caamtech, Inc. 2-(2,5-diethoxy-4-(ethylthio)phenyl)ethane-1-aminium chloride
CN121127458A (zh) * 2023-03-02 2025-12-12 亚历山大舒尔金研究所有限公司 苯烷胺前药
TW202529748A (zh) * 2023-10-11 2025-08-01 義大利帕多瓦大學 使用賽洛西賓（ｐｓｉｌｏｃｙｂｉｎ）及賽洛辛（ｐｓｉｌｏｃｉｎ）衍生物之治療方法
US20260048069A1 (en) 2024-07-26 2026-02-19 Arena Pharmaceuticals, Inc. Methods of treatment
WO2026043678A1 (en) 2024-08-23 2026-02-26 Arena Pharmaceuticals, Inc. Bexicaserin for use in a method of treatment of seizure-induced sudden unexpected death in epilepsy
US20260091039A1 (en) 2024-10-01 2026-04-02 Arena Pharmaceuticals, Inc. Hydrochloric acid salt of a 5-ht2c agonist

Citations (3)

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WO2002036596A2 (en) * 2000-11-03 2002-05-10 Wyeth CYCLOALKYL[b][1,4]DIAZEPINO[6,7,1-hi]INDOLES AND DERIVATIVES
WO2002042304A2 (en) * 2000-11-03 2002-05-30 Wyeth Cyclopenta[b][1,4] diazepino[6,7,1-hi]indoles as 5ht2c antagonists
CN101792417A (zh) * 2003-06-17 2010-08-04 艾尼纳制药公司 用于治疗5ht2c受体相关疾病的苯并氮杂卓衍生物

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Patent Citations (3)

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WO2002036596A2 (en) * 2000-11-03 2002-05-10 Wyeth CYCLOALKYL[b][1,4]DIAZEPINO[6,7,1-hi]INDOLES AND DERIVATIVES
WO2002042304A2 (en) * 2000-11-03 2002-05-30 Wyeth Cyclopenta[b][1,4] diazepino[6,7,1-hi]indoles as 5ht2c antagonists
CN101792417A (zh) * 2003-06-17 2010-08-04 艾尼纳制药公司 用于治疗5ht2c受体相关疾病的苯并氮杂卓衍生物

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HUE047169T2 (hu) 2020-04-28
US10392390B2 (en) 2019-08-27
EA201792356A1 (ru) 2018-05-31
BR112017023088A2 (pt) 2018-07-10
PT3288946T (pt) 2019-11-27
JP6675688B2 (ja) 2020-04-01
IL255171A0 (en) 2017-12-31
US20180186797A1 (en) 2018-07-05
BR112017023088B1 (pt) 2023-10-03
MX373319B (es) 2020-06-13
MX2020005898A (es) 2020-08-13
ES2757922T3 (es) 2020-04-30
WO2016176177A1 (en) 2016-11-03
EP3288946A1 (en) 2018-03-07
JP2018519251A (ja) 2018-07-19
KR20170140317A (ko) 2017-12-20
HRP20192044T1 (hr) 2020-02-07
CN107873030A (zh) 2018-04-03
CA3002544A1 (en) 2016-11-03
EA034446B1 (ru) 2020-02-10
NZ737412A (en) 2021-06-25
KR102275505B1 (ko) 2021-07-08
AU2016255009A1 (en) 2017-12-14
AU2016255009B2 (en) 2020-10-08
CA3002544C (en) 2024-03-05
EP3288946B1 (en) 2019-08-21
HK1244005B (en) 2020-04-17
MX2017013902A (es) 2018-03-16
DK3288946T3 (da) 2019-11-25

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