CN107854719A - A kind of double load medicine Wound antibiotic dressing and preparation method thereof - Google Patents
A kind of double load medicine Wound antibiotic dressing and preparation method thereof Download PDFInfo
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- CN107854719A CN107854719A CN201711141465.9A CN201711141465A CN107854719A CN 107854719 A CN107854719 A CN 107854719A CN 201711141465 A CN201711141465 A CN 201711141465A CN 107854719 A CN107854719 A CN 107854719A
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- Prior art keywords
- sodium alginate
- spinning
- polyvinyl alcohol
- medicine
- weighed
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
Abstract
The invention discloses a kind of double load medicine Wound antibiotic dressing and preparation method thereof, its preparation method is：The first step：Using polyvinyl alcohol and sodium alginate as carrier, polyvinyl alcohol, sodium alginate spinning solution are prepared, static spinning membrane is prepared, determines spinning optimum condition；Second step：Prepare vancomycin and Cefepime joint decoction, ratio 1:2；3rd step：By vancomycin and Cefepime 1:2 joint decoctions are added in polyvinyl alcohol and sodium alginate spinning solution, it is sufficiently stirred under normal temperature on magnetic stirring apparatus until being completely dissolved, under the conditions of 10~15KV voltages, flow velocity are 0.08~0.2mm/min, reception distance is 10~15cm, spinning 8h prepares polyvinyl alcohol/sodium alginate and carries medicine static spinning membrane, obtains double load medicine Wound antibiotic dressing.Double load medicine Wound antibiotic dressing of the present invention have good bactericidal properties, hygroscopicity, gas permeability, nonirritant, do not cause foreign body reaction, may advantageously facilitate the healing of the surface of a wound.
Description
Technical field
The present invention relates to a kind of double load medicine Wound antibiotic dressing and preparation method thereof, belong to medical material tech field.
Background technology
Human body skin abraded, burn and scald and during operation wound, it is uncommon to be vulnerable to staphylococcus aureus, large intestine angstrom
The invasion of the microorganisms such as bacterium, pseudomonas aeruginosa and cause infection.The use of medical antibacterial dressing controls microorganism to invade in time
Infective wound surface, the micro- wet environment of the surface of a wound, wound healing are maintained, therefore research and develop the wound dressing with antibacterial functions and facing
It is extremely important in bed application.Traditional dressing is temporary covering material, can not keep surface of a wound moist environment so that the surface of a wound is cured
Delay is closed, it is necessary to change in time, and wound is easily adhered in agglutination, causes secondary damage.For in traditional dressing not
Foot, Electrospun nano-fibers are more and more applied to dressing field.Electrostatic spinning nano antiseptic dressing is by antibiotic
With the mixed solution of polymer substance, pass through the nanoscale functional dressings with anti-microbial property made of electrostatic spinning.Using quiet
Nanofiber prepared by Electrospinning has that diameter is small, specific surface area is high, adsorptivity, hemostatic, be advantageous to cellular respiration and
The advantages that wound healing, it is especially suitable for being used as dressing for skin.In recent years, further research and development are quiet with good antibacterial functions
Electrospun dressing has turned into an important development trend in the field.Polyvinyl alcohol is a kind of nontoxic, nonirritant hydrophily
High polymer, there is good chemical stability, biocompatibility, hygroscopicity and film forming.Sodium alginate is a kind of nontoxic delays
Material is released, there is good biological degradability and compatibility.The present invention prepares electrostatic using polyvinyl alcohol and sodium alginate as carrier
Spinning film, and two kinds of antibiotic are merged with static spinning membrane antiseptic dressing is made first, the dressing have sterilization, moisturizing, saturating
Gas, absorbing wound exudate, promote the multi-efficiencies such as wound healing.
The content of the invention
Carry medicine Wound antibiotic dressing and preparation method thereof the invention provides a kind of double, the dressing have good sterilization,
Hygroscopicity, gas permeability, it is nonirritant, the healing of wound can be effectively facilitated.
