CN110025817A - A kind of preparation and application of zein/plants essential oil composite antibacterial fibre dressing - Google Patents

A kind of preparation and application of zein/plants essential oil composite antibacterial fibre dressing Download PDF

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Publication number
CN110025817A
CN110025817A CN201910320388.6A CN201910320388A CN110025817A CN 110025817 A CN110025817 A CN 110025817A CN 201910320388 A CN201910320388 A CN 201910320388A CN 110025817 A CN110025817 A CN 110025817A
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essential oil
zein
plants essential
dressing
preparation
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CN201910320388.6A
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Chinese (zh)
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闫旭
董文昊
刘佳旭
牟小菊
刘国赛
闫芳芳
郭浩
张迪安
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Qingdao University
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Qingdao University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • D—TEXTILES; PAPER
    • D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
    • D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
    • D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
    • D04H1/70—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres
    • D04H1/72—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged
    • D04H1/728—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Textile Engineering (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention discloses a kind of zein/plants essential oil composite antibacterial fibre dressing preparation and application, including corn protein powder is completely dissolved with alcoholic solution, plants essential oil is added in corn protein solution and obtains spinning precursor liquid after mixing evenly, prepared spinning precursor liquid is added in syringe, and syringe is put into electrostatic spinning apparatus in situ, open equipment, spinning parameter is adjusted to there is fiber uniformly to spray, it controls nozzle mouth and receives the spacing distance of wound, it may be implemented in wound and zein/plants essential oil composite fibre antiseptic dressing be prepared in situ.Pure natural antibacterial fiber film dressing perfection can be bonded wound using the effect of electrostatic force by the preparation method, and the nano fibrous membrane has good gas permeability.Meanwhile using zein as carrier, natural material has biocompatibility；Using plants essential oil as antimicrobial component, good anti-bacterial effect has no toxic side effect, nonirritant.

