实施例6
1000mL的反应瓶中,将4g异丙胺加入100mL 0.2M磷酸盐缓冲液中,调pH为7.0~7.5,加入转氨酶SEQ ID NO:7冻干粉质量为0.2g、40mg磷酸吡哆醛,混匀后滴入溶于20mLDMSO的4g主原料3,体系pH为7.0~7.5,35℃±3℃恒温搅拌64h。HPLC检测转化率99.5%,反应结束后,加入100mL的乙酸乙酯进行萃取3次,合并萃取有机相后加入硫酸镁进行干燥,旋转蒸发至干,得产品3.79g,收率94.8%,e.e.值99%。
从以上的描述中,可以看出,本发明上述的实施例实现了如下技术效果:本发明的上述转氨酶突变体是在SEQ ID NO:1所示的转氨酶的基础上,通过定点突变的方法进行突变,从而改变其氨基酸序列,实现蛋白质结构和功能的改变,再通过定向筛选的方法,得到具有上述突变位点的转氨酶,本发明的转氨酶突变体具有酶活性大幅度提高的优势,并且酶特异性也有相应提高,从而大幅度降低了手性胺工业生产中的成本。
以上所述仅为本发明的优选实施例而已,并不用于限制本发明,对于本领域的技术人员来说,本发明可以有各种更改和变化。凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。
序列表
<110> 凯莱英生命科学技术(天津)有限公司
<120> 转氨酶突变体及其应用
<130> PN74794KLY
<160> 60
<170> SIPOSequenceListing 1.0
<210> 1
<211> 341
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 1
Met Thr Ile Ser Lys Asp Ile Asp Tyr Ser Thr Ser Asn Leu Val Ser
1 5 10 15
Val Ala Pro Gly Ala Ile Arg Glu Pro Thr Pro Ala Gly Ser Val Ile
20 25 30
Gln Tyr Ser Asp Tyr Glu Leu Asp Glu Ser Ser Pro Phe Ala Gly Gly
35 40 45
Ala Ala Trp Ile Glu Gly Glu Tyr Val Pro Ala Ala Glu Ala Arg Ile
50 55 60
Ser Leu Phe Asp Thr Gly Phe Gly His Ser Asp Leu Thr Tyr Thr Val
65 70 75 80
Ala His Val Trp His Gly Asn Ile Phe Arg Leu Lys Asp His Ile Asp
85 90 95
Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Leu Gln Ser Pro Leu Thr
100 105 110
Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val Ser Leu Ser Gln
115 120 125
Leu Arg Glu Ser Phe Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Ala
130 135 140
Arg Lys Gly Glu Lys Asp Leu Ser Lys Leu Thr Ser Gln Ile Tyr Ile
145 150 155 160
Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe
165 170 175
Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn
180 185 190
Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala
195 200 205
Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Leu
210 215 220
Asp Ala Asp Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Met
225 230 235 240
Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn Ala Leu Pro Gly
245 250 255
Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu Met Gly Ile Glu
260 265 270
Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr Glu Ala Asp Glu
275 280 285
Leu Ile Ala Val Thr Thr Ala Gly Gly Ile Thr Pro Ile Thr Ser Leu
290 295 300
Asp Gly Glu Pro Leu Gly Asp Gly Thr Pro Gly Pro Val Thr Val Ala
305 310 315 320
Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Pro Ser Ser Leu Val
325 330 335
Glu Ala Ile Glu Tyr
340
<210> 2
<211> 341
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 2
Met Thr Ile Ser Lys Asp Ile Asp Tyr Ser Thr Ser Asn Leu Val Ser
1 5 10 15
Val Ala Pro Gly Ala Ile Arg Glu Pro Thr Pro Ala Gly Ser Val Ile
20 25 30
Gln Tyr Ser Asp Tyr Glu Leu Asp Glu Ser Ser Pro Phe Ala Gly Gly
35 40 45
Ala Ala Trp Ile Glu Gly Glu Tyr Val Pro Ala Ala Glu Ala Arg Ile
50 55 60
Ser Leu Phe Asp Thr Gly Phe Gly His Ser Asp Ala Thr Tyr Thr Val
65 70 75 80
Ala His Val Trp His Gly Asn Ile Phe Arg Leu Lys Asp His Ile Asp
85 90 95
Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Leu Gln Ser Pro Leu Thr
100 105 110
Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val Ser Leu Ser Gln
115 120 125
Leu Ala Glu Ser Phe Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Ala
130 135 140
Arg Lys Gly Glu Lys Asp Leu Ser Lys Leu Thr Ser Gln Ile Tyr Ile
145 150 155 160
Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe
165 170 175
Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn
180 185 190
Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala
195 200 205
Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Leu
210 215 220
Asp Ala Asp Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Met
225 230 235 240
Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn Ala Leu Pro Gly
245 250 255
Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu Met Gly Ile Glu
260 265 270
Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr Glu Ala Asp Glu
275 280 285
Leu Ile Ala Cys Thr Thr Gly Gly Gly Ile Thr Pro Ile Thr Ser Leu
290 295 300
Asp Gly Glu Pro Leu Gly Asp Gly Thr Pro Gly Pro Val Thr Val Ala
305 310 315 320
Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Pro Ser Ser Leu Val
325 330 335
Glu Ala Ile Glu Tyr
340
<210> 3
<211> 341
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 3
Met Thr Ile Ser Lys Asp Ile Asp Tyr Ser Thr Ser Asn Leu Val Ser
1 5 10 15
Val Ala Pro Gly Ala Ile Arg Glu Pro Thr Pro Ala Gly Ser Val Ile
20 25 30
Gln Tyr Ser Asp Tyr Glu Leu Asp Glu Ser Ser Pro Phe Ala Gly Gly
35 40 45
Ala Ala Trp Ile Glu Gly Glu Tyr Val Pro Ala Ala Glu Ala Arg Ile
50 55 60
Ser Leu Phe Asp Thr Gly Phe Gly His Ser Asp Leu Thr Tyr Thr Val
65 70 75 80
Ala His Val Trp His Gly Asn Ile Phe Arg Leu Lys Asp His Ile Asp
85 90 95
Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Ile Gln Ser Pro Leu Thr
100 105 110
Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val Ser Leu Ser Gln
115 120 125
Leu Arg Glu Ser Phe Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Ala
130 135 140
Arg Lys Gly Glu Lys Asp Leu Ser Lys Leu Thr Ser Gln Ile Tyr Ile
145 150 155 160
Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe
165 170 175
Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn
180 185 190
Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala
195 200 205
Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Leu
210 215 220
Asp Ala Asp Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Met
225 230 235 240
Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn Ala Leu Pro Gly
245 250 255
Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu Met Gly Ile Glu
260 265 270
Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr Glu Ala Asp Glu
275 280 285
Leu Ile Ala Val Thr Thr Gly Gly Gly Ile Thr Pro Ile Thr Ser Leu
290 295 300
Asp Gly Glu Pro Leu Gly Asp Gly Thr Pro Gly Pro Val Thr Val Ala
305 310 315 320
Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Pro Ser Ser Leu Val
325 330 335
Glu Ala Ile Glu Tyr
340
<210> 4
<211> 341
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 4
Met Thr Ile Ser Lys Asp Ile Asp Tyr Ser Thr Ser Asn Leu Val Ser
1 5 10 15
Val Ala Pro Gly Ala Ile Arg Glu Pro Thr Pro Ala Gly Ser Val Ile
20 25 30
Gln Tyr Ser Asp Tyr Glu Leu Asp Glu Ser Asn Pro Phe Ala Gly Gly
35 40 45
Ala Ala Trp Ile Glu Gly Glu Tyr Val Pro Ala Ala Glu Ala Arg Ile
50 55 60
Ser Leu Phe Asp Thr Gly Phe Leu His Ser Asp Leu Thr Tyr Thr Val
65 70 75 80
Ala His Val Trp His Gly Asn Ile Phe Arg Leu Lys Asp His Ile Asp
85 90 95
Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Leu Gln Ser Pro Leu Thr
100 105 110
Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val Ser Leu Ser Gln
115 120 125
Leu Arg Glu Ser Phe Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Ala
130 135 140
Arg Lys Gly Glu Lys Asp Leu Ser Lys Leu Thr Ser Gln Ile Tyr Ile
145 150 155 160
Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe
165 170 175
Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn
180 185 190
Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala
195 200 205
Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Leu
210 215 220
Asp Ala Asp Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Met
225 230 235 240
Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn Ala Leu Pro Gly
245 250 255
Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu Met Gly Ile Glu
260 265 270
Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr Glu Ala Asp Glu
275 280 285
Leu Ile Ala Val Thr Thr Gly Gly Gly Ile Thr Pro Ile Thr Ser Leu
290 295 300
Asp Gly Glu Pro Leu Gly Asp Gly Thr Pro Gly Pro Val Thr Val Ala
305 310 315 320
Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Pro Ser Ser Leu Val
325 330 335
Glu Ala Ile Glu Tyr
340
<210> 5
<211> 341
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 5
Met Thr Ile Ser Lys Asp Ile Asp Tyr Ser Thr Ser Asn Leu Val Ser
1 5 10 15
Val Ala Pro Gly Ala Ile Arg Glu Pro Thr Pro Ala Gly Ser Val Ile
20 25 30
Gln Tyr Ser Asp Tyr Glu Leu Asp Glu Ser Ser Pro Phe Ala Gly Gly
35 40 45
Ala Ala Trp Ile Glu Gly Glu Tyr Val Pro Ala Ala Glu Ala Arg Ile
50 55 60
Ser Leu Phe Asp Thr Gly Phe Gly His Ser Asp Leu Thr Tyr Thr Val
65 70 75 80
Ala His Val Trp His Gly Asn Ile Phe Arg Leu Lys Asp His Ile Asp
85 90 95
Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Leu Gln Ser Pro Leu Thr
100 105 110
Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val Ser Leu Ser Gln
115 120 125
Leu Arg Glu Ser Phe Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Ala
130 135 140
Arg Lys Gly Glu Lys Asp Leu Ser Lys Leu Thr Ser Gln Ile Tyr Ile
145 150 155 160
Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe
165 170 175
Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn
180 185 190
Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala
195 200 205
Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Leu
210 215 220
Asp Ala Asp Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Met
225 230 235 240
Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn Ala Leu Pro Gly
245 250 255
Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu Met Gly Ile Glu
260 265 270
Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr Glu Ala Asp Glu
275 280 285
Leu Ile Ala Val Thr Thr Ala Gly Gly Ile Thr Pro Ile Thr Ser Leu
290 295 300
Asp Gly Glu Pro Leu Gly Asp Gly Thr Pro Gly Pro Val Thr Val Ala
305 310 315 320
Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Pro Ser Ser Leu Val
325 330 335
Glu Ala Ile Glu Tyr
340
<210> 6
<211> 341
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 6
Met Thr Ile Ser Lys Asp Ile Asp Tyr Ser Thr Ser Asn Leu Val Ser
1 5 10 15
Val Ala Pro Gly Ala Ile Arg Glu Pro Thr Pro Ala Gly Ser Val Ile
20 25 30
Gln Tyr Ser Asp Tyr Glu Leu Asp Glu Ser Ser Pro Phe Ala Gly Gly
35 40 45
Ala Ala Trp Ile Glu Gly Glu Tyr Val Pro Ala Ala Glu Ala Arg Ile
50 55 60
Ser Leu Phe Asp Thr Gly Phe Gly His Ser Asp Ala Thr Tyr Thr Val
65 70 75 80
Ala His Val Trp His Gly Asn Ile Phe Arg Leu Lys Asp His Ile Asp
85 90 95
Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Leu Gln Ser Pro Leu Thr
100 105 110
Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val Ala Leu Ser Gln
115 120 125
Leu Arg Glu Ser Phe Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Ala
130 135 140
Arg Lys Gly Glu Lys Asp Leu Ser Lys Leu Thr Ser Gln Ile Tyr Ile
145 150 155 160
Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe
165 170 175
Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn
180 185 190
Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala
195 200 205
Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Leu
210 215 220
Asp Gly Asp Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Met
225 230 235 240
Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn Ala Leu Pro Gly
245 250 255
Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu Met Gly Ile Glu
260 265 270
Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr Glu Ala Asp Glu
275 280 285
Leu Ile Ala Val Thr Thr Gly Gly Gly Ile Thr Pro Ile Thr Ser Leu
290 295 300
Asp Gly Glu Pro Leu Gly Asp Gly Thr Pro Gly Pro Val Thr Val Ala
305 310 315 320
Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Pro Ser Ser Leu Val
325 330 335
Glu Ala Ile Glu Tyr
340
<210> 7
<211> 341
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 7
Met Thr Ile Ser Lys Asp Ile Asp Tyr Ser Thr Ser Asn Leu Val Ser
1 5 10 15
Val Ala Pro Gly Ala Ile Arg Glu Pro Thr Pro Ala Gly Ser Val Ile
20 25 30
Gln Tyr Ser Asp Tyr Glu Leu Asp Glu Ser Ser Pro Phe Ala Gly Gly
35 40 45
Ala Ala Trp Ile Glu Gly Glu Tyr Val Pro Ala Ala Glu Ala Arg Ile
50 55 60
Ser Leu Phe Asp Thr Gly Phe Gly His Ser Asp Ala Thr Tyr Thr Val
65 70 75 80
Ala His Val Trp His Gly Asn Ile Phe Arg Leu Lys Asp His Ile Asp
85 90 95
Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Leu Gln Ser Pro Leu Thr
100 105 110
Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val Ala Leu Ser Gln
115 120 125
Leu Arg Glu Ala Phe Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Ala
130 135 140
Arg Lys Gly Glu Lys Asp Leu Ser Lys Leu Thr Ser Gln Ile Tyr Ile
145 150 155 160
Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe
165 170 175
Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn
180 185 190
Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala
195 200 205
Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Leu
210 215 220
Asp Gly Asp Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Met
225 230 235 240
Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn Ala Leu Pro Gly
245 250 255
Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu Met Gly Ile Glu
260 265 270
Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr Glu Ala Asp Glu
275 280 285
Leu Ile Ala Val Thr Thr Gly Gly Gly Ile Thr Pro Ile Thr Ser Leu
290 295 300
Asp Gly Glu Pro Leu Gly Asp Gly Thr Pro Gly Pro Val Thr Val Ala
305 310 315 320
Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Pro Ser Ser Leu Val
325 330 335
Glu Ala Ile Glu Tyr
340
<210> 8
<211> 341
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 8
Met Thr Ile Ser Lys Asp Ile Asp Tyr Ser Thr Ser Asn Leu Val Ser
1 5 10 15
Val Ala Pro Gly Ala Ile Arg Glu Pro Thr Pro Ala Gly Ser Val Ile
20 25 30
Gln Tyr Ser Asp Tyr Glu Leu Asp Glu Ser Ser Pro Phe Ala Gly Gly
35 40 45
Ala Ala Trp Ile Glu Gly Glu Tyr Val Pro Ala Ala Glu Ala Arg Ile
50 55 60
Ser Leu Phe Asp Thr Gly Phe Gly His Ser Asp Ala Thr Tyr Thr Val
65 70 75 80
Ala His Val Trp His Gly Asn Ile Phe Arg Leu Lys Asp His Ile Asp
85 90 95
Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Leu Gln Ser Pro Leu Thr
100 105 110
Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val Ala Leu Ser Gln
115 120 125
Leu Arg Glu Ala Phe Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Ala
130 135 140
Arg Lys Gly Glu Lys Asp Leu Ser Lys Leu Thr Ser Gln Ile Tyr Ile
145 150 155 160
Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe
165 170 175
Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn
180 185 190
Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala
195 200 205
Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Leu
210 215 220
Asp Gly Asp Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Met
225 230 235 240
Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn Ala Leu Pro Gly
245 250 255
Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu Met Gly Ile Glu
260 265 270
Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr Glu Ala Asp Glu
275 280 285
Leu Ile Ala Val Thr Thr Gly Gly Gly Ile Thr Pro Ile Thr Ser Leu
290 295 300
Asp Gly Glu Pro Leu Gly Asp Gly Thr Pro Gly Pro Val Thr Val Ala
305 310 315 320
Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Pro Ser Ser Leu Val
325 330 335
Glu Ala Ile Glu Tyr
340
<210> 9
<211> 341
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 9
Met Thr Ile Ser Lys Asp Ile Asp Tyr Ser Thr Ser Asn Leu Val Ser
1 5 10 15
Val Ala Pro Gly Ala Ile Arg Glu Pro Thr Pro Ala Gly Ser Val Ile
20 25 30
Gln Tyr Ser Asp Tyr Glu Leu Asp Glu Ser Ser Pro Phe Ala Gly Gly
35 40 45
Ala Ala Trp Ile Glu Gly Glu Tyr Val Pro Ala Ala Glu Ala Arg Ile
50 55 60
Ser Leu Phe Asp Thr Gly Phe Leu His Ser Asp Leu Thr Tyr Thr Val
65 70 75 80
Ala His Val Trp His Gly Asn Ile Phe Arg Leu Lys Asp His Ile Asp
85 90 95
Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Leu Gln Ser Pro Leu Thr
100 105 110
Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val Ser Leu Ser Gln
115 120 125
Leu Arg Glu Ser Phe Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Ala
130 135 140
Arg Lys Gly Glu Lys Asp Leu Ser Lys Leu Thr Ser Gln Ile Tyr Ile
145 150 155 160
Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe
165 170 175
Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn
180 185 190
Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala
195 200 205
Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Leu
210 215 220
Asp Ala Asp Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Met
225 230 235 240
Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn Ala Leu Pro Gly
245 250 255
Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu Met Gly Ile Glu
260 265 270
Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr Glu Ala Asp Glu
275 280 285
Leu Ile Ala Val Thr Thr Gly Gly Gly Ile Thr Pro Ile Thr Ser Leu
290 295 300
Asp Gly Glu Pro Leu Gly Asp Gly Thr Pro Gly Pro Val Thr Val Ala
305 310 315 320
Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Pro Ser Ser Leu Val
325 330 335
Glu Ala Ile Glu Tyr
340
<210> 10
<211> 341
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 10
Met Thr Ile Ser Lys Asp Ile Asp Tyr Ser Thr Ser Asn Leu Val Ser
1 5 10 15
Val Ala Pro Gly Ala Ile Arg Glu Pro Thr Pro Ala Gly Ser Val Ile
20 25 30
Gln Tyr Ser Asp Tyr Glu Leu Asp Glu Ser Ser Pro Phe Ala Gly Gly
35 40 45
Ala Ala Trp Ile Glu Gly Glu Tyr Val Pro Ala Ala Glu Ala Arg Ile
50 55 60
Ser Leu Phe Asp Thr Gly Phe Leu His Ser Asp Leu Thr Tyr Thr Val
65 70 75 80
Ala His Val Trp His Gly Asn Ile Phe Arg Leu Lys Asp His Ile Asp
85 90 95
Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Leu Gln Ser Pro Leu Thr
100 105 110
Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val Ser Leu Ser Gln
115 120 125
Leu Arg Glu Ala Phe Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Ala
130 135 140
Arg Lys Gly Glu Lys Asp Leu Ser Lys Leu Thr Ser Gln Ile Tyr Ile
145 150 155 160
Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe
165 170 175
Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn
180 185 190
Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala
195 200 205
Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Leu
210 215 220
Asp Ala Asp Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Met
225 230 235 240
Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn Ala Leu Pro Gly
245 250 255
Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu Met Gly Ile Glu
260 265 270
Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr Glu Ala Asp Glu
275 280 285
Leu Ile Ala Val Thr Thr Gly Gly Gly Ile Thr Pro Ile Thr Ser Leu
290 295 300
Asp Gly Glu Pro Leu Gly Asp Gly Thr Pro Gly Pro Val Thr Val Ala
305 310 315 320
Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Pro Ser Ser Leu Val
325 330 335
Glu Ala Ile Glu Tyr
340
<210> 11
<211> 341
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 11
Met Thr Ile Ser Lys Asp Ile Asp Tyr Ser Thr Ser Asn Leu Val Ser
1 5 10 15
Val Ala Pro Gly Ala Ile Arg Glu Pro Thr Pro Ala Gly Ser Val Ile
20 25 30
Gln Tyr Ser Asp Tyr Glu Leu Asp Glu Ser Ser Pro Phe Ala Gly Gly
35 40 45
Ala Ala Trp Ile Glu Gly Glu Tyr Val Pro Ala Ala Glu Ala Arg Ile
50 55 60
Ser Leu Phe Asp Thr Gly Phe Leu His Ser Asp Leu Thr Tyr Thr Val
65 70 75 80
Ala His Val Trp His Gly Asn Ile Phe Arg Leu Lys Asp His Ile Asp
85 90 95
Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Leu Gln Ser Pro Leu Thr
100 105 110
Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val Ser Leu Ser Gln
115 120 125
Leu Arg Glu Ser Phe Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Ala
130 135 140
Arg Lys Gly Glu Lys Asp Leu Ser Lys Leu Thr Ser Gln Ile Tyr Ile
145 150 155 160
Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe
165 170 175
Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn
180 185 190
Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala
195 200 205
Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Leu
210 215 220
Asp Ala Asp Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Met
225 230 235 240
Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn Ala Leu Pro Gly
245 250 255
Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu Met Gly Ile Glu
260 265 270
Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr Glu Ala Asp Glu
275 280 285
Leu Ile Ala Cys Thr Thr Gly Gly Gly Ile Thr Pro Ile Thr Ser Leu
290 295 300
Asp Gly Glu Pro Leu Gly Asp Gly Thr Pro Gly Pro Val Thr Val Ala
305 310 315 320
Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Pro Ser Ser Leu Val
325 330 335
Glu Ala Ile Glu Tyr
340
<210> 12
<211> 341
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 12
Met Thr Ile Ser Lys Asp Ile Asp Tyr Ser Thr Ser Asn Leu Val Ser
1 5 10 15
Val Ala Pro Gly Ala Ile Arg Glu Pro Thr Pro Ala Gly Ser Val Ile
20 25 30
Gln Tyr Ser Asp Tyr Glu Leu Asp Glu Ser Ser Pro Phe Ala Gly Gly
35 40 45
Ala Ala Trp Ile Glu Gly Glu Tyr Val Pro Ala Ala Glu Ala Arg Ile
50 55 60
Ser Leu Phe Asp Thr Gly Phe Leu His Ser Asp Ala Thr Tyr Thr Val
65 70 75 80
Ala His Val Trp His Gly Asn Ile Phe Arg Leu Lys Asp His Ile Asp
85 90 95
Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Leu Gln Ser Pro Leu Thr
100 105 110
Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val Ser Leu Ser Gln
115 120 125
Leu Arg Glu Ser Phe Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Ala
130 135 140
Arg Lys Gly Glu Lys Asp Leu Ser Lys Leu Thr Ser Gln Ile Tyr Ile
145 150 155 160
Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe
165 170 175
Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn
180 185 190
Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala
195 200 205
Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Leu
210 215 220
Asp Ala Asp Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Met
225 230 235 240
Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn Ala Leu Pro Gly
245 250 255
Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu Met Gly Ile Glu
260 265 270
Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr Glu Ala Asp Glu
275 280 285
Leu Ile Ala Cys Thr Thr Gly Gly Gly Ile Thr Pro Ile Thr Ser Leu
290 295 300
Asp Gly Glu Pro Leu Gly Asp Gly Thr Pro Gly Pro Val Thr Val Ala
305 310 315 320
Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Pro Ser Ser Leu Val
325 330 335
Glu Ala Ile Glu Tyr
340
<210> 13
<211> 341
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 13
Met Thr Ile Ser Lys Asp Ile Asp Tyr Ser Thr Ser Asn Leu Val Ser
1 5 10 15
Val Ala Pro Gly Ala Ile Arg Glu Pro Thr Pro Ala Gly Ser Val Ile
20 25 30
Gln Tyr Ser Asp Tyr Glu Leu Asp Glu Ser Ser Pro Phe Ala Gly Gly
35 40 45
Ala Ala Trp Ile Glu Gly Glu Tyr Val Pro Ala Ala Glu Ala Arg Ile
50 55 60
Ser Leu Phe Asp Thr Gly Phe Leu His Ser Asp Leu Thr Tyr Thr Val
65 70 75 80
Ala His Val Trp His Gly Asn Ile Phe Arg Leu Lys Asp His Ile Asp
85 90 95
Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Leu Gln Ser Pro Leu Thr
100 105 110
Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val Ser Leu Ser Gln
115 120 125
Leu Arg Glu Ser Phe Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Ala
130 135 140
Arg Lys Gly Glu Lys Asp Leu Ser Lys Leu Thr Ser Gln Ile Tyr Ile
145 150 155 160
Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe
165 170 175
Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn
180 185 190
Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala
195 200 205
Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Leu
210 215 220
Asp Ala Asp Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Met
225 230 235 240
Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn Ala Leu Pro Gly
245 250 255
Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu Met Gly Ile Glu
260 265 270
Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr Glu Ala Asp Glu
275 280 285
Leu Ile Ala Val Thr Thr Ala Gly Gly Ile Thr Pro Ile Thr Ser Leu
290 295 300
Asp Gly Glu Pro Leu Gly Asp Gly Thr Pro Gly Pro Val Thr Val Ala
305 310 315 320
Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Pro Ser Ser Leu Val
325 330 335
Glu Ala Ile Glu Tyr
340
<210> 14
<211> 341
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 14
Met Thr Ile Ser Lys Asp Ile Asp Tyr Ser Thr Ser Asn Leu Val Ser
1 5 10 15
Val Ala Pro Gly Ala Ile Arg Glu Pro Thr Pro Ala Gly Ser Val Ile
20 25 30
Gln Tyr Ser Asp Tyr Glu Leu Asp Glu Ser Ser Pro Phe Ala Gly Gly
35 40 45
Ala Ala Trp Ile Glu Gly Glu Tyr Val Pro Ala Ala Glu Ala Arg Ile
50 55 60
Ser Leu Phe Asp Thr Gly Phe Gly His Ser Asp Ala Thr Tyr Thr Val
65 70 75 80
Ala His Val Trp His Gly Asn Ile Phe Arg Leu Lys Asp His Ile Asp
85 90 95
Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Leu Gln Ser Pro Leu Thr
100 105 110
Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val Ser Leu Ser Gln
115 120 125
Leu Arg Glu Ser Phe Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Ala
130 135 140
Arg Lys Gly Glu Lys Asp Leu Ser Lys Leu Thr Ser Gln Ile Tyr Ile
145 150 155 160
Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe
165 170 175
Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn
180 185 190
Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala
195 200 205
Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Leu
210 215 220
Asp Ala Asp Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Met
225 230 235 240
Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn Ala Leu Pro Gly
245 250 255
Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu Met Gly Ile Glu
260 265 270
Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr Glu Ala Asp Glu
275 280 285
Leu Ile Ala Val Thr Thr Ala Gly Gly Ile Thr Pro Ile Thr Ser Leu
290 295 300
Asp Gly Glu Pro Leu Gly Asp Gly Thr Pro Gly Pro Val Thr Val Ala
305 310 315 320
Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Pro Ser Ser Leu Val
325 330 335
Glu Ala Ile Glu Tyr
340
<210> 15
<211> 341
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 15
Met Thr Ile Ser Lys Asp Ile Asp Tyr Ser Thr Ser Asn Leu Val Ser
1 5 10 15
Val Ala Pro Gly Ala Ile Arg Glu Pro Thr Pro Ala Gly Ser Val Ile
20 25 30
Gln Tyr Ser Asp Tyr Glu Leu Asp Glu Ser Ser Pro Phe Ala Gly Gly
35 40 45
Ala Ala Trp Ile Glu Gly Glu Tyr Val Pro Ala Ala Glu Ala Arg Ile
50 55 60
Ser Leu Phe Asp Thr Gly Phe Gly His Ser Asp Leu Thr Tyr Thr Val
65 70 75 80