The technical solution adopted for the present invention to solve the technical problems is：
It is a kind of it is double carry medicine Wound antibiotic dressing preparation method be：
The first step：Using polyvinyl alcohol and sodium alginate as carrier, static spinning membrane is prepared：
（1）Appropriate polyvinyl alcohol is weighed, using distilled water as solvent, in the stirred in water bath that temperature is 80 DEG C until being completely dissolved system
It is standby into poly-vinyl alcohol solution, concentration 12%；
（2）Appropriate sodium alginate is weighed, using distilled water as solvent, is sufficiently stirred under normal temperature on magnetic stirring apparatus, is prepared into sea
Solution of sodium alginate, concentration 2%；
（3）It is 8 by volume:2 take polyvinyl alcohol and sodium alginate soln to stir respectively, at room temperature in Static Spinning
Spinning in silk equipment, it is 10~15cm that receiving voltage, which is 10~15 KV, flow velocity is 0.08~0.2mm/min, receives distance, spinning
The silk time is 8~12h；
Second step：Prepare vancomycin and Cefepime admixing medical solutions：
5mg vancomycins and 10mg Cefepimes are weighed respectively, is dissolved in 100ml distilled water, are configured to two kinds of medicine mixing medicines
Liquid, ratio 1:2；
3rd step：Prepare double load medicine static spinning membranes：
By vancomycin and Cefepime 1:2 admixing medical solutions are added in polyvinyl alcohol and sodium alginate spinning solution, under normal temperature
Be sufficiently stirred on magnetic stirring apparatus until be completely dissolved, 10~15KV voltages, flow velocity be 0.08~0.2mm/min, receive away from
Under the conditions of for 10~15cm, spinning 8h prepares polyvinyl alcohol/sodium alginate and carries medicine static spinning membrane, obtains double medicine wounds that carry and resists
Bacterium dressing.
Preferably, a kind of double preparation methods for carrying medicine Wound antibiotic dressing：
The first step：Using polyvinyl alcohol and sodium alginate as carrier, static spinning membrane is prepared：
（1）Appropriate polyvinyl alcohol is weighed, using distilled water as solvent, in the stirred in water bath that temperature is 80 DEG C until being completely dissolved system
It is standby into poly-vinyl alcohol solution, concentration 12%；
（2）Appropriate sodium alginate is weighed, using distilled water as solvent, is sufficiently stirred under normal temperature on magnetic stirring apparatus, is prepared into sea
Solution of sodium alginate, concentration 2%；
（3）It is 8 by volume:2 take polyvinyl alcohol and sodium alginate soln to stir respectively, at room temperature in Static Spinning
Spinning in silk equipment, receiving voltage 15KV, flow velocity 0.08mm/min, reception distance are 10cm, the spinning time is 8h；
Second step：Prepare vancomycin and Cefepime admixing medical solutions：
5mg vancomycins and 10mg Cefepimes are weighed respectively, is dissolved in 100ml distilled water, are configured to two kinds of medicine mixing medicines
Liquid, ratio 1:2；
3rd step：Prepare double load medicine static spinning membranes：
By vancomycin and Cefepime 1:2 joint decoctions are added in polyvinyl alcohol and sodium alginate spinning solution, under normal temperature
It is sufficiently stirred on magnetic stirring apparatus until be completely dissolved, is 15KV, flow velocity 0.08mm/min, receives distance and be in receiving voltage
10cm, spinning 8h prepare polyvinyl alcohol/sodium alginate and carry medicine static spinning membrane, obtain double load medicine Wound antibiotic dressing.
The beneficial effects of the invention are as follows：Double load medicine Wound antibiotic dressing of the present invention have good bactericidal properties, hygroscopicity, saturating
Gas, it is nonirritant, do not cause foreign body reaction, may advantageously facilitate the healing of the surface of a wound.It is a kind of strong antibacterial, biocompatibility
Good, good permeability can promote wound healing, and stability is good, the medical dressing having no toxic side effect.