Description

A kind of preparation and application of zein/plants essential oil composite antibacterial fibre dressing
Technical field
The invention belongs to medical dressing fields, and in particular to a kind of zein/plants essential oil composite antibacterial fibre dressing Preparation and application.
Background technique
Skin is the maximum organ of human body, is the first barrier of protecting human body, it makes in vivo, and various tissues and organ are exempted from By physical, mechanicalness, chemically with the invasion of pathogenic microorganism, but its moment is exposed in external environment and will lead to difference The damage of type, mainly includes acute (such as operation and traumatic wound, scratch and burn) and chronic (such as diabetes are routed Ulcer and pressure sore).According to the estimation of the World Health Organization (WHO), there are about 41,000,000 wound cases, annual economy is negative in the annual whole world Load is more than 670,000,000,000 dollars.As it can be seen that human skin wound to global medical health system bring it is sizable society and Financial burden.
The treatment of skin wound depends primarily on the size of wound, depth and extent of the destruction, and dependent on wound dressing Auxiliary.It includes: that can be suitble to shape of wound that ideal wound dressing, which needs to have various features, absorbs wound fluid without increasing Bacterial multiplication causes excessive dehydration, controls the liquids and gases of outflow, protects wound and surrounding tissue, eliminates pain, promotes Reparation phase re-epithelialization is easy to apply and remove and patient is made to feel comfortable.Domestic inventor has been developed at present A variety of wound dressings include as Chinese invention patent (CN201310613174.0) discloses a kind of high penetration rate film dressing Polyurethane film and coating, Chinese invention patent (CN201310655235.X) disclose a kind of silver ionized water gel dressing Preparation method, Chinese invention patent (CN201510130794.8) disclose a kind of foam dressing containing compound silver-colored zinc anti-biotic material And preparation method thereof equal foam dressings and hydrophilic fibers dressing etc., it is such as ventilative more or less to there are some problems in these dressing Property, wellability, antibiotic property and the inconvenience of replacement etc., and lack the ability for reappearing Skin Cell epimatrix (ECM) structure.
In recent years, due to high specific surface area, high porosity and morphology controllable etc. are excellent for electrospinning fibre and its tunica fibrosa Point causes many concerns in terms of wound healing, electrospun fiber membrane on the one hand can physical isolation virus and bacterium, and can Air permeable humidity retaining builds a good healing environment to wound；On the other hand, the aperture of the diameter of electrospinning fibre and tunica fibrosa With the comparable dimensions of extracellular matrix, cell can be promoted to grow, accelerating wound healing speed reduces scar and generates, therefore There is unique advantage in terms of wound dressing.In terms of electrospinning fibre is used as antiseptic dressing, Chinese invention patent (CN201310574818.X) a kind of preparation method of chitosan-based electrostatic spinning combined wound dressing is disclosed, Chinese invention is special Sharp (CN201610479265.3) discloses a kind of method for preparing imitative extracellular matrix nanofiber dressing using electrostatic spinning, Chinese invention patent (CN201710076435.8) discloses a kind of preparation method etc. of antibacterial nano fiber wound dressing.However The preparation and application of these electrospinning fibre film dressings are all divided into two steps, i.e. the first step prepares electrospun fiber membrane, and second step will be fine Dimension film dressing is applied at skin trauma.This traditional application method proposes very high requirement to nursing staff, i.e., cannot Secondary injury is caused to wound, and fiber film dressing is difficult to be bonded well with the surface of a wound.And the antibacterial of these anti-bacterial fibre dressing Property is mostly from the inorganic antibacterials ingredient such as Nano silver grain, and for the toxicity of these nanoparticles, there are still disputes at present.
Summary of the invention
The technical problem to be solved by the present invention is overcome prior art defect, providing one kind, that antibacterial is prepared in situ is micro-nano The method of fiber dressing, this dressing has good antibacterial, permeability, can promote wound healing, convenient to use, It can be bonded the various types surface of a wound, complete preservation is provided to the surface of a wound, be particularly suitable for large area dispersivity wound care.
To solve the above-mentioned problems, the present invention provides a kind of zein/plants essential oil composite antibacterial fibre dressing Preparation and application, comprising the following steps:
Step 1: corn protein powder being completely dissolved with the mixed solvent of dehydrated alcohol and deionized water, zein is made Solution；The volume ratio of the dehydrated alcohol and deionized water is 4:1；The corn protein solution concentration is 10-20wt%；
Step 2: it is jade that plants essential oil, which is added in corn protein solution prepared by step 1 to the quality of plants essential oil, The 1-5wt% of rice gluten content, stirring to obtaining spinning precursor liquid after substantially uniformity, the plants essential oil include Peppermint essential oil, Laurin oil, thyme essential oil, cinnamon essential oil etc.；
Step 3: spinning precursor liquid prepared in step 2 being added in syringe, and syringe is put into portable In electrostatic spinning apparatus, open equipment, adjust spinning parameter, control nozzle mouth and receive wound spacing distance, it can be achieved that Nanofiber antiseptic dressing is prepared in situ in wound.
Further, the syringe is 5-10ml injector for medical purpose, and it is the flat of 0.3-1.5mm that syringe needle, which selects internal diameter, Head metal needle；The portable electric spinning equipment is portable electric spinning equipment or the electrospinning in situ dress with hand-held spray head It sets；
It further, include 8-20 kilovolts of spinning voltage in spinning parameter, 5-15 centimetres of spinning distance.
Further, electro spinning nano fiber antiseptic dressing in situ with a thickness of 80-1000 microns.
