CN107847537A - 包含川续断提取物及隔山消提取物作为有效成分的用于增强运动能力及肌肉的组合物 - Google Patents
包含川续断提取物及隔山消提取物作为有效成分的用于增强运动能力及肌肉的组合物 Download PDFInfo
- Publication number
- CN107847537A CN107847537A CN201680039519.8A CN201680039519A CN107847537A CN 107847537 A CN107847537 A CN 107847537A CN 201680039519 A CN201680039519 A CN 201680039519A CN 107847537 A CN107847537 A CN 107847537A
- Authority
- CN
- China
- Prior art keywords
- extract
- teasel
- strengthen
- locomitivity
- cynanchum wilfordii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 51
- 239000000284 extract Substances 0.000 title claims abstract description 48
- 241000331432 Cynanchum wilfordii Species 0.000 title claims abstract description 31
- 241000123589 Dipsacus Species 0.000 title claims abstract description 30
- 210000003205 muscle Anatomy 0.000 title claims abstract description 21
- 239000004480 active ingredient Substances 0.000 title claims abstract description 14
- 238000011161 development Methods 0.000 claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 235000013305 food Nutrition 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 7
- 229910052799 carbon Inorganic materials 0.000 claims description 5
- 239000012046 mixed solvent Substances 0.000 claims description 5
- 238000000638 solvent extraction Methods 0.000 claims description 5
- 230000033001 locomotion Effects 0.000 description 17
- 230000018109 developmental process Effects 0.000 description 10
- 239000003795 chemical substances by application Substances 0.000 description 8
- 239000000796 flavoring agent Substances 0.000 description 8
- 230000009182 swimming Effects 0.000 description 8
- 238000012360 testing method Methods 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 238000005728 strengthening Methods 0.000 description 6
- 235000019634 flavors Nutrition 0.000 description 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000002708 enhancing effect Effects 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 235000015203 fruit juice Nutrition 0.000 description 4
- 235000013402 health food Nutrition 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 235000002639 sodium chloride Nutrition 0.000 description 4
- 239000003826 tablet Substances 0.000 description 4
- 229940088594 vitamin Drugs 0.000 description 4
- 229930003231 vitamin Natural products 0.000 description 4
- 235000013343 vitamin Nutrition 0.000 description 4
- 239000011782 vitamin Substances 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 235000010443 alginic acid Nutrition 0.000 description 3
- 239000000783 alginic acid Substances 0.000 description 3
- 229920000615 alginic acid Polymers 0.000 description 3
- 229960001126 alginic acid Drugs 0.000 description 3
- 150000004781 alginic acids Chemical class 0.000 description 3
