CN109457395A - A kind of tannic acid static spinning membrane and its preparation method and application - Google Patents
A kind of tannic acid static spinning membrane and its preparation method and application Download PDFInfo
- Publication number
- CN109457395A CN109457395A CN201811313604.6A CN201811313604A CN109457395A CN 109457395 A CN109457395 A CN 109457395A CN 201811313604 A CN201811313604 A CN 201811313604A CN 109457395 A CN109457395 A CN 109457395A
- Authority
- CN
- China
- Prior art keywords
- tannic acid
- spinning
- preparation
- static spinning
- spinning membrane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H3/00—Non-woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length
- D04H3/02—Non-woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length characterised by the method of forming fleeces or layers, e.g. reorientation of yarns or filaments
- D04H3/03—Non-woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length characterised by the method of forming fleeces or layers, e.g. reorientation of yarns or filaments at random
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0015—Electro-spinning characterised by the initial state of the material
- D01D5/003—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H3/00—Non-woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length
- D04H3/005—Synthetic yarns or filaments
- D04H3/007—Addition polymers
-
- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2321/00—Fibres made from polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds
- D10B2321/06—Fibres made from polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds polymers of unsaturated alcohols, e.g. polyvinyl alcohol, or of their acetals or ketals
-
- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2509/00—Medical; Hygiene
- D10B2509/02—Bandages, dressings or absorbent pads
- D10B2509/022—Wound dressings
Abstract
The present invention provides a kind of tannic acid static spinning membranes and its preparation method and application, belong to technical field of preparation for inorganic material.Tannic acid static spinning membrane provided by the invention is by including that the raw material of PVA and tannic acid are made through electrostatic spinning, tannic acid is evenly distributed on static spinning membrane, this allows what the pharmacological property of tannic acid mitigated to release, it is suitable for being directly used as infected wound dressing, it solves tannic acid in the prior art and stops the bad technical problem of effect due to directly using absorption too fast.
Description
Technical field
The present invention relates to technical field of preparation for inorganic material more particularly to a kind of tannic acid static spinning membrane and its preparation sides
Method and application.
Background technique
Tannic acid is also known as tannic acid, tannin, is yellow or the amorphous bulky powder of brown color, color gradually becomes in air
It is deep；There is strong hygroscopicity；Soluble easily in water, ethyl alcohol, acetone；Aqueous solution puckery；It is decomposed at 210~215 DEG C.Tannic acid is not single
Compound, chemical composition is more complicated, is roughly divided into two kinds: 1. condensed tannin acid, is flavane 01 derivatives, flavanols in molecule
2 by carbon-carbon bond in conjunction with catechol or benzenetriol；2. hydrolyzable tannic acid has ester bond in molecule, is glucose
Gallate is common tannic acid.The chemical constituent of tannic acid is different with raw material sources, the list obtained by Chinese Gallnuts
Peaceful acid contains glucose about 12%；The tannic acid obtained by Turkey Chinese gall is containing glucose about 16.5%.
Tannic acid is hemostat, interior in medicine once for treating sphagitis, tonsillitis, hemorrhoid and skin blister disease etc.
With diarrhea, enterorrhagia etc. can be prevented.Tannic acid energy precipitating proteins can be formed insoluble with alkaloid, glucoside and heavy metal etc.
Compound has detoxication to these substances.
Clinical most common method is that tannic acid solution or tannic acid powder are directly used in wound at present, due to tannic acid
Chemical composition is complicated, if concentration is too high directly in affected part tannic acid powder or solution, absorption is too fast, and stops effect
Fruit is bad, needs frequent drug administration.
Summary of the invention
In consideration of it, the purpose of the present invention is to provide a kind of tannic acid static spinning membranes and its preparation method and application.This
It invents tannic acid in the tannic acid static spinning membrane provided to be evenly distributed, what the pharmacological property of tannic acid can mitigate releases, solution
Tannic acid in the prior art of having determined stops the bad technical problem of effect due to directly using absorption too fast.