Ala His Val Trp His Gly Asn Ile Phe Arg Leu Lys Asp His Ile Asp
85 90 95
Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Ile Gln Ser Pro Leu Thr
100 105 110
Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val Ser Leu Ser Gln
115 120 125
Leu Arg Glu Ser Phe Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Ala
130 135 140
Arg Lys Gly Glu Lys Asp Leu Ser Lys Leu Thr Ser Gln Ile Tyr Ile
145 150 155 160
Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe
165 170 175
Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn
180 185 190
Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala
195 200 205
Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Leu
210 215 220
Asp Ala Asp Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Met
225 230 235 240
Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn Ala Leu Pro Gly
245 250 255
Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu Met Gly Ile Glu
260 265 270
Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr Glu Ala Asp Glu
275 280 285
Leu Ile Ala Val Thr Thr Ala Gly Gly Ile Thr Pro Ile Thr Ser Leu
290 295 300
Asp Gly Glu Pro Leu Gly Asp Gly Thr Pro Gly Pro Val Thr Val Ala
305 310 315 320
Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Pro Ser Ser Leu Val
325 330 335
Glu Ala Ile Glu Tyr
340
<210> 16
<211> 341
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 16
Met Thr Ile Ser Lys Asp Ile Asp Tyr Ser Thr Ser Asn Leu Val Ser
1 5 10 15
Val Ala Pro Gly Ala Ile Arg Glu Pro Thr Pro Ala Gly Ser Val Ile
20 25 30
Gln Tyr Ser Asp Tyr Glu Leu Asp Glu Ser Ser Pro Phe Ala Gly Gly
35 40 45
Ala Ala Trp Ile Glu Gly Glu Tyr Val Pro Ala Ala Glu Ala Arg Ile
50 55 60
Ser Leu Phe Asp Thr Gly Phe Gly His Ser Asp Leu Thr Tyr Thr Val
65 70 75 80
Ala His Val Trp His Gly Asn Ile Phe Arg Leu Gly Asp His Ile Asp
85 90 95
Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Leu Gln Ser Pro Leu Thr
100 105 110
Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val Ser Leu Ser Gln
115 120 125
Leu Arg Glu Ser Phe Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Ala
130 135 140
Arg Lys Gly Glu Lys Asp Leu Ser Lys Leu Thr Ser Gln Ile Tyr Ile
145 150 155 160
Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe
165 170 175
Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn
180 185 190
Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala
195 200 205
Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Leu
210 215 220
Asp Ala Asp Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Met
225 230 235 240
Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn Ala Leu Pro Gly
245 250 255
Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu Met Gly Ile Glu
260 265 270
Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr Glu Ala Asp Glu
275 280 285
Leu Ile Ala Val Thr Thr Ala Gly Gly Ile Thr Pro Ile Thr Ser Leu
290 295 300
Asp Gly Glu Pro Leu Gly Asp Gly Thr Pro Gly Pro Val Thr Val Ala
305 310 315 320
Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Pro Ser Ser Leu Val
325 330 335
Glu Ala Ile Glu Tyr
340
<210> 17
<211> 341
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 17
Met Thr Ile Ser Lys Asp Ile Asp Tyr Ser Thr Ser Asn Leu Val Ser
1 5 10 15
Val Ala Pro Gly Ala Ile Arg Glu Pro Thr Pro Ala Gly Ser Val Ile
20 25 30
Gln Tyr Ser Asp Tyr Glu Leu Asp Glu Ser Ser Pro Phe Ala Gly Gly
35 40 45
Ala Ala Trp Ile Glu Gly Glu Tyr Val Pro Ala Ala Glu Ala Arg Ile
50 55 60
Ser Leu Phe Asp Thr Gly Phe Gly His Ser Asp Leu Thr Tyr Thr Val
65 70 75 80
Ala His Val Trp His Gly Asn Ile Phe Arg Leu Lys Asp His Ile Asp
85 90 95
Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Leu Gln Ser Pro Leu Thr
100 105 110
Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val Ala Leu Ser Gln
115 120 125
Leu Arg Glu Ser Phe Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Ala
130 135 140
Arg Lys Gly Glu Lys Asp Leu Ser Lys Leu Thr Ser Gln Ile Tyr Ile
145 150 155 160
Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe
165 170 175
Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn
180 185 190
Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala
195 200 205
Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Leu
210 215 220
Asp Ala Asp Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Met
225 230 235 240
Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn Ala Leu Pro Gly
245 250 255
Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu Met Gly Ile Glu
260 265 270
Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr Glu Ala Asp Glu
275 280 285
Leu Ile Ala Val Thr Thr Ala Gly Gly Ile Thr Pro Ile Thr Ser Leu
290 295 300
Asp Gly Glu Pro Leu Gly Asp Gly Thr Pro Gly Pro Val Thr Val Ala
305 310 315 320
Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Pro Ser Ser Leu Val
325 330 335
Glu Ala Ile Glu Tyr
340
<210> 18
<211> 341
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 18
Met Thr Ile Ser Lys Asp Ile Asp Tyr Ser Thr Ser Asn Leu Val Ser
1 5 10 15
Val Ala Pro Gly Ala Ile Arg Glu Pro Thr Pro Ala Gly Ser Val Ile
20 25 30
Gln Tyr Ser Asp Tyr Glu Leu Asp Glu Ser Ser Pro Phe Ala Gly Gly
35 40 45
Ala Ala Trp Ile Glu Gly Glu Tyr Val Pro Ala Ala Glu Ala Arg Ile
50 55 60
Ser Leu Phe Asp Thr Gly Phe Gly His Ser Asp Leu Thr Tyr Thr Val
65 70 75 80
Ala His Val Trp His Gly Asn Ile Phe Arg Leu Lys Asp His Ile Asp
85 90 95
Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Leu Gln Ser Pro Leu Thr
100 105 110
Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val Ser Leu Ser Gln
115 120 125
Leu Arg Glu Ala Phe Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Ala
130 135 140
Arg Lys Gly Glu Lys Asp Leu Ser Lys Leu Thr Ser Gln Ile Tyr Ile
145 150 155 160
Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe
165 170 175
Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn
180 185 190
Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala
195 200 205
Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Leu
210 215 220
Asp Ala Asp Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Met
225 230 235 240
Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn Ala Leu Pro Gly
245 250 255
Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu Met Gly Ile Glu
260 265 270
Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr Glu Ala Asp Glu
275 280 285
Leu Ile Ala Val Thr Thr Ala Gly Gly Ile Thr Pro Ile Thr Ser Leu
290 295 300
Asp Gly Glu Pro Leu Gly Asp Gly Thr Pro Gly Pro Val Thr Val Ala
305 310 315 320
Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Pro Ser Ser Leu Val
325 330 335
Glu Ala Ile Glu Tyr
340
<210> 19
<211> 341
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 19
Met Thr Ile Ser Lys Asp Ile Asp Tyr Ser Thr Ser Asn Leu Val Ser
1 5 10 15
Val Ala Pro Gly Ala Ile Arg Glu Pro Thr Pro Ala Gly Ser Val Ile
20 25 30
Gln Tyr Ser Asp Tyr Glu Leu Asp Glu Ser Ser Pro Phe Ala Gly Gly
35 40 45
Ala Ala Trp Ile Glu Gly Glu Tyr Val Pro Ala Ala Glu Ala Arg Ile
50 55 60
Ser Leu Phe Asp Thr Gly Phe Gly His Ser Asp Leu Thr Tyr Thr Val
65 70 75 80
Ala His Val Trp His Gly Asn Ile Phe Arg Leu Lys Asp His Ile Asp
85 90 95
Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Leu Gln Ser Pro Leu Thr
100 105 110
Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val Ser Leu Ser Gln
115 120 125
Leu Arg Glu Ser Phe Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Ala
130 135 140
Arg Lys Gly Glu Lys Asp Leu Ser Lys Leu Thr Ser Gln Ile Tyr Ile
145 150 155 160
Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe
165 170 175
Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn
180 185 190
Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala
195 200 205
Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Leu
210 215 220
Asp Gly Asp Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Met
225 230 235 240
Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn Ala Leu Pro Gly
245 250 255
Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu Met Gly Ile Glu
260 265 270
Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr Glu Ala Asp Glu
275 280 285
Leu Ile Ala Val Thr Thr Ala Gly Gly Ile Thr Pro Ile Thr Ser Leu
290 295 300
Asp Gly Glu Pro Leu Gly Asp Gly Thr Pro Gly Pro Val Thr Val Ala
305 310 315 320
Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Pro Ser Ser Leu Val
325 330 335
Glu Ala Ile Glu Tyr
340
<210> 20
<211> 341
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 20
Met Thr Ile Ser Lys Asp Ile Asp Tyr Ser Thr Ser Asn Leu Val Ser
1 5 10 15
Val Ala Pro Gly Ala Ile Arg Glu Pro Thr Pro Ala Gly Ser Val Ile
20 25 30
Gln Tyr Ser Asp Tyr Glu Leu Asp Glu Ser Ser Pro Phe Ala Gly Gly
35 40 45
Ala Ala Trp Ile Glu Gly Glu Tyr Val Pro Ala Ala Glu Ala Arg Ile
50 55 60
Ser Leu Phe Asp Thr Gly Phe Gly His Ser Asp Leu Thr Tyr Thr Val
65 70 75 80
Ala His Val Trp His Gly Asn Ile Phe Arg Leu Lys Asp His Ile Asp
85 90 95
Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Leu Gln Ser Pro Leu Thr
100 105 110
Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val Ser Leu Ser Gln
115 120 125
Leu Arg Glu Ser Phe Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Ala
130 135 140
Arg Lys Gly Glu Lys Asp Leu Ser Lys Leu Thr Ser Gln Ile Tyr Ile
145 150 155 160
Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe
165 170 175
Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn
180 185 190
Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala
195 200 205
Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Leu
210 215 220
Asp Ala Asp Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Met
225 230 235 240
Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn Ala Leu Pro Gly
245 250 255
Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu Met Gly Ile Glu
260 265 270
Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr Glu Ala Asp Glu
275 280 285
Leu Ile Ala Cys Thr Thr Ala Gly Gly Ile Thr Pro Ile Thr Ser Leu
290 295 300
Asp Gly Glu Pro Leu Gly Asp Gly Thr Pro Gly Pro Val Thr Val Ala
305 310 315 320
Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Pro Ser Ser Leu Val
325 330 335
Glu Ala Ile Glu Tyr
340
<210> 21
<211> 341
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 21
Met Thr Ile Ser Lys Asp Ile Asp Tyr Ser Thr Ser Asn Leu Val Ser
1 5 10 15
Val Ala Pro Gly Ala Ile Arg Glu Pro Thr Pro Ala Gly Ser Val Ile
20 25 30
Gln Tyr Ser Asp Tyr Glu Leu Asp Glu Ser Ser Pro Phe Ala Gly Gly
35 40 45
Ala Ala Trp Ile Glu Gly Glu Tyr Val Pro Ala Ala Glu Ala Arg Ile
50 55 60
Ser Leu Phe Asp Thr Gly Phe Gly His Ser Asp Leu Thr Tyr Thr Val
65 70 75 80
Ala His Val Trp His Gly Asn Ile Phe Arg Leu Lys Asp His Ile Asp
85 90 95
Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Leu Gln Ser Pro Leu Thr
100 105 110
Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val Ser Leu Ser Gln
115 120 125
Leu Arg Glu Ser Phe Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Ala
130 135 140
Arg Lys Gly Glu Lys Asp Leu Ser Lys Leu Thr Ser Gln Ile Tyr Ile
145 150 155 160
Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe
165 170 175
Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn
180 185 190
Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala
195 200 205
Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Leu
210 215 220
Asp Ala Asp Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Met
225 230 235 240
Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn Ala Leu Pro Gly
245 250 255
Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu Met Gly Ile Glu
260 265 270
Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr Glu Ala Asp Glu
275 280 285
Leu Ile Ala Val Thr Thr Gly Gly Gly Ile Thr Pro Ile Thr Ser Leu
290 295 300
Asp Gly Glu Pro Leu Gly Asp Gly Thr Pro Gly Pro Val Thr Val Ala
305 310 315 320
Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Pro Ser Ser Leu Val
325 330 335
Glu Ala Ile Glu Tyr
340
<210> 22
<211> 341
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 22
Met Thr Ile Ser Lys Asp Ile Asp Tyr Ser Thr Ser Asn Leu Val Ser
1 5 10 15
Val Ala Ser Gly Ala Ile Arg Glu Pro Thr Pro Ala Gly Ser Val Ile
20 25 30
Gln Tyr Ser Asp Tyr Glu Leu Asp Glu Ser Ser Pro Phe Ala Gly Gly
35 40 45
Ala Ala Trp Ile Glu Gly Glu Tyr Val Pro Ala Ala Glu Ala Arg Ile
50 55 60
Ser Leu Phe Asp Thr Gly Phe Gly His Ser Asp Leu Thr Tyr Thr Val
65 70 75 80
Ala His Val Trp His Gly Asn Ile Phe Arg Leu Lys Asp His Ile Asp
85 90 95
Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Leu Gln Ser Pro Leu Thr
100 105 110
Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val Ser Leu Ser Gln
115 120 125
Leu Arg Glu Ser Phe Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Ala
130 135 140
Arg Lys Gly Glu Lys Asp Leu Ser Lys Leu Thr Ser Gln Ile Tyr Ile
145 150 155 160
Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe
165 170 175
Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn
180 185 190
Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala
195 200 205
Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Leu
210 215 220
Asp Ala Asp Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Met
225 230 235 240
Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn Ala Leu Pro Gly
245 250 255
Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu Met Gly Ile Glu
260 265 270
Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr Glu Ala Asp Glu
275 280 285
Leu Ile Ala Val Thr Thr Ala Gly Gly Ile Thr Pro Ile Thr Ser Leu
290 295 300
Asp Gly Glu Pro Leu Gly Asp Gly Thr Pro Gly Pro Val Thr Val Ala
305 310 315 320
Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Pro Ser Ser Leu Val
325 330 335
Glu Ala Ile Glu Tyr
340
<210> 23
<211> 341
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 23
Met Thr Ile Ser Lys Asp Ile Asp Tyr Ser Thr Ser Asn Leu Val Ser
1 5 10 15
Val Ala Pro Gly Ala Ile Arg Glu Pro Thr Pro Ala Gly Ser Val Ile
20 25 30
Gln Tyr Ser Asp Tyr Glu Leu Asp Ser Ser Ser Pro Phe Ala Gly Gly
35 40 45
Ala Ala Trp Ile Glu Gly Glu Tyr Val Pro Ala Ala Glu Ala Arg Ile
50 55 60
Ser Leu Phe Asp Thr Gly Phe Gly His Ser Asp Leu Thr Tyr Thr Val
65 70 75 80
Ala His Val Trp His Gly Asn Ile Phe Arg Leu Lys Asp His Ile Asp
85 90 95
Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Leu Gln Ser Pro Leu Thr
100 105 110
Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val Ser Leu Ser Gln
115 120 125
Leu Arg Glu Ser Phe Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Ala
130 135 140
Arg Lys Gly Glu Lys Asp Leu Ser Lys Leu Thr Ser Gln Ile Tyr Ile
145 150 155 160
Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe
165 170 175
Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn
180 185 190
Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala
195 200 205
Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Leu
210 215 220
Asp Ala Asp Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Met
225 230 235 240
Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn Ala Leu Pro Gly
245 250 255
Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu Met Gly Ile Glu
260 265 270
Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr Glu Ala Asp Glu
275 280 285
Leu Ile Ala Val Thr Thr Ala Gly Gly Ile Thr Pro Ile Thr Ser Leu
290 295 300
Asp Gly Glu Pro Leu Gly Asp Gly Thr Pro Gly Pro Val Thr Val Ala
305 310 315 320
Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Pro Ser Ser Leu Val
325 330 335
Glu Ala Ile Glu Tyr
340
<210> 24
<211> 281
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 24
Glu Ala Arg Ile Ser Leu Phe Asp Thr Gly Phe Gly His Ser Asp Leu
1 5 10 15
Thr Tyr Thr Val Ala His Val Trp His Gly Asn Ile Phe Arg Leu Lys
20 25 30
Asp His Ile Asp Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Leu Gln
35 40 45
Ser Pro Leu Thr Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val
50 55 60
Ser Leu Ser Gln Leu Arg Glu Ser Phe Val Asn Ile Thr Ile Thr Arg
65 70 75 80
Gly Tyr Gly Ala Arg Lys Gly Glu Lys Asp Leu Ser Lys Leu Thr Ser
85 90 95
Gln Ile Tyr Ile Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu
100 105 110
Glu Gln Ile Phe Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg
115 120 125
Ala Gly Arg Asn Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly
130 135 140
Asp Leu Thr Ala Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr
145 150 155 160
Ala Ile Leu Leu Asp Ala Asp Asn Cys Val Ala Glu Gly Pro Gly Phe
165 170 175
Asn Val Val Met Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn
180 185 190
Ala Leu Pro Gly Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu
195 200 205
Met Gly Ile Glu Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr
210 215 220
Glu Ala Asp Glu Leu Ile Ala Val Thr Thr Ala Gly Gly Ile Thr Pro
225 230 235 240
Ile Thr Ser Leu Asp Gly Glu Pro Leu Gly Asp Gly Thr Pro Gly Pro
245 250 255
Val Thr Val Ala Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Pro
260 265 270
Ser Ser Leu Val Glu Ala Ile Glu Tyr
275 280
<210> 25
<211> 341
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 25
Met Thr Ile Ser Lys Asp Ile Asp Tyr Ser Thr Ser Asn Leu Val Ser
1 5 10 15
Val Ala Pro Gly Ala Ile Arg Glu Pro Thr Pro Ala Gly Ser Val Ile
20 25 30
Gln Tyr Ser Asp Tyr Glu Leu Asp Glu Ser Ser Pro Phe Ala Gly Gly
35 40 45
Ala Ala Trp Ile Glu Gly Glu Tyr Val Pro Ala Ala Glu Ala Arg Ile
50 55 60
Ser Leu Phe Asp Thr Gly Phe Gly His Ser Asp Leu Thr Tyr Thr Val
65 70 75 80
Ala His Val Trp His Gly Asn Ile Phe Arg Leu Lys Asp His Ile Asp
85 90 95
Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Leu Gln Ser Pro Leu Thr
100 105 110
Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val Ser Leu Ser Gln
115 120 125
Leu Arg Glu Ser Phe Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Ala
130 135 140
Arg Lys Gly Glu Lys Asp Leu Ser Lys Leu Thr Ser Gln Ile Tyr Ile
145 150 155 160
Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe
165 170 175
Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn
180 185 190
Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala
195 200 205
Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Leu
210 215 220
Asp Ala Asp Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Met
225 230 235 240
Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn Ala Leu Pro Gly
245 250 255
Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu Met Gly Ile Glu
260 265 270
Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr Glu Ala Asp Glu
275 280 285
Leu Ile Ala Val Thr Thr Ala Gly Gly Ile Thr Pro Ile Thr Ser Leu
290 295 300
Asp Gly Glu Ser Leu Gly Asp Gly Thr Pro Gly Pro Val Thr Val Ala
305 310 315 320
Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Pro Ser Ser Leu Val
325 330 335
Glu Ala Ile Glu Tyr
340
<210> 26
<211> 341
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 26
Met Thr Ile Ser Lys Asp Ile Asp Tyr Ser Thr Ser Asn Leu Val Ser
1 5 10 15
Val Ala Pro Gly Ala Ile Arg Glu Pro Thr Pro Ala Gly Ser Val Ile
20 25 30
Gln Tyr Ser Asp Tyr Glu Leu Asp Glu Ser Ser Pro Phe Ala Gly Gly
35 40 45
Ala Ala Trp Ile Glu Gly Glu Tyr Val Pro Ala Ala Glu Ala Arg Ile
50 55 60
Ser Leu Phe Asp Thr Gly Phe Gly His Ser Asp Leu Thr Tyr Thr Val
65 70 75 80
Ala His Val Trp His Gly Asn Ile Phe Arg Leu Lys Asp His Ile Asp
85 90 95
Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Leu Gln Ser Pro Leu Thr
100 105 110
Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val Ser Leu Ser Gln
115 120 125
Leu Arg Glu Ser Phe Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Ala
130 135 140
Arg Lys Gly Glu Lys Asp Leu Ser Lys Leu Thr Ser Gln Ile Tyr Ile
145 150 155 160
Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe
165 170 175
Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn
180 185 190
Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala
195 200 205
Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Leu
210 215 220
Asp Ala Asp Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Met
225 230 235 240
Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn Ala Leu Pro Gly
245 250 255
Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu Met Gly Ile Glu
260 265 270
Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr Glu Ala Asp Glu
275 280 285
Leu Ile Ala Val Thr Thr Ala Gly Gly Ile Thr Pro Ile Thr Ser Leu
290 295 300
Asp Gly Glu Pro Leu Gly Asp Gly Thr Pro Gly Pro Val Thr Val Ala
305 310 315 320
Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Ser Ser Ser Leu Val
325 330 335
Glu Ala Ile Glu Tyr
340
<210> 27
<211> 341
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 27
Met Thr Ile Ser Lys Asp Ile Asp Tyr Ser Thr Ser Asn Leu Val Ser
1 5 10 15
Val Ala Pro Gly Ala Ile Arg Glu Pro Thr Pro Ala Gly Ser Val Ile
20 25 30
Gln Tyr Ser Asp Tyr Glu Leu Asp Glu Ser Ser Pro Phe Ala Gly Gly
35 40 45
Ala Ala Trp Ile Glu Gly Glu Tyr Val Pro Ala Ala Glu Ala Arg Ile
50 55 60
Ser Leu Phe Asp Thr Gly Phe Gly His Ser Asp Ala Thr Tyr Thr Val
65 70 75 80
Ala His Val Trp His Gly Asn Ile Phe Arg Leu Lys Asp His Ile Asp
85 90 95
Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Ile Gln Ser Gln Leu Thr
100 105 110
Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val Ser Leu Ser Gln
115 120 125
Leu Arg Glu Ser Phe Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Ala
130 135 140
Arg Lys Gly Glu Lys Asp Leu Ser Lys Leu Thr Ser Gln Ile Tyr Ile
145 150 155 160
Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe
165 170 175
Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn
180 185 190
Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala
195 200 205
Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Leu
210 215 220
Asp Ala Asp Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Met
225 230 235 240
Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn Ala Leu Pro Gly
245 250 255
Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu Met Gly Ile Glu
260 265 270
Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr Glu Ala Asp Glu
275 280 285
Leu Ile Ala Val Thr Thr Ala Gly Gly Ile Thr Pro Ile Thr Ser Leu
290 295 300
Asp Gly Glu Pro Leu Gly Asp Gly Thr Pro Gly Pro Val Thr Val Ala
305 310 315 320
Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Pro Ser Ser Leu Val
325 330 335
Glu Ala Ile Glu Tyr
340
<210> 28
<211> 341
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 28
Met Thr Ile Ser Lys Asp Ile Asp Tyr Ser Thr Ser Asn Leu Val Ser
1 5 10 15
Val Ala Pro Gly Ala Ile Arg Glu Pro Thr Pro Ala Gly Ser Val Ile
20 25 30
Gln Tyr Ser Asp Tyr Glu Leu Asp Glu Ser Ser Pro Phe Ala Gly Gly
35 40 45
Ala Ala Trp Ile Glu Gly Glu Tyr Val Pro Ala Ala Glu Ala Arg Ile
50 55 60
Ser Leu Phe Asp Thr Gly Phe Gly His Ser Asp Ala Thr Tyr Thr Val
65 70 75 80
Ala His Val Trp His Gly Asn Ile Phe Arg Leu Lys Asp His Ile Asp
85 90 95
Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Leu Gln Ser Pro Leu Thr
100 105 110
Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val Ala Leu Ser Gln
115 120 125
Leu Arg Glu Ser Phe Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Ala
130 135 140
Arg Lys Gly Glu Lys Asp Leu Ser Lys Leu Thr Ser Gln Ile Tyr Ile
145 150 155 160
Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe
165 170 175
Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn
180 185 190
Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala
195 200 205
Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Leu
210 215 220
Asp Gly Asp Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Met
225 230 235 240
Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn Ala Leu Pro Gly
245 250 255
Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu Met Gly Ile Glu
260 265 270
Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr Glu Ala Asp Glu
275 280 285
Leu Ile Ala Val Thr Thr Ala Gly Gly Ile Thr Pro Ile Thr Ser Leu
290 295 300
Asp Gly Glu Pro Leu Gly Asp Gly Thr Pro Gly Pro Val Thr Val Ala
305 310 315 320
Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Pro Ser Ser Leu Val
325 330 335
Glu Ala Ile Glu Tyr
340
<210> 29
<211> 341
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 29
Met Thr Ile Ser Lys Asp Ile Asp Tyr Ser Thr Ser Asn Leu Val Ser
1 5 10 15
Val Ala Pro Gly Ala Ile Arg Glu Pro Thr Pro Ala Gly Ser Val Ile
20 25 30
Gln Tyr Ser Asp Tyr Glu Leu Asp Glu Ser Ser Pro Phe Ala Gly Gly
35 40 45
Ala Ala Trp Ile Glu Gly Glu Tyr Val Pro Ala Ala Glu Ala Arg Ile
50 55 60
Ser Leu Phe Asp Thr Gly Phe Gly His Ser Asp Ala Thr Tyr Ser Val
65 70 75 80
Ala His Val Trp His Gly Asn Ile Phe Arg Leu Lys Asp His Ile Asp
85 90 95
Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Leu Gln Ser Pro Leu Thr
100 105 110
Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val Ser Leu Ser Gln
115 120 125
Leu Arg Glu Ser Phe Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Ala
130 135 140
Arg Lys Gly Glu Lys Asp Leu Ser Lys Leu Thr Ser Gln Ile Tyr Ile
145 150 155 160
Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe
165 170 175
Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn
180 185 190
Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala
195 200 205
Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Leu
210 215 220
Asp Ala Asp Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Met
225 230 235 240
Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn Ala Leu Pro Gly
245 250 255
Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu Met Gly Ile Glu
260 265 270
Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr Glu Ala Asp Glu
275 280 285
Leu Ile Ala Val Thr Thr Gly Gly Gly Ile Thr Pro Ile Thr Ser Leu
290 295 300
Asp Gly Glu Pro Leu Gly Asp Gly Thr Pro Gly Pro Val Thr Val Ala
305 310 315 320
Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Pro Ser Ser Leu Val
325 330 335
Glu Ala Ile Glu Tyr
340
<210> 30
<211> 341
<212> PRT
<213> 放线菌(Actinobacteria sp.)