- 235000013361 beverage Nutrition 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 235000013355 food flavoring agent Nutrition 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 150000003722 vitamin derivatives Chemical class 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 235000005979 Citrus limon Nutrition 0.000 description 2
- 244000131522 Citrus pyriformis Species 0.000 description 2
- 240000000560 Citrus x paradisi Species 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 102000004139 alpha-Amylases Human genes 0.000 description 2
- 108090000637 alpha-Amylases Proteins 0.000 description 2
- 229940024171 alpha-amylase Drugs 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
- 239000000084 colloidal system Substances 0.000 description 2
- 238000004040 coloring Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 235000000639 cyanocobalamin Nutrition 0.000 description 2
- 239000011666 cyanocobalamin Substances 0.000 description 2
- 235000015872 dietary supplement Nutrition 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 235000013376 functional food Nutrition 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 239000007887 hard shell capsule Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 210000002027 skeletal muscle Anatomy 0.000 description 2
- 239000007901 soft capsule Substances 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- AUHDWARTFSKSAC-HEIFUQTGSA-N (2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-(6-oxo-1H-purin-9-yl)oxolane-2-carboxylic acid Chemical compound [C@]1([C@H](O)[C@H](O)[C@@H](CO)O1)(N1C=NC=2C(O)=NC=NC12)C(=O)O AUHDWARTFSKSAC-HEIFUQTGSA-N 0.000 description 1
- DWNBOPVKNPVNQG-LURJTMIESA-N (2s)-4-hydroxy-2-(propylamino)butanoic acid Chemical compound CCCN[C@H](C(O)=O)CCO DWNBOPVKNPVNQG-LURJTMIESA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 244000099147 Ananas comosus Species 0.000 description 1
- 235000007119 Ananas comosus Nutrition 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 239000001736 Calcium glycerylphosphate Substances 0.000 description 1
- 235000007516 Chrysanthemum Nutrition 0.000 description 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- YTBSYETUWUMLBZ-UHFFFAOYSA-N D-Erythrose Natural products OCC(O)C(O)C=O YTBSYETUWUMLBZ-UHFFFAOYSA-N 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- YTBSYETUWUMLBZ-IUYQGCFVSA-N D-erythrose Chemical compound OC[C@@H](O)[C@@H](O)C=O YTBSYETUWUMLBZ-IUYQGCFVSA-N 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 241001050741 Dipsacus asperoides Species 0.000 description 1
- 206010056474 Erythrosis Diseases 0.000 description 1
- 235000016623 Fragaria vesca Nutrition 0.000 description 1
- 240000009088 Fragaria x ananassa Species 0.000 description 1
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920002581 Glucomannan Polymers 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 239000004378 Glycyrrhizin Substances 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- GRSZFWQUAKGDAV-UHFFFAOYSA-N Inosinic acid Natural products OC1C(O)C(COP(O)(O)=O)OC1N1C(NC=NC2=O)=C2N=C1 GRSZFWQUAKGDAV-UHFFFAOYSA-N 0.000 description 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 240000008790 Musa x paradisiaca Species 0.000 description 1