Brief description of the drawings
Fig. 1 is the work of vancomycin and Cefepime with the admixing medical solutions of various concentrations compatibility to staphylococcus aureus
With.
Fig. 2 is vancomycin and Cefepime with effect of the admixing medical solutions of various concentrations compatibility to EHEC.
Fig. 3 is vancomycin and Cefepime with effect of the admixing medical solutions of various concentrations compatibility to pseudomonas aeruginosa.
Fig. 4 be spinning 8h prepare double load medicine Wound antibiotic dressing respectively to staphylococcus aureus, EHEC and
The inhibitory action of pseudomonas aeruginosa.
Embodiment
Below in conjunction with the accompanying drawings and embodiment the present invention is further described.
Embodiment 1
（1）Appropriate polyvinyl alcohol is weighed, using distilled water as solvent, in the stirred in water bath that temperature is 80 DEG C until being completely dissolved system
It is standby into 12% poly-vinyl alcohol solution；
（2）Appropriate sodium alginate is weighed, using distilled water as solvent, is sufficiently stirred under normal temperature on magnetic stirring apparatus, is prepared into 2%
Sodium alginate soln；
（3）It is 8 by volume:2 take polyvinyl alcohol and sodium alginate soln to stir respectively, at room temperature in
Spinning on electrospinning device, in different voltages（10KV、15KV、20KV）Under the conditions of, prepare polyvinyl alcohol/sodium alginate
Static spinning membrane, according to spinning effect, it is 15KV to determine optimum voltage.
Embodiment 2
（1）Appropriate polyvinyl alcohol is weighed, using distilled water as solvent, in the stirred in water bath that temperature is 80 DEG C until being completely dissolved system
It is standby into 12% poly-vinyl alcohol solution；
（2）Appropriate sodium alginate is weighed, using distilled water as solvent, is sufficiently stirred under normal temperature on magnetic stirring apparatus, is prepared into 2%
Sodium alginate soln；
（3）It is 8 by volume:2 take polyvinyl alcohol and sodium alginate soln to stir respectively, at room temperature in
Spinning on electrospinning device, different in flow rate（0.08mm/min、0.15mm/min、0.2mm/min）Under the conditions of, prepare
Polyvinyl alcohol/sodium alginate static spinning membrane, according to spinning effect, it is 0.08mm/min to determine optimum flow rate.
Embodiment 3
（1）Appropriate polyvinyl alcohol is weighed, using distilled water as solvent, in the stirred in water bath that temperature is 80 DEG C until being completely dissolved system
It is standby into 12% poly-vinyl alcohol solution；
（2）Appropriate sodium alginate is weighed, using distilled water as solvent, is sufficiently stirred under normal temperature on magnetic stirring apparatus, is prepared into 2%
Sodium alginate soln；
（3）It is 8 by volume:2 take polyvinyl alcohol and sodium alginate soln to stir respectively, at room temperature in
Spinning on electrospinning device, in different reception distances（10cm、15cm、20cm）Under the conditions of, prepare polyvinyl alcohol/marine alga
Sour sodium static spinning membrane, according to spinning effect, determine that optimum reception distance is 10cm.
Embodiment 4
（1）Appropriate polyvinyl alcohol is weighed, using distilled water as solvent, in the stirred in water bath that temperature is 80 DEG C until being completely dissolved system
It is standby into 12% poly-vinyl alcohol solution；
（2）Appropriate sodium alginate is weighed, using distilled water as solvent, is sufficiently stirred under normal temperature on magnetic stirring apparatus, is prepared into 2%
Sodium alginate soln；
（3）It is 8 by volume:2 take polyvinyl alcohol and sodium alginate soln to stir respectively, at room temperature in Static Spinning
Spinning in silk equipment, in the different spinning times（8h、10h、12h）Under the conditions of, prepare polyvinyl alcohol/sodium alginate electrostatic spinning
Film, according to spinning effect, determine that the spinning time can obtain preferable static spinning membrane for 8h.
