CN107823627A - A kind of application of reduced glutathione in preparing treatment diabetes and smearing medicament - Google Patents
A kind of application of reduced glutathione in preparing treatment diabetes and smearing medicament Download PDFInfo
- Publication number
- CN107823627A CN107823627A CN201711251318.7A CN201711251318A CN107823627A CN 107823627 A CN107823627 A CN 107823627A CN 201711251318 A CN201711251318 A CN 201711251318A CN 107823627 A CN107823627 A CN 107823627A
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- CN
- China
- Prior art keywords
- medicament
- reduced glutathione
- application
- bag
- diabetes
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Abstract
The invention discloses a kind of application of reduced glutathione in preparing treatment diabetes and smearing medicament, the medicament that smears is the bag and thing that cyclodextrin bag and reduced glutathione are prepared.The present invention, change the traditional treatment method of reduced glutathione, using the therapeutic modality of painting type, it is easy to use, test proves that, effectively it can produce effect in affected part, ulcer, the infection aspect triggered to diabetes has the effect of very notable, application and therapy field newly-increased and that expanded reduced glutathione, the practical application mode of initiative is provided for current medical treatments, has highly important directive significance.
Description
Technical field
The present invention relates to preparing to treat diabetes medicine, more particularly to a kind of reduced glutathione is preparing treatment sugar
Urine foot disease smears the application in medicament.
Background technology
Diabetic because merge DPN and it is various in various degree peripheral vessel lesion can cause foot soft tissue and
The destruction of osteoarticular system and deformity, trigger diabetes, and serious meeting produces ulcer, infection.15% diabetic can
Pedopathy can occur, and 85% patient's amputation reason is ulcer of foot.
At present, it is operation wound clearing to treat diabetes to trigger ulcer, the major way of infection, is had very big traumatic.
And on reduced glutathione (GSH) for treating diabetes effect be also limited to diabetic neuropathy, diabetic nephropathy,
The treatment of the complication such as diabetic fatty liver.Main reason is that the reduced form paddy such as current intravenous injection, capsule, tablet
The sweet peptide formulation of Guang, because the half-life period of GSH in blood is shorter, therefore, it is small that these formulations reach periphery after being absorbed by the body
During blood vessel, effect almost all loses, therefore can not play effective therapeutic effect.
Chinese invention patent CN102100904B discloses a kind of reduced glutathione percutaneous absorption preparation and its preparation
Method, there is the advantages of rapid-action, long half time, high bioavilability, easy to use, no pain.But the patent of invention is not
Disclose its treatment that can be used for diabetes.
The content of the invention
The technical problems to be solved by the invention are how reduced glutathione (GSH) is preparing treatment diabetes painting
The problem of being applied in foam medicament.
In order to solve the above-mentioned technical problem, the technical solution adopted in the present invention is to provide a kind of reduced glutathione and existed
Prepare treatment diabetes and smear application in medicament, it is described smear medicament as cyclodextrin bag and reduced glutathione prepare and
Into bag and thing.
In such scheme, the molar composition ratio of Subjective and Objective is 1 in the bag and thing:1 or 1:2.
In such scheme, the cyclodextrin is α, β, γ cyclodextrin and its derivative.
In such scheme, detailed directions are as follows:After physiological saline debridement, medicament, volume and the surface of a wound face of medicament are extracted
Product is directly proportional, and is used in 9cm per 1mL medicaments2Wound area on, uniformly smear affected part, the surface of a wound is not added with covering after coating, daily
Twice, continuous 2 weeks~4 weeks.
The present invention, the traditional treatment method of reduced glutathione is changed, using the therapeutic modality of painting type, user
Just, test proves that, effect effectively can be produced in affected part, ulcer, the infection aspect triggered to diabetes has very aobvious
The effect of work.
Embodiment
The present invention is described in detail with reference to embodiment.
First, reduced glutathione as a kind of antioxidant has the function that fibrocyte can be promoted to generate.It is logical
Cyclodextrin bag is crossed with after, smears the affected part for being covered in diabetes, cyclodextrin forms layer protecting film in affected part, completely cut off the external world
Air, bacterium can be avoided to invade.Meanwhile the pH value for smearing medicament is 5.5~6.6, affected part is kept a kind of weak acid environment,
The growth of bacterium is inhibited, so as to be effectively facilitated affected part healing.
The reduced glutathione percutaneous absorption preparation that the present invention is proposed based on Chinese invention patent CN102100904B,
Substantial amounts of research and experiment, composite score have been carried out in terms for the treatment of diabetes, it was demonstrated that this smears medicament in treatment glycosuria
There is good effect in terms of foot disease.
Bag and thing of the present invention to smear medicament, being prepared for cyclodextrin bag and reduced glutathione, prepare
Process is using cyclodextrin bag and technique, wherein the molar composition ratio of Subjective and Objective is 1 in bag and thing:1 or 1:2.
Wherein, cyclodextrin α, β, γ cyclodextrin and its derivative.
It is used for the experiment of diabetes for daubing medicament of the present invention below：
First, the heretofore described experiment for smearing medicament on treatment diabetes.
1. test method
Comprehensive treating diabetes, the situation of Control experiment patient are as follows：
Fasting blood-glucose ＜ 8.0mmol/L, 2h-plasma glucose ＜ 11.1mmol/L；Improve microcirculation, prevent general infection, it is right
Foot infection wound secretion carries out Bacteria Culture and drug sensitivity test, selects reasonable antibacterial drug therapy.