- 235000018290 Musa x paradisiaca Nutrition 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- -1 NaAsp Chemical compound 0.000 description 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229920002230 Pectic acid Polymers 0.000 description 1
- 229920001100 Polydextrose Polymers 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 241000220324 Pyrus Species 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 102000006463 Talin Human genes 0.000 description 1
- 108010083809 Talin Proteins 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 244000290333 Vanilla fragrans Species 0.000 description 1
- 235000009499 Vanilla fragrans Nutrition 0.000 description 1
- 235000012036 Vanilla tahitensis Nutrition 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- LPQOADBMXVRBNX-UHFFFAOYSA-N ac1ldcw0 Chemical compound Cl.C1CN(C)CCN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN3CCSC1=C32 LPQOADBMXVRBNX-UHFFFAOYSA-N 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 108010042362 beta-Lipotropin Proteins 0.000 description 1
- 235000013734 beta-carotene Nutrition 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000007767 bonding agent Substances 0.000 description 1
- 229960001948 caffeine Drugs 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 235000011148 calcium chloride Nutrition 0.000 description 1
- UHHRFSOMMCWGSO-UHFFFAOYSA-L calcium glycerophosphate Chemical compound [Ca+2].OCC(CO)OP([O-])([O-])=O UHHRFSOMMCWGSO-UHFFFAOYSA-L 0.000 description 1
- 229940095618 calcium glycerophosphate Drugs 0.000 description 1
- 235000019299 calcium glycerylphosphate Nutrition 0.000 description 1
- 229960002079 calcium pantothenate Drugs 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 229960002104 cyanocobalamin Drugs 0.000 description 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229960002413 ferric citrate Drugs 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 235000001497 healthy food Nutrition 0.000 description 1
- 230000000887 hydrating effect Effects 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 235000013902 inosinic acid Nutrition 0.000 description 1
- 239000004245 inosinic acid Substances 0.000 description 1
- 229940028843 inosinic acid Drugs 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- NPFOYSMITVOQOS-UHFFFAOYSA-K iron(III) citrate Chemical compound [Fe+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NPFOYSMITVOQOS-UHFFFAOYSA-K 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 235000014380 magnesium carbonate Nutrition 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 235000011147 magnesium chloride Nutrition 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 229940099596 manganese sulfate Drugs 0.000 description 1