<400> 30
Met Thr Ile Ser Lys Asp Ile Asp Tyr Ser Thr Ser Asn Leu Val Ser
1 5 10 15
Val Ala Pro Gly Ala Ile Arg Glu Pro Thr Pro Ala Gly Ser Val Ile
20 25 30
Gln Tyr Ser Asp Tyr Glu Leu Asp Glu Ser Ser Pro Phe Ala Gly Gly
35 40 45
Ala Ala Trp Ile Glu Gly Glu Tyr Val Pro Ala Ala Glu Ala Arg Ile
50 55 60
Ser Leu Phe Asp Thr Gly Phe Gly His Ser Asp Ala Thr Tyr Thr Val
65 70 75 80
Ala His Val Trp His Gly Asn Ile Phe Arg Leu Lys Asp His Ile Asp
85 90 95
Arg Val Phe Asp Gly Ala Gln Lys Leu Arg Ile Gln Ser Gln Leu Thr
100 105 110
Lys Ala Glu Val Glu Asp Ile Thr Lys Arg Cys Val Ser Leu Ser Gln
115 120 125
Leu Arg Glu Ser Phe Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Ala
130 135 140
Arg Lys Gly Glu Lys Gly Leu Ser Lys Leu Thr Ser Gln Ile Tyr Ile
145 150 155 160
Tyr Ala Ile Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe
165 170 175
Gly Thr Ser Ala Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn
180 185 190
Thr Val Asp Pro Thr Val Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala
195 200 205
Ala Ser Phe Glu Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Leu
210 215 220
Asp Ala Asp Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Met
225 230 235 240
Val Lys Asp Gly Lys Leu Ser Ser Pro Ser Arg Asn Ala Leu Pro Gly
245 250 255
Ile Thr Arg Leu Thr Val Met Glu Met Ala Asp Glu Met Gly Ile Glu
260 265 270
Phe Thr Leu Arg Asp Ile Thr Ser Arg Glu Leu Tyr Glu Ala Asp Glu
275 280 285
Leu Ile Ala Val Thr Thr Ala Gly Gly Ile Thr Pro Ile Thr Ser Leu
290 295 300
Asp Gly Glu Pro Leu Gly Asp Gly Thr Pro Gly Pro Val Thr Val Ala
305 310 315 320
Ile Arg Asp Arg Phe Trp Ala Met Met Asp Glu Pro Ser Ser Leu Val
325 330 335
Glu Ala Ile Glu Tyr
340
<210> 31
<211> 1026
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 31
atgaccatta gcaaagacat tgactatagc accagcaacc tggtgagtgt ggccccgggt 60
gcaatccgtg aacctacccc ggcaggcagc gtgatccagt acagtgacta cgagctggat 120
gaaagcagcc cgtttgccgg tggtgcagcc tggattgaag gtgagtatgt tccggcagca 180
gaggcccgta ttagcctgtt tgataccggc ttcggccata gcgatctgac ctacaccgtt 240
gcccatgttt ggcacggcaa catctttcgc ctgaaagacc acattgaccg cgtgtttgat 300
ggcgcccaga aactgcgtct gcagagcccg ctgaccaagg ccgaagtgga ggatattacc 360
aaacgctgcg tgagcctgag tcagctgcgc gagagcttcg tgaacatcac cattacccgc 420
ggttatggcg cccgcaaagg cgagaaagat ctgagcaaat taaccagcca gatctacatc 480
tacgccatcc cgtacctgtg ggcctttcct ccggaagagc agatcttcgg tacaagtgcc 540
attgtgccgc gtcatgttcg tcgcgcaggc cgtaataccg ttgatcctac cgttaagaac 600
taccagtggg gtgatctgac cgcagcttct tttgaagcaa aagatcgtgg cgcccgcacc 660
gcaatcctgc tggatgcaga caactgtgtg gccgagggtc cgggctttaa cgtggtgatg 720
gtgaaggatg gcaaactgag tagcccgagc cgtaatgccc tgccgggtat tacacgtctg 780
accgtgatgg agatggccga tgaaatgggc atcgaattca ccctgcgcga tatcaccagc 840
cgtgagttat atgaggccga cgaactgatc gccgtgacca ccgcaggtgg cattaccccg 900
attaccagtc tggatggcga accgctgggc gatggtaccc ctggtcctgt gacagtggcc 960
attcgcgatc gcttttgggc catgatggat gagccgagca gtctggtgga ggccattgaa 1020
tattaa 1026
<210> 32
<211> 1026
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 32
atgaccatta gcaaagacat tgactatagc accagcaacc tggtgagtgt ggccccgggt 60
gcaatccgtg aacctacccc ggcaggcagc gtgatccagt acagtgacta cgagctggat 120
gaaagcagcc cgtttgccgg tggtgcagcc tggattgaag gtgagtatgt tccggcagca 180
gaggcccgta ttagcctgtt tgataccggc ttcggccata gcgatgcgac ctacaccgtt 240
gcccatgttt ggcacggcaa catctttcgc ctgaaagacc acattgaccg cgtgtttgat 300
ggcgcccaga aactgcgtct gcagagcccg ctgaccaagg ccgaagtgga ggatattacc 360
aaacgctgcg tgagcctgag tcagctggcc gagagcttcg tgaacatcac cattacccgc 420
ggttatggcg cccgcaaagg cgagaaagat ctgagcaaat taaccagcca gatctacatc 480
tacgccatcc cgtacctgtg ggcctttcct ccggaagagc agatcttcgg tacaagtgcc 540
attgtgccgc gtcatgttcg tcgcgcaggc cgtaataccg ttgatcctac cgttaagaac 600
taccagtggg gtgatctgac cgcagcttct tttgaagcaa aagatcgtgg cgcccgcacc 660
gcaatcctgc tggatgcaga caactgtgtg gccgagggtc cgggctttaa cgtggtgatg 720
gtgaaggatg gcaaactgag tagcccgagc cgtaatgccc tgccgggtat tacacgtctg 780
accgtgatgg agatggccga tgaaatgggc atcgaattca ccctgcgcga tatcaccagc 840
cgtgagttat atgaggccga cgaactgatc gcctgcacca ccggaggtgg cattaccccg 900
attaccagtc tggatggcga accgctgggc gatggtaccc ctggtcctgt gacagtggcc 960
attcgcgatc gcttttgggc catgatggat gagccgagca gtctggtgga ggccattgaa 1020
tattaa 1026
<210> 33
<211> 1026
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 33
atgaccatta gcaaagacat tgactatagc accagcaacc tggtgagtgt ggccccgggt 60
gcaatccgtg aacctacccc ggcaggcagc gtgatccagt acagtgacta cgagctggat 120
gaaagcagcc cgtttgccgg tggtgcagcc tggattgaag gtgagtatgt tccggcagca 180
gaggcccgta ttagcctgtt tgataccggc ttcggccata gcgatctgac ctacaccgtt 240
gcccatgttt ggcacggcaa catctttcgc ctgaaagacc acattgaccg cgtgtttgat 300
ggcgcccaga aactgcgtat acagagcccg ctgaccaagg ccgaagtgga ggatattacc 360
aaacgctgcg tgagcctgag tcagctgcgc gagagcttcg tgaacatcac cattacccgc 420
ggttatggcg cccgcaaagg cgagaaagat ctgagcaaat taaccagcca gatctacatc 480
tacgccatcc cgtacctgtg ggcctttcct ccggaagagc agatcttcgg tacaagtgcc 540
attgtgccgc gtcatgttcg tcgcgcaggc cgtaataccg ttgatcctac cgttaagaac 600
taccagtggg gtgatctgac cgcagcttct tttgaagcaa aagatcgtgg cgcccgcacc 660
gcaatcctgc tggatgcaga caactgtgtg gccgagggtc cgggctttaa cgtggtgatg 720
gtgaaggatg gcaaactgag tagcccgagc cgtaatgccc tgccgggtat tacacgtctg 780
accgtgatgg agatggccga tgaaatgggc atcgaattca ccctgcgcga tatcaccagc 840
cgtgagttat atgaggccga cgaactgatc gccgtgacca ccggaggtgg cattaccccg 900
attaccagtc tggatggcga accgctgggc gatggtaccc ctggtcctgt gacagtggcc 960
attcgcgatc gcttttgggc catgatggat gagccgagca gtctggtgga ggccattgaa 1020
tattaa 1026
<210> 34
<211> 1026
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 34
atgaccatta gcaaagacat tgactatagc accagcaacc tggtgagtgt ggccccgggt 60
gcaatccgtg aacctacccc ggcaggcagc gtgatccagt acagtgacta cgagctggat 120
gaaagcaacc cgtttgccgg tggtgcagcc tggattgaag gtgagtatgt tccggcagca 180
gaggcccgta ttagcctgtt tgataccggc ttcctacata gcgatctgac ctacaccgtt 240
gcccatgttt ggcacggcaa catctttcgc ctgaaagacc acattgaccg cgtgtttgat 300
ggcgcccaga aactgcgtct gcagagcccg ctgaccaagg ccgaagtgga ggatattacc 360
aaacgctgcg tgagcctgag tcagctgcgc gagagcttcg tgaacatcac cattacccgc 420
ggttatggcg cccgcaaagg cgagaaagat ctgagcaaat taaccagcca gatctacatc 480
tacgccatcc cgtacctgtg ggcctttcct ccggaagagc agatcttcgg tacaagtgcc 540
attgtgccgc gtcatgttcg tcgcgcaggc cgtaataccg ttgatcctac cgttaagaac 600
taccagtggg gtgatctgac cgcagcttct tttgaagcaa aagatcgtgg cgcccgcacc 660
gcaatcctgc tggatgcaga caactgtgtg gccgagggtc cgggctttaa cgtggtgatg 720
gtgaaggatg gcaaactgag tagcccgagc cgtaatgccc tgccgggtat tacacgtctg 780
accgtgatgg agatggccga tgaaatgggc atcgaattca ccctgcgcga tatcaccagc 840
cgtgagttat atgaggccga cgaactgatc gccgtgacca ccggaggtgg cattaccccg 900
attaccagtc tggatggcga accgctgggc gatggtaccc ctggtcctgt gacagtggcc 960
attcgcgatc gcttttgggc catgatggat gagccgagca gtctggtgga ggccattgaa 1020
tattaa 1026
<210> 35
<211> 1026
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 35
atgaccatta gcaaagacat tgactatagc accagcaacc tggtgagtgt ggccccgggt 60
gcaatccgtg aacctacccc ggcaggcagc gtgatccagt acagtgacta cgagctggat 120
gaaagcagcc cgtttgccgg tggtgcagcc tggattgaag gtgagtatgt tccggcagca 180
gaggcccgta ttagcctgtt tgataccggc ttcggccata gcgatctgac ctacaccgtt 240
gcccatgttt ggcacggcaa catctttcgc ctgaaagacc acattaaccg cgtgtttgat 300
ggcgcccaga tactgcgtct gcagagcccg ctgaccaagg ccgaagtgga ggatattacc 360
aaacgctgcg tgagcctgag tcagctgcgc gagagcttcg tgaacatcac cattacccgc 420
ggttatggcg cccgcaaagg cgagaaagat ctgagcaaat taaccagcca gatctacatc 480
tacgccatcc cgtacctgtg ggcctttcct ccggaagagc agatcttcgg tacaagtgcc 540
attgtgccgc gtcatgttcg tcgcgcaggc cgtaataccg ttgatcctac cgttaagaac 600
taccagtggg gtgatctgac cgcagcttct tttgaagcaa aagatcgtgg cgcccgcacc 660
gcaatcctgc tggatgcaga caactgtgtg gccgagggtc cgggctttaa cgtggtgatg 720
gtgaaggatg gcaaactgag tagcccgagc cgtaatgccc tgccgggtat tacacgtctg 780
accgtgatgg agatggccga tgaaatgggc atcgaattca ccctgcgcga tatcaccagc 840
cgtgagttat atgaggccga cgaactgatc gccgtgacca ccggaggtgg cattaccccg 900
attaccagtc tggatggcga accgctgggc gatggtaccc ctggtcctgt gacagtggcc 960
attcgcgatc gcttttgggc catgatggat gagccgagca gtctggtgga ggccattgaa 1020
tattaa 1026
<210> 36
<211> 1026
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 36
atgaccatta gcaaagacat tgactatagc accagcaacc tggtgagtgt ggccccgggt 60
gcaatccgtg aacctacccc ggcaggcagc gtgatccagt acagtgacta cgagctggat 120
gaaagcagcc cgtttgccgg tggtgcagcc tggattgaag gtgagtatgt tccggcagca 180
gaggcccgta ttagcctgtt tgataccggc ttcggccata gcgatgcgac ctacaccgtt 240
gcccatgttt ggcacggcaa catctttcgc ctgaaagacc acattgaccg cgtgtttgat 300
ggcgcccaga aactgcgtct gcagagcccg ctgaccaagg ccgaagtgga ggatattacc 360
aaacgctgcg tggccctgag tcagctgcgc gagagcttcg tgaacatcac cattacccgc 420
ggttatggcg cccgcaaagg cgagaaagat ctgagcaaat taaccagcca gatctacatc 480
tacgccatcc cgtacctgtg ggcctttcct ccggaagagc agatcttcgg tacaagtgcc 540
attgtgccgc gtcatgttcg tcgcgcaggc cgtaataccg ttgatcctac cgttaagaac 600
taccagtggg gtgatctgac cgcagcttct tttgaagcaa aagatcgtgg cgcccgcacc 660
gcaatcctgc tggatgcgga caactgtgtg gccgagggtc cgggctttaa cgtggtgatg 720
gtgaaggatg gcaaactgag tagcccgagc cgtaatgccc tgccgggtat tacacgtctg 780
accgtgatgg agatggccga tgaaatgggc atcgaattca ccctgcgcga tatcaccagc 840
cgtgagttat atgaggccga cgaactgatc gccgtgacca ccggaggtgg cattaccccg 900
attaccagtc tggatggcga accgctgggc gatggtaccc ctggtcctgt gacagtggcc 960
attcgcgatc gcttttgggc catgatggat gagccgagca gtctggtgga ggccattgaa 1020
tattaa 1026
<210> 37
<211> 1026
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 37
atgaccatta gcaaagacat tgactatagc accagcaacc tggtgagtgt ggccccgggt 60
gcaatccgtg aacctacccc ggcaggcagc gtgatccagt acagtgacta cgagctggat 120
gaaagcagcc cgtttgccgg tggtgcagcc tggattgaag gtgagtatgt tccggcagca 180
gaggcccgta ttagcctgtt tgataccggc ttcggccata gcgatgcgac ctacaccgtt 240
gcccatgttt ggcacggcaa catctttcgc ctgaaagacc acattgaccg cgtgtttgat 300
ggcgcccaga aactgcgtct gcagagcccg ctgaccaagg ccgaagtgga ggatattacc 360
aaacgctgcg tggccctgag tcagctgcgc gaggccttcg tgaacatcac cattacccgc 420
ggttatggcg cccgcaaagg cgagaaagat ctgagcaaat taaccagcca gatctacatc 480