In order to achieve the above-mentioned object of the invention, the present invention the following technical schemes are provided:
A kind of tannic acid static spinning membrane, is interwoven by nanofiber, and the nanofiber is by including PVA and tannin
The raw material of acid is made through electrostatic spinning.
Preferably, the diameter of the nanofiber is 100nm~105nm.
Preferably, the mass percentage of tannic acid is 30%~60% in the nanofiber.
The present invention also provides the preparation methods of the tannic acid static spinning membrane described in above-mentioned technical proposal, including walk as follows
It is rapid:
It is heated after tannic acid, PVA and water are mixed, obtains spinning solution；
The spinning solution is subjected to electrostatic spinning, obtains tannic acid static spinning membrane.
Preferably, the mass ratio of the tannic acid and PVA are 0.5~1.5:1.5~2.5.
Preferably, the electrostatic spinning includes the following steps:
Syringe equipped with the spinning solution is mounted on electrostatic spinning machine, is covered on electrostatic spinning planar receiver
One layer of substrate of lid, for receiving electrospun fibers.
Preferably, distance of the syringe needle apart from Electrospun receiver is 10~18cm.
Preferably, the fltting speed of the syringe is 0.0005~0.001mm/s.
Preferably, the cathode voltage of the electrostatic spinning machine is 15~20kv, and cathode voltage is 1~2kv.
The present invention also provides the tannic acid static spinning membranes described in above-mentioned technical proposal in preparing infected wound dressing
Application.
The present invention provides a kind of tannic acid static spinning membranes, are interwoven by nanofiber, and the nanofiber is by wrapping
The raw material for including PVA and tannic acid is made through electrostatic spinning.In the present invention, tannic acid is evenly distributed on static spinning membrane, this makes
Tannic acid releasing of can mitigating of pharmacological property, be suitable for being directly used as infected wound dressing.Embodiment the result shows that, this
The tannic acid static spinning membrane that invention provides is used as infected wound dressing, and speed of wound healing is fast, the weight fluctuations range of mouse
It is small, it is small to the health negative effect of mouse.And tannic acid static spinning membrane provided by the invention, it can be reserved for and place, it is easy to use,
Property is stablized.
The preparation method of tannic acid static spinning membrane provided by the invention, easy to operate, material is easy to get, and utilization rate is high.
The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.
Detailed description of the invention
Fig. 1 is tannic acid electrospun fibers film photo；
Fig. 2 is that blank control group, tannic acid static spinning membrane group, pure tannic acid solution film group and pure PVA tunica fibrosa group are applied
Material is to mouse infection Wound healing situation comparative test photo；
Fig. 3 is that blank control group, tannic acid static spinning membrane group, pure tannic acid solution film group and pure PVA tunica fibrosa group are small
Mouse weight is with topical application of drug time variation diagram.
Specific embodiment
The present invention provides a kind of tannic acid static spinning membranes, are interwoven by nanofiber, and the nanofiber is by wrapping
The raw material for including PVA and tannic acid is made through electrostatic spinning.
In the present invention, the diameter of the nanofiber is preferably 100nm~105nm.
In the present invention, the mass percentage of tannic acid is preferably 30%~60% in the nanofiber, more preferably
It is 40%~50%, most preferably 45%.
In the present invention, tannic acid is evenly distributed on static spinning membrane, this allows what the pharmacological property of tannic acid mitigated to release
It releases.
The present invention also provides the preparation methods of the tannic acid static spinning membrane described in above-mentioned technical proposal, including walk as follows
It is rapid:
It is heated after tannic acid, PVA and water are mixed, obtains spinning solution；
The spinning solution is subjected to electrostatic spinning, obtains tannic acid static spinning membrane.