- 239000011702 manganese sulphate Substances 0.000 description 1
- 235000007079 manganese sulphate Nutrition 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 235000013923 monosodium glutamate Nutrition 0.000 description 1
- 230000004220 muscle function Effects 0.000 description 1
- 210000000715 neuromuscular junction Anatomy 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000007968 orange flavor Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 235000021017 pears Nutrition 0.000 description 1
- LCLHHZYHLXDRQG-ZNKJPWOQSA-N pectic acid Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)O[C@H](C(O)=O)[C@@H]1OC1[C@H](O)[C@@H](O)[C@@H](OC2[C@@H]([C@@H](O)[C@@H](O)[C@H](O2)C(O)=O)O)[C@@H](C(O)=O)O1 LCLHHZYHLXDRQG-ZNKJPWOQSA-N 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000001259 polydextrose Substances 0.000 description 1
- 235000013856 polydextrose Nutrition 0.000 description 1
- 229940035035 polydextrose Drugs 0.000 description 1
- 239000010318 polygalacturonic acid Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 150000004804 polysaccharides Chemical class 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 1
- 235000008160 pyridoxine Nutrition 0.000 description 1
- 239000011677 pyridoxine Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229940108325 retinyl palmitate Drugs 0.000 description 1
- 235000019172 retinyl palmitate Nutrition 0.000 description 1
- 239000011769 retinyl palmitate Substances 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 235000010378 sodium ascorbate Nutrition 0.000 description 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
- 229960005055 sodium ascorbate Drugs 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229940073490 sodium glutamate Drugs 0.000 description 1
- 235000009518 sodium iodide Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- PRZPUYBFEJPNPF-UHFFFAOYSA-J tetrasodium 3-carboxy-3,5-dihydroxy-5-oxopentanoate 2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Na+].C(CC(O)(C(=O)[O-])CC(=O)[O-])(=O)[O-].[Na+].[Na+].[Na+].C(CC(O)(C(=O)O)CC(=O)O)(=O)[O-] PRZPUYBFEJPNPF-UHFFFAOYSA-J 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/316—Foods, ingredients or supplements having a functional effect on health having an effect on regeneration or building of ligaments or muscles
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/20—Natural extracts
- A23V2250/21—Plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Mycology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
本发明涉及包含川续断提取物及隔山消提取物作为有效成分的用于增强运动能力和/或肌肉形成的组合物。当摄取本发明的组合物时，有利于增强运动执行能力及肌肉的发育。
Description
技术领域
本发明涉及包含川续断(Dipsacus Asperoides)提取物及隔山消(Cynanchumwilfordii)提取物作为有效成分的用于增强运动能力和/或肌肉发育的组合物。
背景技术