tacgccatcc cgtacctgtg ggcctttcct ccggaagagc agatcttcgg tacaagtgcc 540
attgtgccgc gtcatgttcg tcgcgcaggc cgtaataccg ttgatcctac cgttaagaac 600
taccagtggg gtgatctgac cgcagcttct tttgaagcaa aagatcgtgg cgcccgcacc 660
gcaatcctgc tggatgcgga caactgtgtg gccgagggtc cgggctttaa cgtggtgatg 720
gtgaaggatg gcaaactgag tagcccgagc cgtaatgccc tgccgggtat tacacgtctg 780
accgtgatgg agatggccga tgaaatgggc atcgaattca ccctgcgcga tatcaccagc 840
cgtgagttat atgaggccga cgaactgatc gccgtgacca ccggaggtgg cattaccccg 900
attaccagtc tggatggcga accgctgggc gatggtaccc ctggtcctgt gacagtggcc 960
attcgcgatc gcttttgggc catgatggat gagccgagca gtctggtgga ggccattgaa 1020
tattaa 1026
<210> 38
<211> 1026
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 38
atgaccatta gcaaagacat tgactatagc accagcaacc tggtgagtgt ggccccgggt 60
gcaatccgtg aacctacccc ggcaggcagc gtgatccagt acagtgacta cgagctggat 120
gaaagcagcc cgtttgccgg tggtgcagcc tggattgaag gtgagtatgt tccggcagca 180
gaggcccgta ttagcctgtt tgataccggc ttcggccata gcgatctgac ctacaccgtt 240
gcccatgttt ggcacggcaa catctttcgc ctgaaagacc acattgaccg cgtgtttgat 300
ggcgcccaga aactgcgtct gcagagcccg ctgaccaagg ccgaagtgga ggatattacc 360
aaacgctgcg tgagcctgag tcagctgcgc gaggccttcg tgaacatcac cattacccgc 420
ggttatggcg cccgcaaagg cgagaaagat ctgagcaaat taaccagcca gatctacatc 480
tacgccatcc cgtacctgtg ggcctttcct ccggaagagc agatcttcgg tacaagtgcc 540
attgtgccgc gtcatgttcg tcgcgcaggc cgtaataccg ttgatcctac cgttaagaac 600
taccagtggg gtgatctgac cgcagcttct tttgaagcaa aagatcgtgg cgcccgcacc 660
gcaatcctgc tggatgcaga caactgtgtg gccgagggtc cgggctttaa cgtggtgatg 720
gtgaaggatg gcaaactgag tagcccgagc cgtaatgccc tgccgggtat tacacgtctg 780
accgtgatgg agatggccga tgaaatgggc atcgaattca ccctgcgcga tatcaccagc 840
cgtgagttat atgaggccga cgaactgatc gccgtgacca ccggaggtgg cattaccccg 900
attaccagtc tggatggcga accgctgggc gatggtaccc ctggtcctgt gacagtggcc 960
attcgcgatc gcttttgggc catgatggat gagccgagca gtctggtgga ggccattgaa 1020
tattaa 1026
<210> 39
<211> 1026
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 39
atgaccatta gcaaagacat tgactatagc accagcaacc tggtgagtgt ggccccgggt 60
gcaatccgtg aacctacccc ggcaggcagc gtgatccagt acagtgacta cgagctggat 120
gaaagcagcc cgtttgccgg tggtgcagcc tggattgaag gtgagtatgt tccggcagca 180
gaggcccgta ttagcctgtt tgataccggc ttcctacata gcgatctgac ctacaccgtt 240
gcccatgttt ggcacggcaa catctttcgc ctgaaagacc acattgaccg cgtgtttgat 300
ggcgcccaga aactgcgtct gcagagcccg ctgaccaagg ccgaagtgga ggatattacc 360
aaacgctgcg tgagcctgag tcagctgcgc gagagcttcg tgaacatcac cattacccgc 420
ggttatggcg cccgcaaagg cgagaaagat ctgagcaaat taaccagcca gatctacatc 480
tacgccatcc cgtacctgtg ggcctttcct ccggaagagc agatcttcgg tacaagtgcc 540
attgtgccgc gtcatgttcg tcgcgcaggc cgtaataccg ttgatcctac cgttaagaac 600
taccagtggg gtgatctgac cgcagcttct tttgaagcaa aagatcgtgg cgcccgcacc 660
gcaatcctgc tggatgcaga caactgtgtg gccgagggtc cgggctttaa cgtggtgatg 720
gtgaaggatg gcaaactgag tagcccgagc cgtaatgccc tgccgggtat tacacgtctg 780
accgtgatgg agatggccga tgaaatgggc atcgaattca ccctgcgcga tatcaccagc 840
cgtgagttat atgaggccga cgaactgatc gccgtgacca ccggaggtgg cattaccccg 900
attaccagtc tggatggcga accgctgggc gatggtaccc ctggtcctgt gacagtggcc 960
attcgcgatc gcttttgggc catgatggat gagccgagca gtctggtgga ggccattgaa 1020
tattaa 1026
<210> 40
<211> 1026
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 40
atgaccatta gcaaagacat tgactatagc accagcaacc tggtgagtgt ggccccgggt 60
gcaatccgtg aacctacccc ggcaggcagc gtgatccagt acagtgacta cgagctggat 120
gaaagcagcc cgtttgccgg tggtgcagcc tggattgaag gtgagtatgt tccggcagca 180
gaggcccgta ttagcctgtt tgataccggc ttcctacata gcgatctgac ctacaccgtt 240
gcccatgttt ggcacggcaa catctttcgc ctgaaagacc acattgaccg cgtgtttgat 300
ggcgcccaga aactgcgtct gcagagcccg ctgaccaagg ccgaagtgga ggatattacc 360
aaacgctgcg tgagcctgag tcagctgcgc gaggccttcg tgaacatcac cattacccgc 420
ggttatggcg cccgcaaagg cgagaaagat ctgagcaaat taaccagcca gatctacatc 480
tacgccatcc cgtacctgtg ggcctttcct ccggaagagc agatcttcgg tacaagtgcc 540
attgtgccgc gtcatgttcg tcgcgcaggc cgtaataccg ttgatcctac cgttaagaac 600
taccagtggg gtgatctgac cgcagcttct tttgaagcaa aagatcgtgg cgcccgcacc 660
gcaatcctgc tggatgcaga caactgtgtg gccgagggtc cgggctttaa cgtggtgatg 720
gtgaaggatg gcaaactgag tagcccgagc cgtaatgccc tgccgggtat tacacgtctg 780
accgtgatgg agatggccga tgaaatgggc atcgaattca ccctgcgcga tatcaccagc 840
cgtgagttat atgaggccga cgaactgatc gccgtgacca ccggaggtgg cattaccccg 900
attaccagtc tggatggcga accgctgggc gatggtaccc ctggtcctgt gacagtggcc 960
attcgcgatc gcttttgggc catgatggat gagccgagca gtctggtgga ggccattgaa 1020
tattaa 1026
<210> 41
<211> 1026
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 41
atgaccatta gcaaagacat tgactatagc accagcaacc tggtgagtgt ggccccgggt 60
gcaatccgtg aacctacccc ggcaggcagc gtgatccagt acagtgacta cgagctggat 120
gaaagcagcc cgtttgccgg tggtgcagcc tggattgaag gtgagtatgt tccggcagca 180
gaggcccgta ttagcctgtt tgataccggc ttcctacata gcgatctgac ctacaccgtt 240
gcccatgttt ggcacggcaa catctttcgc ctgaaagacc acattgaccg cgtgtttgat 300
ggcgcccaga aactgcgtct gcagagcccg ctgaccaagg ccgaagtgga ggatattacc 360
aaacgctgcg tgagcctgag tcagctgcgc gagagcttcg tgaacatcac cattacccgc 420
ggttatggcg cccgcaaagg cgagaaagat ctgagcaaat taaccagcca gatctacatc 480
tacgccatcc cgtacctgtg ggcctttcct ccggaagagc agatcttcgg tacaagtgcc 540
attgtgccgc gtcatgttcg tcgcgcaggc cgtaataccg ttgatcctac cgttaagaac 600
taccagtggg gtgatctgac cgcagcttct tttgaagcaa aagatcgtgg cgcccgcacc 660
gcaatcctgc tggatgcaga caactgtgtg gccgagggtc cgggctttaa cgtggtgatg 720
gtgaaggatg gcaaactgag tagcccgagc cgtaatgccc tgccgggtat tacacgtctg 780
accgtgatgg agatggccga tgaaatgggc atcgaattca ccctgcgcga tatcaccagc 840
cgtgagttat atgaggccga cgaactgatc gcctgcacca ccggaggtgg cattaccccg 900
attaccagtc tggatggcga accgctgggc gatggtaccc ctggtcctgt gacagtggcc 960
attcgcgatc gcttttgggc catgatggat gagccgagca gtctggtgga ggccattgaa 1020
tattaa 1026
<210> 42
<211> 1026
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 42
atgaccatta gcaaagacat tgactatagc accagcaacc tggtgagtgt ggccccgggt 60
gcaatccgtg aacctacccc ggcaggcagc gtgatccagt acagtgacta cgagctggat 120
gaaagcagcc cgtttgccgg tggtgcagcc tggattgaag gtgagtatgt tccggcagca 180
gaggcccgta ttagcctgtt tgataccggc ttcctacata gcgatgcgac ctacaccgtt 240
gcccatgttt ggcacggcaa catctttcgc ctgaaagacc acattgaccg cgtgtttgat 300
ggcgcccaga aactgcgtct gcagagcccg ctgaccaagg ccgaagtgga ggatattacc 360
aaacgctgcg tgagcctgag tcagctgcgc gagagcttcg tgaacatcac cattacccgc 420
ggttatggcg cccgcaaagg cgagaaagat ctgagcaaat taaccagcca gatctacatc 480
tacgccatcc cgtacctgtg ggcctttcct ccggaagagc agatcttcgg tacaagtgcc 540
attgtgccgc gtcatgttcg tcgcgcaggc cgtaataccg ttgatcctac cgttaagaac 600
taccagtggg gtgatctgac cgcagcttct tttgaagcaa aagatcgtgg cgcccgcacc 660
gcaatcctgc tggatgcaga caactgtgtg gccgagggtc cgggctttaa cgtggtgatg 720
gtgaaggatg gcaaactgag tagcccgagc cgtaatgccc tgccgggtat tacacgtctg 780
accgtgatgg agatggccga tgaaatgggc atcgaattca ccctgcgcga tatcaccagc 840
cgtgagttat atgaggccga cgaactgatc gcctgcacca ccggaggtgg cattaccccg 900
attaccagtc tggatggcga accgctgggc gatggtaccc ctggtcctgt gacagtggcc 960
attcgcgatc gcttttgggc catgatggat gagccgagca gtctggtgga ggccattgaa 1020
tattaa 1026
<210> 43
<211> 1026
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 43
atgaccatta gcaaagacat tgactatagc accagcaacc tggtgagtgt ggccccgggt 60
gcaatccgtg aacctacccc ggcaggcagc gtgatccagt acagtgacta cgagctggat 120
gaaagcagcc cgtttgccgg tggtgcagcc tggattgaag gtgagtatgt tccggcagca 180
gaggcccgta ttagcctgtt tgataccggc ttcctacata gcgatctgac ctacaccgtt 240
gcccatgttt ggcacggcaa catctttcgc ctgaaagacc acattgaccg cgtgtttgat 300
ggcgcccaga aactgcgtct gcagagcccg ctgaccaagg ccgaagtgga ggatattacc 360
aaacgctgcg tgagcctgag tcagctgcgc gagagcttcg tgaacatcac cattacccgc 420
ggttatggcg cccgcaaagg cgagaaagat ctgagcaaat taaccagcca gatctacatc 480
tacgccatcc cgtacctgtg ggcctttcct ccggaagagc agatcttcgg tacaagtgcc 540
attgtgccgc gtcatgttcg tcgcgcaggc cgtaataccg ttgatcctac cgttaagaac 600
taccagtggg gtgatctgac cgcagcttct tttgaagcaa aagatcgtgg cgcccgcacc 660
gcaatcctgc tggatgcaga caactgtgtg gccgagggtc cgggctttaa cgtggtgatg 720
gtgaaggatg gcaaactgag tagcccgagc cgtaatgccc tgccgggtat tacacgtctg 780
accgtgatgg agatggccga tgaaatgggc atcgaattca ccctgcgcga tatcaccagc 840
cgtgagttat atgaggccga cgaactgatc gccgtgacca ccgcaggtgg cattaccccg 900
attaccagtc tggatggcga accgctgggc gatggtaccc ctggtcctgt gacagtggcc 960
attcgcgatc gcttttgggc catgatggat gagccgagca gtctggtgga ggccattgaa 1020
tattaa 1026
<210> 44
<211> 1026
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 44
atgaccatta gcaaagacat tgactatagc accagcaacc tggtgagtgt ggccccgggt 60
gcaatccgtg aacctacccc ggcaggcagc gtgatccagt acagtgacta cgagctggat 120
gaaagcagcc cgtttgccgg tggtgcagcc tggattgaag gtgagtatgt tccggcagca 180
gaggcccgta ttagcctgtt tgataccggc ttcggccata gcgatgcgac ctacaccgtt 240
gcccatgttt ggcacggcaa catctttcgc ctgaaagacc acattgaccg cgtgtttgat 300
ggcgcccaga aactgcgtct gcagagcccg ctgaccaagg ccgaagtgga ggatattacc 360
aaacgctgcg tgagcctgag tcagctgcgc gagagcttcg tgaacatcac cattacccgc 420
ggttatggcg cccgcaaagg cgagaaagat ctgagcaaat taaccagcca gatctacatc 480
tacgccatcc cgtacctgtg ggcctttcct ccggaagagc agatcttcgg tacaagtgcc 540
attgtgccgc gtcatgttcg tcgcgcaggc cgtaataccg ttgatcctac cgttaagaac 600
taccagtggg gtgatctgac cgcagcttct tttgaagcaa aagatcgtgg cgcccgcacc 660
gcaatcctgc tggatgcaga caactgtgtg gccgagggtc cgggctttaa cgtggtgatg 720
gtgaaggatg gcaaactgag tagcccgagc cgtaatgccc tgccgggtat tacacgtctg 780
accgtgatgg agatggccga tgaaatgggc atcgaattca ccctgcgcga tatcaccagc 840
cgtgagttat atgaggccga cgaactgatc gccgtgacca ccgcaggtgg cattaccccg 900
attaccagtc tggatggcga accgctgggc gatggtaccc ctggtcctgt gacagtggcc 960
attcgcgatc gcttttgggc catgatggat gagccgagca gtctggtgga ggccattgaa 1020
tattaa 1026
<210> 45
<211> 1026
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 45
atgaccatta gcaaagacat tgactatagc accagcaacc tggtgagtgt ggccccgggt 60
gcaatccgtg aacctacccc ggcaggcagc gtgatccagt acagtgacta cgagctggat 120
gaaagcagcc cgtttgccgg tggtgcagcc tggattgaag gtgagtatgt tccggcagca 180
gaggcccgta ttagcctgtt tgataccggc ttcggccata gcgatctgac ctacaccgtt 240