The present invention heats after mixing tannic acid, PVA and water, obtains spinning solution.In the present invention, the tannic acid and
The mass ratio of PVA is preferably 0.5~1:1.5~2.5, more preferably 1:2.Source of the present invention for the tannic acid and PVA
And specific type is not particularly limited, and commercial product is prepared or selected using conventional method in that art.Of the invention real
It applies in example, the tannic acid is preferably bought from Aladdin, and No. CAS: 1401-55-4, the PVA is preferably bought from Mike woods, CAS
Number: 9002-89-5.In the present invention, when the quality of the tannic acid is 0.5~1.5g, the volume of the water is preferably
10mL.The volume of water is preferably 10mL by the present invention, be in order to avoid water is too many, spinning solution it is excessively dilute and can not spinning or water
Very little, spinning solution it is excessively sticky and can not spinning.
The present invention does not have special restriction to the hybrid mode of the tannic acid, PVA and water, using those skilled in the art
Well known hybrid mode, specifically, such as magnetic agitation.The present invention does not have special limit to the revolving speed of the stirring and time
Fixed, capable of making tannic acid and PVA, infinite swelling is to viscous solution is obtained in water, specifically, such as in room temperature, mixing speed
To stir 0.5h under 100~1000 turns/min.
In the present invention, the heating is preferably oil bath heating, and the medium of the oil bath heating is preferably dimethicone.
The present invention is not particularly limited the source of the dimethicone, is prepared or is selected commercially available using conventional method in that art
Product.In the present invention, the temperature of the oil bath heating is preferably > 63 DEG C, and in embodiments of the present invention, the oil bath adds
The temperature of heat is more preferably 67 DEG C~75 DEG C.The present invention is not particularly limited the oil bath heating device, using ability
Oil bath heating device known to field technique personnel, specifically, such as electric heating constant temperature oil bath pan.The present invention is in the oil bath heating
It is preferred in the process to carry out magnetic agitation.The present invention does not have special restriction to the revolving speed of the stirring and time, can make tannin
Acid and PVA dissolve in water, specifically, as stirred 1.5h under 100~1000 turns/min of low whipping speed.
After the completion of heating, the present invention preferably will obtain the spinning solution after Heated Products cooled to room temperature.
After obtaining spinning solution, the spinning solution is carried out electrostatic spinning by the present invention, obtains tannic acid static spinning membrane.
In the present invention, the electrostatic spinning preferably includes following steps:
Syringe equipped with the spinning solution is mounted on electrostatic spinning machine, is covered on electrostatic spinning planar receiver
Lid layer of substance, for receiving electrospun fibers.
The present invention is not particularly limited the source of the syringe, selects commercial product.Implement in the present invention
In example, the syringe is further preferably bought from KDL, and the syringe capacity is not particularly limited, and selects commercially available syringe
Capacity, specifically, such as 1mL~50mL.In the present invention, distance of the syringe needle apart from Electrospun receiver is excellent
It is selected as 10~18cm, more preferably 12~16cm, most preferably 14cm.In the present invention, the fltting speed of the syringe is excellent
It is selected as 0.0005~0.001mm/s, more preferably 0.0006~0.0009mm/s.The present invention is for the electrostatic spinning machine
Model is not particularly limited, and selects commercially available model.In embodiments of the present invention, the electrostatic spinning machine model is further excellent
It is selected as cloud sail science and technology Tianjin, Tianjin cloud sail science and technology YFSP-GIII electrostatic spinning machine.In the present invention, the electrostatic spinning machine is being just
Pole tension is preferably 15~20kv, and cathode voltage is preferably 1~2kv, in embodiments of the present invention, the electrostatic spinning machine
Cathode voltage is more preferably 20kv, and cathode voltage is more preferably 1kv.The present invention connects to electrostatic spinning plane is covered on
The substrate received on device is not particularly limited, and using smooth surface, conductive energy is easy to cut down nano fibrous membrane and
Substrate, specifically, such as masking foil.
Obtain cut have the substrate of nano fibrous membrane after, the present invention removes substrate, obtains tannic acid static spinning membrane.This hair
The bright concrete mode to the removing does not have special restriction, using removing mode well known to those skilled in the art.
The present invention also provides the tannic acid static spinning membranes described in above-mentioned technical proposal in preparing infected wound dressing
Application.