The beneficial effect of the preparation method is directly can to deposit corn egg in wound using electrostatic spinning technique in situ Anti-bacterial fibre film dressing perfection can be bonded wound, and the nanometer using the effect of electrostatic force by white antibacterial micro nanometer fiber film Tunica fibrosa has good gas permeability.Meanwhile using zein as carrier, natural material has biocompatibility；It adopts Use plants essential oil as antimicrobial component, good anti-bacterial effect has no toxic side effect, nonirritant.
Detailed description of the invention
Fig. 1: zein prepared by the present invention/thyme essential oil nanofiber antiseptic dressing scanning electron microscope sem picture；
Fig. 2: zein prepared by the present invention/clove oil nanofiber antiseptic dressing scanning electron microscope sem picture.
Specific embodiment
In order to clarify the technical characteristics of the invention, being illustrated below by embodiment to this programme.Implementing Be respectively adopted in example 1,2 and embodiment 3 a kind of Portable hand electrostatic spinning apparatus (China Patent No.: CN201510214221.3) and a kind of electrostatic spinning apparatus (China Patent No.: CN201410560189.X) in situ etc. is portable Electrostatic spinning apparatus.
Embodiment 1:
Step 1: weigh 1.5 grams of zeins, be all dissolved in 8.5 grams of concentration be 80% alcohol (dehydrated alcohol: go from Sub- water=4:1) in, magnetic agitation 10 hours to being completely dissolved at room temperature, obtains the corn egg that Solute mass fraction is 15wt% White solution；
Step 2: weighing 0.5 gram of thyme essential oil and be distributed in step 1 in configured corn protein solution, stirring 2 is small When, it is uniformly mixed it, then uniform and stable spinning precursor liquid is made after standing 12 hours；
Step 3: spinning precursor liquid prepared in step 2 is added in 5ml syringe (1.0 millimeters of needle diameter), And be installed on portable electrostatic spinning apparatus, it with portable lifting device, turns on the power switch, adjusting voltage is 15 kilovolts, solution Per hour for 2 milliliters, adjustment distance carries out spinning under conditions of being 10 centimetres from wound to injection speed, directly heavy in wound Product zein/thyme essential oil micro nanometer fiber antiseptic dressing, obtained zein/thyme essential oil micro nanometer fiber film With a thickness of 200 microns, fibre diameter is about 900 nanometers, and fiber morphology is as shown in Figure 1.
It is 12.5 with the zein prepared in simulated body fluid SBF testing procedure 3/thyme essential oil tunica fibrosa contact angle Degree shows that zein/thyme essential oil dressing of electrospinning preparation in situ has good wellability, can quickly absorb wound Diffusate, keep wound moist.Zein/thyme essential oil tunica fibrosa gas permeability is 314.7 in testing procedure 3 11.43 squares of metre per second (m/s)s are 20 times higher than the gas permeability of traditional adhesive bandage.By the zein prepared in step 3/thyme essence Oily tunica fibrosa is placed on the aseptic filter paper that diameter is 5 millimeters, and is placed on and is coated with Gram-negative bacteria Escherichia coli and leather orchid On the solid culture primary surface of family name's positive bacterium S. aureus bacterium solution, seen after being cultivated 24 hours in 37 DEG C of constant incubators Examining the antiseptic dressing for observing prepared by step 3 is 13.6 millimeters to the inhibition zone of Escherichia coli, the suppression to staphylococcus aureus Bacterium circle is 14.2 millimeters, shows that the antiseptic dressing of this method preparation has outstanding antibiotic property.
Embodiment 2:
Step 1: weigh 1.8 grams of zeins, be all dissolved in 8.2 grams of concentration be 80% alcohol (dehydrated alcohol: go from Sub- water=4:1) in, magnetic agitation 10 hours to being completely dissolved at room temperature, obtains the corn egg that Solute mass fraction is 18wt% White solution；
Step 2: it weighs 0.6 gram of clove oil and is distributed in step 1 in configured corn protein solution, stir 2 hours, It is uniformly mixed it, then uniform and stable spinning precursor liquid is made after standing 12 hours；
Step 3: spinning precursor liquid prepared in step 2 is added in 5ml syringe (0.8 millimeter of needle diameter), And be installed on air-flow assisted in situ electrostatic spinning apparatus, it turns on the power switch, adjusting voltage is 18 kilovolts, the injection speed of solution Per hour for 5 milliliters, air-flow size is 10 ls/h to degree, and adjustment distance carries out spinning under conditions of being 12 centimetres from wound, Zein/clove oil micro nanometer fiber antiseptic dressing directly is deposited in wound, obtained zein/clove oil is micro- Nano fibrous membrane is with a thickness of 300 microns, and fibre diameter is about 1100 nanometers, and fiber morphology is as shown in Figure 2.
It is 22.7 with the zein prepared in simulated body fluid SBF testing procedure 3/clove oil tunica fibrosa contact angle Degree shows that zein/thyme essential oil dressing of electrospinning preparation in situ has good wellability, can quickly absorb wound Diffusate, keep wound moist.Zein/thyme essential oil tunica fibrosa gas permeability is 212.3 in testing procedure 3 23.54 squares of metre per second (m/s)s are 20 times higher than the gas permeability of traditional adhesive bandage.Zein/the clove oil that will be prepared in step 3 Tunica fibrosa is placed on the aseptic filter paper that diameter is 5 millimeters, and is placed on and is coated with Gram-negative bacteria Escherichia coli and gram On the solid culture primary surface of positive bacterium S. aureus bacterium solution, observed after being cultivated 24 hours in 37 DEG C of constant incubators The antiseptic dressing for observing prepared by step 3 is 11.2 millimeters to the inhibition zone of Escherichia coli, to the antibacterial of staphylococcus aureus Circle is 10.6 millimeters, shows that the antiseptic dressing of this method preparation has outstanding antibiotic property.
Embodiment enumerated above is not to technical solution described in the invention only for understanding that the present invention is used Restriction, the those of ordinary skill in relation to field on the basis of the technical solution described in claim, can also make a variety of changes Change or deformation, all equivalent variations or deformation should all be covered within the scope of the claims of the present invention.The present invention is not Place is described in detail, is the well-known technique of those skilled in the art of the present technique.

