CN1078472C - Application of theachrome in preparing medicine for plateau erythrocytosis - Google Patents
Application of theachrome in preparing medicine for plateau erythrocytosis Download PDFInfo
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- CN1078472C CN1078472C CN97116635A CN97116635A CN1078472C CN 1078472 C CN1078472 C CN 1078472C CN 97116635 A CN97116635 A CN 97116635A CN 97116635 A CN97116635 A CN 97116635A CN 1078472 C CN1078472 C CN 1078472C
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Abstract
The present invention discloses a new medicinal use of tea pigment, namely that the tea pigment can be used for curing plateau erythrocythemia.
Description
The present invention relates to the new medicine use of tea pigment, be specifically related to the application of tea pigment in the medicine of preparation high altitude erythrocytosis, belong to the field of Chinese medicines.
Tea pigment is the natural plant pigment that extracts from Folium Camelliae sinensis, is a kind of active pigment complex that catechin forms through peroxidating in the tea polyphenols.Tea pigment is made up of theaflavin, thearubigins and abrownin.For the existing bibliographical information of the research of tea pigment.CN1074618A discloses tea pigment and production method thereof.This production process is, Folium Camelliae sinensis is through decocting extracting juice, and alkalization concentrates, and acidify adds alcohol reflux, and alcohol reflux liquid alkalizes and obtains tea pigment crystallization product, through vacuum drying, promptly obtains this tea pigment.Theaflavin, thearubigins and abrownin three have constant ratio in the tea pigment that makes with this method, can be used as medicinal.Medical value report for tea pigment may be summarized to be reduction blood viscosity, blood fat reducing, cholesterol reducing, prevention and treatment cardiovascular disease.But up to the present, the relevant tea pigment of Shang Weijian is used for the treatment of the report of plateau cytosis.The direct murderous case of high altitude erythrocytosis is few, but can make large quantities of builder's forfeitures or reduce work capacity such as aid Tibet.Current main treatment measure is to withdraw the plateau, reduces labor intensity or slowly acclimatization and adaptation.Present oral Chinese medicine and western medicine medicine still can not prevent and control the outbreak of high red disease, and composite treatment comprises Hyperbaric oxygen chamber, quantum tachometer etc., though curative effect reaches 88.3%, is mostly to enter the result of low altitude area treatment.Seeking on-site treatment and the oral drugs of preventive effect are arranged is plateau medicine worker pursuits for many years.
The object of the invention provides a kind of new pharmaceutical applications of tea pigment, i.e. the application of tea pigment in the medicine of preparation treatment high altitude erythrocytosis.
High altitude erythrocytosis is common a kind of chronic high altitude disease.Oxygen-derived free radicals is apparently higher than healthy people in this disease patient blood, and superoxide dismutase is starkly lower than healthy people, causes oxygen-derived free radicals to be accumulated for a long time in vivo, causes the infringement of histoorgan and function.Tea pigment treatment high altitude erythrocytosis of the present invention has good curative effect.
The extracting method of tea pigment of the present invention can extract according to known extraction process, preferably the tea pigment that extracts according to following method:
(1), with Folium Camelliae sinensis by 1: after 15-30 multiple proportions example added water, through once or the decoction extracting juice once, fried liquid is used in the aqueous solution can produce OH
-Ionic chemical compound alkalizes, and regulates PH8-10, at the 1/4-1/10 that heats concentrated this alkaline solution to the original volume amount down less than 70 ℃, gets concentrated solution then; (2) concentrated solution transfers to PH3-6 with acid, and acidifying solution adds ethanol 1-10 volume doubly to be measured, and backflow 0.5-2 hour, gets alcohol reflux liquid; (3) alcohol reflux liquid is used in the aqueous solution and can produces OH
-Ionic chemical compound is regulated PH7-10, and post precipitation filters, and gets the tea pigment crystallization, and the tea pigment crystallization promptly gets the tea pigment product through vacuum drying.
Tea pigment of the present invention is a kind of active constituents of medicine, preparation process according to routine, can be main active constituent with tea pigment, add excipient substances such as conventional excipient, flavoring agent, disintegrating agent, antiseptic, lubricant, wetting agent, binding agent, solvent, thickening agent, solubilizing agent, make any dosage form that is suitable for using clinically, as tablet, capsule, granule, oral liquid, injection etc.