通常，当肌肉不连续运动时，因老化而降低肌肉功能并减少肌肉量及肌肉神经接点(neuromuscular junction，motor unit)，并且容易感到疲劳、乏力，从而降低生活的活力，并且生活的质量急剧下降(J.Appl.Physiol.2003，95，p1717-1727)。为了防止这种情况，持续进行如抗阻力运动(resistance training)等运动(韩国公开专利10-2009-0089815)，并且建议与此一同进行适当的膳食疗法。像这样，为了提高生活的质量，需要进行有规则的运动，在日常生活中，不仅运动员而且普通人也需要更多的精力及耐力。然而，被繁忙生活追逐的现代人倾向于依赖膳食补充品(dietary supplement)而不是运动。因此，用于提高体育运动执行能力的辅助剂、功能性食品、食品组合物等的研究已经持续了很长时间，实际上，已知，若服用类固醇、咖啡因等化合物，则运动能力增加。但是，这些药物可能伴随着致命的副作用，因此限制其的使用。
现有专利文献
韩国专利公开编号第1020110079564号
发明内容
本发明要解决的技术问题
为了解决上述问题并且鉴于上述需求而提出本发明，本发明的目的在于，提供用于提高运动能力的新型组合物。
本发明的另一目的在于，提供用于增强肌肉发育的组合物。
技术方案
为了实现上述目的，本发明提供包含川续断提取物及隔山消提取物作为有效成分的用于增强运动能力的食品组合物。
在本发明的一实例中，优选地，上述川续断提取物及隔山消提取物由水或选自由具有1个至6个碳数的醇及它们的混合溶剂组成的组中的一种溶剂提取而成，但不限定于此。
在本发明的优选实施例中，优选地，川续断提取物和隔山消提取物的混合比例以1:0.1至1:10的重量比进行混合，更优选地，以1:1的重量比进行混合，但不限定于此。
并且，本发明提供包含川续断提取物及隔山消提取物作为有效成分的用于增强肌肉发育的食品组合物。
并且，本发明提供包含川续断提取物及隔山消提取物作为有效成分的用于增强运动能力的药学组合物。
并且，本发明提供包含川续断提取物及隔山消提取物作为有效成分的用于增强肌肉发育的药学组合物。
以下，说明本发明。
本发明人进行了寻找提高运动能力并增强肌肉发育的天然物质的研究，结果，当摄取川续断提取物和隔山消提取物的混合物时，显著提高运动能力，呈现出优秀的肌肉发育增强效果，从而完成了本发明。
本发明的用于增强运动能力或肌肉发育的组合物的剂型无特别限制，但可以为例如药学组合物或健康食品组合物。
当本发明的组合物为药学组合物时，可根据常规的方法以配制成口服剂型、外用剂、栓剂及灭菌注射液等形态的方法来使用。
并且，根据需要，可在上述组合物中添加下述添加剂的一种或两种以上。上述添加剂可包含：各种果汁，例如葡萄柚、苹果、橙子、柠檬、菠萝、香蕉、梨等(也可以采用浓缩果汁、粉末果汁等)；维生素类(棕榈酸视黄酯、核黄素、吡哆醇、氰钴胺素(cyanocobalamine)、抗坏血酸钠、烟酰胺、泛酸钙、叶酸、生物素、胆钙化醇(cholecalciferol)、重酒石酸胆碱、生育酚或β-胡萝卜素等水溶性及脂溶性维生素类)；香味料(柠檬香精、橙子香精、草莓香精、葡萄柚香精或香草香精等)；氨基酸、核酸及其盐类(谷氨酸、谷氨酸钠、甘氨酸、丙氨酸、天冬氨酸、天冬氨酸钠、肌苷酸等)；植物纤维(聚葡萄糖、胶质、黄原胶、葡甘露聚糖或海藻酸等)；或矿物质类(氯化钠、乙酸钠、硫酸镁、氯化钾、氯化镁、碳酸镁、氯化钙、磷酸二钾、磷酸一钠、甘油磷酸钙、柠檬酸亚铁钠、柠檬酸铁铵、柠檬酸铁、硫酸锰、硫酸铜、碘化钠，山梨酸钾、锌、锰、铜、碘或钴等)。
上述组合物还可包含防腐剂、稳定剂、水合剂或乳化促进剂、用于调节渗透压的盐和/或缓冲剂等药剂学辅助剂及其他治疗方面有效的物质，根据通常的方法，能够以口服或非口服给药的多种形态进行剂型化。
口服剂型还可包含：例如片剂、丸剂、硬胶囊或软胶囊、液体药剂、悬浮剂、乳化剂、糖浆剂，颗粒剂等，除了有效成分外，这种剂型包含稀释剂(例如乳糖、葡萄糖、蔗糖、甘露醇、山梨糖醇、纤维素及甘氨酸)、润滑剂(例如二氧化硅、滑石、硬脂酸及其镁或钙盐及聚乙二醇)。片剂还可包含如硅酸镁铝、淀粉糊、明胶、黄芪胶、甲基纤维素、羧甲基纤维素钠及聚乙烯吡咯烷酮等结合剂，根据情况，可包含如淀粉、琼脂、海藻酸或其钠盐等崩解剂、吸收剂、着色剂、调味剂及甜味剂等药剂学添加剂。片剂可通过常规的混合、制粒或包衣方法来制备。并且，作为代表性的用于非口服给药的剂型为注射用剂型，优选为等张性水溶液或悬浮液。
并且，当本发明的组合物为健康食品组合物时，可配制成例如各种食品类、饮料、口香糖、茶、维生素复合物或健康功能性食品类等。本发明使用的隔山消及川续断几乎不存在毒性及副作用，因此在以预防目的长期服用时，也可放心使用。
本发明的健康食品组合物除了以指定的比例含有本发明的提取物以外的其他成分作为必需成分，并不存在特别的限制，可含有如普通饮料等各种调味剂或天然碳水化合物等作为追加成分。上述天然碳水化合物的例包含：单糖，例如葡萄糖、果糖等；双糖，例如麦芽糖、蔗糖等；多糖，例如糊精、环糊精等常规的糖；以及糖醇，木糖醇、山梨糖醇、赤藓糖醇等。作为除了上述以外的调味剂，可有效地使用天然调味剂(索马甜、舔菊提取物(例如莱鲍迪甙A、甘草甜素等)和合成调味剂(糖精、阿斯巴甜等)。相对于每100ml的本发明的组合物，上述天然碳水化合物的比例通常为约1～20g，优选为约5～12g。
除了上述以外，本发明的组合物还可含有多种营养剂、维生素、矿物质(电解质)、合成风味剂及天然风味剂等风味剂、着色剂及增味剂、果胶酸及其盐、海藻酸及其盐、有机酸、保护胶体增稠剂、pH调节剂、稳定剂、防腐剂、甘油、醇或碳酸饮料中使用的碳酸化剂等。此外，本发明的多种组合物可含有用于制备天然果汁及果汁饮料及蔬菜饮料的果肉。可单独或组合使用这种成分。这种添加剂的比例并非很重要，但是相对于本发明的组合物总重量，一般情况下，在0～20重量百分比的范围内进行选择。
上述本发明的提取物的给药量可以限定在本领域技术人员的范围内，本发明的组合物的每日给药量可以根据给药对象的进展程度、发病时期、年龄、健康状态、并发症等多种因素发生变化，但是以成人为基准时，通常可给药上述所提及的重量比组成的组合物1mg/kg至5000mg/kg，优选地，30mg/kg至1000mg/kg，可分为每日一次至两次来进行给药，上述给药量不以任何方式限制本发明的范围。
上述本发明的提取物的含量并不存在特别的限制，然而，相对于组合物的总重量，优选地，包含10～90重量百分比。考虑到在制备片剂及软胶囊时，粉末及功能性成分的含量可以为10～60％，在制备硬胶囊时，粉末及功能性成分的含量可以为10～90％，可提供含有10～90％的本发明的提取物的健康食品组合物或药学组合物。
本发明的一实施方式可以在运动前、运动期间和/或运动后摄取上述定义的组合物。“休息前”是指睡前的晚上，“运动”是指任何可以产生肌肉力量的行为，例如体操、步行、慢跑、骑行、高尔夫、网球、游泳、马拉松或三项竞技。“运动后”是指运动后1小时，优选地，当运动期间存在时间间隔时，意味着运动后。并且，在长时间运动的情况下，例如在马拉松或三项竞技的情况下，优选地，在运动期间摄取本发明的组合物。