gcccatgttt ggcacggcaa catctttcgc ctgaaagacc acattgaccg cgtgtttgat 300
ggcgcccaga aactgcgtat acagagcccg ctgaccaagg ccgaagtgga ggatattacc 360
aaacgctgcg tgagcctgag tcagctgcgc gagagcttcg tgaacatcac cattacccgc 420
ggttatggcg cccgcaaagg cgagaaagat ctgagcaaat taaccagcca gatctacatc 480
tacgccatcc cgtacctgtg ggcctttcct ccggaagagc agatcttcgg tacaagtgcc 540
attgtgccgc gtcatgttcg tcgcgcaggc cgtaataccg ttgatcctac cgttaagaac 600
taccagtggg gtgatctgac cgcagcttct tttgaagcaa aagatcgtgg cgcccgcacc 660
gcaatcctgc tggatgcaga caactgtgtg gccgagggtc cgggctttaa cgtggtgatg 720
gtgaaggatg gcaaactgag tagcccgagc cgtaatgccc tgccgggtat tacacgtctg 780
accgtgatgg agatggccga tgaaatgggc atcgaattca ccctgcgcga tatcaccagc 840
cgtgagttat atgaggccga cgaactgatc gccgtgacca ccgcaggtgg cattaccccg 900
attaccagtc tggatggcga accgctgggc gatggtaccc ctggtcctgt gacagtggcc 960
attcgcgatc gcttttgggc catgatggat gagccgagca gtctggtgga ggccattgaa 1020
tattaa 1026
<210> 46
<211> 1026
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 46
atgaccatta gcaaagacat tgactatagc accagcaacc tggtgagtgt ggccccgggt 60
gcaatccgtg aacctacccc ggcaggcagc gtgatccagt acagtgacta cgagctggat 120
gaaagcagcc cgtttgccgg tggtgcagcc tggattgaag gtgagtatgt tccggcagca 180
gaggcccgta ttagcctgtt tgataccggc ttcggccata gcgatctgac ctacaccgtt 240
gcccatgttt ggcacggcaa catctttcgc ctgggagacc acattgaccg cgtgtttgat 300
ggcgcccaga aactgcgtct gcagagcccg ctgaccaagg ccgaagtgga ggatattacc 360
aaacgctgcg tgagcctgag tcagctgcgc gagagcttcg tgaacatcac cattacccgc 420
ggttatggcg cccgcaaagg cgagaaagat ctgagcaaat taaccagcca gatctacatc 480
tacgccatcc cgtacctgtg ggcctttcct ccggaagagc agatcttcgg tacaagtgcc 540
attgtgccgc gtcatgttcg tcgcgcaggc cgtaataccg ttgatcctac cgttaagaac 600
taccagtggg gtgatctgac cgcagcttct tttgaagcaa aagatcgtgg cgcccgcacc 660
gcaatcctgc tggatgcaga caactgtgtg gccgagggtc cgggctttaa cgtggtgatg 720
gtgaaggatg gcaaactgag tagcccgagc cgtaatgccc tgccgggtat tacacgtctg 780
accgtgatgg agatggccga tgaaatgggc atcgaattca ccctgcgcga tatcaccagc 840
cgtgagttat atgaggccga cgaactgatc gccgtgacca ccgcaggtgg cattaccccg 900
attaccagtc tggatggcga accgctgggc gatggtaccc ctggtcctgt gacagtggcc 960
attcgcgatc gcttttgggc catgatggat gagccgagca gtctggtgga ggccattgaa 1020
tattaa 1026
<210> 47
<211> 1026
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 47
atgaccatta gcaaagacat tgactatagc accagcaacc tggtgagtgt ggccccgggt 60
gcaatccgtg aacctacccc ggcaggcagc gtgatccagt acagtgacta cgagctggat 120
gaaagcagcc cgtttgccgg tggtgcagcc tggattgaag gtgagtatgt tccggcagca 180
gaggcccgta ttagcctgtt tgataccggc ttcggccata gcgatctgac ctacaccgtt 240
gcccatgttt ggcacggcaa catctttcgc ctgaaagacc acattgaccg cgtgtttgat 300
ggcgcccaga aactgcgtct gcagagcccg ctgaccaagg ccgaagtgga ggatattacc 360
aaacgctgcg tggccctgag tcagctgcgc gagagcttcg tgaacatcac cattacccgc 420
ggttatggcg cccgcaaagg cgagaaagat ctgagcaaat taaccagcca gatctacatc 480
tacgccatcc cgtacctgtg ggcctttcct ccggaagagc agatcttcgg tacaagtgcc 540
attgtgccgc gtcatgttcg tcgcgcaggc cgtaataccg ttgatcctac cgttaagaac 600
taccagtggg gtgatctgac cgcagcttct tttgaagcaa aagatcgtgg cgcccgcacc 660
gcaatcctgc tggatgcaga caactgtgtg gccgagggtc cgggctttaa cgtggtgatg 720
gtgaaggatg gcaaactgag tagcccgagc cgtaatgccc tgccgggtat tacacgtctg 780
accgtgatgg agatggccga tgaaatgggc atcgaattca ccctgcgcga tatcaccagc 840
cgtgagttat atgaggccga cgaactgatc gccgtgacca ccgcaggtgg cattaccccg 900
attaccagtc tggatggcga accgctgggc gatggtaccc ctggtcctgt gacagtggcc 960
attcgcgatc gcttttgggc catgatggat gagccgagca gtctggtgga ggccattgaa 1020
tattaa 1026
<210> 48
<211> 1026
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 48
atgaccatta gcaaagacat tgactatagc accagcaacc tggtgagtgt ggccccgggt 60
gcaatccgtg aacctacccc ggcaggcagc gtgatccagt acagtgacta cgagctggat 120
gaaagcagcc cgtttgccgg tggtgcagcc tggattgaag gtgagtatgt tccggcagca 180
gaggcccgta ttagcctgtt tgataccggc ttcggccata gcgatctgac ctacaccgtt 240
gcccatgttt ggcacggcaa catctttcgc ctgaaagacc acattgaccg cgtgtttgat 300
ggcgcccaga aactgcgtct gcagagcccg ctgaccaagg ccgaagtgga ggatattacc 360
aaacgctgcg tgagcctgag tcagctgcgc gaggccttcg tgaacatcac cattacccgc 420
ggttatggcg cccgcaaagg cgagaaagat ctgagcaaat taaccagcca gatctacatc 480
tacgccatcc cgtacctgtg ggcctttcct ccggaagagc agatcttcgg tacaagtgcc 540
attgtgccgc gtcatgttcg tcgcgcaggc cgtaataccg ttgatcctac cgttaagaac 600
taccagtggg gtgatctgac cgcagcttct tttgaagcaa aagatcgtgg cgcccgcacc 660
gcaatcctgc tggatgcaga caactgtgtg gccgagggtc cgggctttaa cgtggtgatg 720
gtgaaggatg gcaaactgag tagcccgagc cgtaatgccc tgccgggtat tacacgtctg 780
accgtgatgg agatggccga tgaaatgggc atcgaattca ccctgcgcga tatcaccagc 840
cgtgagttat atgaggccga cgaactgatc gccgtgacca ccgcaggtgg cattaccccg 900
attaccagtc tggatggcga accgctgggc gatggtaccc ctggtcctgt gacagtggcc 960
attcgcgatc gcttttgggc catgatggat gagccgagca gtctggtgga ggccattgaa 1020
tattaa 1026
<210> 49
<211> 1026
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 49
atgaccatta gcaaagacat tgactatagc accagcaacc tggtgagtgt ggccccgggt 60
gcaatccgtg aacctacccc ggcaggcagc gtgatccagt acagtgacta cgagctggat 120
gaaagcagcc cgtttgccgg tggtgcagcc tggattgaag gtgagtatgt tccggcagca 180
gaggcccgta ttagcctgtt tgataccggc ttcggccata gcgatctgac ctacaccgtt 240
gcccatgttt ggcacggcaa catctttcgc ctgaaagacc acattgaccg cgtgtttgat 300
ggcgcccaga aactgcgtct gcagagcccg ctgaccaagg ccgaagtgga ggatattacc 360
aaacgctgcg tgagcctgag tcagctgcgc gagagcttcg tgaacatcac cattacccgc 420
ggttatggcg cccgcaaagg cgagaaagat ctgagcaaat taaccagcca gatctacatc 480
tacgccatcc cgtacctgtg ggcctttcct ccggaagagc agatcttcgg tacaagtgcc 540
attgtgccgc gtcatgttcg tcgcgcaggc cgtaataccg ttgatcctac cgttaagaac 600
taccagtggg gtgatctgac cgcagcttct tttgaagcaa aagatcgtgg cgcccgcacc 660
gcaatcctgc tggatggaga caactgtgtg gccgagggtc cgggctttaa cgtggtgatg 720
gtgaaggatg gcaaactgag tagcccgagc cgtaatgccc tgccgggtat tacacgtctg 780
accgtgatgg agatggccga tgaaatgggc atcgaattca ccctgcgcga tatcaccagc 840
cgtgagttat atgaggccga cgaactgatc gccgtgacca ccgcaggtgg cattaccccg 900
attaccagtc tggatggcga accgctgggc gatggtaccc ctggtcctgt gacagtggcc 960
attcgcgatc gcttttgggc catgatggat gagccgagca gtctggtgga ggccattgaa 1020
tattaa 1026
<210> 50
<211> 1026
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 50
atgaccatta gcaaagacat tgactatagc accagcaacc tggtgagtgt ggccccgggt 60
gcaatccgtg aacctacccc ggcaggcagc gtgatccagt acagtgacta cgagctggat 120
gaaagcagcc cgtttgccgg tggtgcagcc tggattgaag gtgagtatgt tccggcagca 180
gaggcccgta ttagcctgtt tgataccggc ttcggccata gcgatctgac ctacaccgtt 240
gcccatgttt ggcacggcaa catctttcgc ctgaaagacc acattgaccg cgtgtttgat 300
ggcgcccaga aactgcgtct gcagagcccg ctgaccaagg ccgaagtgga ggatattacc 360
aaacgctgcg tgagcctgag tcagctgcgc gagagcttcg tgaacatcac cattacccgc 420
ggttatggcg cccgcaaagg cgagaaagat ctgagcaaat taaccagcca gatctacatc 480
tacgccatcc cgtacctgtg ggcctttcct ccggaagagc agatcttcgg tacaagtgcc 540
attgtgccgc gtcatgttcg tcgcgcaggc cgtaataccg ttgatcctac cgttaagaac 600
taccagtggg gtgatctgac cgcagcttct tttgaagcaa aagatcgtgg cgcccgcacc 660
gcaatcctgc tggatgcaga caactgtgtg gccgagggtc cgggctttaa cgtggtgatg 720
gtgaaggatg gcaaactgag tagcccgagc cgtaatgccc tgccgggtat tacacgtctg 780
accgtgatgg agatggccga tgaaatgggc atcgaattca ccctgcgcga tatcaccagc 840
cgtgagttat atgaggccga cgaactgatc gcctgcacca ccgcaggtgg cattaccccg 900
attaccagtc tggatggcga accgctgggc gatggtaccc ctggtcctgt gacagtggcc 960
attcgcgatc gcttttgggc catgatggat gagccgagca gtctggtgga ggccattgaa 1020
tattaa 1026
<210> 51
<211> 1026
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 51
atgaccatta gcaaagacat tgactatagc accagcaacc tggtgagtgt ggccccgggt 60
gcaatccgtg aacctacccc ggcaggcagc gtgatccagt acagtgacta cgagctggat 120
gaaagcagcc cgtttgccgg tggtgcagcc tggattgaag gtgagtatgt tccggcagca 180
gaggcccgta ttagcctgtt tgataccggc ttcggccata gcgatctgac ctacaccgtt 240
gcccatgttt ggcacggcaa catctttcgc ctgaaagacc acattgaccg cgtgtttgat 300
ggcgcccaga aactgcgtct gcagagcccg ctgaccaagg ccgaagtgga ggatattacc 360
aaacgctgcg tgagcctgag tcagctgcgc gagagcttcg tgaacatcac cattacccgc 420
ggttatggcg cccgcaaagg cgagaaagat ctgagcaaat taaccagcca gatctacatc 480
tacgccatcc cgtacctgtg ggcctttcct ccggaagagc agatcttcgg tacaagtgcc 540
attgtgccgc gtcatgttcg tcgcgcaggc cgtaataccg ttgatcctac cgttaagaac 600
taccagtggg gtgatctgac cgcagcttct tttgaagcaa aagatcgtgg cgcccgcacc 660
gcaatcctgc tggatgcaga caactgtgtg gccgagggtc cgggctttaa cgtggtgatg 720
gtgaaggatg gcaaactgag tagcccgagc cgtaatgccc tgccgggtat tacacgtctg 780
accgtgatgg agatggccga tgaaatgggc atcgaattca ccctgcgcga tatcaccagc 840
cgtgagttat atgaggccga cgaactgatc gccgtgacca ccggaggtgg cattaccccg 900
attaccagtc tggatggcga accgctgggc gatggtaccc ctggtcctgt gacagtggcc 960
attcgcgatc gcttttgggc catgatggat gagccgagca gtctggtgga ggccattgaa 1020
tattaa 1026
<210> 52
<211> 1026
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 52
atgaccatta gcaaagacat tgactatagc accagcaacc tggtgagtgt ggcctcgggt 60
gcaatccgtg aacctacccc ggcaggcagc gtgatccagt acagtgacta cgagctggat 120
gaaagcagcc cgtttgccgg tggtgcagcc tggattgaag gtgagtatgt tccggcagca 180
gaggcccgta ttagcctgtt tgataccggc ttcggccata gcgatctgac ctacaccgtt 240
gcccatgttt ggcacggcaa catctttcgc ctgaaagacc acattgaccg cgtgtttgat 300
ggcgcccaga aactgcgtct gcagagcccg ctgaccaagg ccgaagtgga ggatattacc 360
aaacgctgcg tgagcctgag tcagctgcgc gagagcttcg tgaacatcac cattacccgc 420
ggttatggcg cccgcaaagg cgagaaagat ctgagcaaat taaccagcca gatctacatc 480
tacgccatcc cgtacctgtg ggcctttcct ccggaagagc agatcttcgg tacaagtgcc 540
attgtgccgc gtcatgttcg tcgcgcaggc cgtaataccg ttgatcctac cgttaagaac 600
taccagtggg gtgatctgac cgcagcttct tttgaagcaa aagatcgtgg cgcccgcacc 660
gcaatcctgc tggatgcaga caactgtgtg gccgagggtc cgggctttaa cgtggtgatg 720
gtgaaggatg gcaaactgag tagcccgagc cgtaatgccc tgccgggtat tacacgtctg 780
accgtgatgg agatggccga tgaaatgggc atcgaattca ccctgcgcga tatcaccagc 840
cgtgagttat atgaggccga cgaactgatc gccgtgacca ccgcaggtgg cattaccccg 900
attaccagtc tggatggcga accgctgggc gatggtaccc ctggtcctgt gacagtggcc 960
attcgcgatc gcttttgggc catgatggat gagccgagca gtctggtgga ggccattgaa 1020
tattaa 1026
<210> 53
<211> 1026
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 53
atgaccatta gcaaagacat tgactatagc accagcaacc tggtgagtgt ggccccgggt 60