Because the present invention discloses the pharmacologic action of tea pigment treatment high altitude erythrocytosis first; therefore; tea pigment cooperated separately or with other active constituents or adjuvant make medicament,, all belong to protection scope of the present invention so long as this medicament is used for the treatment of high altitude erythrocytosis.
Tea pigment of the present invention all has the effect of treatment high altitude erythrocytosis when making any dosage form.Any medicament; if contain tea pigment in its tissue or only prepare patent medicine with the tea pigment single component; on signs such as its packing or description or on other any propaganda materials, need only effect dated or that prompting has the treatment high altitude erythrocytosis, then fall within protection scope of the present invention.
Tea pigment of the present invention is the natural plants Folium Camelliae sinensis that derives from medicine-food two-purpose.Therefore, also tea pigment can be made health food or health care medicine.Health food or health care medicine with tea pigment is made have the effect for the treatment of high altitude erythrocytosis if indicate or point out on signs such as its packing or description, also fall within protection scope of the present invention.
Embodiment 1
Prescription
Tea pigment 125 grams
Medical starch 875 grams
Above-mentioned component is gone into blender, and fully stirring and evenly mixing is encapsulated with capsule machine, and every filling 1 gram makes 1000 of tea pigment capsules, and every capsules contains 125 milligrams of tea pigments.
Embodiment 2
Tea pigment 250 grams
2000 milligrams of distilled water
Stevioside 1 gram
Tea pigment is dissolved in the distilled water, and fully mixing adds stevioside, and stirring and evenly mixing is once more packed in the vial with can packing machine, and every bottled 10 milliliters, sterilization makes the tea pigment oral liquid.
Experimental example 1 tea pigment capsule is to the observation of curative effect of high altitude erythrocytosis
1, data
1.1 area: location, mansion, Golog state, Qinghai Province (3,719m), atmospheric pressure 63.98kpa, aerial oxygen dividing potential drop 7.28kpa.
1.2 object: officers and men People's Armed Police of the army of state in the Golog and family members 50 routine high altitude erythrocytosis patients, male's 42 examples wherein, women's 8 examples: the age, between year, the mean age was 29 years old at 9-53.The diagnostic criteria of 50 routine high altitude erythrocytosiss meets professor Wu Tianyi and waits " erythrocyte＞6.5 * 10 in the proposition blood parameters
12/ L, hemoglobin＞200g/L, packed cell volume＞0.651/L " standard.And got rid of the illness of the secondary polycythemia that chronic bronchitis, chronic cardiopulmonary disease, polycythemia vera, congenital heart disease etc. cause on inspection.
1.3 medicament sources: tea pigment capsule is provided by the green pharmaceutical Co. Ltd in Jiangxi; Authentication code: the accurate word of medicine (94) 139-1 number defended in Jiangxi, product batch number: 940804, and every of specification contains tea pigment 125mg.Usage: 125mg, every day 3 times, be a course of treatment February.Medication period is withdrawn relevant other medicines.
2, methods of clinical observation:
2.1 observation item: hematochrome, red blood cell count(RBC) and three indexs of packed cell volume.
2.2 observational technique: measure hematochrome, erythrocyte, packed cell volume before experimenter's oral drugs, measuring process is finished by same position doctor.
2.3 efficacy assessment standard: produce effects: patient's hematochrome drops to 142-159g/L, red blood cell count(RBC) drops to 4.5-5.2 * 10
12/ L, packed cell volume are reduced to 0.45-0.52L/L.Effectively: patient's hematochrome is reduced to 160g-180g/L, red blood cell count(RBC) is reduced to 5.2-6.0 * 10
12/ L, packed cell volume are reduced to 0.52-0.6L/L.Invalid: as though patient's blood bag is plain decline is arranged, but still more than 200g/L, red blood cell count(RBC) to be in 6.0-6.6 * 10
12/ L, packed cell volume is more than 0.65L/L.Produce effects 22 examples account for 44%; Effective 26 examples account for 52%, and invalid 2 examples account for 4%, and total effective rate is 96%.