有益效果
因此，本发明提供包含川续断提取物及隔山消提取物作为有效成分的用于提高运动能力或增强肌肉发育的食品组合物。本发明增强肌肉发育和提高运动能力，从而有效地制备具有增强肌肉发育或提高运动能力的功能性的食品。
附图说明
图1为摄取本发明的组合物或对照组的组合物后进行强制游泳运动来测定最大运动能力的结果图表。
图2为摄取本发明的组合物或对照组的组合物后进行平板运动来测定最大运动能力的结果图表。
图3为摄取本发明的组合物或对照组的组合物后的测定腓肠肌的肌肉量的结果图表。
具体实施方式
以下，通过实施例对本发明进行详细说明。但是，下述实施例仅用于例示本发明，本发明的内容并不限定于下述实施例。
实施例1
隔山消及川续断提取物的制备
分别将100g的干燥的隔山消和川续断以2～5mm左右的大小进行粉碎后，混合2L的水并搅拌10小时，从而进行加热提取。将提取溶液冷却至70℃，相对于隔山消和川续断的重量，将3％的α-淀粉酶添加到提取液中并在70℃的温度下反应6小时。提取液在95℃的温度下加热15分钟后，立即进行急冷从而停止α-淀粉酶的活性。通过以15000rpm进行离心分离20分钟来分离上清液后，加入20g的活性炭并在常温下搅拌30分钟。在常温下进行过滤并浓缩滤液后使用。
实施例2
2-1.实验动物
将4周龄的ICR类雄性老鼠适应1周后，将实验动物以每5只分为如下的实验组。设定对照组、运动组、实验组等3个组，实验组和运动组每天进行实施例2-2及实施例2-3所述的运动。在实验组中，将3mg/kg的川续断及隔山消混合提取物以口服的方式进行给药，一日一次，共2周，在对照组和运动组中，作为对照物质，使用蒸馏水。
2-2.强制游泳实验
在塑料水槽(直径15cm×高度22cm)中装满25℃的水并使其在水槽中游泳。在尾巴上悬挂相当于体重的5％的锥子并使其以每日20分钟连续游泳两周。两周后，在结束实验物质给药时进行了强制游泳实验，从而测定并比较了运动能力。测定老鼠虚脱时的游泳时间，当老鼠的鼻子沉入水面以下后，无法上升至水面5秒以上时，判断为虚脱。其结果，如图1所示，与未运动的对照组相比，摄取对照物质的运动组的游泳时间增加，但是在统计学上并不显著。与此相反，与对照组相比，实验组的运动时间在统计学上显著增加。与运动的运动组相比，川续断、隔山消混合提取物(实验组)在统计学上显著提高游泳时间。
由此证实，本发明的组合物在提高运动能力方面具有优异的功效。
2-3.平板实验(treadmill test)
实验组及运动组在第一周每日以15m/min的速度进行了平板运动20分钟，在第二周每日以20m/min的速度进行了平板运动30分钟。在平板后方，施加1A的弱电流，使老鼠可以持续地运动。两周后，在实验物质给药结束时测定了最大运动能力。测定以20m/min的速度运动的老鼠虚脱时的运动时间，当无法在平板上奔跑，从而被推倒电极上并停留10秒以上，并且无法进入平板时，判断为虚脱。其结果，如图2所示，与未运动的对照组相比，摄取对照物质的运动组跑步时间增加，但是在统计学上并不显著。与此相反，与对照组相比，实验组的运动时间在统计学上显著增加。与进行相同的运动的运动组相比，川续断、隔山消混合提取物的跑步时间在统计学上显著提高。
由此证实，本发明的组合物在提高运动能力方面具有优异的功效。
2-4.腓肠肌(gastrocnemius)肌肉量测定
结束两周的实验物质摄取期，处死老鼠来分离并称重腓肠肌。其结果，如图3所示，与未运动的对照组相比，摄取对照物质的运动组的腓肠肌的量增加，但是在统计学上并不显著。与此相反，与对照组相比，实验组的腓肠肌肌肉量在统计学上显著增加。与进行运动的运动组相比，川续断、隔山消混合提取物的腓肠肌量在统计学上显著提高。
由此证实，本发明的组合物在增强肌肉发育方面具有优异的功效。
Claims (10)
1.一种用于增强运动能力的食品组合物，其特征在于，包含川续断提取物及隔山消提取物作为有效成分。
2.根据权利要求1所述的用于增强运动能力的食品组合物，其特征在于，上述川续断提取物及隔山消提取物由水或选自由具有1个至6个碳数的醇及它们的混合溶剂组成的组中的一种溶剂提取而成。
3.根据权利要求1所述的用于增强运动能力的食品组合物，其特征在于，上述川续断提取物及隔山消提取物的混合比例为1:1重量比。
4.一种用于增强肌肉发育的食品组合物，其特征在于，包含川续断提取物及隔山消提取物作为有效成分。
5.根据权利要求4所述的用于增强肌肉发育的食品组合物，其特征在于，上述川续断提取物及隔山消提取物由水或选自由具有1个至6个碳数的醇及它们的混合溶剂组成的组中的一种溶剂提取而成。
6.一种用于增强运动能力的药学组合物，其特征在于，包含川续断提取物及隔山消提取物作为有效成分。
7.根据权利要求6所述的用于增强运动能力的药学组合物，其特征在于，上述川续断提取物及隔山消提取物由水或选自由具有1个至6个碳数的醇及它们的混合溶剂组成的组中的一种溶剂提取而成。
8.根据权利要求6所述的用于增强运动能力的药学组合物，其特征在于，上述川续断提取物及隔山消提取物的混合比例为1:1重量比。
9.一种用于增强肌肉发育的药学组合物，其特征在于，包含川续断提取物及隔山消提取物作为有效成分。
10.根据权利要求9所述的用于增强肌肉发育的药学组合物，其特征在于，上述川续断提取物及隔山消提取物由水或选自由具有1个至6个碳数的醇及它们的混合溶剂组成的组中的一种溶剂提取而成。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020150098183A KR101794607B1 (ko) | 2015-07-10 | 2015-07-10 | 속단 및 백수오 추출물을 유효성분으로 포함하는 운동능력 및 근육 증진용 조성물 |
| KR10-2015-0098183 | 2015-07-10 | ||
| PCT/KR2016/007344 WO2017010735A1 (ko) | 2015-07-10 | 2016-07-07 | 속단 및 백수오 추출물을 유효성분으로 포함하는 운동능력 및 근육 증진용 조성물 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107847537A true CN107847537A (zh) | 2018-03-27 |
Family
ID=57757976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680039519.8A Pending CN107847537A (zh) | 2015-07-10 | 2016-07-07 | 包含川续断提取物及隔山消提取物作为有效成分的用于增强运动能力及肌肉的组合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10660927B2 (zh) |