Tannic acid static spinning membrane provided by the invention and its preparation method and application is carried out below with reference to embodiment detailed
Thin explanation, but they cannot be interpreted as limiting the scope of the present invention.
Embodiment 1
By 3gPVA, 1g tannic acid is dissolved in 10mL water, after half an hour is stirred at room temperature, at 67 DEG C, and oil bath heating
And 1.5h is stirred, room temperature is naturally cooled to, spinning solution is obtained.
Spinning solution is put into 10mL syringe, is mounted on electrostatic spinning machine, syringe needle is apart from Electrospun receiver
Distance is 14cm, one layer of masking foil is covered on electrostatic spinning planar receiver, for receiving electrospinning fibre.Syringe promotes speed
Degree is 0.0007mm/s, cathode voltage 20kv, cathode voltage 1kv.
The tunica fibrosa interior thickness spun on masking foil is uniformly located, lays diameter as 0.6cm circle, removes masking foil, obtain
To tannic acid static spinning membrane, it is attached to b6 mouse infection wound, tannic acid static spinning membrane photo is as shown in Figure 1.It can by Fig. 1
To find out, nanofiber membrane stage is complete.
Different dressing include the following steps: b6 mouse wound infection check experiment
Setting tannic acid static spinning membrane group, pure PVA tunica fibrosa group, blank control group, pure tannic acid solution film group, every group
7 mouse, take pictures weigh to mouse every time.
- 2 days: punching took pictures, causes the surface of a wound, and bacterium solution is added to form infection
0 day: taking pictures+be administered
2 days: bacterium being taken to apply bacterium
4 days: bacterium of taking pictures+take applied bacterium+administration
7 days: bacterium of taking pictures+take, which applies bacterium+every group and kills three, took tissue+remaining 4 administrations
10 days: taking pictures
14 days: taking pictures
17 days: mouse of taking pictures+kill took tissue
Blank control group, tannic acid static spinning membrane group, pure tannic acid solution film group and pure PVA tunica fibrosa group dressing are to small
Mouse infected wound Cure comparative test photo is as shown in Figure 2.
Blank control group, tannic acid static spinning membrane group, pure tannic acid solution film group and pure PVA tunica fibrosa group mice weights
It is as shown in Figure 3 with topical application of drug time variation diagram.
Figure it is seen that tannic acid static spinning membrane provided by the invention is used as infected wound dressing compared to blank
Control group, pure tannic acid solution film group and pure PVA tunica fibrosa group dressing, speed of wound healing are fast.
From figure 3, it can be seen that using tannic acid static spinning membrane provided by the invention be used as infected wound dressing compared to
Blank control group, pure tannic acid solution film group and pure PVA tunica fibrosa group dressing, the weight fluctuations range of mouse is small, to mouse
Health negative effect is small.
Embodiment 2
By 4gPVA, 2g tannic acid is dissolved in 10mL water, after half an hour is stirred at room temperature, at 70 DEG C, and oil bath heating
And 1.5h is stirred, room temperature is naturally cooled to, spinning solution is obtained.
After spinning solution is cooled to room temperature, puts into 10mL syringe, be mounted on electrostatic spinning machine, syringe needle distance electricity
The distance of spinning receiver is 10cm, one layer of masking foil is covered on electrostatic spinning planar receiver, for receiving electrospinning fibre.
Syringe fltting speed is 0.0010mm/s, cathode voltage 20kv, cathode voltage 2kv.
The tunica fibrosa interior thickness spun on masking foil is uniformly located, lays diameter as 0.6cm circle, removes masking foil, obtain
To tannic acid static spinning membrane, it is attached to b6 mouse infection wound, tannic acid static spinning membrane photo is as shown in Figure 1.
Different dressing include the following steps: b6 mouse wound infection check experiment
Setting tannic acid static spinning membrane group, pure PVA tunica fibrosa group, blank control group, pure tannic acid solution film group, every group
7 mouse, take pictures weigh to mouse every time.