gcaatccgtg aacctacccc ggcaggcagc gtgatccagt acagtgacta cgagctggat 120
tcaagcagcc cgtttgccgg tggtgcagcc tggattgaag gtgagtatgt tccggcagca 180
gaggcccgta ttagcctgtt tgataccggc ttcggccata gcgatctgac ctacaccgtt 240
gcccatgttt ggcacggcaa catctttcgc ctgaaagacc acattgaccg cgtgtttgat 300
ggcgcccaga aactgcgtct gcagagcccg ctgaccaagg ccgaagtgga ggatattacc 360
aaacgctgcg tgagcctgag tcagctgcgc gagagcttcg tgaacatcac cattacccgc 420
ggttatggcg cccgcaaagg cgagaaagat ctgagcaaat taaccagcca gatctacatc 480
tacgccatcc cgtacctgtg ggcctttcct ccggaagagc agatcttcgg tacaagtgcc 540
attgtgccgc gtcatgttcg tcgcgcaggc cgtaataccg ttgatcctac cgttaagaac 600
taccagtggg gtgatctgac cgcagcttct tttgaagcaa aagatcgtgg cgcccgcacc 660
gcaatcctgc tggatgcaga caactgtgtg gccgagggtc cgggctttaa cgtggtgatg 720
gtgaaggatg gcaaactgag tagcccgagc cgtaatgccc tgccgggtat tacacgtctg 780
accgtgatgg agatggccga tgaaatgggc atcgaattca ccctgcgcga tatcaccagc 840
cgtgagttat atgaggccga cgaactgatc gccgtgacca ccgcaggtgg cattaccccg 900
attaccagtc tggatggcga accgctgggc gatggtaccc ctggtcctgt gacagtggcc 960
attcgcgatc gcttttgggc catgatggat gagccgagca gtctggtgga ggccattgaa 1020
tattaa 1026
<210> 54
<211> 1026
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 54
atgaccatta gcaaagacat tgactatagc accagcaacc tggtgagtgt ggccccgggt 60
gcaatccgtg aacctacccc ggcaggcagc gtgatccagt acagtgacta cgagctggat 120
gaaagcaacc cgtttgccgg tggtgcagcc tggattgaag gtgagtatgt tccggcagca 180
gaggcccgta ttagcctgtt tgataccggc ttcggccata gcgatctgac ctacaccgtt 240
gcccatgttt ggcacggcaa catctttcgc ctgaaagacc acattgaccg cgtgtttgat 300
ggcgcccaga aactgcgtct gcagagcccg ctgaccaagg ccgaagtgga ggatattacc 360
aaacgctgcg tgagcctgag tcagctgcgc gagagcttcg tgaacatcac cattacccgc 420
ggttatggcg cccgcaaagg cgagaaagat ctgagcaaat taaccagcca gatctacatc 480
tacgccatcc cgtacctgtg ggcctttcct ccggaagagc agatcttcgg tacaagtgcc 540
attgtgccgc gtcatgttcg tcgcgcaggc cgtaataccg ttgatcctac cgttaagaac 600
taccagtggg gtgatctgac cgcagcttct tttgaagcaa aagatcgtgg cgcccgcacc 660
gcaatcctgc tggatgcaga caactgtgtg gccgagggtc cgggctttaa cgtggtgatg 720
gtgaaggatg gcaaactgag tagcccgagc cgtaatgccc tgccgggtat tacacgtctg 780
accgtgatgg agatggccga tgaaatgggc atcgaattca ccctgcgcga tatcaccagc 840
cgtgagttat atgaggccga cgaactgatc gccgtgacca ccgcaggtgg cattaccccg 900
attaccagtc tggatggcga accgctgggc gatggtaccc ctggtcctgt gacagtggcc 960
attcgcgatc gcttttgggc catgatggat gagccgagca gtctggtgga ggccattgaa 1020
tattaa 1026
<210> 55
<211> 935
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 55
tgatccagta cagtgactac gagctggatg aaagcagccc gtttgccggt ggtgcagcct 60
ggattgaagg tgagtatgtt ccggcagcag aggcccgtat tagcctgttt gataccggct 120
tcggccatag cgatctgacc tacaccgttg cccatgtttg gcacggcaac atctttcgcc 180
tgaaagacca cattgaccgc gtgtttgatg gcgcccagaa actgcgtctg cagagcccgc 240
tgaccaaggc cgaagtggag gatattacca aacgctgcgt gagcctgagt cagctgcgcg 300
agagcttcgt gaacatcacc attacccgcg gttatggcgc ccgcaaaggc gagaaagatc 360
tgagcaaatt aaccagccag atctacatct acgccatccc gtacctgtgg gcctttcctc 420
cggaagagca gatcttcggt acaagtgcca ttgtgccgcg tcatgttcgt cgcgcaggcc 480
gtaataccgt tgatcctacc gttaagaact accagtgggg tgatctgacc gcagcttctt 540
ttgaagcaaa agatcgtggc gcccgcaccg caatcctgct ggatgcagac aactgtgtgg 600
ccgagggtcc gggctttaac gtggtgatgg tgaaggatgg caaactgagt agcccgagcc 660
gtaatgccct gccgggtatt acacgtctga ccgtgatgga gatggccgat gaaatgggca 720
tcgaattcac cctgcgcgat atcaccagcc gtgagttata tgaggccgac gaactgatcg 780
ccgtgaccac cgcaggtggc attaccccga ttaccagtct ggatggcgaa tcgctgggcg 840
atggtacccc tggtcctgtg acagtggcca ttcgcgatcg cttttgggcc atgatggatg 900
agccgagcag tctggtggag gccattgaat attaa 935
<210> 56
<211> 1026
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 56
atgaccatta gcaaagacat tgactatagc accagcaacc tggtgagtgt ggccccgggt 60
gcaatccgtg aacctacccc ggcaggcagc gtgatccagt acagtgacta cgagctggat 120
gaaagcagcc cgtttgccgg tggtgcagcc tggattgaag gtgagtatgt tccggcagca 180
gaggcccgta ttagcctgtt tgataccggc ttcggccata gcgatctgac ctacaccgtt 240
gcccatgttt ggcacggcaa catctttcgc ctgaaagacc acattgaccg cgtgtttgat 300
ggcgcccaga aactgcgtct gcagagcccg ctgaccaagg ccgaagtgga ggatattacc 360
aaacgctgcg tgagcctgag tcagctgcgc gagagcttcg tgaacatcac cattacccgc 420
ggttatggcg cccgcaaagg cgagaaagat ctgagcaaat taaccagcca gatctacatc 480
tacgccatcc cgtacctgtg ggcctttcct ccggaagagc agatcttcgg tacaagtgcc 540
attgtgccgc gtcatgttcg tcgcgcaggc cgtaataccg ttgatcctac cgttaagaac 600
taccagtggg gtgatctgac cgcagcttct tttgaagcaa aagatcgtgg cgcccgcacc 660
gcaatcctgc tggatgcaga caactgtgtg gccgagggtc cgggctttaa cgtggtgatg 720
gtgaaggatg gcaaactgag tagcccgagc cgtaatgccc tgccgggtat tacacgtctg 780
accgtgatgg agatggccga tgaaatgggc atcgaattca ccctgcgcga tatcaccagc 840
cgtgagttat atgaggccga cgaactgatc gccgtgacca ccgcaggtgg cattaccccg 900
attaccagtc tggatggcga accgctgggc gatggtaccc ctggtcctgt gacagtggcc 960
attcgcgatc gcttttgggc catgatggat gagtcgagca gtctggtgga ggccattgaa 1020
tattaa 1026
<210> 57
<211> 1026
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 57
atgaccatta gcaaagacat tgactatagc accagcaacc tggtgagtgt ggccccgggt 60
gcaatccgtg aacctacccc ggcaggcagc gtgatccagt acagtgacta cgagctggat 120
gaaagcagcc cgtttgccgg tggtgcagcc tggattgaag gtgagtatgt tccggcagca 180
gaggcccgta ttagcctgtt tgataccggc ttcggccata gcgatgcgac ctacaccgtt 240
gcccatgttt ggcacggcaa catctttcgc ctgaaagacc acattgaccg cgtgtttgat 300
ggcgcccaga aactgcgtat acagagccag ctgaccaagg ccgaagtgga ggatattacc 360
aaacgctgcg tgagcctgag tcagctgcgc gagagcttcg tgaacatcac cattacccgc 420
ggttatggcg cccgcaaagg cgagaaagat ctgagcaaat taaccagcca gatctacatc 480
tacgccatcc cgtacctgtg ggcctttcct ccggaagagc agatcttcgg tacaagtgcc 540
attgtgccgc gtcatgttcg tcgcgcaggc cgtaataccg ttgatcctac cgttaagaac 600
taccagtggg gtgatctgac cgcagcttct tttgaagcaa aagatcgtgg cgcccgcacc 660
gcaatcctgc tggatgcaga caactgtgtg gccgagggtc cgggctttaa cgtggtgatg 720
gtgaaggatg gcaaactgag tagcccgagc cgtaatgccc tgccgggtat tacacgtctg 780
accgtgatgg agatggccga tgaaatgggc atcgaattca ccctgcgcga tatcaccagc 840
cgtgagttat atgaggccga cgaactgatc gccgtgacca ccgcaggtgg cattaccccg 900
attaccagtc tggatggcga accgctgggc gatggtaccc ctggtcctgt gacagtggcc 960
attcgcgatc gcttttgggc catgatggat gagccgagca gtctggtgga ggccattgaa 1020
tattaa 1026
<210> 58
<211> 1026
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 58
atgaccatta gcaaagacat tgactatagc accagcaacc tggtgagtgt ggccccgggt 60
gcaatccgtg aacctacccc ggcaggcagc gtgatccagt acagtgacta cgagctggat 120
gaaagcagcc cgtttgccgg tggtgcagcc tggattgaag gtgagtatgt tccggcagca 180
gaggcccgta ttagcctgtt tgataccggc ttcggccata gcgatgcgac ctacaccgtt 240
gcccatgttt ggcacggcaa catctttcgc ctgaaagacc acattgaccg cgtgtttgat 300
ggcgcccaga aactgcgtct gcagagcccg ctgaccaagg ccgaagtgga ggatattacc 360
aaacgctgcg tggccctgag tcagctgcgc gagagcttcg tgaacatcac cattacccgc 420
ggttatggcg cccgcaaagg cgagaaagat ctgagcaaat taaccagcca gatctacatc 480
tacgccatcc cgtacctgtg ggcctttcct ccggaagagc agatcttcgg tacaagtgcc 540
attgtgccgc gtcatgttcg tcgcgcaggc cgtaataccg ttgatcctac cgttaagaac 600
taccagtggg gtgatctgac cgcagcttct tttgaagcaa aagatcgtgg cgcccgcacc 660
gcaatcctgc tggatggaga caactgtgtg gccgagggtc cgggctttaa cgtggtgatg 720
gtgaaggatg gcaaactgag tagcccgagc cgtaatgccc tgccgggtat tacacgtctg 780
accgtgatgg agatggccga tgaaatgggc atcgaattca ccctgcgcga tatcaccagc 840
cgtgagttat atgaggccga cgaactgatc gccgtgacca ccgcaggtgg cattaccccg 900
attaccagtc tggatggcga accgctgggc gatggtaccc ctggtcctgt gacagtggcc 960
attcgcgatc gcttttgggc catgatggat gagccgagca gtctggtgga ggccattgaa 1020
tattaa 1026
<210> 59
<211> 1026
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 59
atgaccatta gcaaagacat tgactatagc accagcaacc tggtgagtgt ggccccgggt 60
gcaatccgtg aacctacccc ggcaggcagc gtgatccagt acagtgacta cgagctggat 120
gaaagcagcc cgtttgccgg tggtgcagcc tggattgaag gtgagtatgt tccggcagca 180
gaggcccgta ttagcctgtt tgataccggc ttcggccata gcgatgcgac ctacagcgtt 240
gcccatgttt ggcacggcaa catctttcgc ctgaaagacc acattgaccg cgtgtttgat 300
ggcgcccaga aactgcgtct gcagagcccg ctgaccaagg ccgaagtgga ggatattacc 360
aaacgctgcg tgagcctgag tcagctgcgc gagagcttcg tgaacatcac cattacccgc 420
ggttatggcg cccgcaaagg cgagaaagat ctgagcaaat taaccagcca gatctacatc 480
tacgccatcc cgtacctgtg ggcctttcct ccggaagagc agatcttcgg tacaagtgcc 540
attgtgccgc gtcatgttcg tcgcgcaggc cgtaataccg ttgatcctac cgttaagaac 600
taccagtggg gtgatctgac cgcagcttct tttgaagcaa aagatcgtgg cgcccgcacc 660
gcaatcctgc tggatgcaga caactgtgtg gccgagggtc cgggctttaa cgtggtgatg 720
gtgaaggatg gcaaactgag tagcccgagc cgtaatgccc tgccgggtat tacacgtctg 780
accgtgatgg agatggccga tgaaatgggc atcgaattca ccctgcgcga tatcaccagc 840
cgtgagttat atgaggccga cgaactgatc gccgtgacca ccggaggtgg cattaccccg 900
attaccagtc tggatggcga accgctgggc gatggtaccc ctggtcctgt gacagtggcc 960
attcgcgatc gcttttgggc catgatggat gagccgagca gtctggtgga ggccattgaa 1020
tattaa 1026
<210> 60
<211> 1026
<212> DNA
<213> 放线菌(Actinobacteria sp.)
<400> 60
atgaccatta gcaaagacat tgactatagc accagcaacc tggtgagtgt ggccccgggt 60
gcaatccgtg aacctacccc ggcaggcagc gtgatccagt acagtgacta cgagctggat 120
gaaagcagcc cgtttgccgg tggtgcagcc tggattgaag gtgagtatgt tccggcagca 180
gaggcccgta ttagcctgtt tgataccggc ttcggccata gcgatgcgac ctacaccgtt 240
gcccatgttt ggcacggcaa catctttcgc ctgaaagacc acattgaccg cgtgtttgat 300
ggcgcccaga aactgcgtat acagagccag ctgaccaagg ccgaagtgga ggatattacc 360
aaacgctgcg tgagcctgag tcagctgcgc gagagcttcg tgaacatcac cattacccgc 420
ggttatggcg cccgcaaagg cgagaaaggt ctgagcaaat taaccagcca gatctacatc 480
tacgccatcc cgtacctgtg ggcctttcct ccggaagagc agatcttcgg tacaagtgcc 540
attgtgccgc gtcatgttcg tcgcgcaggc cgtaataccg ttgatcctac cgttaagaac 600
taccagtggg gtgatctgac cgcagcttct tttgaagcaa aagatcgtgg cgcccgcacc 660
gcaatcctgc tggatgcaga caactgtgtg gccgagggtc cgggctttaa cgtggtgatg 720
gtgaaggatg gcaaactgag tagcccgagc cgtaatgccc tgccgggtat tacacgtctg 780
accgtgatgg agatggccga tgaaatgggc atcgaattca ccctgcgcga tatcaccagc 840
cgtgagttat atgaggccga cgaactgatc gccgtgacca ccgcaggtgg cattaccccg 900
attaccagtc tggatggcga accgctgggc gatggtaccc ctggtcctgt gacagtggcc 960
attcgcgatc gcttttgggc catgatggat gagccgagca gtctggtgga ggccattgaa 1020
tattaa 1026