| EP (1) | EP3320785A4 (zh) |
| JP (2) | JP2018520704A (zh) |
| KR (1) | KR101794607B1 (zh) |
| CN (1) | CN107847537A (zh) |
| AU (1) | AU2016293900B2 (zh) |
| BR (1) | BR112017028559A2 (zh) |
| CA (1) | CA2991286A1 (zh) |
| RU (1) | RU2694736C1 (zh) |
| WO (1) | WO2017010735A1 (zh) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190053572A (ko) | 2017-11-10 | 2019-05-20 | 주식회사 씨앤씨네이처 | 알긴산을 유효성분으로 함유하는 운동능력 및 지구력 향상용 조성물 |
| KR20220084527A (ko) | 2020-12-14 | 2022-06-21 | 김용숙 | 근육 증강, 운동능력 향상 및 운동피로 회복용 조성물 |
| KR20230172664A (ko) | 2022-06-15 | 2023-12-26 | 김경언 | 백수오 추출물을 이용한 여성 갱년기 증상 예방 또는 완화를 위한 조성물 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100696830B1 (ko) * | 2006-01-24 | 2007-03-30 | 고장호 | 운동 후 와 성생활 후의 신체회복능력 향상 한방 음료 |
| KR100714464B1 (ko) * | 2006-03-08 | 2007-05-04 | 최영진 | 스포츠 기능성 식품 |
| CN104353032A (zh) * | 2014-10-23 | 2015-02-18 | 王小英 | 药酒组合物及其用途 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1140123A4 (en) | 1999-11-12 | 2006-03-15 | Karen M Slimak | USE OF TROPICAL ROOTS IN EFFECTIVE INTERVENTION STRATEGIES FOR TREATING DIFFICULT AND COMPLEX CASES AND CHRONIC DISEASES |
| US6984405B1 (en) | 2000-12-15 | 2006-01-10 | Naturalendo Tech Co., Ltd. | Compositions for inducing secretion of insulin-like growth factor-1 |
| KR20020090077A (ko) | 2001-05-23 | 2002-11-30 | 정성일 | 노화예방, 정력보강, 간과 신을돕고 허손을 보호,근력튼튼, 안색이 아름답고 흰머리예방 |
| KR100382040B1 (en) * | 2002-08-06 | 2003-04-26 | Naturalendo Tech Co Ltd | Composition for stimulating estrogen secretion and regenerating female reproductive tissue cells |
| KR100406837B1 (en) | 2002-10-14 | 2003-11-21 | Natural Endotech Co Ltd | Health food composition containing natural product extract for reducing blood glucose level through the promotion of insulin release |
| KR20050050291A (ko) * | 2003-11-25 | 2005-05-31 | 이광현 | 한약 치료제 |
| KR100714414B1 (ko) | 2004-10-21 | 2007-05-07 | 박수영 | 입력된 정보를 정보제공원의 위치와 함께 처리하는 정보입력 기기 및 이를 관리하는 정보 관리 서버 |
| JP2006335721A (ja) * | 2005-06-03 | 2006-12-14 | Taiyo Kagaku Co Ltd | 肩こり改善組成物、及びそれを含有する飲食品、医薬部外品、医薬品 |
| JP2008007473A (ja) * | 2006-06-30 | 2008-01-17 | Suntory Ltd | 決明子抽出物 |
| JP2008019170A (ja) * | 2006-07-10 | 2008-01-31 | Unitika Ltd | 胃腸障害改善・予防作用を有する飲食品 |
| KR100847343B1 (ko) | 2006-12-08 | 2008-07-21 | 경희대학교 산학협력단 | 생약복합재 추출물을 함유하는 골길이 성장 촉진용 조성물 |
| JP5117092B2 (ja) * | 2007-04-09 | 2013-01-09 | 株式会社ノエビア | 保湿剤、抗老化剤、美白剤、抗酸化剤、痩身剤、トリートメント剤、アルギナーゼ活性促進剤及び皮膚外用剤 |
| KR100974290B1 (ko) | 2008-02-11 | 2010-08-06 | (주)내츄럴엔도텍 | 탈모방지 또는 발모촉진용 조성물 |
| KR101106110B1 (ko) | 2009-03-23 | 2012-01-18 | (주)내츄럴엔도텍 | 불면증 예방 또는 치료용 조성물 |
| KR101189605B1 (ko) | 2012-06-28 | 2012-10-11 | 홍상근 | 인슐린 유사 성장인자 분비 및 뼈 골격 성장 촉진용 백하수오 추출물과 속단 추출물 및 그 제조방법 |
| CN103877235A (zh) | 2012-12-21 | 2014-06-25 | 李冬梅 | 一种强筋壮骨药丸 |
| CN104116923A (zh) | 2014-07-30 | 2014-10-29 | 刘德强 | 一种治疗骨折、骨裂的药物组合物 |