- 2 days: punching took pictures, causes the surface of a wound, and bacterium solution is added to form infection
0 day: taking pictures+be administered
2 days: bacterium being taken to apply bacterium
4 days: bacterium of taking pictures+take applied bacterium+administration
7 days: bacterium of taking pictures+take, which applies bacterium+every group and kills three, took tissue+remaining 4 administrations
10 days: taking pictures
14 days: taking pictures
17 days: mouse of taking pictures+kill took tissue
Blank control group, tannic acid static spinning membrane group, pure tannic acid solution film group and pure PVA tunica fibrosa group dressing are to small
Mouse infected wound Cure comparative test result is similar with result in embodiment 1.
Blank control group, tannic acid static spinning membrane group, pure tannic acid solution film group and pure PVA tunica fibrosa group mice weights
It is similar with result in embodiment 1 with topical application of drug time change result.
Embodiment 3
By 1gPVA, 0.5g tannic acid is dissolved in 10mL water, and after half an hour is stirred at room temperature, at 75 DEG C, oil bath adds
Heat simultaneously stirs 1.5h, naturally cools to room temperature, obtains spinning solution.
After spinning solution is cooled to room temperature, puts into 10mL syringe, be mounted on electrostatic spinning machine, syringe needle distance electricity
The distance of spinning receiver is 18cm, one layer of masking foil is covered on electrostatic spinning planar receiver, for receiving electrospinning fibre.
Syringe fltting speed is 0.0005mm/s, cathode voltage 15kv, cathode voltage 1kv.
The tunica fibrosa interior thickness spun on masking foil is uniformly located, lays diameter as 0.6cm circle, removes masking foil, obtain
To tannic acid static spinning membrane, it is attached to b6 mouse infection wound, tannic acid static spinning membrane photo is as shown in Figure 1.
Different dressing include the following steps: b6 mouse wound infection check experiment
Setting tannic acid static spinning membrane group, pure PVA tunica fibrosa group, blank control group, pure tannic acid solution film group, every group
7 mouse, take pictures weigh to mouse every time.
- 2 days: punching took pictures, causes the surface of a wound, and bacterium solution is added to form infection
0 day: taking pictures+be administered
2 days: bacterium being taken to apply bacterium
4 days: bacterium of taking pictures+take applied bacterium+administration
7 days: bacterium of taking pictures+take, which applies bacterium+every group and kills three, took tissue+remaining 4 administrations
10 days: taking pictures
14 days: taking pictures
17 days: mouse of taking pictures+kill took tissue
Blank control group, tannic acid static spinning membrane group, pure tannic acid solution film group and pure PVA tunica fibrosa group dressing are to small
Mouse infected wound Cure comparative test result is similar with result in embodiment 1.
Blank control group, tannic acid static spinning membrane group, pure tannic acid solution film group and pure PVA tunica fibrosa group mice weights
It is similar with result in embodiment 1 with topical application of drug time change result.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of tannic acid static spinning membrane, is interwoven by nanofiber, the nanofiber is by including PVA and tannic acid
Raw material is made through electrostatic spinning.
2. tannic acid static spinning membrane according to claim 1, which is characterized in that the diameter of the nanofiber is
100nm~105nm.
3. tannic acid static spinning membrane according to claim 1, which is characterized in that the matter of tannic acid in the nanofiber
Measuring percentage composition is 30%~60%.
4. the preparation method of tannic acid static spinning membrane described in claim 1,2 or 3, includes the following steps:
It is heated after tannic acid, PVA and water are mixed, obtains spinning solution；
The spinning solution is subjected to electrostatic spinning, obtains tannic acid static spinning membrane.
5. the preparation method according to claim 4, which is characterized in that the mass ratio of the tannic acid and PVA be 0.5~
1.5:1.5~2.5.
6. the preparation method according to claim 4, which is characterized in that the electrostatic spinning includes the following steps:
Syringe equipped with the spinning solution is mounted on electrostatic spinning machine, covers one on electrostatic spinning planar receiver
Layer substrate, for receiving electrospun fibers.