Claims (9)

1. a kind of zein/plants essential oil composite antibacterial fibre dressing preparation and application, comprising the following steps:
Step 1: corn protein powder being completely dissolved with the mixed solvent of dehydrated alcohol and deionized water, it is molten that zein is made Liquid；
Step 2: it is zein that plants essential oil, which is added in corn protein solution prepared by step 1 to the quality of plants essential oil, The 1-5wt% of content obtains spinning precursor liquid after stirring to substantially uniformity；
Step 3: spinning precursor liquid prepared in step 2 being added in syringe, and syringe is put into portable electrostatic In device for spinning, equipment is opened, adjusts spinning parameter to there is fiber uniformly to spray, nozzle mouth is controlled and receives the interval distance of wound From, it can be achieved that nanofiber antiseptic dressing is prepared in situ in wound.
2. a kind of preparation and application of zein/plants essential oil composite antibacterial fibre dressing as described in claim 1, special Sign is that the volume ratio of the dehydrated alcohol and deionized water is 4:1；The corn protein solution concentration is 10- 20wt%.
3. a kind of preparation and application of zein/plants essential oil composite antibacterial fibre dressing as described in claim 1, special Sign is that the plants essential oil includes clove oil, laurin oil, thyme essential oil, cinnamon essential oil etc..
4. a kind of preparation and application of zein/plants essential oil composite antibacterial fibre dressing as described in claim 1, special Sign is that the syringe is 5-10ml injector for medical purpose, and it is the flattened metal needle of 0.3-1.5mm that syringe needle, which selects internal diameter, Head.
5. a kind of preparation and application of zein/plants essential oil composite antibacterial fibre dressing as described in claim 1, described Portable electric spinning equipment be portable electric spinning equipment or the electric spinning equipment in situ with hand-held spray head.
6. a kind of preparation and application of zein/plants essential oil composite antibacterial fibre dressing as claimed in claim 5, described Electric spinning equipment in situ voltage, fltting speed it is adjustable, and the adjusting range of voltage are as follows: 0-30 kilovolts, the model of fltting speed It encloses are as follows: 0-100 mls/hour.
7. a kind of preparation and application of zein/plants essential oil composite antibacterial fibre dressing as described in claim 1, described Spinning parameter be spinning voltage 8-20 kilovolts, 5-20 centimetres of spinning distance.
8. a kind of preparation and application of zein/plants essential oil composite antibacterial fibre dressing as described in claim 1, described Fiber dressing be that direct electrospinning deposits to wound, directly contact wound without hand.
9. a kind of preparation and application of zein/plants essential oil composite antibacterial fibre dressing as claimed in claim 7, in situ Electro spinning nano fiber antiseptic dressing with a thickness of 80-1000 microns.
CN201910320388.6A 2019-04-19 2019-04-19 A kind of preparation and application of zein/plants essential oil composite antibacterial fibre dressing Pending CN110025817A (en)

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CN111349977A (en) * 2020-05-06 2020-06-30 浙江大学 Wheat gluten protein nano-fiber and preparation method and application thereof
CN112376124A (en) * 2020-11-20 2021-02-19 上海市第六人民医院 Antibacterial dressing
CN112391697A (en) * 2020-08-24 2021-02-23 江苏大学 Antibacterial nanofiber containing ilex essential oil/lycium barbarum polysaccharide and preparation method and application of antibacterial nanofiber
CN112647193A (en) * 2020-12-31 2021-04-13 上海市第六人民医院 Preparation method of electron beam irradiation crosslinked calcium peroxide-carbon quantum dot @ zein antibacterial film
CN115645602A (en) * 2022-10-31 2023-01-31 西安建筑科技大学 Basil essential oil core-shell nanoparticle hydrogel wound dressing and preparation method thereof

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111349977A (en) * 2020-05-06 2020-06-30 浙江大学 Wheat gluten protein nano-fiber and preparation method and application thereof
CN112391697A (en) * 2020-08-24 2021-02-23 江苏大学 Antibacterial nanofiber containing ilex essential oil/lycium barbarum polysaccharide and preparation method and application of antibacterial nanofiber
CN112391697B (en) * 2020-08-24 2023-03-21 江苏大学 Antibacterial nanofiber containing ilex essential oil/lycium barbarum polysaccharide and preparation method and application of antibacterial nanofiber
CN112376124A (en) * 2020-11-20 2021-02-19 上海市第六人民医院 Antibacterial dressing
CN112647193A (en) * 2020-12-31 2021-04-13 上海市第六人民医院 Preparation method of electron beam irradiation crosslinked calcium peroxide-carbon quantum dot @ zein antibacterial film
CN115645602A (en) * 2022-10-31 2023-01-31 西安建筑科技大学 Basil essential oil core-shell nanoparticle hydrogel wound dressing and preparation method thereof
CN115645602B (en) * 2022-10-31 2023-12-15 西安建筑科技大学 Ocimum basilicum essential oil core-shell nanoparticle hydrogel wound dressing and preparation method thereof

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Application publication date: 20190719