3, result
The results are shown in following table
Physiochemical indice changed before and after tea pigment capsule was taken medicine to 50 routine high altitude erythrocytosis patients:
| Test item | Before the treatment | After the treatment | The t value |
| Hb(g/L) | 218±38.4 | 164±36.86 | 1.872 |
| Rbc(×10 12/L) | 6.85±0.75 | 5.1±0.68 | 2.871 |
| HCT(L/L) | 0.678±0.086 | 0.525±0.075 | 2.872 |
Annotate: with preceding relatively P＜0.05 of treatment
Discuss:
1, high altitude erythrocytosis is common a kind of chronic high altitude disease.Environment of low oxygen plateau is regarded as influencing the main cause that the person healthy and some people in plateau suffers from high altitude erythrocytosis.Also there is the scholar to propose to be because of some people who lives in the plateau because of hypoxia stress, causes that a kind of pathologic that hemopoietic function or its regulatory mechanism get muddled changes.It is because hypoxia increases kidney erythropoitinogen enzyme secretion, and erythropoietin increases, and the latter makes the hemocytoblast in the bone marrow also promote later on further hypertrophy and maturation.In recent years discover, oxygen-derived free radicals is apparently higher than healthy people in high altitude erythrocytosis patient's blood, and the superoxide dismutase of removing oxygen-derived free radicals is starkly lower than healthy people, causes oxygen-derived free radicals to be accumulated for a long time in human body, causes the infringement of histoorgan and function.
2, tea pigment is a green tea extract, has the blood fat of improvement, anticoagulant, molten fibre, removes free radical, improves vascular endothelial function, can prevent and treat aspect diseases such as many hearts, cerebrovascular.We use tea pigment capsule 50 routine high altitude erythrocytosiss are carried out clinical observation, and the result has obtained good curative effect.Hb, Rbc, Hct significantly descend (P＜0.05) before than treatment, reduce to not see in normal range and continue to descend, and the mental status, appetite, physical strength, memory obviously improve.The author thinks that this medicine can improve the utilization of body to blood oxygen, has anti-hypoxia, the scarce O of enhancing body tolerance
2Ability; Can regulate the physiological process of body hemopoietic function disorder, make it to transform towards normally helping the body aspect.With the removing oxygen-derived free radicals, reduce it and in body, accumulate, damage relevant in addition.This medicine improves plateau the army and the people's health and has opened up another new approach for preventing and treating high altitude erythrocytosis.
Experimental example 2 tea pigments treatment high altitude erythrocytosis 222 routine observation of curative effect
1, data and method:
1.1 the diagnostic criteria of high red disease is based on hematological examination.Hb 〉=200 gram/L, Rbc 〉=6.5 * 10
12/ L, Hct 〉=65Vol% can make a definite diagnosis.Hematological variation and microcirculation disturbance, peripheral blood silt resistance and hemorheology slow blood flow, hypercoagulability, SOD lowers relevant.Tea pigment is to the existing many reports of the influence of nail fold microcirculation, hemorheology, blood fat, SOD.But the influence to hematology Hb, Rbc, Hct is not reported.
1.2 offer medicine on the spot in high altitude localities more than 3000 meters, inspection on the scene guarantees the integrity and the accuracy of high raw data, and its conclusion is reliable.The purpose of research is the survival ability after protection fighting capacity and individuality enter the plateau.So the improvement of clinical symptoms is observed it in detail as a concrete index.In respect of: dizzy, have a headache, breathe hard, uncomfortable in chest, edema, cardiopalmus, arthralgia, poor appetite, nauseating, fidgety, become thin, chest pain, weak, insomnia, xerosis cutis, diarrhoea, blurred vision, tinnitus, auditory dysesthesia, acroanesthesia, menoxenia, lip cyanosis, finger tip are livid purple, conjunctival congestion, fingernail cave in, more than totally 25.
1.3 four medical team are left for different regions.Qinghai red cross hospital sets up an office on the Hao Men farm, (3100 meters-3600 meters of height above sea level), Xining hospital of Railway Bureau sets up an office at the Hai Xihaer lid, (3300 meters of height above sea level), People's Armed Police Qinghai hospital of army unit sets up an office in Golog Da Wu area, (3500 meters-4300 meters of height above sea level), the communication hospital, Qinghai selects case along Qinghai-Tibet Highway in workman of railway maintenance squad and civilian worker.(3000 meters-4500 meters of height above sea level).Four unified standards of taking medicine of group, 125 milligrams, day 3 clothes, 40 days is a course of treatment.The unified regulation of criterion of therapeutical effect.