7. preparation method according to claim 6, which is characterized in that the syringe needle is apart from Electrospun receiver
Distance is 10~18cm.
8. preparation method according to claim 6, which is characterized in that the fltting speed of the syringe be 0.0005~
0.001mm/s。
9. preparation method according to claim 6, which is characterized in that the cathode voltage of the electrostatic spinning machine be 15~
20kv, cathode voltage are 1~2kv.
10. being made described in tannic acid static spinning membrane or claim 4~9 any one described in claims 1 to 3 any one
Tannic acid static spinning membrane made from Preparation Method is preparing the application in infected wound dressing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811313604.6A CN109457395A (en) | 2018-11-06 | 2018-11-06 | A kind of tannic acid static spinning membrane and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811313604.6A CN109457395A (en) | 2018-11-06 | 2018-11-06 | A kind of tannic acid static spinning membrane and its preparation method and application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109457395A true CN109457395A (en) | 2019-03-12 |
Family
ID=65609624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811313604.6A Pending CN109457395A (en) | 2018-11-06 | 2018-11-06 | A kind of tannic acid static spinning membrane and its preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109457395A (en) |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101062426A (en) * | 2006-04-26 | 2007-10-31 | 北京化工大学 | Antibacterial type blended electro spinning nanometer fiber membrane biological dressing and the preparing method thereof |
| CN102345175A (en) * | 2010-08-05 | 2012-02-08 | 同济大学 | Method for constructing micro-nano fiber for loading tea active component |
| CN103409939A (en) * | 2013-08-21 | 2013-11-27 | 浙江和也健康科技有限公司 | Novel composite nanofiber membrane as well as preparation method and application thereof |
| CN105220361A (en) * | 2015-11-04 | 2016-01-06 | 苏州大学 | The preparation method of a kind of Tea Polyphenols/cellulose acetate nano fibrous membrane |
| CN106319757A (en) * | 2016-11-15 | 2017-01-11 | 天津捷盛东辉保鲜科技有限公司 | Electrospun polyvinyl alcohol-based tannic acid anti-oxidation nanofiber membrane |
| CN106668931A (en) * | 2017-01-05 | 2017-05-17 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | Biological adhesive and preparation method thereof |
| CN107854719A (en) * | 2017-11-17 | 2018-03-30 | 齐齐哈尔医学院 | A kind of double load medicine Wound antibiotic dressing and preparation method thereof |
| CN107998435A (en) * | 2018-01-06 | 2018-05-08 | 广州润虹医药科技股份有限公司 | A kind of polyvinyl alcohol/chitosan oligosaccharide/silver composite fibre dressing and preparation method thereof |
| CN108286126A (en) * | 2018-01-24 | 2018-07-17 | 上海理工大学 | A kind of preparation method of quick-acting haemostatic powder composite cellulosic membrane |
| CN108396461A (en) * | 2018-03-01 | 2018-08-14 | 苏州甫众塑胶有限公司 | A kind of promoting healing nanofiber film dressing and preparation method thereof |
-
2018
- 2018-11-06 CN CN201811313604.6A patent/CN109457395A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101062426A (en) * | 2006-04-26 | 2007-10-31 | 北京化工大学 | Antibacterial type blended electro spinning nanometer fiber membrane biological dressing and the preparing method thereof |
| CN102345175A (en) * | 2010-08-05 | 2012-02-08 | 同济大学 | Method for constructing micro-nano fiber for loading tea active component |
| CN103409939A (en) * | 2013-08-21 | 2013-11-27 | 浙江和也健康科技有限公司 | Novel composite nanofiber membrane as well as preparation method and application thereof |
| CN105220361A (en) * | 2015-11-04 | 2016-01-06 | 苏州大学 | The preparation method of a kind of Tea Polyphenols/cellulose acetate nano fibrous membrane |
| CN106319757A (en) * | 2016-11-15 | 2017-01-11 | 天津捷盛东辉保鲜科技有限公司 | Electrospun polyvinyl alcohol-based tannic acid anti-oxidation nanofiber membrane |
| CN106668931A (en) * | 2017-01-05 | 2017-05-17 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | Biological adhesive and preparation method thereof |