Embodiment 5
（1）Appropriate vancomycin and Cefepime are weighed, using distilled water as solvent, respectively with various concentrations（1:1,1:2,1:3,
1:4,1:5）Compatibility, two kinds of medicine admixing medical solutions are configured to, determine every kind of compatibility concentration respectively and staphylococcus aureus is killed
Bacterium effect；
（2）Appropriate vancomycin and Cefepime are weighed, using distilled water as solvent, respectively with various concentrations（1:1,1:2,1:3,
1:4,1:5）Compatibility, two kinds of medicine admixing medical solutions are configured to, determine sterilization effect of every kind of compatibility concentration to EHEC respectively
Fruit；
（3）Appropriate vancomycin and Cefepime are weighed, using distilled water as solvent, respectively with various concentrations（1:1,1:2,1:3,
1:4,1:5）Compatibility, two kinds of medicine admixing medical solutions are configured to, determine sterilization of every kind of compatibility concentration to pseudomonas aeruginosa respectively
Effect；
（4）Bacterial action effect is compared according to the joint decoction of various concentrations compatibility, vancomycin is determined by Fig. 1, Fig. 2, Fig. 3
Optimal compatibility concentration with Cefepime is 1:2.
Embodiment 6
（1）By vancomycin and Cefepime 1:2 joint decoctions are added in polyvinyl alcohol and sodium alginate spinning mixed solution, often
It is sufficiently stirred under temperature on magnetic stirring apparatus until being completely dissolved, preparation carries the electrostatic spinning solution of medicine；
（2）It is that 10cm conditions carry out spinning using 15KV voltages, flow velocity 0.08mm/min, reception distance on electrostatic spinning machine,
Spinning 8h at room temperature, the double load medicine static spinning membranes of polyvinyl alcohol/sodium alginate are obtained, are placed one day at aeration-drying, it is standby
With.
Embodiment 7
（1）The static spinning membrane of preparation is prepared into diameter 6mm disks with card punch；
（2）By staphylococcus aureus, EHEC, the intensive streak inoculation of pseudomonas aeruginosa on MH culture mediums, incite somebody to action（1）
The disk of preparation is put in media surface, and 18-24h is incubated in 37 DEG C of insulating boxs, observes result；
（3）Figure 4, it can be seen that the double medicine static spinning membranes that carry of polyvinyl alcohol/sodium alginate prepared by the present invention have well
Bacteriostasis.
Claims (2)
- A kind of 1. double preparation methods for carrying medicine Wound antibiotic dressing, it is characterised in that：The first step：Using polyvinyl alcohol and sodium alginate as carrier, static spinning membrane is prepared：（1）Appropriate polyvinyl alcohol is weighed, using distilled water as solvent, in the stirred in water bath that temperature is 80 DEG C until being completely dissolved system It is standby into poly-vinyl alcohol solution, concentration 12%；（2）Appropriate sodium alginate is weighed, using distilled water as solvent, is sufficiently stirred under normal temperature on magnetic stirring apparatus, is prepared into sea Solution of sodium alginate, concentration 2%；（3）It is 8 by volume:2 take polyvinyl alcohol and sodium alginate soln to stir respectively, at room temperature in Static Spinning Spinning in silk equipment, it is 10~15cm that receiving voltage, which is 10~15 KV, flow velocity is 0.08~0.2mm/min, receives distance, spinning The silk time is 8~12h；Second step：Prepare vancomycin and Cefepime admixing medical solutions：5mg vancomycins and 10mg Cefepimes are weighed respectively, is dissolved in 100ml distilled water, are configured to two kinds of medicine mixing medicines Liquid, ratio 1:2；3rd step：Prepare double load medicine static spinning membranes：By vancomycin and Cefepime 1:2 admixing medical solutions are added in polyvinyl alcohol and sodium alginate spinning solution, under normal temperature Be sufficiently stirred on magnetic stirring apparatus until be completely dissolved, 10~15KV voltages, flow velocity be 0.08~0.2mm/min, receive away from Under the conditions of for 10~15cm, spinning 8h prepares polyvinyl alcohol/sodium alginate and carries medicine static spinning membrane, obtains double medicine wounds that carry and resists Bacterium dressing.