2, efficacy assessment standard:
2.1 produce effects: Hb≤180 gram/L, Rbc≤5.5 * 10
12/ L, Hct≤55Vol%; Nail fold microcirculation takes a turn for the better one more than the grade, and hemorheology whole blood, plasma viscosity obviously change general; Antisecosis, original symptom improve more than 1/2, can adhere to plateau work.
2.2 effectively: Hb decline less than 20 gram/L, Rbc decline less than 1 * 10
12/ L, the Hct not enough 10Vol% that descends; Nail fold microcirculation, hemorheology obviously improve; Muscle power has recovery, and original symptom is partly improved.Adhere to that the plateau work has certain difficulty.
2.3 invalid: blood test, nail fold microcirculation, hemorheology, clinical shape do not improve, or change the low altitude area therapist midway over to.
3, observed result:
The results are shown in following table:
| Unit | Height above sea level | The example number | Produce effects | Effectively | Invalid | Total effective rate |
| Communication hospital, Xining railway hospital of Qinghai red cross hospital People's Armed Police Qinghai army unit hospital Qinghai adds up to | 3100 meters-3600 meters 3300 meters 3500 meters-4300 meters 3000 meters-4500 meters | 52 90 50 30 222 | 12(23％) 42(46.6％) 22(44％) 13(43％) 89(40％) | 15(28.8％) 28(31.1％) 26(52％) 15(50) 84(37.8％) | 25(48％) 20(22.2％) 2(4％) 2(6.6％) 49(22％) | 52％ 77.8％ 96％ 93.4％ 78％ |
There were significant differences (P＜0.01) that 52 examples are treated by Qinghai red cross hospital for four medical center therapeutic effect, and wherein produce effects 12 examples account for 23%, and effective 15 examples account for 28.8%, and invalid 25 examples account for 48%; Xining railway hospitalize 90 examples, wherein produce effects 42 examples account for 46.6%, and effective 28 examples account for 31.1%, and invalid 20 examples account for 22.2%; People's Armed Police Qinghai army unit hospitalize 50 examples, produce effects 22 examples account for 44%, and effective 26 examples account for 52%, and invalid 2 examples account for 4%, and 30 examples are treated by the communication hospital, Qinghai, and produce effects 13 examples account for 43%, and effective 15 examples account for 50%, and invalid 2 examples account for 6.6%.
The reason that significant difference occurs.The one, the time difference of migrating the plateau is big, and the 2nd, age difference is big.Red cross hospital's treatment target is the farm cadre, and the inhabitation time is many more than 10 years, 51 years old mean age.Armed Police contingent's hospitalize is to liking the officers and men of army, enter the plateau majority within 5 years, 29 years old mean age, Xining railway hospital and communication hospital's treatment target are railway, highway worker, the civilian worker who goes into the plateau when part is seasonality, wherein person between twenty and fifty occupy the majority.This explanation tea pigment is treated high red disease, and medical history is short more, and the age, low more effect was good more, and the red disease effect of chronic height is then weaker.
Tea pigment is treated high red disease certain curative effect, and effective percentage reaches 78%, and clinical observation is similar to Rhodiola kirilowii (Regel) Maxim..Be better than Western medicine diethylstilbestrol (effective percentage is 63.3%).It is one of optional medicine of treatment high altitude erythrocytosis.
Claims (1)
1, the application of tea pigment in the medicine of preparation treatment high altitude erythrocytosis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97116635A CN1078472C (en) | 1997-08-08 | 1997-08-08 | Application of theachrome in preparing medicine for plateau erythrocytosis |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97116635A CN1078472C (en) | 1997-08-08 | 1997-08-08 | Application of theachrome in preparing medicine for plateau erythrocytosis |
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| Publication Number | Publication Date |
|---|---|
| CN1207913A CN1207913A (en) | 1999-02-17 |
| CN1078472C true CN1078472C (en) | 2002-01-30 |
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| CN97116635A Expired - Fee Related CN1078472C (en) | 1997-08-08 | 1997-08-08 | Application of theachrome in preparing medicine for plateau erythrocytosis |
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| CN101715957B (en) * | 2009-11-18 | 2012-10-24 | 南京中医药大学 | Compound tea pigment with the function of improving hypoxia tolerance, preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1081575A (en) * | 1992-12-29 | 1994-02-09 | 武汉市职工医学院 | The extracting method of Tea Pigment |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1081575A (en) * | 1992-12-29 | 1994-02-09 | 武汉市职工医学院 | The extracting method of Tea Pigment |
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