CN107857754A - 一种化合物及其在制备预防/治疗类风湿性关节炎药物中的应用 - Google Patents
一种化合物及其在制备预防/治疗类风湿性关节炎药物中的应用 Download PDFInfo
- Publication number
- CN107857754A CN107857754A CN201810033319.2A CN201810033319A CN107857754A CN 107857754 A CN107857754 A CN 107857754A CN 201810033319 A CN201810033319 A CN 201810033319A CN 107857754 A CN107857754 A CN 107857754A
- Authority
- CN
- China
- Prior art keywords
- compound
- rheumatoid arthritis
- formula
- medicine
- treating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CCCC(N(C)C=C(C)C)OC1*CCC1 Chemical compound CCCC(N(C)C=C(C)C)OC1*CCC1 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
Description
不同R基团的式(Ⅰ) | IC50(nM) |
73 | |
57 |
组别 | TNF-α(pg/mL) | IL-12(pg/mL) |
空白组 | 53.5±4.6 | 22.4±0.8 |
模型组 | 96.3±6.7 | 43.6±1.3 |
阳性药组 | 62.4±5.4* | 29.4±1.2* |
待测药物组实施例4 | 71.7±6.2* | 30.3±1.5* |
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810033319.2A CN107857754B (zh) | 2018-01-15 | 2018-01-15 | 一种化合物及其在制备预防/治疗类风湿性关节炎药物中的应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810033319.2A CN107857754B (zh) | 2018-01-15 | 2018-01-15 | 一种化合物及其在制备预防/治疗类风湿性关节炎药物中的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN107857754A true CN107857754A (zh) | 2018-03-30 |
CN107857754B CN107857754B (zh) | 2018-11-09 |
Family
ID=61707624
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201810033319.2A Expired - Fee Related CN107857754B (zh) | 2018-01-15 | 2018-01-15 | 一种化合物及其在制备预防/治疗类风湿性关节炎药物中的应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN107857754B (zh) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1394201A (zh) * | 2000-01-21 | 2003-01-29 | 格吕伦塔尔有限公司 | 取代的戊二酰亚胺及其作为il-12产生抑制剂的用途 |
WO2006053109A1 (en) * | 2004-11-10 | 2006-05-18 | Synta Pharmaceuticals Corp. | Heteroaryl compounds |
CN104903301A (zh) * | 2012-11-08 | 2015-09-09 | 百时美施贵宝公司 | 可用于调节IL-12、IL-23和/或IFNα的烷基酰胺取代的嘧啶化合物 |
US20170369476A1 (en) * | 2016-06-27 | 2017-12-28 | Rigel Pharmaceuticals, Inc. | 2,4-diamino-pyrimidine compounds and method for making and using the compounds |
-
2018
- 2018-01-15 CN CN201810033319.2A patent/CN107857754B/zh not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1394201A (zh) * | 2000-01-21 | 2003-01-29 | 格吕伦塔尔有限公司 | 取代的戊二酰亚胺及其作为il-12产生抑制剂的用途 |
WO2006053109A1 (en) * | 2004-11-10 | 2006-05-18 | Synta Pharmaceuticals Corp. | Heteroaryl compounds |
CN104903301A (zh) * | 2012-11-08 | 2015-09-09 | 百时美施贵宝公司 | 可用于调节IL-12、IL-23和/或IFNα的烷基酰胺取代的嘧啶化合物 |
US20170369476A1 (en) * | 2016-06-27 | 2017-12-28 | Rigel Pharmaceuticals, Inc. | 2,4-diamino-pyrimidine compounds and method for making and using the compounds |
Non-Patent Citations (1)
Title |
---|
王小茜等: "IL-12家族在自身免疫性疾病中的免疫调节作用", 《军事医学》 * |
Also Published As
Publication number | Publication date |
---|---|
CN107857754B (zh) | 2018-11-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6071884A (en) | Pharmaceutical compositions and therapeutic methods | |
SG174548A1 (en) | New salvianolic acid compound l, preparation method and use thereof | |
CN106883279B (zh) | 一种前药、其制备方法、药物组合物及其用途 | |
WO2018081959A1 (en) | Extracts of andrographis paniculata, methods for preparation and use thereof | |
JP6726192B2 (ja) | アムホテリシンbの尿素誘導体の簡便な合成法 | |
RU2443415C2 (ru) | Антрацендионовые соединения | |
CN110090236B (zh) | 药物组合物及其用途 | |
CN107857754B (zh) | 一种化合物及其在制备预防/治疗类风湿性关节炎药物中的应用 | |
CN101723997A (zh) | 葛根素糖基化衍生物、其药物组合物、及其制备方法和用途 | |
CN107903245B (zh) | 一种化合物及其在制备治疗类风湿性关节炎药物中的应用 | |
JP2006515276A (ja) | 骨粗鬆症の予防及び治療効果を有するフラン誘導体並びにこれを含む薬学的組成物 | |
CN107903253A (zh) | 一种化合物、合成路线及其在制备预防/治疗类风湿性关节炎药物中的应用 | |
CN110183459A (zh) | α-倒捻子素衍生物及其制备方法和应用 | |
JPH10218769A (ja) | 抗潰瘍剤 | |
CN107880043A (zh) | 一种化合物及其在制备预防/治疗自身免疫性疾病药物中的用途 | |
CN108358889A (zh) | 一种化合物及其在制备预防和/或治疗自身免疫性疾病药物中的用途 | |
CN108047239A (zh) | 一种化合物、制备方法及其在制备预防/治疗自身免疫性疾病药物中的应用 | |
CN110857285B (zh) | 取代吡唑类化合物、其制备方法、药物组合物及用途 | |
CN108299385A (zh) | 一种化合物、合成路线及其在制备预防/治疗自身免疫性疾病药物中的应用 | |
CN108101888A (zh) | 一种化合物及其在制备预防/治疗自身免疫性疾病药物中的应用 | |
CN105085391B (zh) | 用作白三烯受体拮抗剂的环丙基不饱和喹啉化合物及应用 | |
CN108084156A (zh) | 一种化合物及其医药用途 | |
CN108358890A (zh) | 一种化合物及其在制备预防/治疗自身免疫性疾病药物中的应用 | |
CN109096190A (zh) | 一种青藤碱衍生物及其制备方法、用途和药物组合物 | |
DE69916571T2 (de) | Hemmer der angiogenese und der urokinase produktion und seine medizinische anwendung |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB03 | Change of inventor or designer information | ||
CB03 | Change of inventor or designer information |
Inventor after: Wang Defeng Inventor after: Fan Xihai Inventor after: Tao Ru Inventor after: Tian Tian Inventor after: Lu Chao Inventor after: Wang Lingxi Inventor before: Tian Tian Inventor before: Lu Chao Inventor before: Wang Lingxi |
|
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20180930 Address after: No. 2, Ying Sheng Dong Road, Taishan District, Tai'an, Shandong Province Applicant after: Taishan Hospital Address before: 264200 Jinhaiwan International Apartment Community, Ximen, Shandong University (Weihai Campus), 180 Wenxi Road, Huancui District, Weihai City, Shandong Province Applicant before: Tian Tian |
|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20181109 Termination date: 20200115 |