| KR20160011174A (ko) * | 2015-09-18 | 2016-01-29 | 재단법인 전남생물산업진흥원 | 테스토스테론 분비 증강 효과를 갖는 백수오 추출물을 포함하는 건강식품 조성물 |
-
2015
- 2015-07-10 KR KR1020150098183A patent/KR101794607B1/ko active IP Right Grant
-
2016
- 2016-07-07 EP EP16824652.8A patent/EP3320785A4/en not_active Withdrawn
- 2016-07-07 BR BR112017028559-2A patent/BR112017028559A2/pt not_active Application Discontinuation
- 2016-07-07 US US15/742,827 patent/US10660927B2/en active Active
- 2016-07-07 CN CN201680039519.8A patent/CN107847537A/zh active Pending
- 2016-07-07 RU RU2018104977A patent/RU2694736C1/ru active
- 2016-07-07 WO PCT/KR2016/007344 patent/WO2017010735A1/ko active Application Filing
- 2016-07-07 JP JP2018521165A patent/JP2018520704A/ja active Pending
- 2016-07-07 CA CA2991286A patent/CA2991286A1/en not_active Abandoned
- 2016-07-07 AU AU2016293900A patent/AU2016293900B2/en not_active Ceased
-
2019
- 2019-09-30 JP JP2019181028A patent/JP2020072659A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100696830B1 (ko) * | 2006-01-24 | 2007-03-30 | 고장호 | 운동 후 와 성생활 후의 신체회복능력 향상 한방 음료 |
| KR100714464B1 (ko) * | 2006-03-08 | 2007-05-04 | 최영진 | 스포츠 기능성 식품 |
| CN104353032A (zh) * | 2014-10-23 | 2015-02-18 | 王小英 | 药酒组合物及其用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112017028559A2 (pt) | 2018-09-04 |
| US20190000906A1 (en) | 2019-01-03 |
| JP2018520704A (ja) | 2018-08-02 |
| AU2016293900B2 (en) | 2019-07-18 |
| CA2991286A1 (en) | 2017-01-19 |
| WO2017010735A1 (ko) | 2017-01-19 |
| AU2016293900A1 (en) | 2018-01-25 |
| EP3320785A4 (en) | 2019-04-10 |
| KR101794607B1 (ko) | 2017-11-07 |
| KR20170006865A (ko) | 2017-01-18 |
| RU2694736C1 (ru) | 2019-07-16 |
| US10660927B2 (en) | 2020-05-26 |
| EP3320785A1 (en) | 2018-05-16 |
| JP2020072659A (ja) | 2020-05-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101296693B (zh) | 持久力提高剂 | |
| CA2641667C (en) | Composition for optimizing muscle performance during exercise | |
| US6037375A (en) | Nutrient composition | |
| WO2012013975A1 (en) | Nutritional compositions | |
| WO2004110175A1 (en) | Weight management beverage | |
| CN103918965A (zh) | 一种缓解体力疲劳的饮料 | |
| CN101868238B (zh) | 配合有芝麻素类和维生素b1类的组合物 | |
| CN107847537A (zh) | 包含川续断提取物及隔山消提取物作为有效成分的用于增强运动能力及肌肉的组合物 | |
| CN104522675A (zh) | 抗耐力型疲劳的组合物及其制备方法 | |
| CN102228103A (zh) | 柠檬菊花茶饮料及其制备方法 | |
| WO2008004333A1 (fr) | Agent pour l'amélioration de la puissance musculaire | |
| US20150064310A1 (en) | Endurance sports drink utilizing tapioca starch | |
| JP6365921B2 (ja) | スターアニス抽出物を含む容器詰炭酸飲料 | |
| WO2021198409A1 (en) | Composition comprising a source of nitrate derived from amaranthus leaf and/or rhubarb | |
| CN107205919A (zh) | 牛磺酸或其衍生物、生物素和葡萄提取物的组合用于对抗细的毛发的用途 | |
| JP6178196B2 (ja) | アラニン含有液状組成物 | |
| CA2127445C (en) | Nutrient composition | |
| US20120308634A1 (en) | Gum delivery system | |
| JP2017212915A (ja) | 果汁入り分離液状調味料 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180327 |