Therapeutic modality is：The use of 1ml of the present invention is 4 drops after debridement, surface of a wound area is 9cm2Within, uniformly smeared with cotton swab
At wound surface and surrounding skin.Twice daily, continuous 2 weeks~4 weeks.
2. evaluation criterion
Efficacy evaluation is carried out after treating 4 weeks；
Cure：Ulcer wound surface heals, and inflammatory resolution, blood fortune are normal；
Take a turn for the better：Ulcer area reduces ＞ 60%, and surface of a wound sign is obviously improved；
It is effective：Ulcer surface reduces 20%~60%, and surface of a wound sign part improves；
It is invalid：Ulcer area reduces ＜ 20%, and sign is not improved or even aggravated.
3. specific test result
4. interpretation of result
The reduced glutathione daubing medicament of the results showed that present invention more than changes reduced form gluathione
The traditional treatment method of peptide, it is easy to use using the therapeutic modality of painting type, test proves that, effectively it can be produced in affected part
Effect, there is the effect of very notable in terms of the ulcer triggered to diabetes, infection, increase and expanded reduced form gluathione newly
The application of peptide and therapy field, the practical application mode of initiative is provided for current medical treatments, had very heavy
The directive significance wanted.
The present invention is not limited to above-mentioned preferred forms, and anyone should learn that the knot made under the enlightenment of the present invention
Structure changes, and the technical schemes that are same or similar to the present invention, each falls within protection scope of the present invention.
Claims (4)
1. a kind of application of reduced glutathione daubing medicament in preparing treatment diabetes and smearing medicament, its feature exist
In the medicament that smears is the bag and thing that cyclodextrin bag and reduced glutathione are prepared.
2. application as claimed in claim 1, it is characterised in that the molar composition ratio of Subjective and Objective is 1 in the bag and thing:1 or
1:2。
3. application as claimed in claim 1, it is characterised in that the cyclodextrin is α, β, γ cyclodextrin and its derivative.
4. application as claimed in claim 1, it is characterised in that detailed directions are as follows:After physiological saline debridement, medicament is extracted,
The volume of medicament is directly proportional to surface of a wound area, and is used in 9cm per 1mL medicaments2Wound area on, uniformly smear affected part, coating
The surface of a wound is not added with covering afterwards, twice daily, continuous 2 weeks~4 weeks.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711251318.7A CN107823627A (en) | 2017-12-01 | 2017-12-01 | A kind of application of reduced glutathione in preparing treatment diabetes and smearing medicament |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711251318.7A CN107823627A (en) | 2017-12-01 | 2017-12-01 | A kind of application of reduced glutathione in preparing treatment diabetes and smearing medicament |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107823627A true CN107823627A (en) | 2018-03-23 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711251318.7A Pending CN107823627A (en) | 2017-12-01 | 2017-12-01 | A kind of application of reduced glutathione in preparing treatment diabetes and smearing medicament |
Country Status (1)
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| CN (1) | CN107823627A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2408207A (en) * | 2003-11-24 | 2005-05-25 | Johnson & Johnson Medical Ltd | Wound dressing for the controlled release of therapeutic agents comprising also an inhibitor of a protease enzyme & a linker group cleavable by such an enzyme |
| CN1753968A (en) * | 2003-01-27 | 2006-03-29 | 三菱商事株式会社 | Antioxidative composition and composition for external use |
| CN101969922A (en) * | 2008-01-16 | 2011-02-09 | 药物基因股份公司 | Method for stabilization of s-nitrosoglutathione and composition prepared by the same |
| CN102100904A (en) * | 2011-01-25 | 2011-06-22 | 成都卓阳生物科技有限公司 | Reduced glutathione percutaneous absorption preparation and preparation method thereof |
| CN105979975A (en) * | 2013-11-07 | 2016-09-28 | Bsn医疗有限公司 | Medical dressing |
| US20160338993A1 (en) * | 2015-05-21 | 2016-11-24 | The Regents Of The University Of California | Wound healing |
-
2017
- 2017-12-01 CN CN201711251318.7A patent/CN107823627A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1753968A (en) * | 2003-01-27 | 2006-03-29 | 三菱商事株式会社 | Antioxidative composition and composition for external use |
| GB2408207A (en) * | 2003-11-24 | 2005-05-25 | Johnson & Johnson Medical Ltd | Wound dressing for the controlled release of therapeutic agents comprising also an inhibitor of a protease enzyme & a linker group cleavable by such an enzyme |
| CN101969922A (en) * | 2008-01-16 | 2011-02-09 | 药物基因股份公司 | Method for stabilization of s-nitrosoglutathione and composition prepared by the same |
| CN102100904A (en) * | 2011-01-25 | 2011-06-22 | 成都卓阳生物科技有限公司 | Reduced glutathione percutaneous absorption preparation and preparation method thereof |
| CN105979975A (en) * | 2013-11-07 | 2016-09-28 | Bsn医疗有限公司 | Medical dressing |
| US20160338993A1 (en) * | 2015-05-21 | 2016-11-24 | The Regents Of The University Of California | Wound healing |
Non-Patent Citations (3)
| Title |
|---|
| BRADLEY P. MUDGE等: "Role of glutathione redox dysfunction in diabetic wounds", 《WOUND REPAIR AND REGENERATION》 * |
| MARY E. ANDERSON等: "Glutathione Monoesters", 《ANALYTICAL BIOCHEMISTRY》 * |
| 赵正保主编: "《有机化学》", 31 January 2016, 中国医药科技出版社 * |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180323 |