| CN107854719A (en) * | 2017-11-17 | 2018-03-30 | 齐齐哈尔医学院 | A kind of double load medicine Wound antibiotic dressing and preparation method thereof |
| CN107998435A (en) * | 2018-01-06 | 2018-05-08 | 广州润虹医药科技股份有限公司 | A kind of polyvinyl alcohol/chitosan oligosaccharide/silver composite fibre dressing and preparation method thereof |
| CN108286126A (en) * | 2018-01-24 | 2018-07-17 | 上海理工大学 | A kind of preparation method of quick-acting haemostatic powder composite cellulosic membrane |
| CN108396461A (en) * | 2018-03-01 | 2018-08-14 | 苏州甫众塑胶有限公司 | A kind of promoting healing nanofiber film dressing and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Ziyadi et al. | An investigation of factors affecting the electrospinning of poly (vinyl alcohol)/kefiran composite nanofibers | |
| Wang et al. | Co-loading of inorganic nanoparticles and natural oil in the electrospun janus nanofibers for a synergetic antibacterial effect | |
| CN102560887B (en) | Silk fibroin nano-fiber film loaded with vitamins A and E and preparation method thereof | |
| CN107261196A (en) | A kind of antibacterial fibroin material and preparation method thereof | |
| CN106048744A (en) | Method for preparing extracellular matrix-simulated nanometer fiber dressing through electrostatic spinning | |
| Zhou et al. | Integrating Chinese herbs and western medicine for new wound dressings through handheld electrospinning | |
| CN110025817A (en) | A kind of preparation and application of zein/plants essential oil composite antibacterial fibre dressing | |
| CN110124094A (en) | A kind of Chinese herbal medicine based micro-nano fibre antibacterial dressing be prepared in situ and application method | |
| CN106924171A (en) | A kind of injectable nano short fiber of carried anticancer medicine thing and its preparation method and application | |
| TW201212955A (en) | Method for making bacterial cellulose with controlled pore size and its use in wound dressing film | |
| Liu et al. | Polycaprolactone nanofibres loaded with 20 (S)-protopanaxadiol for in vitro and in vivo anti-tumour activity study | |
| Chi et al. | Fabrication of gelatin nanofibers by electrospinning—Mixture of gelatin and polyvinyl alcohol | |
| CN105568558A (en) | Thermocured electrospun egg-white protein micro-nanofiber membrane and preparation method therefor | |
| CN113842498B (en) | Electrospun membrane scaffold for promoting healing of rotator cuff tendon and bone and inhibiting muscle fat infiltration and preparation method thereof | |
| Li et al. | Dissolving microneedles based on ZnO nanoparticles and an ionic liquid as synergistic antibacterial agents | |
| CN109457395A (en) | A kind of tannic acid static spinning membrane and its preparation method and application | |
| CN104474595B (en) | Production method of dilayer compounding coated esophageal stent with esophageal cancer treatment assisting function | |
| CN109395083A (en) | A kind of medicine carrying membrane and preparation method thereof with antibacterial activity | |
| CN101658495A (en) | Hydrobromic acid lappaconitine solid lipid nano particle and preparation method thereof | |
| CN114668778B (en) | Microneedle for promoting wound healing | |
| CN108926572A (en) | A kind of Preparation method and use of pharmaceutical composition and gel with liquid crystal structure preparation prepared therefrom | |
| CN110354102B (en) | Biphase transdermal drug delivery system and preparation method thereof | |
| CN106512013A (en) | Drug-loaded composite nanofiber membrane used for drug release, and making method thereof | |
| CN105727358B (en) | Drug-loaded biological high-molecular composite nanometer tunica fibrosa and preparation method thereof | |
| CN115364270A (en) | Preparation method of antibacterial and antioxidant fiber film dressing containing traditional Chinese medicines |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190312 |
|
| RJ01 | Rejection of invention patent application after publication |