- A kind of 2. double preparation methods for carrying medicine Wound antibiotic dressing, it is characterised in that：The first step：Using polyvinyl alcohol and sodium alginate as carrier, static spinning membrane is prepared：（1）Appropriate polyvinyl alcohol is weighed, using distilled water as solvent, in the stirred in water bath that temperature is 80 DEG C until being completely dissolved system It is standby into poly-vinyl alcohol solution, concentration 12%；（2）Appropriate sodium alginate is weighed, using distilled water as solvent, is sufficiently stirred under normal temperature on magnetic stirring apparatus, is prepared into sea Solution of sodium alginate, concentration 2%；（3）It is 8 by volume:2 take polyvinyl alcohol and sodium alginate soln to stir respectively, at room temperature in Static Spinning Spinning in silk equipment, receiving voltage 15KV, flow velocity 0.08mm/min, reception distance are 10cm, the spinning time is 8h；Second step：Prepare vancomycin and Cefepime admixing medical solutions：5mg vancomycins and 10mg Cefepimes are weighed respectively, is dissolved in 100ml distilled water, are configured to two kinds of medicine mixing medicines Liquid, ratio 1:2；3rd step：Prepare double load medicine static spinning membranes：By vancomycin and Cefepime 1:2 joint decoctions are added in polyvinyl alcohol and sodium alginate spinning solution, under normal temperature It is sufficiently stirred on magnetic stirring apparatus until be completely dissolved, is 15KV, flow velocity 0.08mm/min, receives distance and be in receiving voltage 10cm, spinning 8h prepare polyvinyl alcohol/sodium alginate and carry medicine static spinning membrane, obtain double load medicine Wound antibiotic dressing.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711141465.9A CN107854719A (en) | 2017-11-17 | 2017-11-17 | A kind of double load medicine Wound antibiotic dressing and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711141465.9A CN107854719A (en) | 2017-11-17 | 2017-11-17 | A kind of double load medicine Wound antibiotic dressing and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109395154A (en) * | 2018-11-06 | 2019-03-01 | 东北林业大学 | A kind of high porosity carries the preparation method of medicine wound dressing |
| CN109457395A (en) * | 2018-11-06 | 2019-03-12 | 温州医科大学 | A kind of tannic acid static spinning membrane and its preparation method and application |
| CN113384738A (en) * | 2021-06-10 | 2021-09-14 | 山东良福制药有限公司 | Preparation method of tretinoin dressing for promoting wound healing |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102036692A (en) * | 2008-02-22 | 2011-04-27 | 西洛诺瓦生物科学公司 | Multi-functional wound dressing matrices and related methods |
| CN106178065A (en) * | 2015-04-30 | 2016-12-07 | 中国人民解放军第三军医大学第三附属医院 | A kind of preparation method carrying Moxifloxacin electrospun membrane antiseptic dressing |
-
2017
- 2017-11-17 CN CN201711141465.9A patent/CN107854719A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102036692A (en) * | 2008-02-22 | 2011-04-27 | 西洛诺瓦生物科学公司 | Multi-functional wound dressing matrices and related methods |
| CN106178065A (en) * | 2015-04-30 | 2016-12-07 | 中国人民解放军第三军医大学第三附属医院 | A kind of preparation method carrying Moxifloxacin electrospun membrane antiseptic dressing |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109395154A (en) * | 2018-11-06 | 2019-03-01 | 东北林业大学 | A kind of high porosity carries the preparation method of medicine wound dressing |
| CN109457395A (en) * | 2018-11-06 | 2019-03-12 | 温州医科大学 | A kind of tannic acid static spinning membrane and its preparation method and application |
| CN113384738A (en) * | 2021-06-10 | 2021-09-14 | 山东良福制药有限公司 | Preparation method of tretinoin dressing for promoting wound healing |
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Application publication date: 20180330 |